Resonance frequency analysis of osseo-integrated implants for bone conduction in a pediatric population – A novel approach for assessing stability for early loading

Objectives

The purpose of our study was to directly measure the stability of a bone anchored hearing device (BAHD) abutment using resonance frequency analysis (RFA) in a pediatric population. RFA was used to guide early loading of the abutment following single stage surgery.

Methods

The principle behind RFA is to obtain a numerical value relating to stability. A Smartpeg (1 cm commercially manufactured attachment) is screwed onto the abutment – its resonance in a magnetic field is measured with an Osstell recording device. The degree of movement (vibration) is inversely proportional to the stability of the abutment and a numerical figure, the Implant Stability Quotient (ISQ), is derived. RFA measurements were obtained at surgery, 4 weeks and 16 weeks post implant surgery. Patients were fitted with the new CochlearTM Baha^® BI300 series implant using a one-stage procedure and based on RFA stability measures, loading of the sound processor occurred any time from 1 week after implant surgery if the RFA measure was 60 units or over.

Results

Twenty two consecutive patients were recruited. Eight patients had bilateral BAHD's fitted giving a total of 30 implants. The age range was 2–16 years with an average age of 9 years at time of fitting. The time interval from surgery to loading the processor ranged from 1 to 16 weeks, with an average time of 6 weeks. The mean ISQ value at time of surgery was 61.29 (95% CI = 2.03), at 4 weeks was 61.92 (95% CI = 2.97) and at 16 weeks was 63.45 (95% CI = 3.18).

Conclusions

Our study shows we have been able to operate a successful program of earlier BAHD loading using single stage surgery in children. This is supported by favorable RFA measures of implant stability with average ISQ values of over 60 units.     

Tone burst stimulus for auditory brainstem responses: Prediction of hearing threshold at 1 kHz

Objective

To assess differences in hearing threshold estimation of four different ABR tone-bursts at 1 kHz.

Methods

Twenty-one (21) ears from 11 subjects were tested with pure-tone audiometry (PTA): 5 ears (24%) were normal hearing, 5 (24%) affected by mild hearing loss, 7 (33%) showed moderate hearing loss and 4 (19%) severe hearing loss. After PTA each subject underwent tone-burst ABR test at 1 kHz using a linear gated (L_ABR) or Blackman windowed (B_ABR) stimuli with (nn_ABR) and without ipsilateral notched noise. Stimulation rate and filters settings were unchanged.

Results

Overall correlation between PTA and all ABRs thresholds was high, ranging from 0.84 to 0.94. In normal hearing ears none of the differences was significant, except for those measured with B_nn_ABR, which showed a mean 16 dB overestimation of the pure-tone threshold (p < 0.05). In mild hearing loss group none of the differences between thresholds were significant. In moderate and severe hearing loss groups significant differences were measured with L_nn_ABR (p < 0.05) with a mean 7.5 dB underestimation of PTA.

Conclusions

Although very similar, some significant differences were found when considering specific group of patients with different degrees of hearing loss.     

BAHA results in children at one year follow-up: A prospective longitudinal study

Objective

To evaluate audiometric and clinical results of children fitted with a bone-anchored hearing aid with specific emphasis on speech discrimination in different sound environments after one year of use.

Methods

We performed a prospective longitudinal study. Seventeen patients between the ages of 5 and 18 years old were included. All patients underwent a complete tonal and vocal evaluation at four pre-determined intervals between the pre-operative period and one-year of bone-anchored hearing aid (BAHA) use. Basic pure-tone average and speech reception threshold were measured in different sound environments. Speech discrimination improvement was tested with the voice originating from the side of the BAHA-fitted ear and with the voice originating from a source directly in front of the patient. These measures were repeated with confounding noise facing the patient then from the side of the affected ear. All tonal and vocal evaluations were performed pre-operatively, the day of processor insertion, 6 months and 12 months after processor insertion.A variance analysis was performed to compare differences in hearing gain with BAHA over time.

