高龄老人血浆超氧化物歧化酶和丙二醛与认知功能的关系

目的:分析高龄老人血浆超氧化物歧化酶(SOD)、丙二醛(MDA)与认知功能的关系。方法:通过问卷调查基本信息、生活方式及认知功能等,测定血浆相关生化指标及SOD和MDA水平。logistic回归分析和多元线性回归模型研究认知功能与SOD、MDA水平的关系。结果:与最低水平组比较,最高水平组SOD下认知受损发生的OR(95%CI)为3.96(1.66-9.45)。SOD水平与认知功能评分之间显著相关(P<0.05),MDA与认知功能评分之间无显著相关性(P>0.05)。结论:高龄老人中血浆SOD活性与认知功能呈负向关系,未发现血浆MDA与认知功能有显著关系。     

自然流产妇女血清MDA、SOD、VitE的测定及意义

目的:通过对自然流产妇女血清氧化应激指标———超氧化物歧化酶(SOD)、丙二醛(MDA)及维生素E(V itE)的测定,分析三个指标在自然流产发病机制中的意义。方法:用化学比色法对30例自然流产妇女及20例正常早孕组妇女血清中SOD、MDA及V it E进行测定。结果:与正常早孕妇女相比,自然流产妇女血清中MDA水平升高(P<0.05),SOD、V it E水平却下降(均P<0.05)。结论:上述三个指标对于预防及治疗自然流产有重要意义。     

血清对氧磷酯酶1联合氧化指标检测在急性有机磷中毒的临床意义

目的探讨抗氧化酶及氧化应激压力在急性有机磷农药中毒（AOPP）中的意义。方法检测28例AOPP患者血清对氧磷酯酶1（PON1）、超氧化物歧化酶（SOD）和丙二醛（MDA）的水平并与36例健康对照组比较。结果28例AOPP患者PON1（58.9±6.4U/ml）和SOD（82.34±9.2U/ml）明显低于对照组PON1（140.1±8.9U/ml）和SOD（125.5±10.9U/m1）（P〈0.01）。MDA的水平（6.65±1.13nmol/ml）明显高于健康对照组（2.31±0.56nmol/ml）（P〈0.01）。中毒组PONl和MDA相关性分析后发现,PONl活性与MDA含量存在明显的负相关（r=-0.821,P〈0.01）。结论PONl等抗氧化酶活性下降,脂质发生过氧化反应,引发的氧化应激损伤在急性有机磷农药中毒病理生理机制中发挥重要作用。     

锰超氧化物歧化酶及其C47T变异对耳蜗毛细胞氧化损伤作用的影响

目的 探讨锰超氧化物歧化酶(SOD2)及其C47T变异在耳蜗毛细胞氧化损伤中的作用.方法 用Ala16型(突变克隆)和Val16型(野生克隆)SOD2转染HEI-OC1细胞,同时设立未转染和空质粒转染对照.噻唑兰(MTr)法检测细胞的增殖情况;黄嘌呤氧化法检测胞内SOD2活力.100 μmol/L叔丁基过氧化氢(t-BHP)对其染毒12 h后,2'-7'-二氯荧光黄双乙酯(DCFH-DA)法检测胞内活性氧(ROS)水平;Annexin V/PI双标记后通过流式细胞仪检测细胞早期凋亡率和坏死率或晚期凋亡率.结果 SOD2表达质粒和空质粒转染不影响HEI-OC1细胞的增殖;Ala16SOD2和Val16 SOD2转染组SOD2活力分别是转染对照组的3.51和3.71倍,差异有统计学意义(P＜0.01),2种不同基因型间SOD2活力的差异无统计学意义(P＞0.05).染毒后,DCFH-DA方法 显示,未转染和空质粒对照组绝大部分细胞均发出++级明亮荧光,Ala16型和Val16型SOD2转染组中均只有约50%细胞发出±～+级别的模糊荧光.HEIOC1细胞早期凋亡率和坏死率或晚期凋亡率均下降,差异有统计学意义(P＜0.01),但是,其在SOD2 2种基因型之间的差异无统计学意义(P＞0.05).结论 SOD2 3.71倍以下高水平的表达可以降低氧化应激耳蜗毛细胞胞内ROS水平,而SOD2 C47T变异则对之无影响.SOD2为NIHL易感基因,rs4880多态性位点则与NIHL遗传易感性无直接功能性的相关.

