Carcinosarcoma of the bladder diverticulum: a case report and review of literature

A 56-year-old man with carcinosarcoma of the bladder diverticulum is reported. Histologically, the tumor contained two elements: carcinomatous and sarcomatous components with a transitional phase between them. The related literature is also reviewed.     

Carcinosarcoma of the bladder: case report and review of the literature

Primary osteosarcomas of the bladder account for about 0.04% of bladder neoplasms. Most of the patients in the literature expired within 6 months and, in almost all of the cases in the literature, radical cystectomy with postoperative chemotherapy was the treatment choice. A 79-year-old gentleman presented with gross hematuria. Cystoscopy demonstrated a 2- to 3-cm tumour along the lateral wall of the bladder. The tumour was resected incompletely via initial transurethral resection of bladder tumour (TURBT), and a second TURBT was subsequently performed to fully resect the residual mass. Surgical pathology from these 2 resections revealed osteosarcoma with invasion into the muscularis propria. A cystoprostatectomy was performed and final pathologic specimen revealed high-grade CIS without evidence of residual osteosarcoma. Postoperatively, the patient did not receive chemotherapy or radiation and currently remains disease-free 2 years post-radical cystectomy. Only 33 well-documented cases of primary osteosarcoma of the bladder have been reported to date. However, there are only 3 cases in which TURBT resulted in complete resection.     

Carcinosarcoma of the prostate: a case report

A 63-year-old Japanese man with a 1-month history of dyschezia and dysuria was referred to our hospital. Transrectal ultrasonography and magnetic resonance imaging demonstrated a mass involving the prostate, measuring about 6.5 cm. The serum prostate specific antigen was 20.3 ng/ml. By the transperineal needle biopsy, it was suspected to be fibrosarcoma. Total pelvic exenteration was performed. Histopathological examination of the tumor revealed carcinosarcoma of the prostate. One month after the operation local recurrence was manifested by perineal pain. The recurrent tumor grew rapidly with severe pain. The patient's condition deteriorated, and finally he died of the disease nine months after the operation. Carcinosarcoma of the prostate is a rare neoplasm and very aggressive. There is no established protocol for its treatment and its prognosis is usually poor. This is the 49th case reported in the literature.     

Carcinosarcoma of the liver: a case report

Primary hepatic carcinosarcoma is a rare malignant hepatic tumor containing both carcinomatous and sarcomatous elements. A 40-year-old man referred to our liver transplant team because of hepatic cirrhosis was on the waiting list, having undergone all liver tests, ultrasonography, and with normal serum alpha fetoprotein markers every 6 months to search for a tumor. He underwent a liver transplantation without complication. The pathologic findings of the original liver indicated carcinosarcoma. We have reviewed the literature on this subject.     

胆囊癌肉瘤一例

正病例患者男性,71岁,因"间断性腹痛10年余,腹胀不适10天"入院。10年前曾因外伤在当地医院行右前臂骨折手术。入院查体:皮肤、巩膜无黄染,无肝掌、蜘蛛痣。神志清楚,无腹壁静脉曲张,未见胃肠型及蠕动波,腹肌软,右上腹稍膨隆,可触及较大张力包块,局部无压痛无反跳痛,Murphy征阳性,肝脾肋下未触及。实验室检查:CA199 42.7 IU/mL,CA125 79.8 IU/mL,铁蛋白329.4 μg/L。     

Carcinosarcoma of the liver: report of a case

A 64-year-old Japanese woman without a history of viral hepatitis was admitted for investigation of a huge liver mass. The tumor, measuring 14 × 12 × 22 cm, had invaded the diaphragm, right lung, and inferior vena cava. Serum examinations demonstrated high levels of carbohydrate antigen 19-9 (CA19-9), and the Child-Pugh score was A. She underwent right lobectomy of the liver and partial resection of the right diaphragm, right lung, and inferior vena cava. Radio- and chemotherapy were also given, but she died of recurrence 3 months after surgery. Microscopically, the tumor exhibited intermingled adenocarcinomatous and atypical mesenchymal components. The carcinomatous component was positive for cytokeratins 7, 19, and 20, chromogranin A, epithelial membrane antigen, c-KIT, and vimentin. The sarcomatous component was positive for vimentin and c-KIT. A review of 36 cases of hepatic carcinosarcoma revealed the following: chronic hepatitis or cirrhosis in 57 % of the patients; increased serum CA19-9 levels in 30 %; a mean tumor diameter of 10 cm; invasion of the adjacent organs or metastasis to distant organs in 47 %; wide intrahepatic infiltration in 44 %; and 50 % survival of only 5 months. Significant differences were seen according to tumor diameter (diameter >5 cm; p < 0.05), wide intrahepatic infiltration (p < 0.05), and extrahepatic invasion/metastasis (p < 0.01). Neither chemotherapy nor radiotherapy contributed to prognosis, but surgical resection resulted in some improvement (p < 0.05).     

