共查询到20条相似文献，搜索用时 15 毫秒
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The adverse consequences of heavy Trichuris infection 总被引：3，自引：0，他引：3
R H Gilman Y H Chong C Davis B Greenberg H K Virik H B Dixon 《Transactions of the Royal Society of Tropical Medicine and Hygiene》1983,77(4):432-438
Sixty-seven children with heavy Trichuris trichiura infection (Group A) were compared to 73 control children of similar socio-economic status but with light or no T. trichiura (Group B), for nutritional status, rates of concomitant bacterial and protozoal, and symptoms and clinical signs associated with heavy T. trichiura infection. Anoscopy was used to determine heavy T. trichiura infection. Measurements and physical examination were done on Group A on admission to and discharge from hospital; 46% were seen on follow-up visit two to eight months later. Children in Group B were seen only once. There were significant differences for nutritional status (p less than 0.01) and rates of bacterial and protozoal co-infection (p less than 0.01) and a significantly greater rate of invasive amoebiasis in Group A. After treatment, nutritional parameters of Group A children improved significantly, symptoms and clinical signs decreased and there was also a significant decrease in the rate of concomitant bacterial and protozoal infection. Subgroups of Group A children, with and without concomitant enteropathogens, revealed that infection with Entamoeba histolytica and bacterial enteropathogens had had no significant impact on clinical and nutritional status. 相似文献
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Jonathan T. Unkart Matthew A. Allison Michael H. Criqui Mary M. McDermott Alexis C. Wood Aaron R. Folsom Donald Lloyd-Jones Laura J. Rasmussen-Torvik Norrina Allen Gregory Burke Moyses Szklo Mary Cushman Robyn L. McClelland Christina L. Wassel 《American journal of preventive medicine》2019,56(2):262-270
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Mark Reinhard Jan Frystyk Else Randers Bo Martin Bibby Per Ivarsen 《Journal of renal nutrition》2018,28(3):175-182
Objective
Patients on maintenance hemodialysis (HD) are unable to compensate for an enlarged mineral load with increased excretion of calcium and phosphate in the urine. Hence, excess calcium and phosphate must be neutralized by other mechanisms to avoid toxicity. The present study examined the acute handling of a mineral load in HD patients as compared with healthy subjects.Design
Controlled intervention study.Subjects
Twelve HD patients and 12 matched healthy subjects.Intervention
After a weight-adjusted standardized meal, blood samples were collected for the following 9 hours for ionized calcium, phosphate, parathyroid hormone (PTH), and fibroblast growth factor-23 (FGF23). The fractional excretion of calcium and phosphate was measured in controls. The patients were not allowed to take phosphate binders 24 hours before the experiment, and the study was performed on a non-HD day.Results
In healthy subjects, plasma calcium and phosphate did not change significantly from baseline, whereas HD patients demonstrated a decrease in plasma phosphate from 60 to 120 minutes by maximum 10% ([6; 13%], mean [95% confidence interval], P < .001) below baseline. PTH increased in both HD patients and controls and peaked 300 minutes after the meal 11% ([4; 19%], P < .004) above baseline in both groups. No changes in FGF23 were observed in HD patients, whereas FGF23 steadily decreased in controls, reaching nadir values at the end of the study 16% ([10; 21%], P < .001) below baseline. Control subjects demonstrated an immediate postprandial increase in the fractional excretion of both calcium and phosphateConclusions
In HD patients, the mineral load paradoxically induced a decrease in plasma phosphate, whereas ionized calcium remained unchanged although PTH increased. These findings suggest that excess calcium and phosphate may be disposed of by mineral deposition, which may include soft tissue and vascular calcification. 相似文献16.
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Kimberly Narain Bevanne Bean-Mayberry Donna L. Washington Ismelda A. Canelo Jill E. Darling Elizabeth M. Yano 《Women's health issues》2018,28(3):267-272