Results

Hearing gain with BAHA was clinically and statistically significant at all intervals. Conventional tonal evaluation revealed significantly improved hearing gain after BAHA insertion compared with pre-operative testing with BAHA (26.3 dB vs. 17.3 dB), and this improvement was maintained at one year (27.9 dB). Speech discrimination gain at one year was better than immediately post-insertion (21.9% vs. 11.7%). Maximal gain with BAHA was found with the voice originating from the side of the affected ear and with confounding noise facing the patient (27.1% at one year), whereas the least gain was found in a silent room with the voice coming from straight ahead (11.9% at one year).

Conclusions

Pure-tone average gain at one year post-insertion was similar to immediate post-insertion gain. BAHA aids speech discrimination most when the voice originates from the side of the affected ear with confounding noise facing the patient. Speech discrimination gain improves with time, suggesting an underlying learning process. The best BAHA gain in speech discrimination occurred with background noise.     

A cohort study of patients with tinnitus and sensorineural hearing loss in a Swedish population

Objective

We aimed to describe a large cohort of patients with tinnitus and sensorineural hearing loss (SNHL) in Sweden, and also to explore the possibility of finding potential possible differences between various diagnoses within SNHL. It is also of great interest to see how a multidisciplinary team was used in the different subgroups and the frequency of hearing aids use in patients with tinnitus.

Methods

Medical records of all patients who had received the diagnosis SNHL in Östergötland County, Sweden between 2004 and 2007 were reviewed. Patients between 20 and 80 years with tinnitus and a pure tone average (PTA) lower than 70 dB HL were included in the study. Patients were excluded from the analyses if they had a cochlear implantation, middle ear disorders or had a hearing loss since birth or childhood. The investigators completed a form for each included patient, covering background facts, and audiograms taken at the yearly check up.

Results

Of a total 1672 patients’ medical record review, 714 patients were included. The majority of patients (79%) were in the age group over 50 years. In male patients with bilateral tinnitus, the PTA for the left ear was significantly higher than for the right ear. The results regarding the configuration of hearing loss revealed that 555 patients (78%) had symmetric and 159 (22%) asymmetric hearing loss. Retrocochlear examinations were done in 372 patients and MRI was the most common examination.In all patients, 400 had no hearing aids and out of those 220 had unilateral tinnitus and 180 patients had bilateral tinnitus. 219 patients had a PTA > 20 dB HL and did not have any hearing aid. Results demonstrated that the Stepped Care model was not used widely in the daily practice. In our study, patients with bilateral-, unilateral hearing loss or Mb Ménière were the most common patients included in the Stepped Care model.

Conclusion

In a large cohort of patients with SNHL and tinnitus, despite their hearing loss only 39% had hearing aids. It was observed that the medical record review often showed a lack of information about many background factors, such as; patients’ general health condition, which could be a quality factor that needs improvement. Our results show that the Stepped Care model could be an effective option for providing a better access for tinnitus-focused treatment, although the number of patients in this study who were included in the Stepped Care model was low.     

The audiological characteristics of a hereditary Y-linked hearing loss in a Chinese ethnic Tujia pedigree

Objective

To investigate audiometric characteristics of hearing loss in a large Chinese ethnic Tujia family and determine its hereditary type.

Methods

Total 76 live individuals were investigated in the notable 84 members of this family. The detailed audiometric evaluations were undertaken for the proband and his 47 family members. The degrees of sensorineural hearing impairment were defined as an air/bone gap <15 dB hearing loss averaged over 0.5, 1 and 2 kHz. The severity of hearing loss was established based on the hearing ability of the better ear, averaged over 0.5, 1, 2 and 4 kHz, and classified into four categories: mild, moderate, severe and profound.

Results

Nineteen patrilineal relatives of the 76 live members had hearing impairment. The age of onset ranged from 7 to 21 years old with the average of 13.2 years. The audiometric defect was described by auditory curves of a high frequency in 47% of the patients. Affected members in this family demonstrated a non-syndromic, late onset, bilateral, symmetrical, postlingual and sensorineural hearing loss.

