共查询到20条相似文献,搜索用时 15 毫秒
1.
Hong-Guang Jin Qinglong Jin A. Ryun Kim Hyemin Choi Je Hyun Lee Yeong Shik Kim Dong Gun Lee Eun-Rhan Woo 《Archives of pharmacal research》2012,35(11):1919-1926
A new triterpenoid, named alisol Q 23-acetate, as well as fourteen known terpenes, alisol B 23-acetate (2), alisol B (3), alismol (4), 10-O-methyl-alismoxide (5), alismoxide (6), 11-deoxyalisol C (7), 13??,17??-epoxyalisol B 23-acetate (8), 4??,12-dihydroxyguaian-6,10-diene (9), alisol C 23-acetate (10), alisolide (11), 16??-methoxyalisol B monoacetate (12), alisol A (13), 16??-hydroxyalisol B 23-acetate (14), alisol A 24-acetate (15) were isolated from the rhizomes of Alisma orientale. The structures of compounds (1?C15) were identified based on 1D and 2D NMR, including 1H-1H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Among these isolates, antibacterial effect of compounds 2, 3, 10, and 15, major constituents of A. orientale was examined. The MIC values of compounds 2, 10, and 15 were 5?C10 ??g/mL against eight antibiotic resistant strains, which were lower than those from the positive controls (MICs of chloramphenicol and ampicillin were 5?C80 ??g/mL). Therefore, compounds 2, 10 and 15 exhibited the potent antibacterial activity. 相似文献
2.
Yeun-Kyung Lee Chang-Seob Seo Chong-Soon Lee Kyong-Seon Lee Shin-Jung Kang Yurngdong Jahng Hyun Wook Chang Jong-Keun Son 《Archives of pharmacal research》2009,32(10):1409-1415
Thirteen lignans, erythro-austrobailignan-6 (1), meso-dihydroguaiaretic acid (2), sauchinone (3), 1′-epi-sauchinone (4), saucerneol D (5), manassantin B (6), manassantin A (7), nectandrin B (8), machilin D (9), saucerneol F (10), saucerneol G (11), saucerneol H (12) and saucerneol I (13), were isolated from the ethyl acetate extract of the roots of Saururus chinensis. Among these compounds, 5 showed potent inhibitory activities against DNA topoisomerase I and II, and 5, 6, 7 and 10 showed mild cytotoxicities against HT-29 (IC50 values; 13, 12, 11, and 10 µM, respectively) and HepG2 cell lines (IC50 values; 16, 11, 12, and 11 µM, respectively). 相似文献
3.
Jia Xian Zhu Jie Ren Jiang Jiang Qin Xiang Rong Cheng Qi Zeng Fei Zhang Shi Kai Yan Hui Zi Jin Wei Dong Zhang 《Archives of pharmacal research》2012,35(10):1739-1747
A new phenylpropanoid derivative (1), along with five phenylpropanoids (2–6), two monoepoxy lignans (8–9), one bisepoxy lignan (10), two cyclolignans (11–12), six neolignans (7, 13–17), two mixed lignan-neolignans (18–19), two lignan glycosides (20–21), and four flavonolignans (22–25), were isolated from the stems and twigs of Euonymus acanthocarpus. Compounds 2–3, 6–8, 12, and 14–25 were obtained from Celastraceae family for the first time, and compounds 5 and 9 were isolated from Euonymus genus for the first time. All the compounds were tested for cytotoxicity against SK-OV-3 and MCG-803 human tumor cell lines. Compounds 3, 10, 12, and 18 showed weak cytotoxicity against SK-OV-3 cell line, and compounds 3–4, 10–13, and 19 showed weak cytotoxicity against MCG-803 cell line. 相似文献
4.
