苦瓜提取物影响Ⅱ型糖尿病小鼠血糖的Meta分析

目的:系统评价苦瓜提取物对Ⅱ型糖尿病小鼠血糖的影响。方法:计算机检索中文期刊数据库、维普中文科技期刊数据库、万方数据库收录的1979年1月至2012年12月发表的关于苦瓜提取物影响Ⅱ型糖尿病小鼠空腹血糖的相关研究,并辅以手工检索,对照纳入标准筛选文献。对符合纳入标准的研究的质量进行评价,用RevMan5.2软件进行Meta分析。结果:共收集到相关文献23篇,其中符合纳入标准的有14篇,Meta分析结果显示,异质性检测I2=5%,合并结果Z=11.38(P0.00001),有统计学意义,小鼠空腹血糖合并效应值采用标准化均数差(SMD),SMD=1.72,95%CI(1.43,2.02)。结论:苦瓜提取物能够降低Ⅱ型糖尿病模型小鼠空腹血糖值。     

护理干预对糖尿病患者血糖控制的护理效果

目的:探讨护理干预对糖尿病患者血糖控制的护理效果。方法:回顾性分析2012年1月至2012年12月我院内分泌科收治的160例2型糖尿病患者的临床资料。结果:干预组80例糖尿病患者经过有针对性的护理干预,血糖控制的有效率为93.75%,明显高于对照组的67.5%,经统计学分析,P<0.05,差异具有统计学意义。结论:良好的护理干预对于糖尿病的血糖控制具有非常重要的临床意义,值得推广应用。     

中医护理对糖尿病患者血糖控制的影响

目的探究中医护理对糖尿病患者血糖控制的影响。方法选取我院收治的糖尿病患者62例,运用随机分法分为观察组和对照组各31例。对照组采用常规治疗护理方法,观察组在对照组的基础上,施以中医全面护理,对比两组患者治疗后的血糖控制情况。结果观察组空腹血糖、餐后2h血糖、糖化血红蛋白控制情况显著优于对照组,差异有统计学意义(P0.05)。结论对糖尿病患者施以中医护理干预,可显著提高患者血糖控制效果,应在临床上加以推广和应用。     

海木氯仿提取物对糖尿病小鼠血糖血脂的影响

目的研究海木氯仿提取物的降血糖、降血脂作用。方法采用腹腔注射四氧嘧啶建立糖尿病小鼠模型。检测小鼠血糖(GLU)、血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、丙二醛(MDA)含量及超氧化物歧化酶(SOD)活性等生化指标。结果与空白对照组比较,低、中、高剂量海木氯仿提取物组的GLU、TC、TG、LDL-C含量显著降低、HDL-C含量显著升高(P<0.05或P<0.01);中、高剂量组的血清SOD活性显著提高、MDA含量显著降低(P<0.05或P<0.01)。结论海木氯仿提取物对四氧嘧啶所致糖尿病小鼠具有显著的降血糖、降血脂作用。     

中西医结合护理干预对糖尿病患者血糖控制效果的影响

目的探讨中西医结合护理干预对糖尿病患者血糖控制效果的影响。方法按随机数字表法将糖尿病患者160例分成2组,对照组仅予常规性护理干预,观察组在常规护理干预的基础上行中西医结合护理干预,对2组患者的血糖控制情况进行比较,比较2组生活方式、住院时间及费用、患者的满意度等情况。结果护理干预后,观察组患者的生活方式以及血糖控制情况均明显优于对照组(P均<0.05),2组患者的满意度、住院时间以及费用比较差异均有统计学意义(P均<0.05)。结论中西医结合护理干预能够有效地控制糖尿病患者血糖,并促进患者早期康复。     

紫檀茎皮提取物对实验动物血糖水平的影响

豆科植物紫檀 Pterocarpus santalinusL.在印度民间有多种治疗用途,用其心材制成的杯子饮水,可治疗糖尿病。该属另一植物囊状紫檀 P.marsupium 心材和树皮亦具抗糖尿病活性,因此作者研究了紫檀对大鼠血     