Abstract：

Objective To study the effect of SOD2 and its C47T mutation on oxidative injury in cochlea hair cells. Methods HEI-OC1 cells were transfected with the SOD2 of Ala16 and Vla16. Cells' proliferation ability was determined by MTT assay. The intracellular SOD2 activities were detected by xanthine oxidase method. Intracellular ROS were determined by DCFH-DA after exposure to 100 μ mol/L t-BHP and the early apoptotic and necrotic rate or late apoptotic rate were quantified by flow cytometry (FCM) using Annexin V/PI double staining. Results MTT method showed the transfection of SOD2 gene and empty plasmid did not affect the proliferation capacity. SOD2 vitality in Ala16 and Val16 SOD2 transfected cells increased 2.51 and 2.71 times respectively (P＜0.01), but the difference between the two transfection groups was not statistically significant (P＞0.05). After exposed to t-BHP, the majority of the untransfected and empty plasmid transfected cells sent '++' class bright fluorescence, while in Ala16 and Val16 SOD2 transfected groups, only about half cells sent '± '～'+' level fuzzy fluorescence, determination of FCM suggested the early apoptotic and necrotic rate or late apoptotic rate decreased after SOD2 transfection (P＜0.01), but the difference between the two genotypes of SOD2 was not statistically significant (P＞0.05). Conclusion High expression of SOD2 below 3.71 times can reduce intracellular ROS level in HEI-OC1 cells, while SOD2 C47T mutation had no effect on them. SOD2 can be considered as NIHL susceptibility gene and its rs4880 SNP may be not directly related to NIHL genetic susceptibility.     

不同程度心理应激对小鼠卵巢内氧化应激水平的影响

目的:探讨不同程度刺激对小鼠卵巢氧化应激水平的影响,以期为不孕症患者辅助心理治疗提供理论依据。方法:80只雌鼠随机分为4组,给予不同程度且不可预知性刺激4周,观察小鼠体质量及行为学改变。造模成功后,检测小鼠血清中超氧化物歧化酶(SOD)含量、活性氧(ROS)水平,小鼠卵巢组织中SOD活性、丙二醛(MDA)含量、SOD2、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)3种抗氧化物酶的m RNA水平。结果:不同程度心理应激组与正常组相比,小鼠体质量降低,不动时间和中央区域滞留时间延长,进入中央区域次数及中央区域活动时间减少,差异有统计学意义(P<0.05);血清中ROS水平升高,SOD含量降低,卵巢组织中SOD活性降低,MDA含量升高,SOD2、CAT及GSH-Px活性降低,差异有统计学意义(P<0.05)。结论:心理应激能够降低小鼠的自主活动欲望和探索欲望,ROS的累积引发机体内氧化应激反应,影响女性生殖功能。     

烹调油烟对职业接触人群氧化抗氧化水平的影响

目的　探讨烹调油烟对职业接触人群氧化抗氧化水平的影响。方法　通过问卷调查从广州市东山区的 2 9家饮食店中筛选出工种为烧烤或掌勺、工龄为 4年或以上的 6 5名厨师作为油烟接触组 (实验组 ) ;选择 4 3名不接触油烟并与实验组年龄、烟酒嗜好等其他条件相近的饮食从业人员作为对照组 ,分别测定其血清丙二醛 (MDA)、超氧化物歧化酶 (SOD)的水平及其工作环境的CO、CO2 、甲醛及可吸入性颗粒等空气质量指标。结果　烹调油烟接触组血清MDA浓度 [(4 1 85± 1 0 6 3)μmol/L]高于对照组 [(3 6 6 4± 1 1 4 3) μmol/L](P <0 0 5 ) ,与其接触工龄、油烟环境中的CO、CO2 、甲醛及可吸入性颗粒呈正相关 (r为 0 4 0 1～ 0 5 78,P <0 0 1 ) ;而接触组的SOD浓度 [(97 2 0 9± 2 3 5 2 5 )μmol/L]与对照组 [(90 834± 2 8 2 74 ) μmol/L]比较差异无显著性 (P >0 0 5 )。 结论　烹调油烟对职业接触人群的氧化抗氧化平衡有一定的损害     

Studies on common illnesses and medical care utilization patterns of adolescents in Hong Kong

Purpose: To estimate the prevalences of common illnesses in Hong Kong adolescents, the sociodemographic and selected risk factors associated with these illnesses, and their health care utilization behavior and attitudes.

