幽门螺杆菌感染与酒渣鼻的相关性

为了研究幽门螺杆菌(HP)感染与酒渣鼻的相关性 ,研究了42例酒渣鼻患者的血清HP IgG浓度、消化道症状及抗HP治疗的疗效 ,并以33例寻常痤疮作对照。发现酒渣鼻患者的血清抗体及消化道症状阳性率及抗HP治疗的疗效明显高于对照组 ,且6例接受胃镜及组织学检查的酒渣鼻患者的检查结果均显示有异常。结果提示 ,HP感染与酒渣鼻可能存在一定的相关性。     

慢性荨麻疹和酒渣鼻患者血清中幽门螺杆菌抗体的检测与评价

目的检测慢性荨麻疹患者和酒渣鼻患者血清中的抗HP IgG抗体.方法采用AssureTM H.pylori IgG抗体层析板测定慢性荨麻疹和酒渣鼻患者血清中的抗HP IgG抗体,并设立正常对照组.结果186例慢性荨麻疹患者血清中有121例抗HP IgG抗体阳性,阳性率为65.05%,其中有88例提示为现症感染;38例酒渣鼻患者血清中有32例抗HP IgG抗体阳性,阳性率为84.21%,其中有21例提示为现症感染;正常对照组血清40例有11例抗HPIgG抗体阳性,阳性率为27.50%.结论慢性荨麻疹组患者血清中抗HPIgG抗体阳性率为65.05%,明显高于正常对照组27.50%(P＜0.01);酒渣鼻组患者血清中抗HP IgG抗体阳性率为84.21%,也明显高于正常对照组27.50%(P＜0.01).     

幽门螺杆菌细胞毒素相关蛋白A与酒渣鼻的相关性

目的探讨幽门螺杆菌(HP)细胞毒素相关蛋白A(CagA)与酒渣鼻发生的关系。方法使用酶联免疫法测定76例酒渣鼻患者及31例健康对照者的血清CagA-Hp抗体,并检测CagA-Hp阳性及阴性情况下IL-8,TNF-α,VEGF水平。结果酒渣鼻组血清CagA-Hp阳性率为71.05%,对照组为22.58%,两组差异有显著性(P<0.05)。CagA-Hp阳性的酒渣鼻患者血清IL-8,TNF-α水平高于CagA-Hp阴性者(P<0.05)。CagA-Hp抗体水平与酒渣鼻病情轻重呈正相关。抗HP治疗可促进酒渣鼻的恢复。结论CagA-Hp阳性菌株感染与酒渣鼻的发生有关,是其发病的危险因素。     

幽门螺杆菌感染与慢性荨麻疹的相关性研究

为了探讨幽门螺杆菌(HP)感染与慢性荨麻疹的相关性，我们研究了110例慢性荨麻疹患者的血清HP-IgG浓度、消化道症状及抗HP治疗的疗效，并以30例正常人作为对照。发现慢性荨麻疹患者的血清抗体浓度明显高于对照组，经抗HP治疗后取得较好疗效。结果显示，HP感染可能与某些慢性荨麻疹的发生有关。     

酒渣鼻与幽门螺杆菌的相关性分析

目的观察酒渣鼻患者幽门螺杆菌感染(Hp)的发生率及根除Hp的三联疗法对酒渣鼻疗效的影响。方法对98例酒渣鼻患者和同期来本院进行健康体检者37例,分别行14C尿素呼气试验(14C-UBT)明确HP感染情况。将Hp感染的酒渣鼻患者随机分为A组和B组,A组予外用过氧苯甲酰凝胶,B组在A组治疗方案的基础上同时予根除HP三联疗法治疗,比较两组患者的临床疗效。结果酒渣鼻患者组Hp阳性率70.41%,健康体检者Hp阳性率29.73%;HP感染的酒渣鼻患者,B组治愈率58.82%;A组26.47%;以上差异均有统计学意义(P均<0.05)。结论酒渣鼻患者Hp阳性率较高,根除Hp与酒渣鼻治愈率提高存在一定的相关性。外用药物联合根除Hp三联疗法可明显提高Hp感染的酒渣鼻患者的治愈率,值得临床上选用。     