Nawal M. Al-Musayeib Gamal A. Mohamed Sabrin R. M. Ibrahim Samir A. Ross 《Medicinal chemistry research》2013,22(11):5297-5302
A new triterpene ester (1) together with eight known compounds (2–9) were isolated from the leaves of Cadaba farinosa Forssk. Their chemical structures were established on the basis of physical, chemical, and spectroscopic methods (IR, 1D and 2D NMR, and mass spectral analyses) to be: lupeol-3-O-decanoate (1), lupeol (2), β-sitosterol (3), ursolic acid (4), 12-aminododecanoic (5), dillenetin-3-O-β-d-glucopyranoside (6), stachydrine (7), 3-hydroxy-stachydrine (8), and quercetin-3-O-β-d-glucopyranoside (9). That is the first report for the isolation of compound 5 from a plant source. Compounds 5, 6, and 9 were evaluated for their antioxidant activity. 相似文献
5.
Nantiya Joycharat Sonesay Thammavong Surasak Limsuwan Sirilux Homlaead Supayang Piyawan Voravuthikunchai Boon-ek Yingyongnarongkul Sukanya Dej-adisai Sanan Subhadhirasakul 《Archives of pharmacal research》2013,36(6):723-730
Albizia myriophylla has been used for long by Thai traditional healers as an important ingredient herb in Thai herbal formulas for caries. In this study, three flavonoids lupinifolin (6), 8-methoxy-7,3′,4′-trihydroxyflavone (7), and 7,8,3′,4′-tetrahydroxyflavone (8), a triterpenoid lupeol (3) as well as four sterols β-sitosterone (1), stigmasta-5,22-dien-3-one (2), β-sitosterol (4), and stigmasterol (5) were isolated from A. myriophylla wood. The antibacterial activity of these compounds against Streptococcus mutans ATCC 25175 was performed using broth microdilution method. All compounds exhibited antibacterial activity against S. mutans with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) ranging from 1–256 and 2–256 μg/ml, respectively. Among the isolated compounds, lupinifolin (6) was found to be the most potent with MIC and MBC of 1 and 2 μg/ml, respectively. Lupinifolin (6) also showed a strong activity against ten clinical isolates of S. mutans with MIC and MBC ranging from 0.25–2 and 0.5–8 μg/ml, respectively. These results reported the bioactive ingredients of A. myriophylla which support its ethnomedical claims as well. Lupinifolin (6) may have a potential to be a natural anticariogenic agent. 相似文献
6.
Kazumasa Zaima Ikumi Koga Nobuhide Iwasawa Takahiro Hosoya Yusuke Hirasawa Toshio Kaneda Intan Safinar Ismail Nordin Hj Lajis Hiroshi Morita 《Journal of natural medicines》2013,67(1):9-16
The aim of this study was to search for bioactive natural products from medicinal plants targeting vasorelaxant activity and we found the methanol extract from bark of Tabernaemontana dichotoma showed vasorelaxant activity on rat aorta. We isolated eight indole alkaloids including 10-methoxyalstonerine (1), a new macroline type indole alkaloid, from bark of T. dichotoma. These were respectively identified as 10-methoxyaffinisine (2), lochnerine (3), cathafoline (4), (?)-alstonerine (5), 19,20-dehydro-10-methoxytalcarpine (6), alstonisine (7), and alstonal (8) based on spectroscopic analysis. Among them, sarpagine type (2 and 3), akuammiline type (4), and macroline oxindole type (7 and 8) showed potent vasorelaxant activity. Mechanism of action on vasorelaxant activity of 10-methoxyaffinisine (2), cathafoline (4), and alstonisine (7) was clarified. Effects of 10-methoxyaffinisine (2), cathafoline (4), and alstonisine (7) were partially mediated the NO release from endothelial cells. Furthermore, 10-methoxyaffinisine (2) and alstonisine (7) attribute to the inhibitory effect of VDC and ROC, and cathafoline (4) have inhibitory effect on Ca2+ influx via ROC. In addition, 10-methoxyaffinisine (2) as a major compound from bark of T. dichotoma showed hypotensive effect on normotensive rats in vivo. 相似文献
7.