Methods: A cross-sectional questionnaire survey of 3355 participating secondary school students (response RATE = 98%).

Results: Self-reported 3-month prevalences were obtained for cough/cold/influenza (55.2%), digestive disorders (34.6%), accidental injuries (29.5%), headache/dizziness (23.6%), chronic anxiety/insomnia (20.1%), skin problems (9.5%), asthma (3.8%), liver disease (1.3%), and menstrual pain (13.8% of female students). Self-perceived poor health, smoking, and alcohol consumption were associated with many of these illnesses. Treatment choice depended on the illness suffered (e.g., most students with respiratory problems consulted medical practitioners, whereas most with chronic anxiety/insomnia did not). Many students lacked trust in their doctors, doctor-shopped, relied heavily on self-medication, did not comply with prescribed treatments, would not seek help about medical problems, felt they had insufficient access to health information, and wanted confidential health care.

Conclusions: This study examined for the first time the common illnesses and health care utilization patterns of Hong Kong adolescents. Students with chronic anxiety/insomnia were much less likely to seek care, indicating a need for better education on mental health. Efforts to prevent smoking and alcohol consumption among adolescents need to be strengthened. The students’ attitudes, poor compliance and help-seeking behaviors suggest suboptimal use of the health care system. Our findings are useful for international comparisons by medical practitioners, health care managers, and researchers.     

Antioxidant responses and oxidative stress after microcystin exposure in the hepatopancreas of an estuarine crab species

Antioxidant responses and oxidative stress were evaluated in the hepatopancreas of the estuarine crab Chasmagnathus granulatus (Decapoda, Brachyura) after oral microcystin administration. Responses were evaluated through antioxidant enzyme activities (catalase-(CAT), superoxide dismutase, glutathione-S-transferase- (GST)). Nonproteic sulfhydril (NP-SH) groups, oxygen consumption, lipid peroxides (LPO), and oxidized proteins were also measured. Microcystin administration increased the oxygen consumption. GST activity and NP-SH concentration showed transient increases and CAT activity showed a peak and then a reduction. Oxidative damage was evidenced with regard to LPO content and suggested by the inhibition of CAT activity at the end of the experiment, indicating that the antioxidant response induced by the toxin was insufficient. A lowering in the number of hepatopancreatic B cells should be related to microcystin elimination.     

The effects of air pollution on mortality in socially deprived urban areas in Hong Kong, China

BACKGROUND: Poverty is a major determinant of population health, but little is known about its role in modifying air pollution effects. OBJECTIVES: We set out to examine whether people residing in socially deprived communities are at higher mortality risk from ambient air pollution. METHODS: This study included 209 tertiary planning units (TPUs), the smallest units for town planning in the Special Administrative Region of Hong Kong, China. The socioeconomic status of each TPU was measured by a social deprivation index (SDI) derived from the proportions of the population with a) unemployment, b) monthly household income < US$250, c) no schooling at all, d) one-person household, e) never-married status, and f ) subtenancy, from the 2001 Population Census. TPUs were classified into three levels of SDI: low, middle, and high. We performed time-series analysis with Poisson regression to examine the association between changes in daily concentrations of ambient air pollution and daily number of deaths in each SDI group for the period from January 1996 to December 2002. We evaluated the differences in pollution effects between different SDI groups using a case-only approach with logistic regression. RESULTS: We found significant associations of nitrogen dioxide, sulfur dioxide, particulate matter with aerodynamic diameter < 10 mum, and ozone with all nonaccidental and cardiovascular mortality in areas of middle or high SDI (p < 0.05). Health outcomes, measured as all nonaccidental, cardiovascular, and respiratory mortality, in people residing in high SDI areas were more strongly associated with SO(2) and NO(2) compared with those in middle or low SDI areas. CONCLUSIONS: Neighborhood socioeconomic deprivation increases mortality risks associated with air pollution.     

