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Late outcomes of adult survivors of childhood non‐Hodgkin lymphoma: A report from the St. Jude Lifetime Cohort Study
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Matthew J. Ehrhardt John T. Sandlund Nan Zhang Wei Liu Kirsten K. Ness Nickhill Bhakta Wassim Chemaitilly Kevin R. Krull Tara M. Brinkman Deborah B. Crom Larry Kun Sue C. Kaste Gregory T. Armstrong Daniel M. Green Kumar Srivastava Leslie L. Robison Melissa M. Hudson Daniel A. Mulrooney 《Pediatric blood & cancer》2017,64(6)
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Oguz A Tayfun T Citak EC Karadeniz C Tatlicioglu T Boyunaga O Bora H 《Pediatric blood & cancer》2007,49(5):699-703
BACKGROUND: The aim of our study was to evaluate the long-term effects of chemotherapy and/or radiotherapy on lung function in 75 childhood Hodgkin disease (HD) and non-Hodgkin lymphoma (NHL) survivors several years after treatment. PATIENTS AND METHODS: We studied 37 HD and 38 NHL survivors. These patients were divided into two groups according to the treatment protocols applied. Group I consisted of 23 patients who were treated with both chemotherapy and thoracic irradiation and Group II consisted of 52 patients who were treated with chemotherapy and no thoracic irradiation. A detailed history of smoking habits, respiratory symptoms, and diseases was recorded. Complete physical examinations and pulmonary function tests [PFT, including spirometry, lung volume, and diffusion capacity for carbon monoxide (DLCO)] were performed on all subjects. RESULTS: No patients reported acute or chronic respiratory symptoms or diseases. Pulmonary function abnormality (reduced lung volume and diffusion capacity) was found in 13% of patients at a median 5 years after diagnosis. The percentage of predicted normal value of forced expiratory volume in the 1st sec (FEV(1)), residual volume (RV), and DLCO were significantly lower in Group I than these values for Group II. There were no significant differences in PFT parameters between patients with HD and NHL (P > 0.05). It appears that the risk of reduced lung function was greater the younger the patient in therapy. CONCLUSION: Chemotherapy or chemo-radiotherapy-induced pulmonary sequalae in childhood may remain asymptomatic for many years. 相似文献
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Gurney JG Ojha RP Ness KK Huang S Sharma S Robison LL Hudson MM Kaste SC 《Pediatric blood & cancer》2012,59(7):1307-1309
Abdominal aortic calcification (AAC), metabolic syndrome, and low bone mineral density (BMD) are risk factors for atherosclerotic disease and cardiovascular morbidity. We evaluated AAC in 662 adult survivors of childhood ALL (median age 31 years). AAC was present in 10% of subjects, metabolic syndrome in 36%, and low BMD in 29%. The adjusted odds ratio (OR) for AAC among women with metabolic syndrome was 2.3 (95% CL = 1.0, 4.3). The adjusted OR for AAC in men with low BMD was 3.1 (95% CL = 1.3, 7.3). A substantial proportion of adult survivors of childhood ALL have AAC and/or metabolic syndrome, suggestive of early atherosclerotic disease. Pediatr Blood Cancer 2012; 59: 1307–1309. © 2012 Wiley Periodicals, Inc. 相似文献
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Daniel M. Green Mingjuan Wang Matthew J. Krasin Andrew M. Davidoff DeoKumar Srivastava Dennis W. Jay Kirsten K. Ness Barry L. Shulkin Sheri L. Spunt Deborah P. Jones Jennifer Q. Lanctot Kyla C. Shelton Rachel C. Brennan Daniel A. Mulrooney Matthew J. Ehrhardt Todd M. Gibson Beth A. Kurt Leslie L. Robison Melissa M. Hudson 《Pediatric blood & cancer》2020,67(10)
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Lene Molgaard‐Hansen MD Anne‐Sofie Skou MD Anders Juul MD Heidi Glosli MD Kirsi Jahnukainen MD Marianne Jarfelt MD Guemundur K. Jónmundsson MD Johan Malmros MD Karsten Nysom MD Henrik Hasle MD On behalf of the Nordic Society of Pediatric Hematology Oncology 《Pediatric blood & cancer》2013,60(12):1988-1995