Conclusions

The audiometric configuration in males of the pedigree is consistent with the hereditary Y-linked hearing loss. Thus we speculate that a putative gene on the Y chromosome could contribute to the cause of the disease.     

Fully implantable hearing device with transducer on the round window as a treatment of mixed hearing loss

Objective

To demonstrate the safety and efficacy of the Otologics Carina Middle Ear Transducer for treatment of mixed hearing loss through a case report.

Methods

A Carina fully implantable device with the MET transducer for conductive applications was implanted in a 48-year-old woman suffering from right mixed hearing loss (mean PTA loss: 80 dB). A facial recess approach was used to access the middle ear. Sclerotic tissue obliterated the stapes footplate so the approach selected was to place the transducer directly on the round window. The mounting bracket was placed on the mastoid and the prosthesis was advanced toward the round window until the Otologics surgical software indicated contact. Effective stimulation of the cochlea was confirmed intraoperatively by ABR monitoring.

Results

Postoperative unaided PTA thresholds were unchanged after surgery. When the implant was activated, the mean PTA functional gain was 39 dB.

Discussion-conclusion

The capability of the Carina MET Ossicular stimulator to provide appropriate gain relative to the degree of hearing loss indicates that the device offers a viable treatment option for mixed hearing loss. However, these promising initial results establish the need for future work on two fronts: (1) further studies are needed including a greater number of patients to confirm these preliminary results; (2) a long term follow-up must be carried out to detect any possible cochlear adverse effects on the cochlea, in particular on the basilar membrane.     

Long-term deterioration of bone-conduction hearing level in patients with labyrinthine fistula

Objective

Although many reports describe the short-term hearing outcomes of surgically managed labyrinthine fistulae, the long-term results remain unknown. We reviewed the long-term postoperative hearing outcomes of 14 ears of patients with cholesteatoma and labyrinthine fistulae.

Methods

Between 1996 and 2010, 84 patients with cholesteatoma and labyrinthine fistula underwent tympanoplasty at Hyogo College of Medicine Hospital. Fistulae were located in the lateral semicircular canal in all patients and in the superior semicircular canal in one. Fourteen patients were followed up for more than 5 years.

Results

The postoperative air-bone gap was ≤10 dB in one patient, between 11 and 20 dB in seven, between 21 and 30 dB in four, and ≥31 dB in two. Mean bone-conduction hearing levels on the operated side had deteriorated by 3, −1 and −2 dB at 1, 2 and 4 kHz, respectively at 1 year postoperatively, and by 8, 6 and 2 dB at 1, 2 and 4 kHz, at 5 years postoperatively. Bone-conduction hearing levels at 1 and 2 kHz were significantly deteriorated at 5 years postoperatively, compared with baseline and 1 year (P < 0.05).     

Transcutaneous bone conductive implants in patients with conductive/mixed hearing loss: audiological outcomes in noise condition

Background: Recently, the use of transcutaneous bone conduction implants (BCIs) has been increased. However, scarce data about BCI hearing recovery in noise conditions have been reported.

Objectives: To investigate the audiological benefits obtained with transcutaneous BCI-Sophono Alpha System in noise conditions. To evaluate post-implantation clinical outcomes and patient satisfaction levels.

Materials and methods: Fourteen patients suffering from conductive or mixed hearing loss implanted with the Sophono Alpha System were evaluated. Patients underwent physical examination, free-field pure-tone and speech audiometry both in unaided and aided conditions. The matrix sentence test was employed with fixed noise at 65?dB, and with a fluctuating primary signal, in three different conditions of noise presentations (S0/N0, S0/Ncontra, S0/Nipsi).

Results: Hearing gain, expressed as the difference between pre-implant AC and post-implant SAS free field, was on average 26.7?dB. The unaided speech recognition score in quiet conditions had a mean value of 64.6%, and improved after SAS implantation, achieving mean values of 98.2%. SRT₅₀ with the matrix sentence test improved in all three conditions of noise presentation.

