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1.

Objective

Conventional MRI does not provide sufficient information to differentiate post-radiotherapy necrosis from brain tumor recurrence, recent studies have investigated the use of more advanced imaging modalities that are able to differentiate between the two entities.

Aim of the study

To assess the usefulness of combined apparent diffusion coefficient (ADC) value and single voxel spectroscopy (SVS) in the differentiation between recurrent brain gliomas and post-radiotherapy necrosis.

Methods

Twenty-two patients with suspected tumor recurrence after surgical resection and radiotherapy treatment were included in our study. MRI with contrast, diffusion weighted MRI with ADC value and MR spectroscopy were done to all patients.

Results

ADC values were ≤1.150?×?10?3?mm2/sec for recurrent high grade gliomas, >1.150–≤1.370?×?10?3?mm2/sec for recurrent low grade gliomas and >1.370?×?10?3?mm2/sec for post radiation necrosis. NAA/Cr ratio could significantly differentiate between recurrent gliomas and post radiation necrosis (p value?=?.019), also Cho/Cr was significant p value?=?.006. Also NAA/Cr and Cho/Cr were statistically significant in differentiating recurrent high grade from low grade gliomas (p value?<?.001).

Conclusion

Combination of calculated ADC value and MR spectroscopy added more information and increase the accuracy of conventional MR imaging in the differentiation of patients with suspected recurrent brain glioma from post-radiotherapy necrosis.  相似文献   

2.

Purpose

To evaluate the role of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in detecting microstructural changes of normal-appearing deep grey matter (NDGM) in multiple sclerosis (MS).

Patient and methods

We examined 40 patients with MS and 20 healthy volunteers using DTI to correlate average ADC and FA of the thalami, lentiform and caudate nuclei between the two groups. Receiver operating characteristic analysis was used to test the diagnostic performance of ADC and FA in detecting NDGM involvement in multiple sclerosis.

Results

Between the two study groups, there was statistically significant difference of ADC of thalami, lentiform, caudate nuclei, and FA of the thalami (p?<?.05). No statistically significant difference of FA of lentiform (p?=?.2) and caudate (p?=?.06) nuclei. For detection of microstructural changes of NDGM, ADC cut off values were 0.762?×?10?3?mm2/s for thalamus (90% sensitivity and 66% specificity), 0.529?×?10?3?mm2/s for lentiform (86% sensitivity and 60% specificity) and 0.784?×?10?3?mm2/s for caudate nuclei (83% sensitivity and 67% specificity).

Conclusion

ADC has better diagnostic performance and is more accurate than FA as a measure to detect microstructural changes of NDGM.  相似文献   

3.

Introduction

Cystic pancreatic lesions are currently discovered at higher rate, hence adequate characterization of these lesions by the radiologist is important in guiding management.

Aim of the work

Was to identify the role of MRI in characterization of cystic pancreatic lesions.

Patients and methods

Thirty patients with suspected cystic lesions of the pancreas were examined by MRI using 1.5?T machines including conventional MRI sequences, dynamic contrast enhanced imaging, DWI and IP/OP sequence.

Results

The study included 30 patients (12 males and 18 females) with their age ranging from 16 to 88?years (mean age 55?years), MRI analysis of the cyst contents and communication with ductal system were used to characterize different cyst types, among these patients we found serous cystadenoma in five patients, mucinous cystadenoma in seven patients, mucinous cystadenocarcinoma in one patient, branch type Intraductal papillary mucinous neoplasms (IPMN) in seven patients, Mixed IPMN in two patients. Cystic neuroendocrine tumors (CNET) in three patients. Solid cystic pancreatic neoplasm (SPN) in two patients. Pseudocyst in one patient and walled off necrosis (WON) in two patients. Pathological assessment of the lesions was done whenever indicated.

Conclusions

MRI with its superior soft tissue resolution is of value in characterization of different cystic pancreatic lesions helping to reach the correct diagnosis.  相似文献   

4.

Objectives

To evaluate the diagnostic accuracy of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in characterization of inconclusive ovarian tumors, with histologic findings as the reference standard.

Patients & methods

DCE-MRI was done in 30 patients with 32 complex ovarian masses, prior to surgical excision. We analyzed the following kinetic parameters: enhancement amplitude (EA) in the form of MRE%, time to peak in the form of T max and maximal slope (MS) and correlated them with histopathology.

Results

DCE-MRI showed higher overall accuracy (96%) and specificity (100%) than conventional MRI. Malignant masses showed higher MRE% than benign (p?=?.004) or borderline masses (p?=?.036). A shorter T max was found in malignant compared to benign (p?=?.0002) and borderline (p?=?.049) masses. MS was best at discrimination between benign, borderline and malignant tumors. Finally, Type III curve showed 100% specificity for invasive malignant tumors.

