共查询到20条相似文献,搜索用时 757 毫秒
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Tumor necrosis factor alpha blockade restores growth hormone signaling in murine colitis 总被引:2,自引:0,他引:2
DiFedele LM He J Bonkowski EL Han X Held MA Bohan A Menon RK Denson LA 《Gastroenterology》2005,128(5):1278-1291
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Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. 总被引:22,自引:0,他引:22
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J A Johnston C M Bacon D S Finbloom R C Rees D Kaplan K Shibuya J R Ortaldo S Gupta Y Q Chen J D Giri et al. 《Proceedings of the National Academy of Sciences of the United States of America》1995,92(19):8705-8709
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Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance 总被引:7,自引:0,他引:7
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Zhou J Wulfkuhle J Zhang H Gu P Yang Y Deng J Margolick JB Liotta LA Petricoin E Zhang Y 《Proceedings of the National Academy of Sciences of the United States of America》2007,104(41):16158-16163
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Schmierer B Tournier AL Bates PA Hill CS 《Proceedings of the National Academy of Sciences of the United States of America》2008,105(18):6608-6613
TGF-beta-induced Smad signal transduction from the membrane into the nucleus is not linear and unidirectional, but rather a dynamic network that couples Smad phosphorylation and dephosphorylation through continuous nucleocytoplasmic shuttling of Smads. To understand the quantitative behavior of this network, we have developed a tightly constrained computational model, exploiting the interplay between mathematical modeling and experimental strategies. The model simultaneously reproduces four distinct datasets with excellent accuracy and provides mechanistic insights into how the network operates. We use the model to make predictions about the outcome of fluorescence recovery after photobleaching experiments and the behavior of a functionally impaired Smad2 mutant, which we then verify experimentally. Successful model performance strongly supports the hypothesis of a dynamic maintenance of Smad nuclear accumulation during active signaling. The presented work establishes Smad nucleocytoplasmic shuttling as a dynamic network that flexibly transmits quantitative features of the extracellular TGF-beta signal, such as its duration and intensity, into the nucleus. 相似文献
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A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation
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Barber DL Beattie BK Mason JM Nguyen MH Yoakim M Neel BG D'Andrea AD Frank DA 《Blood》2001,97(8):2230-2237