复方木尼孜其颗粒治疗女性黄褐斑临床疗效观察

黄褐斑是一种常见的面部色素沉着性疾病,多发于中青年女性,其发病率有逐年增加的趋势,皮损部位以面部两颊为最多见,表现为淡褐色或深褐色的不规则斑片,目前缺乏理想的治疗方法,由于这种疾病严重影响容貌,病因难于查明,又久治不愈,故患者精神心理压力很大,成为爱美女性的心理负担.     

复方木尼孜其颗粒联合异维A酸胶丸治疗重症痤疮的临床观察

目的观察复方木尼孜其颗粒联合异维A酸胶丸治疗重症痤疮的临床疗效。方法治疗组34例服用复方木尼孜其颗粒联合异维A酸胶丸治疗,对照组30例服用异维A酸胶丸治疗。两组均外用阿达帕林凝胶,连用8周。结果治疗组与对照组有效率分别为97.06%、76.67%;两者比较差异有统计学意义(P0.05)。结论复方木尼孜其颗粒联合异维A酸胶丸治疗重症痤疮,起效较快,疗效较好,不良反应发生率低。     

复方木尼孜其颗粒联合氢醌乳膏治疗黄褐斑疗效观察

目的探讨复方木尼孜其颗粒联合氢醌乳膏治疗女性黄褐斑临床疗效。方法 167例女性黄褐斑患者随机分为2组,试验组85例,给予复方木尼孜其颗粒6 g,每日3次口服;每晚外用氢醌乳膏1次;对照组82例,仅每晚外用氢醌乳膏1次。两组患者同时给予维生素C 0.2每日3次;维生素E 0.1每日3次口服。4周为1个疗程,共治疗2个疗程后观察疗效。所有患者治疗前后均采用放射免疫法检测血清性激素(E2、FSH、LH、P)含量。结果试验组的有效率为74.12%;对照组的有效率为56.09%,两组比较差异有统计学意义。治疗后试验组患者血清E 2及LH水平较治疗前显著降低,两组比较差异有统计学意义(P0.05);FSH和P治疗前后差异无统计学意义(P0.05);对照组治疗前后各项指标差异无统计学意义(P0.05)。5例(2.99%)患者发生不良反应。结论复方木尼孜其颗粒联合氢醌乳膏治疗黄褐斑较安全有效,其或可通过调节血清性激素水平等发挥疗效。     

复方木尼孜其颗粒联合氯雷他定治疗亚急性湿疹临床疗效观察

目的:观察复方木尼孜其颗粒联合氯雷他定治疗亚急性湿疹的临床疗效和安全性.方法:将入选患者随机分为治疗组和对照组,治疗组给予复方木尼孜其颗粒,每次6 g,每天三次,同时口服氯雷他定片,每次10 mg,每天一次;对照组单纯采用氯雷他定片,每次10 mg,每天一次.连用28天.在疗程结束时观察两组疗效.结果:在治疗结束时,治疗组和对照组患者的有效率分别为78.33%、55.17%,两组有效率相比,差异具有统计学意义(P＜0.05).结论:复方木尼孜其颗粒联合氯雷他定较单采用氯雷他定治疗亚急性湿疹疗效好.     

维胺脂治疗寻常性痤疮的临床疗效观察

寻常性痤疮的发生与雄激素水平增高所致的皮脂腺分泌多、毛囊的过度角化以及痤疮丙酸杆菌感染等因素有关,维胺脂胶囊对痤疮发生的主要环节均有良好的作用,治疗效果较好,副作用小,男女病人都适用,作者1995年用辽宁锦州制药厂生产的维胺脂胶囊治疗痤疮45例,总有效率为93％,叫显高于用四环素、甲氰水胍等对照组。     

红蓝光动力联合复方木尼孜其颗粒及阿达帕林凝胶治疗重度痤疮疗效评价

目的:评价红蓝光动力联合复方木尼孜其颗粒及阿达帕林凝胶治疗重度痤疮的疗效。方法:实验组和对照组均口服复方木尼孜其颗粒和外搽阿达帕林凝胶,实验组加用红蓝光照射。结果:治疗6周后实验组和对照组总有效率分别为92.6%和72.5%,差异有显著性(P0.01)。结论:红蓝光动力联合复方木尼孜其颗粒及阿达帕林凝胶治疗重度痤疮有效。     