Conclusion

DCE-MRI sequence is a helpful adjunct to conventional MRI for discrimination of inconclusive ovarian masses into benign, borderline and invasive malignant tumors.  相似文献   

5.

Background

The knee menisci are compound anatomical structures with important purposes within the knee. In the long term, meniscal losing results in high risk of developing degenerative osteoarthritis. MRI is an accurate and non-invasive diagnostic method for the knee injuries providing satisfactory guide for conservative treatment and guarding the patients from uncritical arthroscopy.

Objective

This study aimed to detect the MRI accuracy in diagnosis of meniscal lesions compared to arthroscopy.

Patients & methods

This study included 13 females and 17 males presented by pain, swelling, limitation of movement, in the duration from April 2015 to June 2016. All patients were subjected to MRI followed by arthroscopy.

Results

The study revealed that specificity, sensitivity, NPV, PPV and accuracy, in MRI diagnosis of medial meniscal abnormal signals were 50%, 95.8%, 88.4%, 86.6%, and 90% respectively, whereas those for lateral meniscus signals were 84.6% 88.2%, 84.6%, 88.2% and 86.7% respectively.

Conclusion

MRI of the knee will give the orthopedic surgeons ability to select suitable treatment and arthroscopic interference for their patients. MRI has high accuracy in meniscal tears diagnosis allowing accurate grading of them.  相似文献   

6.

Background

Diffusion-weighted imaging is a fundamental tool integrated in MR protocols useful in differentiating benign from malignant mediastinal masses, assessing mediastinal lymphadenopathy and investigating central bronchogenic carcinoma. This method is an excellent alternative to CT or PET/CT in the investigation of mediastinal masses. Current applications of diffusion MRI in malignancies include monitoring the treatment response and detecting recurrent cancer.

Aim of the work

This study aims to assess the value of using MRI diffusion in differentiating benign and malignant mediastinal masses, differentiating central masses from post obstructive collapse and differentiating lymphoma versus sarcoidosis.

Patients and methods

This study included 30 patients; 16 males and 14 females in the period from June 2013 to July 2014. The mean age was 49.3 ± 16.85 (range: 22–82 years).Cases were referred for MRI assessment and were approved by the ethical committee in our department.The complaints varied between dyspnea, chest pain, cough, hemoptysis, fatigue and loss of weight. A superconducting 1.5 T MRI machine with a four-channel body phased-array coil was used for the examination. Biopsy and histopathological assessment was done after that.

Results

MRI examination with diffusion imaging was able to differentiate between benign and malignant mediastinal and hilar lesion confirmed by the biopsy and histopathology.

Conclusion

MRI with diffusion weighted images can detect and stage lung cancer, differentiate benign from malignant mediastinal masses and differentiate lymphoma from sarcoidosis in mediastinal/hilar lymphadenopathy.  相似文献   

7.

Background and purpose

Consistency of pituitary macroadenoma is a crucial information for neurosurgeons. We aimed to assess the role of DW-MRI as non invasive imaging modality in predicting the tumour consistency of pituitary macroadenoma.

Materials and methods

Twenty patients with pituitary macroadenoma underwent conventional MR imaging sequences, pre contrast, post contrast MRI and diffusion weighted MRI with ADC map. The tumour consistency was determined both macroscopic by neurosurgeons and microscopic by histopathologists.

Results

Our study included 12 soft, 4 intermediate and 4 hard tumours. The tumour consistency and the collagen contents were correlated with diffusion and ADC values. The mean ADC value of patients with soft tumours was 0.54?×?10?3?mm2/s while for intermediate tumour was 0.82?×?10?3?mm2/s and for hard tumours was 1.11?×?10?3?mm2/s. Soft and intermediate consistency tumours were successfully managed by endoscopic transsphenoidal approach; suction and curettage. While, hard tumours could not be managed by the transsphenoidal approach and needed further transcranial procedure with sensitivity 95% and specificity 95%.

Conclusion

DWI-MRI is a useful tool to predict the pituitary macroadenoma consistency and the suitable surgical approach for resection.  相似文献   

8.

Objectives

To create a systematic approach using computed tomography (CT) and magnetic resonance imaging (MRI) findings to facilitate identifying the etiology of hearing loss, evaluating the anatomy for surgery, and predicting complications.

