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1.

Aim

To evaluate accuracy of DWI in evaluating HCC response to DEB TACE and compare the results with DCE MRI.

Material and methods

42 patients with 59 lesions underwent precontrast abdominal MRI, DWI, ADC map with ADC value measurement and DCE MRI. The qualitative DWI and ADC values were correlated to the DCE MR findings.

Results

Comparing the qualitative DWI findings to DCE MRI, showed sensitivity of 83.9%, specificity of 64.3%, positive predictive value of 72.2%, and negative predictive value of 78.3% and overall accuracy of 74.5%. The measured ADC values showed significant difference (P value <0.05) between the ADC values measured in the active tumoral areas and necrotic areas with no significant difference between areas of active tumoral enhancement in the different groups. ROC analysis for ADC values showed area under curve 0.7 and maximum combined sensitivity and specificity of 79% and 69.6% respectively at cutoff ADC value of 1.395?mm2/sec.

Conclusion

DWI is useful highly sensitive technique in evaluation of HCC response to DEB TACE, yet it has low specificity related to high number of false positive results preventing using it solely. Also, DWIs is a reliable method in differentiation between active tumor residue/recurrence and benign perilesional enhancement.  相似文献   

2.

Aim of the work

To evaluate the role of diffusion weighted imaging (DWI) in the planning for CT guided biopsy of lung and mediastinal lesions.

Subjects and methods

This cross sectional study included 23 patients with mean age was 42.7?years came with clinical and imaging suspicion of chest malignancy, referred for CT guided transthoracic biopsy. DWI and apparent diffusion coefficient (ADC) were evaluated for all patients to choose the area of maximum restriction.

Results

The study showed that with DWI guidance; all the biopsy specimens were diagnostic and provide adequate material for analysis.

Conclusion

DWI and measurement of ADC value has a very helpful role in the pre-procedural planning of transthoracic biopsies.  相似文献   

3.

Aim of the study

The aim of this study was to explore the role of the DWI in assessment of peri-anal fistula and whether it can replace post contrast study.

Patients and methods

MRI examinations was done for 35 patients. Images were reviewed for the presence and number of visible fistulas, internal openings, secondary extension, horse shoe and abscess. Apparent diffusion coefficient (ADC) measurement of suspected fistula tracks and abscess cavities was done to assess activity. Comparison between TIRM, DWI and post-contrast T1-weighted fat saturated sequences was done. Surgical findings were the reference standard.

Results

Contrast enhanced images were superior to DWI in detection of primary fistula and internal opening while they were equivalent in detection of secondary extensions and abscess. There was no significant difference in overall accuracy of detection of perianal fistula and its complications between combined (DWI and TIRM images) and post contrast images. There was significant difference between ADC values of active and inactive fistulae and between abscess and inflammatory reaction.

Conclusion

Combined DWI and TIRM is equivalent to post contrast images in detection of primary and complicated fistula. DWI is useful in differentiation between abscess and inflammatory reaction, and assessment of disease activity.  相似文献   

4.

Objective

To assess the diagnostic accuracy of diffusion weighted imaging (DWI-MRI) being a non-contrast based MR sequence versus dynamic contrast enhanced MRI (DCE-MRI) in the preoperative loco-regional staging of the cervical carcinoma.

Methodology

Fifty cases of proved cancer cervix prior staging subjected to dynamic post contrast technique: one pre-and six post contrast phases (40?s each). DWI was scanned using different b values and ADC values were measured.

Results

DWI was the most accurate in staging operable cases (93.3%).Parametrial infiltration was overestimated in 3 cases versus 4 cases in DCE-MR. DWI showed 100% sensitivity, positive predictive value and accuracy in the assessment of locally advanced carcinomas. In metastatic lymph nodes, DCE-MR showed the least accuracy of 86%.

Conclusion

DWI is helpful in discriminating local from locally advanced cervical carcinomas. DCE-MR can delineate cervical carcinomas confined to the uterus and exclude bladder/rectal invasion.  相似文献   

5.

Purpose

To assess the role of dynamic contrast- enhanced and diffusion-weighted (DWI) MRI in the evaluation of the response of hepatocellular carcinoma (HCC) after chemoembolization.