Chiobouaphong Phakeovilay Wannaporn Disadee Poolsak Sahakitpichan Somkit Sitthimonchai Prasat Kittakoop Somsak Ruchirawat Tripetch Kanchanapoom 《Journal of natural medicines》2013,67(1):228-233
A new phenylethanoid glycoside, isocassifolioside (8), and two new flavone glycosides, hispidulin 7-O-α-l-rhamnopyranosyl-(1′″ → 2″)-O-β-d-glucuronopyranoside (11) and pectolinaringenin 7-O-α-l-rhamnopyranosyl-(1′″ → 2″)-O-β-d-glucuronopyranoside (12) were isolated from the aerial portions of Ruellia tuberosa L., together with verbascoside (1), isoverbascoside (2), nuomioside (3), isonuomioside (4), forsythoside B (5), paucifloside (6), cassifolioside (7), hispidulin 7-O-β-d-glucuronopyranoside (9) and comanthoside B (10). The structure elucidations were based on analyses of chemical and spectroscopic data including 1D- and 2D-NMR. The isolated compounds 1–12 exhibited radical scavenging activity using ORAC assay. 相似文献
8.
Two novel steroidal saponins designated as spicatosidesA(1) andB(2) were isolated from the tubers ofLiriope spicata and their structures were clucidated as 25(S)-ruscogenin-1-O-β-D-glucopyranosyl (1→2)-[β-D-xylopyranosyl (1→3)]-β-D-fucopyranoside (1) and 26-O-β-D-glucopyranosyl 25(S)-22-O-methyl-furost-5-en-1β, 3β, 26-triol 1-O-β-D-glucopyranosyl (1→2)-[β-D-xylopyranosyl (1→3)]-β-D-fucopyranoside (2), respectively. 相似文献
9.
Wei Li Ya Nan Sun Xi Tao Yan Seo Young Yang Sohyun Kim Young Mi Lee Young-Sang Koh Young Ho Kim 《Archives of pharmacal research》2014,37(2):186-192
Radix Astragali (Astragalus membranaceus) is an important traditional Chinese medicine that is widely used as a tonic to enhance the body’s natural defense mechanisms. In this phytochemical study, 12 flavonoids, isoliquiritigenin (1), liquiritigenin (2), calycosin (3), calycosin 7-O-β-d-glucoside (4), formononetin (5), formononetin 7-O-β-d-glucoside (6), daidzein (7), daidzein 7-O-β-d-glucoside (8), methylnissolin (9), methylnissolin 3-O-β-d-glucoside (10), isomucronulatol (11), and isomucronulatol 7-O-β-d-glucoside (12), were isolated from the roots of A. membranaceus. Their structures were elucidated by comparing spectroscopic data with reported values. The effects of the isolated compounds on lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells were investigated. Compounds 1 and 2 exhibited significant inhibitory effects on LPS-induced IL-6 and IL-12 p40 production, with IC50 values ranging from 2.7 to 6.1 μM. Compound 1 also showed a moderate inhibitory effect on LPS-stimulated production of TNF-α with an IC50 value of 20.1 μM. Further studies of the potential anti-inflammatory effects and benefits of flavonoids from A. membranaceus are warranted. 相似文献
10.