Methods

Twenty nine pediatric patients with congenital or acquired sensory-neural hearing loss (SNHL) requiring cochlear implant (CI) were included. They underwent combined CT, 3D DRIVE MRI axial plane and axial T2WIs for the whole brain. The inner ear, cochlear nerve development, temporal bone anatomy, operative window, normal variants and causes of central hearing loss were assessed.

Results

CT showed that 100% of the patients are suitable for CI while MRI showed that 96.5% of studied patients are suitable. The examined ears were categorized into 4 groups according the candidacy for operation; 86.2% were suitable for CI, 5.1% were suitable for CI but with expected poor response, 1.7% of examined ears were suitable for CI with modification of surgical procedure and 6.8% were not suitable for CI.

Conclusion

In Suez Canal area, the combined CT/MRI approach categorized the majority of patients with SNHL (96.6%) as good candidates for CI.  相似文献   

9.

Objectives

To assess the clinical utility of PET-CT in assessment of thoracic involvement in lymphoma patients prior to, during and after finishing treatment and comparing it to contrast enhanced CT (CECT).

Patients and methods

PET-CT was performed for 30 patients with lymphoma. Thoracic nodal and extranodal involvement was assessed and compared to contrast enhanced CT.

Results

Comparison of CECT and PET-CT in staging and assessment of treatment response reveals significant statistical difference (P?=?.0001 & .04 respectively). CECT shows sensitivity?=?83.3% and specificity?=?75% in evaluation of patients after finishing chemotherapy.

Conclusion

PET-CT plays an important role in staging, detection of response to treatment and restaging of lymphoma after finishing chemotherapy.  相似文献   

10.

Objective

To assess the diagnostic accuracy of diffusion weighted imaging (DWI-MRI) being a non-contrast based MR sequence versus dynamic contrast enhanced MRI (DCE-MRI) in the preoperative loco-regional staging of the cervical carcinoma.

Methodology

Fifty cases of proved cancer cervix prior staging subjected to dynamic post contrast technique: one pre-and six post contrast phases (40?s each). DWI was scanned using different b values and ADC values were measured.

Results

DWI was the most accurate in staging operable cases (93.3%).Parametrial infiltration was overestimated in 3 cases versus 4 cases in DCE-MR. DWI showed 100% sensitivity, positive predictive value and accuracy in the assessment of locally advanced carcinomas. In metastatic lymph nodes, DCE-MR showed the least accuracy of 86%.

Conclusion

DWI is helpful in discriminating local from locally advanced cervical carcinomas. DCE-MR can delineate cervical carcinomas confined to the uterus and exclude bladder/rectal invasion.  相似文献   

11.

Objective

To evaluate the use of diffusion tensor imaging (DTI) and fractional anisotropy (FA) as prognostic tools in anticipating the recovery of stroke patients.

Patients and methods

40 patients were included in our study after exclusion of 23 patients. All patients admitted in Neurology Department with stroke. The patients subjected to National Institute of Health Stroke Scale (NIHSS) followed by MRI with DTI and FA calculation. Follow up after three months was done based on the Modified Rankin Score (MRS). The results were compared and statistically analyzed.

Results

There was a statistical significant between the NIHSS and DTI pattern at the time of admission (p value?<?0.05) reflecting the severity of the stroke with 22 patients showed disrupted fibers (55%), of which 16 patients were categorized as moderate NIHSS and 19 patients showed poor outcome. Relative FA equal 0.8 was found to be the cut off value in predicting the poor or good prognosis using MRS as a reference with 94.4% sensitivity, 90.9% specificity and 0.833 area under curve.

Conclusion

DTI is a prognostic tool in anticipating the recovery of the stroke patients. Moreover, the relative FA score works as more additive value in evaluation of the patient improvement.  相似文献   

12.

Objectives

The objectives of our work were to determine disability and study MRI findings of occupational-related lumbar disc degeneration and also to show the relationship between MRI grading of nerve root compromise with surgical grading.

Participants and methods

The study included 103 workers with lumbar disc prolapse. Nerve roots were assessed on MRI and during surgery for the degree of compromise. Oswestry Disability Index and Visual Analogue Scale were used for assessment of disability and pain intensity pre- and post-operative respectively.

Results

The majority of workers was less than 40 years and suffered from moderate to severe disability. 73.8% had grade IV disc degeneration mostly at the level of L4/L5. Nerve root compromise was found in 86.4% of workers. 48% of nerve roots were deviated and 32% were compressed, with significant correlation between MR grading of nerve root compromise and surgical grading (r = 0.89, P < 0.0001).