Conclusions: Sophono Alpha System devices represent a valid treatment option for hearing rehabilitation of patients with conductive or mixed hearing loss. The audiological results regarding hearing gain in noise conditions were good.     

Bone-anchored hearing aids (Baha) in congenital aural atresia: personal experience

Aims

Aural atresia is a congenital disease constituted by partial or complete lack of development of the external auditory canal, which is generally associated with malformations of the auricle and middle ear.Reconstruction of the auditory canal and correction of any deformities of the middle ear have yielded unpredictable results and variable functional outcomes, and there is a high rate of complications. Therefore, the use of bone-conduction hearing aids, such as the Baha, may represent a valid alternative for subjects who have conductive hearing loss with cochlear reserve that, as a rule, is fully conserved.The aim of this work is to reexamine our experience with the management of conductive and mixed hearing loss using the Baha system in children with bilateral aural atresia.

Methods

We examined 31 patients with bilateral congenital aural atresia in whom a Baha system had been implanted. The patients, 16 males and 15 females, were between 5 and 14 years of age (mean 8.7).The following parameters were assessed for each patient: mean preoperative air and bone conduction for frequencies between 0.5 and 4 kHz; mean preoperative threshold with conventional bone-conduction hearing aids; mean postoperative threshold with the Baha system; improvement in quality of life evaluated with the Glasgow Children's Benefit Inventory; rate and type of surgical complications.

Results

The mean preoperative air- and bone-conduction thresholds were 51.2 ± 12.5 and 14.1 ± 6.3 dB HL, respectively. The mean preoperative threshold with a conventional bone-conduction hearing aid was 29.3 ± 7.2 dB HL, and the mean postoperative threshold with the Baha system was 18.1 ± 7.5 dB HL. Quality of life improved for all operated patients.

Conclusions

The results of our study of the Baha system to treat patients with bilateral aural atresia were extremely satisfactory compared both with those of surgical reconstruction of the auditory canal and those of traditional bone-conduction hearing aids. Furthermore, great improvement was noted in quality of life, while the rate of complications was very low.Therefore, we are convinced that the Baha system is the treatment of choice for hearing loss due to bilateral congenital aural atresia.     

Quantification of hearing loss associated with superior semi-circular canal dehiscence

Introduction

Superior semi-circular canal dehiscence (SSCD) is a known cause of hearing loss. This study quantifies hearing loss in SSCD ears in a frequency-specific fashion.

Methods

A meta-analysis of English language literature pertaining to SSCD was performed, with extraction and evaluation of available human audiometric data. Our own institution's case series of SSCD patients was also similarly analysed. Hearing loss in SSCD ears was compared to same patient control ears and to age-matched normative audiometric data.

Results

Ears with SSCD had statistically significant worse hearing as compared to both normative data and to own normal ear controls at 2000 Hz and below. The effect appears to diminish with increasing frequency.

Discussion

The presence of statistically significant conductive hearing loss in the low frequencies was confirmed for SSCD ears. SSCD may also predispose ears to high frequency sensorineural hearing loss.     

Edaravone,a free radical scavenger,in the treatment of idiopathic sudden sensorineural hearing loss with profound hearing loss

Objective

Edaravone, a free radical scavenger, is a clinical drug that is widely used to reduce neuronal damage after acute cerebral infarction in Japan since 2001. The aim of this study was to investigate whether edaravone could improve treatment result in idiopathic sudden sensorineural hearing loss (ISSHL) patients with severe hearing loss.

Methods

Between 2004 and 2006, 14 patients of ISSHL with the mean hearing levels equal or over 90 dB at the initial visit were treated with edaravone. 14 counterpart control patients were selected from 45 patients who had similar prognostic factors and were treated with hyperbaric oxygenation therapy (HBO) in the past decade.

Results

There were no significant differences between edaravone group and the control group in hearing recovery.

Conclusion

We considered that edaravone was not able to bring remarkable effect compared with conventional treatment regimen for ISSHL.     