妊娠期糖尿病患者血糖控制对妊娠结局的影响

目的:探讨妊娠期糖尿病患者血糖控制对妊娠结局的影响。方法:回顾性分析205例妊娠期糖尿病患者的临床资料。结果:观察组139例患者妊娠期高血压、胎膜早破、产后出血及剖宫产的发生率明显小于对照组,经比较分析差异有统计学意义(P<0.05);观察组患者早产、巨大儿、新生儿窒息、新生儿高胆红素血症的发生率明显小于对照组,经比较分析差异有统计学意义(P<0.05);新生儿低血糖发生情况无明显差异(P>0.05)。结论:早期筛查、确诊妊娠期糖尿病,并给予及时有效的干预治疗,积极控制血糖,对防治妊娠并发症、改善妊娠结局有重要意义。     

神秘果提取物对链脲佐菌素诱导的糖尿病大鼠血糖及脂代谢的影响

目的:研究神秘果提取物对链脲佐菌素诱导的糖尿病大鼠血糖及脂代谢的影响。方法:采用一次性腹腔注射链脲佐菌素制备糖尿病大鼠模型,分别用神秘果提取物0.10、0.05、0.025 g/kg三个剂量灌胃给药5周,测定其血糖、糖耐量、血脂等血清生化指标。结果:连续服用神秘果提取物可以明显降低糖尿病大鼠的血糖,有效改善糖耐量水平,调节血脂含量。结论:该研究表明神秘果提取物对糖尿病大鼠有保护作用。     

冬虫夏草提取物对模型大鼠血糖及氧化应激的影响

目的观察冬虫夏草提取物(CSE)对链脲菌素(Streptozotocin,STZ)诱导的糖尿病模型大鼠血糖、氧自由基及一氧化氮(NO)、一氧化氮合酶(NOS)的影响,初步探讨其可能的作用机制。方法采用STZ腹腔一次注射法(60 mg/kg)建立糖尿病大鼠模型。将成功模型随机分为模型组、二甲双胍组(0.2 g/kg)和CSE(0.5、1.0、1.5 g/kg)组,每组10只。各给药组连续灌肠给药8周,模型组与对照组给予等容量的蒸馏水。第8周末测定空腹血糖(FBG)及糖化血清蛋白(GSP);末次给药24 h后,腹主动脉取血,采用化学比色法分别检测血清和肝脏中的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性及丙二醛(MDA)含量变化,检测血清中NO、总一氧化氮合酶(T-NOS)、诱生型一氧化氮合酶(iNOS)和结构型一氧化氮合酶(cNOS)的含量。结果 CSE(1.0、1.5 g/kg)组能够降低糖尿病大鼠FBG(P<0.05)和GSP(P<0.05);CSE各剂量组均提高糖尿病大鼠血清和肝脏的SOD和GSH-Px水平(P<0.05),降低MDA含量(P<0.05);与模型组比较,CSE(1.0、1.5 g/kg)组血清NO、T-NOS和iNOS含量均明显下降(P<0.05),cNOS含量无明显变化(P>0.05)。结论 CSE可以降低STZ诱导的糖尿病大鼠的血糖,改善糖尿病大鼠体内异常的氧化应激水平,降低血清NO含量可能是通过抑制iNOS的表达实现的。     

泽泻提取物对正常及四氧嘧啶小鼠糖尿病模型的影响

目的 :研究泽泻水提醇沉法提取物 (RAE)的抗糖尿病作用。方法 :给小鼠尾静脉注射四氧嘧啶 90mg·kg- 1 ,造成糖尿病模型。测定血糖 (Glu)、甘油三酯 (Trig)、胆固醇 (Chol)、胰淀粉酶 (Amy)和血清胰岛素 (Ins)。光镜下观察胰腺和胰岛的组织学变化。结果 :RAE可使正常小鼠血糖明显降低。治疗 7天可使四氧嘧啶小鼠Glu和Trig降低。光镜下观察RAE治疗后的四氧嘧啶小鼠 ,胰岛保持正常组织学形态。RAE还可升高血清Ins水平及对抗四氧嘧啶诱发的Amy降低。     