Patient & method

30 patients having 40 HCC lesions underwent transcatheter arterial chemoembolization (TACE). Ages ranged between 41 and 76?years. All examinations were performed using Philips 1.5 Tesla MRI (Achieva). Precontrast T1, T2, Dynamic contrast enhanced and respiratory triggered DWI MR images with (b?=?50, 400, 800?mm/s). DWI MRI images and Contrast-enhanced MRI images after TACE are assessed to evaluate post treatment response. DWI was used to create ADC maps and ADC values were calculated looking for a cut off value using the ROC curve.

Results

Dynamic MRI had a sensitivity of 94.1%, a specificity of 95.6%, PPV value of 94.1%, NPV of 95.6% and an overall agreement of 95% compared to 82%, 73.9%, 70%, 85% and 77.5% respectively of DWI MRI. The difference between the malignant residual and well ablated groups' ADC variables was statistically significant P value 0.009.

Conclusion

Dynamic and diffusion MRI complete each other in assessment of HCC response to therapy, especially in those who cannot properly hold their breath that cause degradation of the dynamic MR quality.  相似文献   

6.

Objective

The aim of this study was to assess the efficacy of quantitative MRI parameters using 1.5 T magnet in evaluation of MN in CTS.

Patients and methods

From August 2015 and July 2016. Twenty patients diagnosed as having CTS and other ten healthy volunteers, underwent a quantitative MRI examination of the wrist with T2 SPAIR and DWI sequences. A computation of SIR, ADC values at different levels and ADC ratio was made.

Results

There was significant increase in SIR in CTS patients at DRUJ and pisiform. SIR at pisiform was significantly correlated with operative documentation of bulbous nerve swelling. There was increase in mean ADC value of MN in CTS when moving from proximal to distal locations, in contrast to normal subjects. SIR and ADC value were specific especially when measured at the pisiform. Cutoff values of 1 for ADC ratio showed high Specificity, and Overall accuracy.

Conclusion

Quantitative 1.5 T MRI is an accurate diagnostic tool in CTS. The increase in MN ADC value from proximal to distal with an ADC ratio cutoff value of 1 is highly accurate in diagnosing CTS.  相似文献   

7.

Background

Neoadjuvant chemotherapy (NAC) has clinically important outcome. Early evaluation of the treatment response is important to avoid unnecessary therapy in non-responders. MRI is the most sensitive imaging for monitoring NAC response.

Aim of this study

Is to test the ability of DWI to detect early response to NAC.

Results

The study was performed on 20 patients, proved pathologically to have invasive breast cancer. All patients underwent breast MRI before initiation of NAC, after one cycle and after completion of the NAC protocol. Regarding the mass size, results showed no significant change in maximum mass diameters occur after the 1st NAC cycle. Absolute value of the ADC show increase all along the treatment course which has no significant correlation with the pathological response. The relative increase ADC more than 20% calculated from subtraction of the pre-treatment ADCmean value from that after the first NAC, subdividing the result on the pre-treatment ADCmean value and multiply it by 100 reflected significantly on the pathological response (p value of 0.011).

Conclusion

ADC value can predict responder from non-responder as early as after the first cycle of chemotherapy.  相似文献   

8.

Objectives

To evaluate accuracy of combined T2 and diffusion weighted images (DWI) in comparison to combined T2WI and dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) for assessment of the depth of myometrial invasion.

Methods

Sixty-two patients diagnosed pathologically as endometrial carcinoma underwent MRI pelvis examination. Technique of examination for each patient includes T1 (axial), T2 (axial, sagittal and oblique sagittal) weighted images. Diffusion weighted images were done with b values of 0 and 1000 s/mm2. Dynamic contrast enhanced-magnetic resonance imaging done after administration of 0.1 mmol/kg gadolinium at 2 ml/s. The pathological diagnosis used as a gold standard for comparison with imaging.