速溶山楂饮料对高脂血症患者血脂、抗氧化酶和免疫功能的作用

目的　探讨速溶山楂饮料调节高脂血症患者脂质紊乱、提高抗氧化酶活力和增强免疫功能的作用。方法　 6 0名年龄 (5 7 9± 8 0 )岁高脂血症受试者 ,采用交叉试验方案 ,每名受试者参加 2次试验。半数受试者于第 1次试验补充速溶山楂饮料 (含 3g山楂干粉、相当于 30g鲜果 ,溶于 10 0ml水及饮料载体 ,1d 2次 ) ,另半数补充对照液 (0 75g瓜儿胶和少量淀粉作为饮料载体 ,1d 2次 )。持续 31d ,间隔 2 8d后 ,开始第 2次试验 ,受试者原补充速溶山楂饮料者 ,改为对照 ;原补充对照改为速溶山楂饮料。结果　补充速溶山楂饮料能显著降低血清总胆固醇 (9 6 % )、甘油三酯 (12 1% )、低密度脂蛋白 (18% ) ;而明显增加超氧化物歧化酶 (SOD)活力 (7 5 % )水平。受试者补充含瓜儿胶对照液虽然对某些血清脂质也有一定的改善作用 ,但效果不如速溶山楂饮料显著 ;而且 ,受试者仅在补充速溶山楂饮料时血清甘油三酯水平显著降低、抗氧化酶SOD水平显著提高 ,补充对照液无作用。结论　补充速溶山楂饮料能有效降低血清总胆固醇、甘油三酯、低密度脂蛋白、丙二醛水平 ,升高ApoA Ⅰ水平、SOD活性和NK细胞活力 ;综合测试表明 :补充速溶山楂饮料和对照比 ,调整血脂、提高抗氧化酶活力效果更显著。     

高压氧对重型脑损伤患者血液流变学及自由基的影响

目的研究高压氧(HBO)对重型脑损伤患者血液流变学及血清脂质过氧化物(LPO)、超氧化物歧化酶(SOD)的影响。方法72例重型脑损伤随机分成高压氧组和对照组各36例,HBO组给予高压氧及临床常规治疗,对照组则单纯给予常规治疗。治疗前及治疗后20 d检测血液流变学指标,LPO、SOD。结果高压氧组血液流变学指标较治疗前明显改善,接近正常水平,对照组血液流变学亦改善,但不如HBO组明显;2组治疗前后相比差异有统计学意义(P<0.01);高压氧组LPO明显下降,SOD明显升高,治疗前后差异有统计学意义(P<0.01),而对照组无明显改善。HBO组总有效率较对照组显著(P<0.05)。结论高压氧可明显改善重型脑损伤患者的血液流变学指标,提高SOD水平,降低LPO水平,临床治疗效果较好。     

大黄对急性氧化乐果中毒大鼠血浆胆碱酯酶和超氧化物歧化酶影响的实验研究

目的研究大黄对急性氧化乐果中毒急诊抢救治疗的辅助作用。方法用sD大鼠作为研究对象。将80只SD大鼠随机分为4组：轻度氧化乐果染毒组、重度氧化乐果染毒组、重度染毒后大黄治疗组和正常对照组。用不同剂量毒物对实验动物进行染毒,造成轻重不同程度的两组染毒动物模型（重度染毒2组、轻度染毒1组）,然后将重度染毒组中的一组给予大黄治疗。结果大黄治疗组动物行为明显优于对照组,而且该组血浆中不同时间点的胆碱酯酶（ChE）和超氧化物歧化酶（SOD）明显高于其它两个中毒对照组（P〈0．01,P〈0．05）。结论大黄对急性氧化乐果中毒急诊抢救治疗有明显的辅助作用。     

Public Health and Air Pollution in Asia (PAPA): a multicity study of short-term effects of air pollution on mortality

Background and objectives

Although the deleterious effects of air pollution from fossil fuel combustion have been demonstrated in many Western nations, fewer studies have been conducted in Asia. The Public Health and Air Pollution in Asia (PAPA) project assessed the effects of short-term exposure to air pollution on daily mortality in Bangkok, Thailand, and in three cities in China: Hong Kong, Shanghai, and Wuhan.

Methods

Poisson regression models incorporating natural spline smoothing functions were used to adjust for seasonality and other time-varying covariates that might confound the association between air pollution and mortality. Effect estimates were determined for each city and then for the cities combined using a random effects method.

Results

In individual cities, associations were detected between most of the pollutants [nitrogen dioxide, sulfur dioxide, particulate matter ≤ 10 μm in aerodynamic diameter (PM₁₀), and ozone] and most health outcomes under study (i.e., all natural-cause, cardiovascular, and respiratory mortality). The city-combined effects of the four pollutants tended to be equal or greater than those identified in studies conducted in Western industrial nations. In addition, residents of Asian cities are likely to have higher exposures to air pollution than those in Western industrial nations because they spend more time outdoors and less time in air conditioning.