Non-organic hearing loss in Chinese teenagers

Objective

To heighten the physician's awareness of non-organic hearing loss in teenagers in China.

Methods

Retrospective cases review of seven patients (six girls and one boy) with sudden hearing loss was conducted.

Results

Five patients presented with hearing loss bilaterally and two patients unilaterally. All patients suffered from severe to profound hearing loss. However, the acoustic reflex test indicated direct and indirect responses were present bilaterally at 1000 Hz 100 dB SPL. The results of ABR test revealed hearing threshold within 20–30 dB nHL. Further investigations indicated non-organic hearing loss was associated with school stress or environment conflict. Satisfactory outcomes were achieved in all patients.

Conclusion

Non-organic hearing loss should be considered when teenagers present with severe to profound sudden hearing loss if the acoustic reflex is present. School and home stresses are associated with the occurrence of non-organic hearing loss in the present study.     

Erratum to “Is sensorineural hearing loss with chronic otitis media due to infection or aging in older patients?” [Auris Nasus Larynx 36 (2009) 269–273]

Objective

To clarify true incidence of sensorineural hearing loss in ears with chronic otitis media (COM).

Methods

Bone conduction (BC) hearing thresholds of 180 preoperative patients (207 ears) with COM and 226 normal individuals (289 ears) were measured by audiometry, and the percentage of ears with BC thresholds being higher than normal range was evaluated in the COM group. In the COM group, the size of the perforation on the eardrum (n = 196) and the cross-sectional area of the mastoid air cells based on the axial CT image (n = 103) were also measured and correlated with the results of BC threshold.

Results

The percentage of ears with BC thresholds being higher than normal range calculated from comparison to the control group tended to increase with age, ranging from 4.5% in the 20s to 34.1% in the 60s with an average of 26.6%. The increase in the BC thresholds did not correlate with the size of eardrum perforation, but correlated well with the size of the mastoid air cells.

Conclusion

These results may suggest that all measures for early cure, including surgery, should be considered as early as possible for patients with COM.     

Effectiveness of a preventive campaign for noise-induced hearing damage in adolescents

Objectives

Many studies have documented a high incidence of hearing loss and tinnitus in adolescents after recreational noise exposure. The prevalence of noise-induced symptoms is in contradiction to the low preventive use of hearing protection. The effects of preventive campaigns on the attitudes toward noise in young people are under debate. The aim of the present study is to investigate whether a preventive campaign can alter attitudes toward noise in adolescents and whether this results in an increase of hearing protection use in this population.

Methods

A cohort of 547 Flemish high school students, aged 14 to 18 years old, completed a questionnaire prior to and after a governmental campaign focusing on the harmful effects of recreational noise and the preventive use of hearing protection. At both occasions the attitudes toward noise and toward hearing protection were assessed by use of the youth attitudes toward noise scale (YANS) and the beliefs about hearing protection and hearing loss (BAHPHL), respectively. These questionnaires fit into the model of the theory of planned behavior which provides a more clear insight into the prediction of a certain behavior and the factors influencing that behavior.

Results

The score on the YANS and the BAHPHL decreased significantly (p < 0.001) implying a more negative attitude toward noise and a more positive attitude toward hearing protection. The use of hearing protection increased significantly from 3.6% prior to the campaign to 14.3% (p = 0.001) post campaign in students familiar with the campaign.

Conclusions

Measurable alteration of all the variables in the theory of planned behavior caused an increase of the intentions to use hearing protection as well as the actual use of hearing protection. The present study shows the usefulness of the theory of planned behavior to change and guide adolescents’ preventive actions toward noise damage. In addition, preventive campaigns can establish attitude and behavioral adjustments. However, the long term effects of preventive campaigns should be investigated in future research.     

Otosclerosis: Incidence of positive findings on temporal bone computed tomography (TBCT) and audiometric correlation in Korean patients

Objective

To assess the incidence of otosclerotic foci identified by temporal bone computed tomography (TBCT) in Korean and to determine the correlation between the extent of otosclerotic foci and audiometric findings.