参与型护理改善胃癌合并糖尿病患者围手术期血糖控制效果观察

目的观察参与型护理对胃癌合并糖尿病患者围手术期血糖控制情况的影响。方法将60例胃癌合并糖尿病围手术期患者随机分为2组,各30例。对照组接受以饮食管理为主的常规护理,观察组在此基础上接受参与型护理,包括饮食指导、中医特色护理、心理指导。观察2组患者术前及术后3个月空腹血糖(FBG)、餐后2h血糖(2hBG)、糖化血红蛋白(HbA1c),空腹胰岛素(FINS)水平,并通过稳态模型(HOMA-IR)评价胰岛素抵抗。结果术后3个月,观察组FBG、2hBG、HbA1c,HOMA-IR均低于对照组(P<0.05)。观察组血糖控制有效率为66.7%,高于对照组的20.0%(P<0.05)。结论参与型护理能有效控制胃癌合并糖尿病患者围手术期血糖,改善胰岛素抵抗。     

The effect of green coffee extract supplementation on blood pressure: A systematic review and meta‐analysis of randomized controlled trials

Given the proliferation in studies investigating green coffee bean extract (GCBE) supplementation, the purpose of this study was to determine the efficacy and effectiveness of GCBE supplementation on indices of blood pressure. The literature search was performed in four databases, namely, PubMed/Medline, Scopus, the Cochrane Library, and Google Scholar, to identify clinical trials that examined the effects of green coffee supplements on systolic blood pressure (SBP) and diastolic blood pressure (DBP) up to February 2019. Mean change and standard deviation (SD) of the outcome measures were used to estimate the mean difference between the intervention group and the control group at follow‐up. Nine studies reported SBP and DBP as an outcome measure. Results revealed significant reduction in SBP (weighted mean difference: ?3.093 mmHg, 95% confidence interval [CI]: ?3.914, ?2.273; I² = 0.0%) and DBP (?2.170 mmHg, 95% CI: ?2.749, ?1.590; I²= 46.5%) after green coffee supplementation with low heterogeneity among the studies. In addition, in subgroup analysis, a significant reduction in SBP and DBP in studies with hypertensive patients, green coffee dosage <400 mg, and administered for 4 weeks was identified. The results of the current meta‐analysis study support the use of GCBE supplementation for the improvement of blood pressure indices, with subgroup analysis highlighting improvements in hypertensive patients.     

Electroacupuncture for control of blood glucose in diabetes: literature review

Electrical stimulation at acupuncture points (acupoints) has been investigated for its utility in lowering blood glucose in hyperglycemic humans and animal models. Only two studies were found using electroacupuncture in human subjects, and in both of these, the participants were normal (nondiabetic) and electrical stimulation was carried out at several acupoints. It had a hypoglycemic effect in obese women with calorific restriction diet using electrical stimulation of 2 Hz for 30 minutes/day for 20 days, but no change occurred in blood glucose of fasted patients in the other study using 1 Hz for 15 minutes. Fourteen animal studies were found, of which, 11 were performed in diabetic and normal rats. A hypoglycemic effect was observed in fasted type 1 diabetic rats using the Zusanli (ST36) leg acupoint with electrical stimulation of 15 Hz for 30 minutes and 60 minutes. In fasted type 2 diabetic rats, blood glucose was lowered using the Zusanli acupoint with electrical stimulation parameters of 15 Hz and 10 mA for 30 minutes. Also, using the Zhongwan (CV12) abdomen acupoint with electrical stimulation parameters of 15 Hz and 10 mA for 90 minutes had a hypoglycemic effect in fasted type 2 diabetic rats. In fasted normal rats, electrical stimulation of 2 Hz or 15 Hz for 30 minutes at the Zusanli or Zhongwan acupoint caused a decrease in blood glucose. Future studies are required in fasted diabetic rats to determine the effect of electroacupuncture on blood levels of insulin, lipids, fatty acids and β-endorphin, and blood flow and nerve conduction velocity. Studies with fasted normal and diabetic human subjects treated by electroacupuncture are warranted using data from animal experiments to inform such studies.     