Hyun Gyu Choi Yeon Ho Choi Ji Hyang Kim Hui-Hun Kim Sang-Hyun Kim Jeong Ah Kim Sang Myung Lee MinKyun Na Seung Ho Lee 《Archives of pharmacal research》2014,37(4):467-472
A new neolignan, linderin A (1), together with six known lignans, (+)-xanthoxyol (2), pluviatilol (3), actiforin (4), (+)-syringaresinol (5), (+)-(7S,8R,8′R)-acuminatolide (6), and (+)-9′-O-trans-feruloyl-5,5′-dimethoxylariciresinol (7) were isolated from the stems of Lindera obtusiloba Blume (Lauraceae). Their chemical structures were elucidated by a combination of spectroscopic analysis and chemical reaction, and the absolute configuration of 1 was determined by Mosher’s esterification. The effect of compounds 1–7 on tumor necrosis factor (TNF)-α, interleukin(IL)-6, and their inhibitory activity of histamine release were examined using human mast cells. Among the lignans tested, compounds 1, 3, 4, 6, and 7 inhibited release of histamine from mast cells. Especially, compounds 1 and 4 suppressed the gene expressions of pro-inflammatory cytokines, TNF-α, and IL-6 in human mast cells. Our findings suggest that the lignan constituents in L. obtusiloba may contribute to its anti-allergic inflammatory effects. 相似文献
11.
Zhang Jun Qing Wang Yong Li Yong Hui Lai Wei Yong Li Hai Long Duan Jin Ao Pei Li Xia 《Archives of pharmacal research》2012,35(12):2143-2146
Chemical investigation of the fruits of Alpinia oxyphylla led to an isolation of the two new natural products, 9-hydroxy epinootkatol (1) and (S)-2-pentanol-2-O-β-D-glucopyranoside (2), in addition to the nine known compounds, pinocembrin (3), tectochrysin (4), izalpinin (5), nookatone (6), yakuchinone A (7), protocatechuic acid (8), β-sitosterol (9), daucosterol (10) and β-sitosterol palmitate (11). Their structures were elucidated on the basis of physicochemical constants and NMR spectral data analysis. The effects of the isolated components on nitric oxide production in LPS-induced RAW 264.7 macrophages were examined. The two new natural compounds showed inhibitory activities with IC50 values of 21.8 and 32.8 μg/mL, respectively. 相似文献
12.
Naohiro Oshima Yuji Narukawa Tadahiro Takeda Fumiyuki Kiuchi 《Journal of natural medicines》2013,67(1):240-245
Fractionation of acetone and methanol extracts of Viola yedoensis, under the guidance of inhibition against Clostridium histolyticum collagenase (ChC), resulted in the isolation of esculetin (1) (IC50 12 μM) and scopoletin (2) (IC50 1.8 μM) as the active constituents, together with trans-p-coumaric acid (3), cis-p-coumaric acid (4), 3-O-β-d-glucosyl-7-O-α-L-rhamnosylkaempferol (5), rutin (6), isovitexin (7), isoorientin (8), vicenin-2 (9), isoscoparin (10), vanillic acid (11) and adenosine (12). Modification of phenolic hydroxy groups of 1 showed that small O-alkyl groups largely increased the activity, whereas larger O-alkyl groups decreased the activity, and 6,7-dimethoxycoumarin (scoparone 13) potently inhibited ChC (IC50 24 nM). 相似文献
13.
Mohamed A. El-Shanawany Hanaa M. Sayed Sabrin R. M. Ibrahim Marwa A. A. Fayed Mohamed M. Radwan Samir A. Ross 《Medicinal chemistry research》2013,22(5):2346-2350
A phytochemical study of the aerial parts of Blepharis ciliaris (L.) B.L. Burtt. led to the isolation of one new isoflavone glycoside caffeic acid ester: genistein-7-O-(6″-O-E-caffeoyl-β-d-glucopyranoside) (4), along with seven known compounds: methyl veratrate (1), methyl vanillate (2), protocatechuic acid (3), naringenin-7-O-(3″-acetyl-6″-E-p-coumaroyl-β-d-glucopyranoside) (5), naringenin-7-O-(6″-E-p-coumaroyl-β-d-glucopyranoside) (6), apigenin-7-O-(6″-E-p-coumaroyl-β-d-glucopyranoside) (7), and acteoside (8). Their structures were established on the basis of detailed analyses of physical, chemical, and spectral data. Compounds 1, 2, 3, 6, and 8 were isolated for the first time from this plant. The antioxidant activity of the different extracts as well as for some of the isolated compounds was evaluated. 相似文献
14.