Methods

Thirty-one patients (37 ears) who were surgically confirmed otosclerosis and underwent preoperative TBCT scan were included. Patients underwent pre- and postoperative audiometric evaluation and TBCT. The mean air conduction (AC) thresholds and bone conduction (BC) thresholds, air–bone gap (ABG), and the difference between pre- and postoperative ABGs were determined. Otosclerotic foci were identified by the presence of hypodense lesions near the fissula ante fenestram and the otic capsule in the TBCT. The areas with hypodense lesions and the density ratio of the otosclerotic foci were compared by pre- and postoperative audiometric parameters.

Results

Hypodense lesions were identified by the TBCT in 27 out of 37 cases (73%). Fenestral types were found in 23 cases and combined fenestral and cochlear types in 4 cases. There was a significant correlation between the density ratio of the otospongiotic foci and the postoperative mean ABG (P = 0.03). However, there was no correlation between the size of the hypodense area and any of the audiometric parameters tested (P > 0.05).

Conclusion

The rate of positive TBCT findings for otosclerosis in our series was 73%. The extent of the hypodense lesion did not correlate with the preoperative hearing levels. However, the density ratio of the hypodense lesion influenced the surgical outcomes.     

A middle ear implant with a titanium canal wall prosthesis for a case of an open mastoid cavity

Objective

Open mastoid cavity rehabilitation should focus on both anatomical and functional aspects. We hereby report the technique and results of a combined strategy to reconstruct the external ear canal using a titanium wall implant and the middle ear using a fully implantable active middle ear device.

Methods

A fully implantable active middle ear implant was used to rehabilitate the mixed hearing loss of a 63-year-old woman, and a titanium posterior canal wall prosthesis was used to reconstruct the external ear canal during the same procedure. The middle ear implant was placed directly on the footplate. The auditory results were compared to the preoperative unaided thresholds and to the amplification of a conventional hearing aid.

Results

Following the procedure, there was an anatomically normal external ear canal with a healed tympanic membrane separating the external from the middle ear spaces. The postoperative auditory gains were on average 31.8 dB on pure-tone audiometry, and 20 dB on speech reception threshold. No complications occurred.

Conclusion

The rehabilitation of the external ear canal in an open mastoid cavity allows for clinical follow-up of the patient, and the implantation of an active middle ear implant provides appropriate auditory gains both in pure tones and in speech reception thresholds.     

Autism spectrum disorders in 24 children who are deaf or hard of hearing

Objectives

Approximately 4% of children who are deaf or hard of hearing have co-occurring autism spectrum disorder (ASD). Making an additional diagnosis of ASD in this population can be challenging, given the complexities of determining whether speech/language and social delays can be accounted for by their hearing loss, or whether these delays might be indicative of a comorbid ASD diagnosis. This exploratory study described a population of 24 children with the dual diagnosis of ASD and hearing loss.

Methods

Children completed a comprehensive ASD evaluation using standardized autism diagnostic instruments (Autism Diagnostic Observation Schedule, language and psychological testing). Children with permanent hearing loss who had a developmental evaluation between 2001 and 2011 and were diagnosed with an ASD based on the results of that evaluation were included. Information on communication modality, language and cognitive abilities was collected.

Results

The median age of diagnosis was 14 months (range 1–71) for hearing loss and 66.5 months (range 33–106) for ASD. Only 25% (n = 6) children were diagnosed with ASD ≤48 months of age and 46% by ≤6 years. Twelve (50%) children were diagnosed with ASD, 11 were diagnosed with pervasive developmental disorder not otherwise specified and 1 child had Asperger's. Most (67%) had profound degree of hearing loss. Fourteen (58%) children had received a cochlear implant, while 3 children had no amplification for hearing loss. Nine (38%) of the 24 children used speech as their mode of communication (oral communicators).