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Ovarian function in survivors of childhood medulloblastoma: Impact of reduced dose craniospinal irradiation and high‐dose chemotherapy with autologous stem cell rescue
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Sadana Balachandar MD Ira J. Dunkel MD Yasmin Khakoo MD Suzanne Wolden MD FACR Jeffrey Allen MD Charles A. Sklar MD 《Pediatric blood & cancer》2015,62(2):317-321
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Leontien C.M. Kremer MD PhD Kevin C. Oeffinger MD Smita Bhatia MD MPH Wendy Landier RN PhD Gill Levitt MD Louis S. Constine MD W. Hamish Wallace MD Huib N. Caron MD PhD Saro H. Armenian MD MPH Roderick Skinner MB PhD Melissa M. Hudson MD 《Pediatric blood & cancer》2013,60(4):543-549
Childhood and young adult cancer survivors should receive optimum care to reduce the consequences of late effects and improve quality of life. We can facilitate achieving this goal by international collaboration in guideline development. In 2010, the International Late Effects of Childhood Cancer Guideline Harmonization Group was initiated. The aim of the harmonization endeavor is to establish a common vision and integrated strategy for the surveillance of late effects in childhood and young adult cancer survivors. With the implementation of our evidence‐based methods, we provide a framework for the harmonization of guidelines for the long‐term follow‐up of childhood and young adult cancer survivors. Pediatr Blood Cancer 2013; 60: 543–549. © 2012 Wiley Periodicals, Inc. 相似文献
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Exercise right heart catheterization for pulmonary hypertension identified on screening echocardiography in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort
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Gregory T. Armstrong James J. Tolle Robert Piana Aimee Santucci James Leathers Kirsten K. Ness Daniel A. Mulrooney Daniel M. Green Vijaya M. Joshi Leslie L Robison Melissa M. Hudson Daniel Lenihan 《Pediatric blood & cancer》2018,65(1)
Pulmonary hypertension, determined noninvasively by tricuspid regurgitant jet velocity on Doppler echocardiography, was previously identified in 25% of long‐term survivors who received chest‐directed radiotherapy. To validate noninvasively defined pulmonary hypertension, survivors (mean age 48 years), exposed to chest radiotherapy, underwent right heart catheterization with planned cardiopulmonary exercise testing during catheterization. Eight participants had an elevated mean pulmonary artery pressure at rest (≥25 mm Hg) or with subsequent exercise (>30 mm Hg), evidence of hemodynamically confirmed pulmonary hypertension by right heart catheterization. Cardiopulmonary exercise testing further defined the magnitude and etiology of cardiopulmonary limitations in this life‐threatening late effect. 相似文献
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Masahito Tsurusawa MD Tetsuya Mori MD Akira Kikuchi MD Tetsuo Mitsui MD Shosuke Sunami MD Ryoji Kobayashi MD Tetsuya Takimoto MD Akiko Saito MD PhD Tomoyuki Watanabe PhD Junichiro Fujimoto MD Atsuko Nakazawa MD Kouichi Ohshima MD Keizo Horibe MD for the lymphoma committee of the Japanese Pediatric Leukemia/Lymphoma Study Group 《Pediatric blood & cancer》2014,61(7):1215-1221
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Psychological risk in long‐term survivors of childhood acute lymphoblastic leukemia and its association with functional health status: A PETALE cohort study
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Annélie S. Anestin Sarah Lippé Philippe Robaey Laurence Bertout Simon Drouin Maja Krajinovic Bruno Michon Émélie Rondeau Mariia Samoilenko Caroline Laverdière Daniel Sinnett Serge Sultan 《Pediatric blood & cancer》2018,65(11)