针刺中脘穴联合自拟茶方对2型糖尿病患者血糖水平的影响

目的:研究针刺中脘穴联合自拟茶方对2型糖尿病(T2DM)患者血糖水平的影响。方法:纳入90例T2DM患者作为研究对象。通过随机抽签法将其等分成茶方组、针刺组以及联合组。其中茶方组予以自拟茶方治疗,针刺组实施中脘穴针刺治疗,联合组予以针刺联合自拟茶方治疗。比较三组治疗前后血糖指标水平,血脂指标水平,胰岛素功能变化情况,血清脂联素水平。结果:治疗后联合组FBG、2hPG、HbA1c水平均高于茶方组与针刺组(均P<0.05)。治疗后联合组TG、TC、LDL-C水平均低于茶方组与针刺组(均P<0.05)。联合组HOMA-IR水平均低于茶方组与针刺组;而HOMA-β水平均高于茶方组与针刺组(均P<0.05)。治疗后三组血清脂联素水平均高于治疗前,且联合组血清脂联素水平均高于茶方组与针刺组(均P<0.05)。结论:针刺中脘穴联合自拟茶方可显著改善T2DM患者的血糖水平,提高胰岛素功能,改善血脂水平与脂联素水平,值得临床应用。     

糖肝康颗粒对糖尿病模型大鼠血糖、血脂及NO含量的影响

目的:观察糖肝康颗粒对糖尿病模型大鼠血糖、血脂及NO含量的影响。方法:用链脲佐菌素联合高脂饮食制作糖尿病高血脂大鼠模型,观察糖肝康对糖尿病高血脂大鼠血糖、血脂及NO含量。结果:糖肝康可显著的降低糖尿病模型大鼠的血糖及糖化血红蛋白,且能明显降低三酰甘油(TG)、胆固醇(TC)水平,而且随着剂量的加大,疗效更加显著,明显优于对照组(P<0.01～0.05)。同时糖肝康可显著改善糖尿病模型大鼠血清中的NO含量,与对照组比较,有显著性差异(P<0.05)。结论:糖肝康有很好的降血糖、降血脂及改善NO含量的作用。     

Effects of green tea or green tea catechin on liver enzymes in healthy individuals and people with nonalcoholic fatty liver disease: A systematic review and meta‐analysis of randomized clinical trials

The therapeutic potential of green tea as a rich source of antioxidants and anti‐inflammatory compounds has been investigated by several studies. The present study aimed to systematically review and analyze randomized clinical trials (RCTs) assessing the effects of green tea, catechin, and other forms of green tea supplementation on levels of liver enzymes. PubMed, SCOPUS, EMBASE, and Cochrane databases were searched until February 2019. All RCTs investigating the effect of green tea or its catechin on liver enzymes including alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and bilirubin were included. A total of 15 RCTs were included. The overall effect of green tea on liver enzymes was nonsignificant (ALT [Standardized mean difference (SMD)= ?0.17, CI ?0.42 to 0.08, p = .19], AST [SMD = ?0.07, CI ?0.43 to 0.29, p = .69], and ALP [SMD = ?0.17, CI ?0.45 to 0.1, p = .22]). However, subgroup analyses showed that green tea reduced the levels of liver enzymes in participants with nonalcoholic fatty liver disease (NAFLD) but in healthy subjects, a small significant increase in liver enzymes was observed. In conclusion, the results of this study suggest that the effect of green tea on liver enzymes is dependent on the health status of individuals. While a moderate reducing effect was observed in patients with NAFLD, in healthy subjects, a small increasing effect was found.     

补肾健脾法配合常规西药治疗2型糖尿病的临床疗效及对血糖和血液流变学的影响

目的 观察补肾健脾法配合常规西药治疗脾肾亏虚型2型糖尿病的临床疗效及对血糖和血液流变学的影响.方法 将140例脾肾亏虚型2型糖尿病患者随机分为2组.对照组60例西医常规治疗,治疗组80例在对照组治疗基础上加补肾健脾方.2组均3个月为1个疗程,1个疗程后统计临床疗效,并观察治疗前后血糖及血液流变学变化情况.结果 治...     

