Classic Kaposi's sarcoma with colonic involvement: a rare presentation with successful treatment with oral etoposide

Kaposi's sarcoma (KS) is currently regarded as a low-grade vascular malignancy. KS is a multicentric and multisystem disease that involves the skin and less commonly visceral organs, such as the gastrointestinal system including colonic involvement. KS with colonic involvement in HIV-negative patients is a rare clinical manifestation. In this regard, we report an immunocompetent, HIV-negative elderly female patient with classic KS presenting with colonic involvement.     

Von-Recklinghausen’s disease a rare presentation

A rare presentation of Von Recklinghausen’s desease in a 8 year old boy is reported. Disease was confined to right side and involved eye, palate, gingiva, face, and external auditory canal.     

Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation, lacking cutaneous involvement: Case series and literature review

The diagnosis of blastic plasmacytoid dendritic cell neoplasm (BPDCN) can be challenging, owing to the absence of traditional lineage-specific markers, but is facilitated by CD4/CD56 co-expression and frequent skin involvement. Herein, we present our collective experiences with three BPDCN cases lacking cutaneous presentation and the inherent diagnostic pitfalls. Taken in context of similar historical cases, we suggest that BPDCN with “leukemic” presentation (L-BPDCN) otherwise presents no major distinguishing features and is at least as aggressive as its cutaneous-involved BPDCN counterpart.     

Specific cutaneous involvement in Hodgkin's disease.

In Hodgkin's disease (HD) specific cutaneous involvement is rare. When it occurs, retrograde lymphatic spread, direct extension from the underlying lymph nodes, and hematogenous dissemination are the mechanisms usually implicated. Among 349 patients with HD diagnosed and followed-up at our institution from 1969 to 1990, three (0.85 per cent) presented specific cutaneous involvement. In two cases with mixed cellularity subtype, skin lesions displayed histologic features similar to those found in the lymph node. Treatment with combination chemotherapy resulted in rapid disappearance of the lesions in two patients but was ineffective in the third. Previous reports of cutaneous involvement in HD, its differential diagnosis, prognostic significance, and treatment are briefly reviewed.     

Basaloid squamous cell carcinoma of the lung: a rare tumour with a rare clinical presentation

Basaloid squamous cell carcinoma of the lung, an uncommon subtype of non-small cell carcinomas was introduced as a distinct entity in the recently revised World Health Organization (WHO) classification of lung tumours. This rare tumour most commonly develops in males older than 60 years. We report a 23-years-old female patient with basaloid squamous cell carcinoma of the lung who was stage IIB post-operatively. The patient is still alive and healthy 18 months after the operation. This is one of the youngest patient reported with this rare type of tumour.     

Haemobilia – a rare presentation of intrabiliary hydatid disease

Intrabiliary hydatid cysts have been known to cause complications. We report a rare case of calcified crumpled intrabiliary hydatid cyst causing massive haemobilia due to a hepatic artery pseudoaneurysm, an unusual complication of intrabiliary hydatid cyst. The patient was successfully treated by stenting of the pseudoaneurysm with overlapping stents.     

Xanthoma disseminatum: a rare condition with non-X, non-lipid cutaneous histiocytopathy

We describe a 35-year-old man with cutaneous, mucosal, pulmonary, and bone involvement of xanthoma disseminatum. The 7-year course of the disease and the results of light and electron microscopic and immunocytochemical examinations are presented.     

Synovial sarcoma:a rare presentation of parapharyngeal mass

Synovial sarcoma is a rare soft tissue sarcoma of the head and neck region involving the parapharyngeal space.The diagnosis of synovial sarcoma can be very challenging to the pathologists.We present a rare case of parapharyngeal synovial sarcoma in a young female patient who had a two-month history of left cervical intumescent mass at level II.The fine needle aspiration cytology of the mass was proved inconclusive.Transcervical excision of the mass was performed and the first case of parapharyngeal sarcoma ...     

Anterior abdominal wall synovial sarcoma: a rare presentation

Synovial sarcoma usually arises in the extremities and in close proximity to large joints. Primary synovial sarcoma of the anterior abdominal wall is rare. A 17-year-old girl was admitted to the hospital with a palpable abdominal mass, and there was a 9.5 cm x 7.5 cm x 6-cm lobulated, cystic, and semisolid lesion of in the external oblique abdominal muscle shown on the abdominal magnetic resonance image. She was then operated and pathology was consistent with synovial sarcoma. The presence of synovial sarcoma in extraarticular sites such as the abdominal wall argues against an origin from arthrogenous mesenchyme.     