Results

Diagnostic accuracy, sensitivity, specificity of combined T2/diffusion weighted images (DWI) were 92%, 90% and 95.6% while for combined T2/dynamic contrast enhancement (DCE) were 79%, 77% and 82.6% for myometrial invasion <50%. The diagnostic accuracy, sensitivity, specificity of combined T2/diffusion weighted images (DWI) were 92%, 95.6% and 90% while for the combined T2/dynamic contrast enhancement (DCE) were 79%, 82.6% and 77% for myometrial invasion >50%.

Conclusion

Combined T2WI-DWI has superior diagnostic accuracy compared to combined T2WI-DCE-MRI in assessment of depth of myometrial invasion in endometrial cancer. T2WI-DWI can eliminate contrast material injection especially for patients who cannot tolerate contrast administration.  相似文献   

9.

Background

MS plaques display different pattern of enhancement with variable clinical course. The purpose is to assess the role of ADC value as a predictive for MS histologic changes with different enhancing pattern and its correlation with disease activity.

Patients and methods

This prospective study included 28 chronic MS patients with 75 lesions, subjected for magnetic resonance imaging and ADC value measurement of the plaques and normally appearing white matter (NAWM) to be correlated with that of normal white matter (NWM) in 20 healthy controls.

Results

T1-Hypointense and confluent lesions had statistical significant higher mean ADC value relative to the isointense and discrete lesions. Statistical significance difference was detected between mean ADC value of homogeneously enhancing lesions (HELs) and ring enhancing lesions (RELs) and between HELs and non-enhancing lesions (NELs), but no difference between NELs and RELs. Statistical significance difference was detected between ADC of NAWM relative to NWM of healthy controls.

Conclusion

ADC value predicts histological changes in MS lesions. Pattern of enhancement doesn't correlate with neurologic deficits but ADC value is more valuable in assessing the disease activity.  相似文献   

10.

Abstract aim

To assess role of MDCT in diagnostic evaluation of different renal sinus lesions.

Methods

A prospective study included 40 patients (25 male; 5 female; mean age, ±SD, 54?±?8?years) proven as renal sinus lesions by US& 64-MDCT. MDCT protocoal included unenhanced and contrast enhanced MDCT (CMP & NP & EP). Comparing MDCT findings with histopathological results were calculated. The study was approved by ethics committee.

Results

Our different pathology were: ?3 parapelvic cysts (0.4%); 2 peripelvic cysts (0.8%); 3R.A.A. (1.2%); 1 AVM (0.4%); 2 lipomatosis (0.8%), 2XGP (0.8%); 2 hematomas (0.8%); 1 abscess (0.4%); 2 SCC (0.4%); 7 TCC (2.8%); 1 AML (0.4%); 1 hemangioma (0.4%); 2 AML (0.8%); 1 NHL (04%); 1CPDN (0.4%),1 MCN (0.4%), 6 RCC (2.4%); 1 retroperitoneal NHL (0.4%), 1 retroperitoneal plasmacytoma (0.4%). Statistically significant difference was found between HU in CMP and EP (P?<?0.001) and between NP & EP (P?<?0.001) in cases of RCC, A significant statistical difference was detected among HU in NP and EP in TCC (P value?=?0.03). Presence of pseudo-capsule in RCC (P?<?0.001), MDCT yields sensitivity 95%, specificity 70%, PPV?=?90.2% & NPV?=?77.8% and overall accuracy 87.5%.

Conclusion

MDCT accurately evaluated different renal sinus lesions and differentiating between benign and malignant lesions as well as clear cell subtype and unclassified subtype of RCC.  相似文献   

11.

Objective

To evaluate the additional diagnostic value of diffusion and perfusion MRI in the differentiation of glioblastoma multiforme (GBM) and solitary brain metastasis.

Patients and methods

This retrospective study included 24 patients with histologically proven brain tumors who underwent conventional MRI with analysis of diffusion (DWI) and perfusion (PWI) MRI findings of each tumor. The Apparent Diffusion Coefficient (ADC) values were calculated in the minimum (ADC-MIN), mean (ADC-MEAN), and maximum (ADC-MAX) in all the tumors and the peritumoral regions. The PWI data was expressed as maximum regional cerebral blood volume (rCBV) of the tumors and peritumoral regions.