Conclusions

Communication delays in children who are deaf or hard of hearing are a serious matter and should not be assumed to be a direct consequence of the hearing loss. Children who received cochlear implants completed a multidisciplinary evaluation including a developmental pediatrician, which may have provided closer monitoring of speech and language progression and subsequently an earlier ASD diagnosis. Because children who are deaf or hard of hearing with ASD are challenging to evaluate, they may receive a diagnosis of ASD at older ages.     

Long-term follow-up of otitis media with effusion in children: Comparisons between a ventilation tube group and a non-ventilation tube group

Objective

The objective of this study was to investigate the long-term outcomes in children with otitis media with effusion who received either medical treatment or ventilation tubes.

Methods

We retrospectively analyzed the medical records of 89 bilateral cases of otitis media with effusion in children who were recommended to receive ventilation tube insertion and were followed up for more than 5 years. Tympanic membrane was inspected by otoscopic examination. Hearing was evaluated with pure tone audiometry. The mean duration of follow-up was 8.4 years (range, 5.2–15.7 years). Twenty-three children were treated without surgery, while 22 were treated once by ventilation tube insertion and 44 were treated more than once by ventilation tube insertion.

Results

At the fifth year of follow-up, both groups of children who underwent ventilation tube insertion had more frequent tympanic membrane abnormalities than the medication group (8.7% in those treated without surgery, 72.7% in those treated once by ventilation tube insertion, and 88.6% in those treated more than once by ventilation tube insertion). Common tympanic membrane abnormalities were retraction (27.0%) and tympanosclerotic plaque (23.6%), regardless of the treatment modality. At the fifth year follow-up, the average air-conduction threshold was 10.0 dB (± 6.5 dB) in patients treated without surgery, 15.9 dB (± 11.2 dB) in patients treated once by ventilation tube insertion, and 17.8 dB (± 7.6 dB) in those treated more than once by ventilation tube insertion. The audiological difference was significant when we compared the hearing level of children treated by medication without surgery to the two ventilation tube groups.

Conclusion

Though ventilation tube insertion can resolve hearing loss quickly, there were more tympanic membrane abnormalities and a decline in hearing levels in our ventilation tube insertion group vs. the observation group measured 5 years later. Physicians should therefore be cautious when applying a ventilation tube in patients with otitis media with effusion and should explain the risks to patients who are a candidate for repeated ventilation tube insertion.     

Sudden Sensorineural Hearing Loss: Results of intratympanic steroids as salvage treatment

Objective

The aim of the present study was to verify the efficacy and the safety of intratympanic dexamethasone to treat sudden sensorineural hearing loss as salvage therapy.

Materials and methods

A prospective study was conducted on patients affected by idiopathic sudden hearing loss who were treated before with some systemic therapy, but without recovery of the hearing The patients able to undergo the study, but who refused salvage treatment were considered as control group. A solution of Dexamethasone 4 mg/ml was then injected through the posterior–inferior quadrant filling completely the middle ear. The follow-up in the following 6 months included an audiogram every month.

Results

The number of patients treated with salvage therapy was 36. The patients who refused treatment were further 10. The salvage treatment was done with a mean delay of 24.3 days from the onset of symptoms. Mean hearing threshold after the onset of sudden hearing loss at PTA was 66.5 dB. After the failed treatment the mean PTA was 59.6 dB. The mean PTA after the intratympanic steroid administration was 46.8 dB, with a mean improvement of 12.8 dB. No hearing change was noted in the 10 patients who refused salvage therapy. The patients that assumed systemic steroid as first therapy showed a better PTA threshold after the salvage intratympanic treatment (p < 0.01). A significant difference (p < 0.05) of hearing recovery was evidenced between non-smoker patients and those with smoking habit.

Conclusions

Our data showed that a salvage treatment with intratympanic dexamethasone should be suggested to all patients who failed the first systemic treatment. The systemic steroid therapy done before the salvage treatment seems to exert a protective role for the inner ear, as shown by our series. On the contrary the smoke habit is a negative prognostic factor in the hearing recovery.