Naphthoquinones from Catalpa ovata and their inhibitory effects on the production of nitric oxide 总被引:1,自引:0,他引:1
Byeong Min Park Seong Su Hong Chul Lee Moon Soon Lee Shin Jung Kang Yu Su Shin Jae-Kyung Jung Jin Tae Hong Youngsoo Kim Mi Kyeong Lee Bang Yeon Hwang 《Archives of pharmacal research》2010,33(3):381-385
Bioassay-guided fractionation of a CH2Cl2-soluble fraction of the stems of Catalpa ovata led to isolation of a new naphthoquinone, 4-hydroxy-2-(2-methoxy-3-hydroxy-3-methyl-but-1-enyl)-4-hydro-1H-naphthalen-1-one (10), together with nine known compounds, catalponol (1), catalponone (2), catalpalactone (3), α-lapachone (4), 9-hydroxy-α-lapachone (5), 4,9-dihydroxy-α-lapachone (6), 9-methoxy-α-lapachone (7), 4-oxo-α-lapachone (8), and 9-methoxy-4-oxo-α-lapachone (9). The structures were elucidated on the basis of spectroscopic analyses. The inhibitory effects of these isolates on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells were evaluated. Among them, catapalactone (3), 9-hydroxy-α-lapachone (5) and 4,9-dihydroxy-α-lapachone (6) exhibited potent inhibitory effects, with IC50 values of 9.80, 4.64 and 2.73 μM, respectively. 相似文献
15.
Usama W. Hawas Ahmed Atef El-Beih Ali M. El-Halawany 《Archives of pharmacal research》2012,35(10):1749-1756
The marine fungus Aspergillus versicolor was isolated from the inner tissue of the Red Sea green alga Halimeda opuntia. The fungus was identified by its morphology and 18s rDNA. Cultivation of this fungal strain led to a new metabolite named isorhodoptilometrin-1-methyl ether (1) along with the known compounds emodin (2), 1-methyl emodin (3), evariquinone (4), 7-hydroxyemodin 6,8-methyl ether (5), siderin (6), arugosin C (7), and variculanol (8). The structures were elucidated on the basis of NMR spectroscopic analysis and mass spectrometry. The biological properties of ethyl acetate extract and compounds 1–3 and 6–8 were explored for antimicrobial activity, anti-cancer activity and inhibition of Hepatitis C virus (HCV) protease. 相似文献
16.
Phan Van Kiem Nguyen Thi Mai Chau Van Minh Nguyen Huu Khoi Nguyen Hai Dang Nguyen Phuong Thao Nguyen Xuan Cuong Nguyen Hoai Nam Nguyen Xuan Nhiem Yvan Vander Heyden Joëlle Quetin-Leclercq Gyo Nam Kim Hae Dong Jang Young Ho Kim 《Archives of pharmacal research》2010,33(2):203-208
Two new 2-C-β-D-glucopyranosyl benzoic acid derivatives named mallonanosides A (1) and B (2) were isolated from the methanolic extract of the leaves of Mallotus nanus along with five known flavonoids, kaempferin (3), juglanin (4), quercitrin (5), myricitrin (6), and rhoifolin (7). Their structures were established on the basis of spectral and chemical evidence. Their antioxidant activities were shown to depend on the number of hydroxyl groups, and the location and species of sugar moiety. 相似文献
17.
G. Thirupathi M. Venkatanarayana P. K. Dubey Y. Bharathi Kumari 《Medicinal chemistry research》2014,23(3):1569-1580
l-Tyrosine is an efficient catalyst for the condensation of substituted indole-3-aldehydes 1(a–d), N-methyl indole-3-aldehydes 4(a–d), and N-ethyl indole-3-aldehydes 6(a–d) with meldrum’s acid (2) containing a cyclic active methylene group to produce 3(a–d), 5(a–d), and 7(a–d), respectively, in water at room temperature for 30 min. The antimicrobial activities of 3(a–d), 5(a–d), and 7(a–d) have been studied. 相似文献
18.