Conclusion

Disability of occupational-related lumbar disc degeneration is a grave health problem between construction workers. MR imaging is a reliable tool for grading nerve root compromise in disc degeneration. Nerve root compromise is a significant factor to explain pain than the morphologic extension of disc material outside the intervertebral space.  相似文献   

13.

Objective

The aim of this work is to evaluate bone mineral density (BMD) in children with idiopathic epilepsy under anti-epileptic drugs and to determine the effect of the type and the duration of drug administration on BMD.

Subjects and methods

This study conducted on 120 children divided into two groups, Epileptic group included 60 children diagnosed as having epilepsy on the basis of clinical examination receiving antiepileptic drugs (AEDS). Control group included 60 healthy children.All patients subjected to clinical examination and determination of bone mineral density.

Results

Among epileptic children, there were 35 children (58.3%) with generalized tonic clonic seizures, 11(18.3%) were partial, 10(16.7%) were partial with secondary generalization, 4(6.7%) were absence seizures. 41(68.3%) epileptic patients were on antiepileptic monotherapy while 19 (31.7%) were on polytherapy. Seventeen children with low bone mineral density state (LBMD) and 43 with normal bone density. Epileptic patients had lower BMD, Z- score, and AM compared with controls (P value?<?.001). Epileptic patients with LBMD had significant decrease in Z score, BMD and AM (P?<?.001) compared with epileptic patients with normal bone state.

Conclusion

Epileptic patients receiving polytherapy showed more decrease in BMD than that of epileptic patients receiving monotherapy with (P?<?.001).  相似文献   

14.

Purpose

To assess the role of dynamic contrast- enhanced and diffusion-weighted (DWI) MRI in the evaluation of the response of hepatocellular carcinoma (HCC) after chemoembolization.

Patient & method

30 patients having 40 HCC lesions underwent transcatheter arterial chemoembolization (TACE). Ages ranged between 41 and 76?years. All examinations were performed using Philips 1.5 Tesla MRI (Achieva). Precontrast T1, T2, Dynamic contrast enhanced and respiratory triggered DWI MR images with (b?=?50, 400, 800?mm/s). DWI MRI images and Contrast-enhanced MRI images after TACE are assessed to evaluate post treatment response. DWI was used to create ADC maps and ADC values were calculated looking for a cut off value using the ROC curve.

Results

Dynamic MRI had a sensitivity of 94.1%, a specificity of 95.6%, PPV value of 94.1%, NPV of 95.6% and an overall agreement of 95% compared to 82%, 73.9%, 70%, 85% and 77.5% respectively of DWI MRI. The difference between the malignant residual and well ablated groups' ADC variables was statistically significant P value 0.009.

Conclusion

Dynamic and diffusion MRI complete each other in assessment of HCC response to therapy, especially in those who cannot properly hold their breath that cause degradation of the dynamic MR quality.  相似文献   

15.

Purpose

to assess the efficacy of FDG PET/CT in detecting unexpected additional primary malignant neoplasms in patients being evaluated by PET/CT for known malignancies compared to conventional staging work-up (CSW).

Patients and methods

Of 1889 patients referred for whole-body FDG PET/CT in the period from February 2015 to May 2016, only 273 were included in this prospective study. Patients included are those with histopathologicaly proven primary malignancy and sent for initial tumor staging before treatment within 1 month of CSW that was performed for the patients according to the site and cell type of the primary tumor. Histopathologic examination was performed for lesions indicating additional primary cancer detected by either PET/CT or CSW.

Results

In 13 out of 273 patients included in the study (4.76%) only were proved to have additional primary cancer, the PPV of PET/CT for detecting an additional primary cancer was 56.5%. Also, it showed high sensitivity of 89.2%, which was significantly higher than 23% from the CSW (P < 0.005).

Conclusion

PET/CT is more accurate than CSW for detecting additional primary cancer with a higher sensitivity and positive predictive value, which consequently affect further management.  相似文献   

16.
Histologic response to neoadjuvant chemotherapy is an essential prognostic criterion in osteosarcoma. Non-invasive assessment of the effect of neoadjuvant chemotherapy influences the timing and method of definitive surgery.

Aim

This study evaluated the use of Dynamic Contrast Enhanced-MRI (DCE-MRI) in preoperative estimation of residual viable tumor present in Osteosarcoma following chemotherapy.

Patients and methods

We conducted a prospective study from July 2011 till April 2013 on 50 pediatric patients with a mean age of 12.8 years diagnosed as Highgrade osteosarcoma in long bones at the Children Cancer Hospital Egypt.Conventional and dynamic MRI performed before definitive surgery was compared with histopathology assessment of necrosis. For DCE-MRI, 3 regions of interest (ROIs) were chosen and the signal intensity was plotted against time. Signal intensity values and curve pattern were compared to percent of necrosis of the corresponding areas on the resected specimens.