Extramedullary liver plasmacytoma a rare presentation

Liver plasmacytoma is a very rare form of solitary plasmacytoma, in fact the presence of plasma cells in the liver is generally associated with a more aggressive form of multiple myeloma. We report an unusual case of liver plasmacytoma without systemic disease, diagnosed by percutaneous needle biopsy of the hepatic lesion, treated with six courses of melphalan and prednisone who achieved a good clinical remission after five years of follow-up.     

多发性皮下Rosai-Dorfman病1例报告并文献复习

目的:探讨多发性皮下Rosai-Dorfman病的临床病理特征、诊断、鉴别诊断。方法:对1例多发性皮下Rosai-Dorfman病进行组织形态学、免疫组化及特殊染色检查,并随访及复习相关文献。结果:肿块分别位于左侧胸壁及右腹股沟区,两处病变组织学上表现相似,呈细胞疏松区和密集区交替分布的结节状结构,细胞疏松区可见淋巴窦样结构,其间有一些体积较大、胞浆丰富淡染的组织细胞,可见胞质内吞噬物和淋巴细胞"伸入运动";细胞密集区散在淋巴滤泡伴较多浆细胞、中性粒细胞等浸润。免疫表型:组织细胞呈S-100、CD163及CD68阳性。结论:多发性皮下Rosai-Dorfman病罕见,确诊主要依靠形态学及免疫组化标记,无论临床及病理均需与纤维组织细胞瘤、Langerhans细胞组织细胞增生症、非特异性肉芽肿、炎性肌纤维母细胞性肿瘤等相鉴别,治疗以手术切除为主,预后较好。     

Dentigerous cyst: A rare presentation

Though Dentigerous cysts are encountered not so frequently by the otolaryngologist, a giant dentigerous cyst causing facial deformity and requiring a major reconstructive surgery is very rare. One such case is described.     

Generalized lymphadenopathy: a rare presentation of disseminated prostate cancer

Prostate cancer most often metastases to regional lymph nodes and bones by hematogenous or lymphatic spread. Metastases to the supradiaphragmatic nodes are rare. A 56-yr-old male smoker with generalized lymphadenopathy was referred to our center with the complaints of weight loss of 15 kg and severe back and leg pain. On computed tomography of the thorax and abdomen, massive mediastinal, intra-abdominal, retroperitoneal, and inguinal lymphadenopathies with hydroureteronephrosis of the left kidney were noted. Excisional biopsy of left cervical lymph node revealed metastasis of prostatic adenocarcinoma and transrectal biopsy of the prostate disclosed poorly differentiated adenocarcinoma. Bone marrow aspiration biopsy, done for the differential diagnosis of anemia, also showed infiltration with prostate-specific antigen positive neoplastic cells. Supradiaphragmatic spread of prostate cancer has been postulated to be by a hematogenous route via the vertebral venous system, or Batson's plexus, accessible via direct extension from the primary cancer site.     

Post-menopausal bleeding: a rare presentation of metastatic uveal melanoma

Uveal melanoma differs from cutaneous melanoma in many ways, including its pattern of metastasis, and exhibits latency with clinical evidence of metastasis sometimes appearing many years after primary diagnosis. Most patients develop metastasis within the liver, but some may present with metastasis to other sites. We report a case of uveal melanoma that presented with post-menopausal bleeding due to metastasis. Further investigation revealed widespread metastatic disease and the patient was not fit for chemotherapy. She died two months after presentation: autopsy revealed metastases in many sites, including the uterus, right ovarian fibroma, kidney, mesentery, liver, lung, thyroid, bone marrow and skin. The immediate cause of death was cardiac tamponade due to a malignant effusion secondary to cardiac metastasis. This case illustrates the widespread metastatic potential of uveal melanoma and highlights the potential for unusual presentation of metastatic disease from this eye tumor.(Pathology Oncology Research Vol 12, No 3, 184–187)     

Association of periodontal disease with oral cancer: a meta-analysis

The objective is to evaluate the association of periodontal disease with the risk of oral cancer. Literature retrieval, selection and assessment, data extraction, and meta-analyses were performed according to the RevMan 5.0 guidelines. In the meta-analysis, we utilized random-effect model to pool the odds ratio (OR) according to the test of heterogeneity. A total of five eligible studies included 1,191 oral cancer patients and 1,992 healthy control subjects were analyzed. By meta-analysis, we found a significant association of periodontal disease with oral cancer [OR?=?3.53, 95 % CI (1.52–8.23); P?=?0.003]. Patients with periodontal disease have increased susceptibility to oral cancer.