Conclusions

Although the social and environmental conditions may be quite different, it is reasonable to apply estimates derived from previous health effect of air pollution studies in the West to Asia.     

纳米颗粒对心血管系统的影响及潜在机制研究进展

随着纳米科技与产业的迅速发展,纳米颗粒对人体健康的影响正成为人们普遍关心的问题。研究表明,纳米颗粒可通过引发内皮细胞、心肌细胞等的氧化损伤,致使其功能受损或死亡,引发心血管系统炎症,改变血液的流体学特征,并影响血管的舒缩功能,使血压升高,加速动脉粥样硬化的发生与发展,增加动脉粥样斑块的不稳定性,促进血栓的形成;另一方面,还可能通过影响心脏自主性神经的功能等机制,从而引发心律不齐、心肌梗塞和心衰竭等心血管疾病。本文综述了纳米颗粒对心血管系统影响及其机制研究的新进展,并对今后深入研究纳米颗粒对心血管细胞毒性作用方面提出展望。     

雄黄与亚砷酸钠亚急性暴露对小鼠砷代谢及氧化应激影响的比较

目的探讨经口染毒雄黄、亚砷酸钠后,小鼠体内砷代谢及氧化应激指标的变化,为评价雄黄的毒性提供实验数据。方法清洁级雌性昆明小鼠随机分为对照组(0.5%羧甲基纤维素钠)、0.5 g/kg雄黄组和0.1 g/kg亚砷酸钠组,各组均灌胃染毒3 d,用氢化物发生-超低温捕集-原子吸收分光光度法分别测定尿液和肝组织中无机砷(iAs)、一甲基胂(MMA)和二甲基胂(DMA)。用试剂盒法测定全血中GSH和肝脏T-AOC水平。结果雄黄组小鼠尿液和肝脏中各形态砷和总砷含量高于对照组,但低于亚砷酸钠组;一甲基化率(FMR)和二甲基化率(SMR)高于亚砷酸钠组,差异均有统计学意义(P<0.05)。雄黄组全血GSH和肝脏T-AOC水平均高于亚砷酸钠组(P<0.05),其全血GSH和肝脏T-AOC水平与对照组相比差异均无统计学意义(P>0.05)。结论与亚砷酸钠相比,雄黄中的砷在小鼠体内代谢较慢,对氧化应激指标影响较小。     

The effects of Nigella sativa extract on hypothyroidism-associated learning and memory impairment during neonatal and juvenile growth in rats

Objectives: It has been shown that hypothyroidism-induced oxidative damage in brain tissue is involved in its adverse effects on learning and memory. Nigella sativa (N. sativa) has been suggested to have antioxidant and neuroprotective effects. The objective of this study was to investigate the effects of hydroalcoholic extract of N. sativa on hypothyroidism-associated learning and memory impairment during neonatal and juvenile growth in rats.

Methods: Thirty pregnant rats were kept in separate cages. After delivery, the mothers and their offspring were randomly divided into six groups including: (1) control, (2) PTU (propylthiouracil), (3) PTU-NS 100, (4) PTU-NS 200, (5) PTU-NS 400, and (6) PTU-Vit C (vitamin C). All dams except the control group received 0.005% PTU in their drinking water during lactation. Besides PTU, dams in groups 3, 4, 5, and 6 received 100, 200, and 400 mg/kg N. sativa extract, or 100 mg/kg Vit C, respectively. After lactation period, pups continued to receive same experimental treatment for the first 8 weeks of their life. Then, 10 male offspring of each group were randomly selected and assessed for the learning and memory abilities by using Morris water maze (MWM) and passive avoidance (PA) tests. Blood samples were collected for thyroxine assessment, animals were euthanized, and the brain tissues were removed and analyzed for total thiol groups and malondialdehyde (MDA) concentrations.