Results

After adding diffusion and perfusion to conventional MRI findings, we found that the accuracy of differentiation between glioblastoma multiforme (GBM) and solitary metastasis increased from 70% to 90%.There is a significant difference in DWI signal intensity between GBM and metastatic tumors (P < 0.05). The ADC values of GBM were lower than that of metastatic tumors. On perfusion MRI, the maximum rCBV of the peritumoral region (rCBVP) of GBM was higher than that of brain metastases (P < 0.001).

Conclusion

The addition of diffusion and perfusion to the MRI protocol increases the accuracy of differentiation between GBM and solitary brain metastasis and should be considered routinely.  相似文献   

12.

Aim

To evaluate the role of using a single shot spin echoplanar DW sequence (SSSEP-DWI) compared to conventional MRI and contrast enhanced T1WI in differentiation between vertebral osteoporotic fractures and malignant compression fractures. The sensitivity and specificity of (SSSEP-DWI) will also be calculated.

Patients and methods

Sixty-eight acute vertebral compression fractures in 41 patients were imaged using conventional MRI, fat suppressed contrast enhanced T1WI and DW sequence on a 1.5 T MR machine. Quantitative assessment of the abnormal signal intensity was done by measuring apparent diffusion coefficients (ADCs). Also, the areas of abnormal signal intensity were compared to adjacent normal marrow.

Results

We had 38 benign fractures, and 30 malignant fractures. Post contrast enhancement showed sensitivity of 92% and specificity of 70% for malignant compression fractures. The hyperintense signal on DWI has 89% PPV for malignancy, while the sensitivity and specificity were 86% and 91% respectively. The mean ADC for malignant fractures was significantly lower than those of osteoporotic fractures (p = 0.0002).

Conclusions

SSSEP-DWI is a reliable adjunct parameter that supports conventional MRI in differentiating benign and malignant vertebral fractures.  相似文献   

13.

Background and purpose

Alzheimer’s disease (AD) is a major cause of dementia in elderly affecting about 30% above the age of 85 years, while mild cognitive impairment (MCI) is the impairment in cognitive functions with intact daily life activities which is described as the preclinical phase of AD.

Purpose

To evaluate the role of DWI and MRS in prediction of pre-Alzheimer’s patients and differentiating them from those with AD.

Patients and methods

This study included 37 patients (24 males and 13 females) with age ranged from 50 to 73 years (mean age = 61.6 years). They were divided into two main groups, the first group pre-Alzheimer’s (MCI) included 24 patients, and the second group (AD) included 13 patients. All patients underwent DWI and MRS using 1.5 T system.

Results

In our study, males were more commonly affected by the two diseases, the mean age was 61.6 years and memory dysfunction followed by depression was the most common clinical symptom. Regarding DWI study, there were statistically higher ADC values in AD (0.97 and 0.94) than in MCI (0.90 and 0.79) in the hippocampal and temporal regions respectively. The NAA/Cr ratio was significantly higher in MCI (1.74 and 1.58) than in AD (1.41 and 1.05) in the hippocampal, temporal regions respectively. Regarding mI/Cr ratio, it was significantly higher in AD (1.51 and 1.47) than in MCI (1.10 and 1.11). The Cho/Cr ratio also was significantly higher in AD (1.27 and 1.38) than in MCI (1.02 and 0.99) in the same regions respectively. From the ROC curve analysis the NAA/Cr ratio was the most sensitive and specific in both regions.

Conclusions

Mild cognitive impairment is a term used to describe the pre-Alzheimer’s stage. Later, most of MCI patients develop Alzheimer’s dementia. The combination of DWI and MRS is promising tool for the detection of early structural changes occurring in MCI patients before the full manifestation of dementia syndrome starts to appear.

Clinical significance

DWI and MRS help in early prediction, follow-up, and treatment of patients with pre-Alzheimer’s disease.  相似文献   

14.

Objective

Conventional MRI does not provide sufficient information to differentiate post-radiotherapy necrosis from brain tumor recurrence, recent studies have investigated the use of more advanced imaging modalities that are able to differentiate between the two entities.