Results

DCE-MRI showed sensitivity of 92.5% and specificity of 96% with positive predictive value of 92% and negative predictive value of 96%. Negative correlation was found between signal intensity values and percent of necrosis.

Conclusions

DCE-MRI can be used preoperatively as a sensitive, specific, and non-invasive method for detection of viability and necrosis within osteosarcoma.  相似文献   

17.

Aim of the work

To evaluate the role of diffusion weighted imaging (DWI) in the planning for CT guided biopsy of lung and mediastinal lesions.

Subjects and methods

This cross sectional study included 23 patients with mean age was 42.7?years came with clinical and imaging suspicion of chest malignancy, referred for CT guided transthoracic biopsy. DWI and apparent diffusion coefficient (ADC) were evaluated for all patients to choose the area of maximum restriction.

Results

The study showed that with DWI guidance; all the biopsy specimens were diagnostic and provide adequate material for analysis.

Conclusion

DWI and measurement of ADC value has a very helpful role in the pre-procedural planning of transthoracic biopsies.  相似文献   

18.

Aim

To evaluate accuracy of DWI in evaluating HCC response to DEB TACE and compare the results with DCE MRI.

Material and methods

42 patients with 59 lesions underwent precontrast abdominal MRI, DWI, ADC map with ADC value measurement and DCE MRI. The qualitative DWI and ADC values were correlated to the DCE MR findings.

Results

Comparing the qualitative DWI findings to DCE MRI, showed sensitivity of 83.9%, specificity of 64.3%, positive predictive value of 72.2%, and negative predictive value of 78.3% and overall accuracy of 74.5%. The measured ADC values showed significant difference (P value <0.05) between the ADC values measured in the active tumoral areas and necrotic areas with no significant difference between areas of active tumoral enhancement in the different groups. ROC analysis for ADC values showed area under curve 0.7 and maximum combined sensitivity and specificity of 79% and 69.6% respectively at cutoff ADC value of 1.395?mm2/sec.

Conclusion

DWI is useful highly sensitive technique in evaluation of HCC response to DEB TACE, yet it has low specificity related to high number of false positive results preventing using it solely. Also, DWIs is a reliable method in differentiation between active tumor residue/recurrence and benign perilesional enhancement.  相似文献   

19.

Objective

To study image quality of MRI scanner using the American College of Radiology (ACR) phantom.

Material and methods

Image quality of 1.5 T MRI scanner was tested using ACR phantom. A standard head coil with standard restraints was used to fix the phantom head position. The phantom included seven modules for measuring MRI scanner image quality. MRI images for each module were analyzed.

Results

For the Geometric accuracy test the inside length of the phantom was 146 mm and the inside diameter was 189.4 mm. For the High-contrast spatial resolution, individual small bright spots on the image were three pairs of hole arrays and were distinguishable. For the slice thickness test, the top signal ramp length was 54.4 mm and bottom signal ramp length was 54.8 mm so the slice thickness was 5.46 mm. For the slice position accuracy, the bar length differences of intensity uniformity a value, called percent integral uniformity (PIU), was 96.15%. For the percent-signal ghosting, ghosting ratio was 0.0002. For the low contrast object detectability, the sum of numbers of complete spokes scored was 30 spokes.

Conclusions

Image quality tests were very important in acceptance of any MRI scanner after installation and during maintenance. Using ACR phantom, these tests approve that the image parameters are acceptable.  相似文献   

20.

Background

The ankle is frequently injured in trauma, overuse syndrome and inflammatory processes. Different imaging modalities assess the ankle, including plain radiography, computed tomography (CT), magnetic resonance imaging (MRI), and ultrasonography (US).

Purpose

Our objective is to assess the role of high resolution US as a valuable tool in the depiction of causes of ankle joint pain.

Patients and methods

The study included 28 patients presented with ankle pain ranging in age from 17 to 60 years. They were examined by US and findings were correlated with MRI.

Results

US was capable to detect various lesions (synovitis, arthritis, plantar fasciitis, tendon and ligamentous lesions). It had a sensitivity of 95.4%, a specificity of 83.3% and an overall accuracy of 92.8%. US had a limited value in detection of avascular necrosis (AVN), bone marrow oedema and fractures.

Conclusion

US can be used as a first step diagnostic tool in cases of ankle pain. MRI should be spared to cases with negative or equivocal US findings.  相似文献   

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