Results: PTU exposure significantly increased the time latency in MWM test, while reduced the time spent in target quadrant, and decreased the latency for entering the dark compartment in PA test. These effects were associated with significant reduction in serum thyroxine levels and brain levels of thiol groups, and significant elevation in hippocampal MDA. Administration of 400 mg/kg N. sativa extract and 100 mg/kg Vit C reduced the time latency, while increased the time spent in target quadrant compared to the PTU group in MWM test. Treatment by 100–400 mg/kg of N. sativa extract and also Vit C significantly increased the time latency for entering the dark compartment in PA test. The serum thyroxine concentrations of the animals treated by all doses of the N. sativa extract as well as by Vit C were higher than that of the PTU group. Two hundred and four hundred milligrams/kilogram of NS extract and 100 mg/kg Vit C decreased the MDA concentration in hippocampal tissues, while increased thiol contents compared to the PTU group.

Discussion: The results of this study demonstrate that the hydroalcoholic extract of N. sativa have protective effects on hypothyroidism-associated learning and memory impairment during neonatal and juvenile growth in rats. The effects were comparable to Vit C and might be due to the protective effects of N. sativa extract against brain tissues’ oxidative damage.     

Chronic accumulation of cadmium and its effects on antioxidant enzymes and malondialdehyde in Oxya chinensis (Orthoptera: Acridoidea)

The accumulation of cadmium (Cd) and its effects on antioxidant enzyme activities and malondialdehyde (MDA) levels of Chinese rice grasshopper (Oxya chinensis) were evaluated under the laboratory conditions. Our results showed that Cd accumulation in O. chinensis exhibited a concentration-dependent increase in both males and females under Cd pollution. Environmental Cd can lead to the absorption of large quantities of Cd, which induces oxidative damage in insects by altering antioxidant defense enzyme systems. Our results demonstrated that Cd stress caused a significant decrease in glutathione peroxidase (GPx) levels and a significant increase in superoxide (SOD) dismutase and catalase (CAT) activities. In the grasshoppers, the MDA content was also enhanced, with an increase in Cd concentrations and a positive correlation between them; for females from second instar nymphs to the adult stage, R² was 0.6467, 0.9136, 0.6516, 0.942 and 0.7182, whereas for males, it was 0.6467, 0.8239, 0.9302, 0.7861, 0.8632, respectively. We also observed differences in the effects of Cd between grasshoppers of different developmental stages and genders, which suggested that the insect’s developmental stage and sex should be considered when studying enzyme activity.     

共轭亚油酸对糖尿病大鼠的治疗和控制作用

目的:研究共轭亚油酸(CLA)对糖尿病大鼠的治疗和控制作用.方法:雄性SD大鼠随机分为正常对照组、糖尿病组和CLA治疗组.腹腔内注射150 mg/kg四氧嘧啶,建立大鼠糖尿病模型.用CLA 1.6g/(kg·d)灌胃治疗5周,实验结束后大鼠颈动脉插管取血,检测血糖、血清胰岛素、糖化血红蛋白(HbA1c)、血清中丙二醛(MDA)、超氧化物歧化酶(SOD)、血脂和动脉粥样硬化指数(AI).取胰腺组织,计算胰腺B细胞面积密度和体积密度.结果:CLA显著降低了糖尿病大鼠的血糖和HbA1c及血清MDA含量(P＜0.01),显著降低了糖尿病大鼠血清中总胆固醇(TC)、三酰甘油(TG)和低密度脂蛋白胆固醇(LDL-C)水平,明显增加了血清高密度脂蛋白胆固醇(HDL-C)水平和SOD活性;增加了胰腺B细胞面积密度和体积密度(P＜0.05),使血清胰岛素含量、超氧化物歧化酶活性(SOD)明显升高(P＜0.05).结论:CLA能有效控制糖尿病大鼠的血糖,改善血脂状况,控制糖尿病并发症的发生和发展.     

中国4城市居室装修状况及对居民健康影响

目的探讨居室装修与人体健康的关系。方法采取整群抽样的方法,选取北京、天津、上海及南京4个城市住户并且常住在家的人员作为研究对象,调查居室装修相关信息和家庭成员的健康状况。结果4城市共调查住户3948户(6681人),结果显示,60%的居民入住新居后有不同程度的不适症状;装修完成与入住的时间间隔及入住时间短与不适症状相关;装修材料中的水性涂料和壁纸、实木地板、地面瓷砖及大理石等有保护作用,而复合地板、化纤地毯和地板革等为危险因素;厨房中开放式厨房和煤气是危险因素,而排油烟设备和开窗通风则有保护作用。结论居民在新装修的居室内会出现不同程度的不适症状,主要为多种因素综合作用的结果。