Deborah K. B. Runyoro Santosh K. Srivastava Mahendra P. Darokar Ngassapa D. Olipa Cosam C. Joseph Mecky I. N. Matee 《Medicinal chemistry research》2013,22(3):1258-1262
Combretum zeyheri Sond (Combretaceae) has been reported to exhibit anticandida activity against Candida kruzei, C. albicans, and C. parapsilosis; however, the active constituents have not been isolated so far. A bioactivity-guided fractionation of MeOH extract of C. zeyheri resulted in the isolation of triterpenoids, ursolic acid (1.1), oleanolic acid (1.2), maslinic acid (2.1), 2α,3β-dihydroxyurs-12-en-28-oic acid (2.2), 6β-hydroxymaslinic acid (3), and terminolic acid (4). These compounds were characterized on the basis of their 1D, 2D NMR, ESI-MS and FT-IR spectroscopic data. All the isolated compounds, 1.2, 2.1, 2.2, 3, and 4 except ursolic acid (1.1) are being reported for the first time from C. zeyheri. Later, the isolated triterpenoids (1–4) were evaluated for their anticandida activity against the three strains of C. albicans and all compounds showed anticandida activity of which terminolic acid (4) was most active. Furthermore, structure–activity relationship of isolated triterpenoids (1–4) was studied, which showed that triterpenoids of oleanane and ursane having 2α,3β,23-trihydroxyl group are more active. 相似文献
19.
A Ryun Kim Qinglong Jin Hong-Guang Jin Hae Ju Ko Eun-Rhan Woo 《Archives of pharmacal research》2014,37(7):845-851
A new biflavonoid, named asteryomenin (1), as well as six known phenolic compounds, esculetin (2), 4-O-β-d-glucopyranoside-3-hydroxy methyl benzoate (3), caffeic acid (4), isoquercitrin (5), isorhamnetin-3-O-glucoside (6), and apigenin (7) were isolated from the aerial parts of Aster yomena. The structures of compounds (1–7) were identified based on 1D and 2D NMR, including 1H–1H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Compounds 2–7 were isolated from this plant for the first time. For these isolates, the inhibitory activity of IL-6 production in the TNF-α stimulated MG-63 cell was examined. Among these isolates, compounds 4 and 7 appeared to have potent inhibitory activity of IL-6 production in the TNF-α stimulated MG-63 cell, while compounds 1–3 and 5–6 showed moderate activity. 相似文献
20.
You Jin Lee No Soo Kim Haejin Kim Jin-Mu Yi Se-Mi Oh Ok-Sun Bang Jun Lee 《Archives of pharmacal research》2013,36(5):536-541
A new sinapoyl glycoside, 1,3-di-O-sinapoyl-β-d-glucopyranose (1) along with 13 known compounds, including, sinapoyl glycosides (2 and 3), cardenolide glycoside (4), flavonoids (5–10), lignan (11), phenolic acids (12 and 13), and phytosterol (14), were isolated from the seeds of Descurainia sophia by chromatographic separation methods. The structures of 1–14 were determined by the interpretation of spectroscopic data as well as by comparison of that data with previously reported values. Compounds 2, 3, 5, 6, and 11 were identified in and isolated from this plant for the first time in this study. All isolates were evaluated for in vitro cytotoxic activities against seven human cancer cell lines and for in vitro anti-inflammatory potential using LPS-stimulated RAW264.7 murine macrophages. Compound 4 showed potent cytotoxicity (IC50 values ranging from 0.034 to 0.596 μM) against all human cancer cell lines tested and was identified as the main active cytotoxic constituent of this plant. Compound 8 (ED50 = 5.45 μM) and 11 (ED50 = 10.02 μM) exerted dose-dependent inhibitory effects on NO production in LPS-stimulated RAW264.7 cells. 相似文献