参麦注射液对急性心肌梗死病死率影响的系统评价

目的系统评价参麦注射液对急性心肌梗死(AMI)病死率的影响。方法根据系统评价要求制定相应的详细的纳入与排除标准,按拟定的标准制定出系统、全面的检索策略。计算机检索Cochrane数据库、PubMed、OVID、CBM、CNKI、CMCC等,手工检索国内心血管疾病和中医药期刊以及会议论文集,筛选参麦注射液治疗AMI的随机对照试验(RCT)或半随机对照试验。采用Cochrane handbook for systematic reviews of interventions 4.2.6中推荐的简单评估法进行质量分级,应用RevMan 4.2.2统计软件进行Meta分析。结果共纳入13个RCT的1 707例AMI患者,纳入研究的文献质量均为C级。Meta分析结果显示,参麦注射液治疗组较对照组的病死率降低(总效应Z=3.58,P=0.000 3)。结论根据当前证据,参麦注射液可以显著降低AMI病死率。由于纳入研究的文献质量较低,且存在一定的发表偏倚,从这些研究中所获得的证据强度不高,需要更高质量的研究加以验证。     

The effects of green tea on acne vulgaris: A systematic review and meta‐analysis of randomized clinical trials

Green tea extract (GTE) has been studied for the treatment of acne based on its anti‐inflammatory/antioxidant properties. This systematic review and meta‐analysis aimed to examine the effects of GTE on acne. Electronic databases, including PubMed, Embase, and the Cochrane Library were systematically searched up to August 2019. The effect size of acne lesion counts is presented as mean differences and 95% confidence intervals (CIs). Five randomized‐controlled studies were included in the meta‐analysis (N; experimental = 125, control = 122). GTE significantly reduced the number of inflammatory lesions (?9.38; 95% CI: ?14.13 to ?4.63). In subgroup analysis, topical GTE application significantly reduced the inflammatory lesion counts (?11.39; 95% CI: ?15.91 to ?6.86) whereas oral GTE intake showed minimal effect (?1.40; 95% CI: ?2.50 to ?0.30). Although GTE did not significantly reduce the number of non‐inflammatory lesions (?21.65; 95% CI: ?47.52 to 4.22), when stratified by the route of admission, non‐inflammatory acne lesions were significantly reduced by topical GTE application (?32.44; 95% CI: ?39.27 to ?25.62) but not with oral GTE administration (0.20; 95% CI: 0.00 to 0.40). This systematic review and meta‐analysis suggest that topical GTE application is beneficial for the treatment of acne without causing significant adverse events while oral GTE intake has limited effects. Further high‐quality clinical trials are warranted.     

The effect of green tea on inflammatory mediators: A systematic review and meta‐analysis of randomized clinical trials

Catechin in green tea might be able to reduce inflammatory mediators; therefore, in this study, we aimed to indicate green tea effects on inflammatory mediators such as tumor necrosis factor‐alpha (TNF‐α), C‐reactive protein (CRP), and interleukin‐6 (IL‐6). The advanced search methods of electronic databases were used to find randomized clinical trials that assessed green tea effect on inflammatory mediators among adult population. Google Scholar, PubMed/Medline, EMBASE, SCOPUS, and ISI Web of Science were searched until January 2019. Delphi checklist was used for assessing the quality of included articles. Mean changes in serum inflammatory biomarkers were calculated by subtracting endpoint values from the baseline in each study arm. Then the effect size for each selected study was estimated as the difference between mean changes in the intervention and control groups. We included 16 articles in our meta‐analysis and 17 articles in systematic review. Our results indicated that green tea could not significantly decrease serum CRP levels and significantly increased IL‐6 and significantly decreased TNF‐α levels. In conclusion, green tea might not be able to change inflammatory mediators especially in diseases with low inflammation, but scientists who want to assess green tea effect on inflammatory mediators should perform their study on patients with high inflammation. Studies exclusive on male or female and considering nutrients intake as a confounding factor are a necessity.