幽门螺杆菌感染与酒渣鼻发病的相关性研究

目的探讨幽门螺杆菌感染对酒渣鼻发病的影响并评价幽门螺杆菌(HP)根治治疗对酒渣鼻病人的治疗作用。方法对56例酒渣鼻病人及20例无酒渣鼻的皮炎湿疹类皮肤病患者进行HP检测,酒渣鼻组HP阳性者随机分为A、B两组,A组用幽门螺杆菌根除治疗,B组用维生素B2、B6治疗,停药4周后观察酒渣鼻的疗效,HP阴性者用1%甲硝唑霜(耐瑞)治疗。结果56例酒渣鼻病人HP检出率为76.8%,显著高于对照组检出率45.0%(P<0.05);HP根治疗法对酒渣鼻的总有效率为63.6%,而维生素B疗法的总有效率为14.3%;1%甲硝唑霜治疗酒渣鼻的总有效率为69.3%。结论提示HP感染对酒渣鼻的发生发展起一定的作用,HP根治治疗对酒渣鼻有效,但HP根治治疗能否作为酒渣鼻的常规治疗尚待进一步研究。     

幽门螺杆菌感染与酒渣鼻、慢性荨麻疹

近年来幽门螺杆菌helieoharter pylori，HP)感染与皮肤病的关系已越来越引起临床重视，现有研究主要集中住HP感染与酒渣鼻、慢性特发性荨麻疹的相关性方面，但结果尚有争议。为进一步探讨HP感染在酒渣鼻、慢性荨麻疹中的作用，我们采用^14C尿素呼吸试验（^14C-UBT)对38例酒渣鼻、32例慢性荨麻疹患者进行HP检测，并对HP阳性者采用根除治疗方案，观察其症状改善程度，现将结果报告如下。     

酒渣鼻与幽门螺杆菌感染关系的初步探讨

近年来,有学者认为酒渣鼻与幽门螺杆菌(Helicobacterium pylori,Hp)感染有关,并且通过根除Hp感染减轻或治愈部分酒渣鼻患者。1997年8月至1998年6月我们应用间接ELISA技术,检测了酒渣鼻患者血清抗Hp-IgG抗体,以探讨Hp感染与酒渣鼻之间的关系。     

幽门螺旋杆菌感染与慢性荨麻疹之间关系的探讨

目的：探讨幽门螺旋杆菌(Helicobacterium Pylori，HP)感染在慢性荨麻疹中的作用。方法：采用金标免疫斑点法技术检测60例慢性荨麻疹患者的血清抗HP抗体。对血清抗HP抗体阳性患者应用息斯敏治疗外，均应用H2受体拮抗剂加铋剂及2种抗生素治疗；对抗HP抗体阴性患者单纯口服息斯敏。结果：60例慢性荨麻疹患者有45例患者血清抗HP抗体阳性，阳性率75％。治愈34例(75．56％)；显效4例(8．89％)；有效5例(11．11％)；无效2例(4．44％)，总有效率：84．45％)。而15例抗}伊抗体阴性患者，显效3例(20％)；有效4例(26．67％)；无效8例(53．33％)。结论：对于久治不愈的慢性荨麻疹患者，建议检测血清抗HP抗体，若血清抗HP抗体阳性在给予抗组织胺药的同时，应加用抗HP感染的药物。     

幽门螺杆菌感染与酒渣鼻发病关系的探讨

酒渣鼻是一种发生于面中部的慢性炎症，影响美观，病因不明，有人研究认为其发病可能与幽门螺杆菌（HP）感染有关。为探讨HP感染在酒渣鼻发病中的作用，我们对酒渣鼻患者采用^14C-尿素呼吸试验检测HP，同时对健康人群HP进行了检测，并对HP阳性者采用根除治疗观察皮疹变化，现将结果报道如下。     

Plasma reactive oxygen species activity and antioxidant potential levels in rosacea patients: correlation with seropositivity to Helicobacter pylori