异维A酸治疗中度寻常痤疮临床疗效观察

目的:评价异维A酸治疗中度痤疮的疗效和安全性。方法:采用随机、阳性药物平行对照的临床试验。试验组患者每日服用异维A酸(泰尔丝);对照组患者每日服用维胺酯,两组患者均治疗6周。治疗2、4、6周,对两组痤疮患者的粉刺、丘疹、脓疱、结节囊肿、皮脂溢出等评分比较。结果:试验组皮损的总评分差值从(0.2166±0.1291)分增至(6.2469±1.1826)分,对照组则从(0.1290±0.3191)分增至(5.6297±1.4489)分,两组间痤疮评分差值比较,差异有显著性。治疗结束时,试验组痊愈率和有效率分别为58.18%和100.00%,对照组分别为22.41%和82.75%,二组间疗效比较差异有显著性。试验组有23例患者出现局部不良反应,对照组有31例患者出现局部不良反应。结论:异维A酸治疗中度寻常痤疮疗效好于维胺酯。     

0.3%维胺酯霜治疗寻常痤疮临床疗效观察

观察 0 .3 %维胺酯霜治疗寻常痤疮的疗效与安全性 ,并与维肤膏进行比较。结果 0 .3 %维胺酯霜治愈率为 2 7.8% ,总有效率为 75 .0 % ;维肤膏治愈率为 18.2 % ,总有效率为 45 .5 %。两组总有效率比较差异有显著性 (P <0 .0 5 )。 0 .3 %维胺酯霜疗效明显高于维肤膏。     

复方木尼孜其颗粒治疗女性黄褐斑临床疗效观察

黄褐斑是一种常见的获得性色素增多性皮肤病,好发于面部,多呈蝶形分布。中青年女性好发,男性也可患病。病因不明,治疗上也无特别有效的方法。由于该病影响美观,患者精神压力较大,成为爱美女性的心理负担。2010年2 - 10月,我们用复方木尼孜其颗粒(新疆维吾尔药业有限责任公司生产,批准文号Z65020166)治疗女性黄褐斑患者40例,取得一定疗效,报道如下。     

维胺酯胶囊治疗寻常型痤疮临床疗效观察

2001年6月～12月,我们采用维胺酯胶囊治疗轻、中度寻常痤疮,现报道如下。1 临床资料1.1 病例选择:(1)入选标准:14岁～30岁的男女轻、中度寻常痤疮自愿受试者。(2)剔除标准:结节囊肿型痤疮者;进入试验前2周内使用其他口服或外用治疗痤疮药物者;4周内系统使用过抗炎或抗生素药物者;对维甲酸类药物过敏者;妊     

安体舒通治疗寻常痤疮疗效观察

本文通过103例寻常痤疮病人随机地分成三组,分别用四环素,每天1.0克;安体舒通,每天60毫克;和安体舒通与四环素并用进行观察,结果示:安体舒通疗效明显优于四环素,安体舒通与四环素并用效果极佳。治疗期间未出现任何明显的副作用。因此,安体舒通作为一种雄激素拮抗剂,短期治疗寻常痤疮是完全可靠的。     

Efficacy of tetracyclines in the treatment of acne vulgaris: a review

BACKGROUND: Oral tetracyclines are routinely used for the management of inflammatory acne. However, there is a lack of evidence-based data on their relative effectiveness and appropriate dosages. OBJECTIVES: To assess the relative effectiveness and the optimal dosage of tetracyclines for the treatment of inflammatory acne. METHODS: We designed a systematic review of the clinical trials (1962-2006) investigating oral tetracyclines for the treatment of inflammatory acne. We obtained data from MEDLINE, PubMed, Current Contents, reference lists and specialist textbooks. RESULTS: There was substantial heterogeneity in the design of the trials. We identified only seven randomized trials which were set up to compare the efficacy of tetracyclines in reducing acne lesion counts. These showed no evidence of superiority of one tetracycline over another. Overall, there was also no significant difference between the available tetracyclines in terms of improvement in inflammatory (32 trials, P=0.898) and noninflammatory (23 trials, P=0.429) lesions. In the range of investigated dosages, the antibiotic dosage had no impact on efficacy in inflammatory (P=0.609) and noninflammatory (P=0.654) lesions. There was no decrease in efficacy during the study period. CONCLUSIONS: There is insufficient evidence to support one tetracycline rather than another in terms of efficacy. In the range of investigated dosages, the antibiotic dosage seems to have no impact on efficacy. Despite increased resistance to antibiotics, oral tetracycline formulations displayed no change in efficacy during the study period. Further studies are, however, required to determine if the anti-inflammatory properties of tetracyclines are sufficient in managing acne.     