Carcinosarcoma of the urinary bladder. Case report

A case of carcinosarcoma in the urinary bladder is presented. On basis of a review of the most recent literature and referring to our own case, radical cystectomy appears to be the most effective treatment of this tumour.     

胆囊癌肉瘤一例报道

病例：女,59岁。因腹痛、黄疸进行性加重2周入院。发病前2月出现右上腹疼痛．伴肩背部放射痛．并出现皮肤巩膜黄染．尿色加深。无皮肤搔痒。无寒战、发热、恶心呕吐。10年前曾因消化道不适症状,B超检查发现胆囊结石。经保守治疗后缓解,以后无类似急性发作史。入院查血常规：白细胞7．9×10^9／L,血色素134g／L,血小板299×10^9/L。     

Carcinosarcoma of the renal pelvis and ureter: a case report

We report a case of carcinosarcoma of the renal pelvis and ureter arising in an 89-year-old man who presented at our hospital with gross hematuria. Abdominal computed tomography, excretory pyelography, and retrograde pyelography demonstrated that left hydronephrosis was caused by an ureteral tumor. Left urine cytology indicated transitional cell carcinoma. The patient underwent chemotherapy and radiation therapy. However, gross hematuria recurred, and the patient underwent left nephroureterectomy. The surgical specimen showed carcinosarcoma in the renal pelvis and ureter histologically. He has been free of cancer for 1.5 years.     

Carcinosarcoma of the corpus uteri--a case report

Sarcomas account for fewer than 5% of all cancers of the uterine corpus. We present the last classification of The International Society of Gynecology Pathologists for pure sarcomas and also for mixed epithelial-nonepithelial tumors of the uterine corpus. The paper concerns with the study of a case of carcinosarcoma, treated in the III-rd Clinic of Gynecology from Ia?i. This morphological diagnostic represents the most common epithelial-nonepithelial tumor affecting the uterus. Immunohistochemistry with EMA confirms the theory of the combined tumor with a unique origin.     

Carcinosarcoma of the esophagus: a case report and review of the literature

A case of carcinosarcoma of the esophagus and a review of literature are presented. The pertinent clinical and pathological data are summarized. There have been 51 reported cases of which 31 underwent surgical resection of the lesion; there have been three five-year survivors. Although the cumulative experience with this malignancy is limited, it is apparent that the presentation and clinical course of this tumor is not substantially different from the more common squamous cell carcinoma. Therefore, the diagnostic and therapeutic management should not vary from that of any malignant esophageal lesion.     

Carcinosarcoma of the gallbladder: a case report and review of the literature

A case of pedunculated carcinosarcoma of the gallbladder, presenting with common duct obstruction is reported; radiological, operative and pathological findings are described. The patient was treated with cholecystectomy, common bile duct exploration and postoperative radiotherapy applied through a t-tube. Only 20 cases of carcinosarcoma of the gallbladder have been described. The current state of knowledge regarding the natural history of these tumors are reviewed.     

Carcinosarcoma of the bladder

We present a case of carcinosarcoma of the bladder, the first in our experience. This tumour is generally considered to be a rare one, has uncertain aetiology and poor prognosis. At present, radical cystectomy is the treatment of choice.     

Carcinosarcoma of the prostate: report of a case with ultrastructural observations.

A carcinosarcoma of the prostate was examined by light and electron microscopy. The epithelial component was comprised of adenosquamous carcinoma. The stromal component demonstrated osseous and cartilaginous differentiation, and appeared mesenchymal by fine structure analysis. Despite aggressive therapy the patient died with disseminated disease 5 months after diagnosis.     

Carcinosarcoma of the bile duct: a case report and review of literature

Carcinosarcomas of the bile ducts are very rare tumors consisting of both epithelial and mesenchymal elements. We report a case of bile duct carcinosarcoma and its clinical, radiological and pathological features and a brief review on this rare condition.     

Pseudolymphoma of the bladder: a case report

We report a 63 year-old female with solid, nonpapillary, and smooth-surfaced bladder tumescence of approximately 30 and 7 mm in diameter. Biopsy of the tumor and other apparently normal epithelium revealed dense lymphocytic infiltrations with formation of many lymph follicles. Because of the relatively large nodular form of the lesion we regarded this to be pseudolymphoma of the bladder rather than follicular cystitis. Pseudolymphoma in the bladder has not yet been reported in English literatures to our knowledge. The tumorous changes have disappeared by 6 months after the initial 3 week chemotherapy.