BACKGROUND: Recent studies have suggested that there might be an etiologic role for Helicobacter pylori (HP) in rosacea. HP is a Gram-negative bacterium that colonizes the gastric mucosa, increases the generation of reactive oxygen species (ROS), and decreases plasma antioxidants such as ascorbic acid. AIM: To investigate plasma ROS activities and antioxidant status, and their relationship with HP infection, in rosacea patients. METHODS: Twenty-nine rosacea patients and 20 age- and sex-matched healthy controls were examined for specific immunoglobulin G (IgG) and IgM against HP, plasma malondialdehyde (MDA), and antioxidant potential (AOP) levels. RESULTS: Compared with controls, the seropositivity of HP for IgM was significantly higher (P = 0.03) and the seropositivity of HP for IgG was significantly lower (P = 0.0001) in patients with rosacea. Plasma MDA levels were higher (P = 0.0001) and AOP levels were lower (P = 0.019) in patients than in controls, regardless of the severity of the disease. Plasma MDA and AOP levels were not affected by the seropositivity of HP for IgM and/or IgG in either group. CONCLUSION: Our results suggest that rosacea is an oxidative stress condition, as reflected by the increased ROS activity and decreased AOP, regardless of HP infection.     

The relationship between Helicobacter pylori IgG antibody and autologous serum test in chronic urticaria

BACKGROUND: In chronic urticaria, suspicious factors are Helicobacter pylori (HP) infection and autoimmunity, as well as other etiologic agents. Autologous serum injection is the first step to identify autoimmune urticaria. Our study was performed to determine the prevalence of HP infection in patients with chronic urticaria, and to evaluate the results of autologous serum testing in chronic urticaria patients who had HP antibodies. METHODS: HP immunoglobulin G (IgG) antibody was defined by an immunochromatographic method in 61 chronic urticaria patients and 15 healthy persons. Autologous serum testing was performed in 32 chronic urticaria patients. RESULTS: HP IgG antibody was found to be positive in 41% of chronic urticaria patients and 26% of healthy controls (chi2= 7.82, P= 0.005). Autologous serum testing was positive in 40% of chronic urticaria patients who had HP IgG antibody. This ratio was 14.3% in chronic urticaria patients who did not have HP IgG antibody (chi2 = 9.23, P= 0.002). CONCLUSIONS: In this study, autologous serum testing was found to highly positive in chronic urticaria patients with HP IgG antibody, but the relationship between autoimmunity and HP infection requires further investigations.     

Helicobacter pylori eradication treatment reduces the severity of rosacea

BACKGROUND: A higher prevalence of Helicobacter pylori infection in rosacea patients than in healthy controls has been reported. OBJECTIVE: The aim of this study was to investigate the effect of H. pylori eradication therapy in patients with rosacea. METHODS: Twenty-five rosacea patients and 87 age- and sex-matched healthy controls were included in this study. We detected IgG and IgA antibodies against H. pylori in both groups. An upper gastrointestinal endoscopy and a rapid urease test were performed on the 13 patients with rosacea who accepted this procedure. Amoxicillin 500 mg 3 times daily, metronidazole 500 mg 3 times daily, and bismuth subcitrate 300 mg 4 times daily were administered to patients positive for H. pylori. The severity of rosacea was scored before and after treatment. RESULTS: There was no statistical difference in seropositivity in either group. In H. pylori-positive rosacea patients there was a significant decrease in the severity of rosacea at the end of the treatment as compared with the initial scores. CONCLUSION: Our findings suggest that H. pylori may be involved in rosacea and that eradication treatment may be beneficial.     

Incidence of anti-Helicobacter pylori and anti-CagA antibodies in rosacea patients

In recent years some authors have reported a possible correlation between Helicobacter pylori (Hp) and dermatological diseases such as rosacea. In this study we evaluated serum IgG and IgA anti-Hp in a group of 48 patients with rosacea. IgG antibodies were present in 81% of the rosacea patients with dyspepsia and 16% of the rosacea patients without dyspeptic symptoms. Serum IgG and IgA anti-Hp were detected by means of an enzymatic immunoabsorption test (enzyme-linked immunosorbent assay: ELISA). In addition, an evaluation of the anti-CagA antibodies by means of an immunoenzymatic method was carried out (ELISA, RADIM). IgA anti-Hp was present in 62% of patients with dyspepsia and in 6% of patients with no upper gastrointestinal symptoms. Anti-CagA antibodies were seen to be present in 75% of patients with both rosacea and gastric symptomatology, and were prevalent in patients affected by rosacea with papular symptoms in respect to rosacea with erythematous symptoms. The data that emerge from our case studies appear to confirm the hypothesis put forward by scientists who propose a correlation between the two clinical presentations rather than an inverse hypothesis of total independence.     