自制复方氯硫咪乳膏治疗寻常痤疮临床疗效观察

目的评价复方氯硫咪乳膏治疗寻常痤疮的疗效、依从性、安全性和复发情况。方法采用随机、平行对照的方法,试验组外用复方氯硫咪乳膏,对照组外用0.025%维A酸霜,两组均加服同样内服药物。疗程4w。观察治疗中和疗程结束后的病情变化并记录。结果治疗1w后,试验组基愈率、显效率和有效率均显著优于对照组(P<0.05,P<0.005,P<0.001)。随着疗程增加,两组疗效有趋近倾向。治疗4w后,试验组基愈率和有效率仍高于对照组(P<0.05),但显效率差异无统计学意义(P>0.05),试验组依从指数高于对照组(P<0.001),不良反应的发生率低于对照组(P<0.001)。疗程结束1m后随访,两组复发率无明显差异(P>0.05)。结论复方氯硫咪乳膏治疗寻常痤疮起效快、疗效满意、安全可靠、患者依从性高。     

复方多黏菌素B软膏治疗寻常痤疮临床疗效观察

目的观察复方多黏菌素B软膏治疗寻常痤疮的疗效及安全性。方法将156例寻常痤疮患者分为两组,试验组外用复方多黏菌素B软膏每日2次,对照组外用5%过氧苯甲酰凝胶每日2次,疗程均为4周。结果试验组患者经治疗4周后皮损数量明显较治疗前减少,与对照组相比差异有统计学意义(P<0.05);皮损消退显效率两组无明显差异(P>0.05);不良反应发生率试验组低于对照组(P<0.05)。结论复方多黏菌素B软膏治疗Ⅰ、Ⅱ级寻常痤疮有效,且不良反应少。     

Efficacy of acne vulgaris treatment protocols according to its clinical forms

To compare results of different treatment regimens based on stratification of acne to prescribe the right treatment protocol according to clinical form and grade of acne. A transversal, cohort study conducted in 230 patients with acne vulgaris. Patients were divided into three groups according to acne severity and the results of each protocol determined in 0, 4, 6, 8, 12, 18 and 24 weeks. Statistical analysis was conducted using Wilcoxon and Mann‐Whitney tests 230 patients (99 females and 131 males) took part in the study. In first grade acne (70 patients), the most effective drug for papulo‐pustular lesions was azelaic acid, where the average value of the reduction was 1.03% per week. For comedone reduction, the most effective drug resulted retinol with 17.7% mean reduction per week. In second grade acne (66 patients), the most effective scheme was: doxycycline + topical retinoid + benzoyl peroxide. In the third grade (92 patients), the most effective drug was oral isotretinoin. Accurate stratification, based on clinical characteristics is required for better outcome. Treatment success is related to the respective individually tailored treatment schemes in patients with acne.     

Effects of mesotherapy introduction of compound glycyrrhizin injection on the treatment of moderate to severe acne

Background

Compound glycyrrhizin has achieved outstanding results in the treatment of various skin diseases. However, the use of mesotherapy to inject compound glycyrrhizin into the skin to treat acne is still understudied.

Aims

This paper aims to explore the effects of mesotherapy introduction of compound glycyrrhizin injection on the acne.

Materials & Methods

A total of 108 patients were included in this study and divided into the control group (n = 54) and the observation group (n = 54). The control group was treated with topical clindamycin gel, while the study group was treated with topical clindamycin gel + mesotherapy and compound glycyrrhizin injection. Skin transepidermal water loss (TEWL), cuticle water content, acne severity, adverse reactions, and inflammatory reactions were documented before and after treatment in the two groups.

Results

The usage of mesotherapy to inject compound glycyrrhizin into the skin of acne patients more effectively treat acne than traditional clindamycin gel. The mesotherapy compound glycyrrhizin can more effectively protect the skin barrier of patients and reduce the loss of skin moisture. Compared with the traditional clindamycin gel, the combination of mesotherapy and compound glycyrrhizin more effectively inhibit the inflammatory reaction in acne patients and reduce skin damage in acne patients.

Discussion/Conclusion

Mesoderm introduction of compound glycyrrhizin injection has better effects on the treatment of moderate to severe acne than clindamycin gel.