Aim of the study

To assess the usefulness of combined apparent diffusion coefficient (ADC) value and single voxel spectroscopy (SVS) in the differentiation between recurrent brain gliomas and post-radiotherapy necrosis.

Methods

Twenty-two patients with suspected tumor recurrence after surgical resection and radiotherapy treatment were included in our study. MRI with contrast, diffusion weighted MRI with ADC value and MR spectroscopy were done to all patients.

Results

ADC values were ≤1.150?×?10?3?mm2/sec for recurrent high grade gliomas, >1.150–≤1.370?×?10?3?mm2/sec for recurrent low grade gliomas and >1.370?×?10?3?mm2/sec for post radiation necrosis. NAA/Cr ratio could significantly differentiate between recurrent gliomas and post radiation necrosis (p value?=?.019), also Cho/Cr was significant p value?=?.006. Also NAA/Cr and Cho/Cr were statistically significant in differentiating recurrent high grade from low grade gliomas (p value?<?.001).

Conclusion

Combination of calculated ADC value and MR spectroscopy added more information and increase the accuracy of conventional MR imaging in the differentiation of patients with suspected recurrent brain glioma from post-radiotherapy necrosis.  相似文献   

15.

Purpose

To evaluate the role of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in detecting microstructural changes of normal-appearing deep grey matter (NDGM) in multiple sclerosis (MS).

Patient and methods

We examined 40 patients with MS and 20 healthy volunteers using DTI to correlate average ADC and FA of the thalami, lentiform and caudate nuclei between the two groups. Receiver operating characteristic analysis was used to test the diagnostic performance of ADC and FA in detecting NDGM involvement in multiple sclerosis.

Results

Between the two study groups, there was statistically significant difference of ADC of thalami, lentiform, caudate nuclei, and FA of the thalami (p?<?.05). No statistically significant difference of FA of lentiform (p?=?.2) and caudate (p?=?.06) nuclei. For detection of microstructural changes of NDGM, ADC cut off values were 0.762?×?10?3?mm2/s for thalamus (90% sensitivity and 66% specificity), 0.529?×?10?3?mm2/s for lentiform (86% sensitivity and 60% specificity) and 0.784?×?10?3?mm2/s for caudate nuclei (83% sensitivity and 67% specificity).

Conclusion

ADC has better diagnostic performance and is more accurate than FA as a measure to detect microstructural changes of NDGM.  相似文献   

16.

Background and purpose

Consistency of pituitary macroadenoma is a crucial information for neurosurgeons. We aimed to assess the role of DW-MRI as non invasive imaging modality in predicting the tumour consistency of pituitary macroadenoma.

Materials and methods

Twenty patients with pituitary macroadenoma underwent conventional MR imaging sequences, pre contrast, post contrast MRI and diffusion weighted MRI with ADC map. The tumour consistency was determined both macroscopic by neurosurgeons and microscopic by histopathologists.

Results

Our study included 12 soft, 4 intermediate and 4 hard tumours. The tumour consistency and the collagen contents were correlated with diffusion and ADC values. The mean ADC value of patients with soft tumours was 0.54?×?10?3?mm2/s while for intermediate tumour was 0.82?×?10?3?mm2/s and for hard tumours was 1.11?×?10?3?mm2/s. Soft and intermediate consistency tumours were successfully managed by endoscopic transsphenoidal approach; suction and curettage. While, hard tumours could not be managed by the transsphenoidal approach and needed further transcranial procedure with sensitivity 95% and specificity 95%.

Conclusion

DWI-MRI is a useful tool to predict the pituitary macroadenoma consistency and the suitable surgical approach for resection.  相似文献   

17.

Objective

To assess DWI and ADC value in characterization of orbital masses (differentiation of benign, inflammatory and malignant orbital masses).

Patients & methods

Cross-sectional study included 38 patients, and diagnosed histopathologically, clinically and radiologically 26 with benign and inflammatory masses and 12 with malignant masses. Their ages ranged from 15 to 63 years. They were examined using 1.5 T MR machine.