慢性荨麻疹患者血清抗幽门螺杆菌抗体的检测及意义

为探讨幽门螺杆菌感染在慢性荨麻疹中的作用，作者采用间接ＥＬＩＳＡ技术检测了２６例生荨麻疹患者的血清抗Ｈｐ抗体。结果显示：２６例慢性荨麻疹患者中有１７例血清抗Ｈｐ ＩｇＧ抗体阳性，应用根除Ｈｐ感染的方案治疗２月后，１７例阳性患者有１２例获得痊愈。由此考虑Ｈｐ感染可能与部分荨麻疹的发生有关。     

抗幽门螺杆菌对腹型过敏性紫癜疗效的研究

目的探讨抗幽门螺旋杆菌（HP）治疗对腹型过敏性紫癜（HSP）预后的影响。方法90例有消化道症状且非侵入性尿素[14C]呼气试验检测HP呈阳性的HSP患者,随机分成二组,分别接受常规治疗（对照组）和常规加抗HP治疗（治疗组）,比较两组疗效及复发率。结果45例对照组痊愈18例,有效15例,无效12例,复发18例,45例治疗组痊愈39例,有效6例,无复发病例。两组有效率和复发率比较均有显著差异性（P〈0．01u=4〉2．58,P〈0．01U=5．47〉2．58）。结论HP感染与HSP预后密切相关。HP感染不仅是HSP病因之一,且消除HP可较快缓解胃肠道症状提高治疗有效率,减少复发。故对有HP感染的HSP患者应在常规治疗的同时加上抗HP三联治疗。     

The link between Helicobacter pylori infection and rosacea

BACKGROUND: Rosacea is a common condition of unknown aetiology that is usually accompanied by gastrointestinal symptoms and responds favourably to treatment with antibiotics. AIMS/METHODS: This study was designed to examine the prevalence of gastric Helicobacter pylori (Hp) infection verified by 13C-UBT, CLO-test, Hp culture and serology (IgG and IgA) and the presence of Hp in the oral cavity evidenced by CLO-test, Hp culture and saliva anti-Hp antibodies (IgG and IgA). During gastroduodenoscopy antral and fundic biopsy samples were taken for histological evaluation (the Sydney system). This study was performed on 60 subjects 30-70 years old with visible cutaneous rosacea symptoms and 60 age- and gender-matched controls without skin diseases but with dyspeptic symptoms similar to those of rosacea and without endoscopic changes in gastroduodenal mucosa (non-ulcer dyspepsia--NUD). RESULTS: The Hp prevalence in rosacea patients was about 88%, compared to 65% in the NUD controls. A noticeable number of rosacea patients showed chronic active gastritis predominantly in antrum but also in the corpus while those with NUD showed only mild gastritis confined to the antrum only. Following the initial examination, a typical 1 week systemic anti-Hp therapy, induding omeprazole (2 x 30 mg), clarithromycin (2 x 500 mg) and metronidazole (2 x 500 mg), plus gargling and application of metronidazole paste in the case of Hp oral cavity infection. After the application of the systemic and local therapy in the oral cavity, Hp was eradicated from the stomach in 97% and from the oral cavity in 73% of treated patients. Within 2-4 weeks, the symptoms of rosacea disappeared or decreased markedly in 51 subjects. SUMMARY: We conclude that: (1) rosacea is a disorder with various gastrointestinal symptoms closely related to gastritis, especially involving the antrum mucosa; (2) the eradication of Hp leads to improvement of symptoms of rosacea and reduction in related gastrointestinal symptoms; (3) the lack of improvement of cutaneous symptoms in rosacea after eradication of Hp from the gastric mucosa could depend on bacteria in the oral cavity; and (4) rosacea could be considered as one of the extragastric symptoms of Hp infection probably mediated by Hp-related cytotoxins and cytokines.