Results

There was a significant difference in ADC value of malignant and benign orbital masses. Malignant masses have a lower ADC values and restricted diffusion, compared with benign masses. Using 0.93 × 10?3 mm2/s as a cutoff value, in differentiating malignant from benign lesions, resulted in a total of 80% sensitivity, 83.3% specificity and 82% accuracy. Lesions with ADC values less than 0.87 × 10?3 mm2/s, had 90% likely to be of malignant nature. Lesions with ADC greater than 1.1 × 10?3 mm2/s, had 90% likely to be of benign nature. In between these two values, lesions are indeterminate.

Conclusion

Diffusion weighted imaging with ADC value, can help in differentiating malignant from benign orbital masses. Malignant orbital masses have a significant lower ADC value than benign masses. We can use ADC cutoff value between malignant and benign masses.  相似文献   

18.

Introduction

Cystic pancreatic lesions are currently discovered at higher rate, hence adequate characterization of these lesions by the radiologist is important in guiding management.

Aim of the work

Was to identify the role of MRI in characterization of cystic pancreatic lesions.

Patients and methods

Thirty patients with suspected cystic lesions of the pancreas were examined by MRI using 1.5?T machines including conventional MRI sequences, dynamic contrast enhanced imaging, DWI and IP/OP sequence.

Results

The study included 30 patients (12 males and 18 females) with their age ranging from 16 to 88?years (mean age 55?years), MRI analysis of the cyst contents and communication with ductal system were used to characterize different cyst types, among these patients we found serous cystadenoma in five patients, mucinous cystadenoma in seven patients, mucinous cystadenocarcinoma in one patient, branch type Intraductal papillary mucinous neoplasms (IPMN) in seven patients, Mixed IPMN in two patients. Cystic neuroendocrine tumors (CNET) in three patients. Solid cystic pancreatic neoplasm (SPN) in two patients. Pseudocyst in one patient and walled off necrosis (WON) in two patients. Pathological assessment of the lesions was done whenever indicated.

Conclusions

MRI with its superior soft tissue resolution is of value in characterization of different cystic pancreatic lesions helping to reach the correct diagnosis.  相似文献   

19.

Purpose

The goal of the study was to highlight the added value of combined DWI and conventional MRI in detecting clinically nonpalpable undescended testes.

Patients and methods

Prospective study included 60 males referred for MRI evaluation of clinically diagnosed 66 nonpalpable undescended testes. MRI studies were performed using 1.5-T MRI machine and included axial and coronal spin-echo T1WIs, axial T2WIs, axial and coronal fat suppressed spin-echo T2WIs, and axial DWIs using three sets of b value (50, 400, and 800 s/mm2). All images were transferred to an independent workstation and evaluated by two radiologists for the presence or absence and location of the undescended testes. The findings were compared to laparoscopy results, and then, sensitivity, specificity, and accuracy were calculated for both conventional and combined (DWI and conventional) MRI.

Results

According to laparoscopic findings, sensitivity, specificity and accuracy of conventional MRI were 73.91%, 100%, and 80% and 69.57%, 100%, and 76.67% for radiologists 1 and 2 respectively, and of combined MRI were 86.9%, 100%, and 90% and 82.61%, 100%, and 86.67% for radiologists 1 and 2 respectively.

Conclusion

Adding DWIs to conventional MRI improves the sensitivity and accuracy of detecting clinically nonpalpable undescended testes.  相似文献   

20.

Purpose

To highlight the relationship between coraco-humeral distance and subscapularis tendon tear.

Material and methods

Sixty-two shoulder MRI studies were examined. Twenty-two patients had partial or complete tear of subscapularis tendon and forty shoulder as a control group. Axial and oblique sagittal MR images were examined to measure the coraco-humeral distance followed by statistical analysis to correlate the distance with tendon tear.

Results

A cut-off value of 8.25?mm for the coraco-humeral distance gave a sensitivity of 77.5% and specificity of 72.7% for subscapularis tendon tear.

Conclusion

There is a well-known relationship between the coraco-humeral distance and the subscapularis tendon tear and its meticulous assessment in subjects with pain in the anterior shoulder region increases the diagnosis of subcoracoid impingement.  相似文献   

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