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《Emerging infectious diseases》2021,27(4):1077
Pneumonia caused by severe acute respiratory syndrome coronavirus 2 emerged in China at the end of 2019. Because of the severe immunomodulation and lymphocyte depletion caused by this virus and the subsequent administration of drugs directed at the immune system, we anticipated that patients might experience fungal superinfection. We collected data from 186 patients who had coronavirus disease–associated pulmonary aspergillosis (CAPA) worldwide during March–August 2020. Overall, 182 patients were admitted to the intensive care unit (ICU), including 180 with acute respiratory distress syndrome and 175 who received mechanical ventilation. CAPA was diagnosed a median of 10 days after coronavirus disease diagnosis. Aspergillus fumigatus was identified in 80.3% of patient cultures, 4 of which were azole-resistant. Most (52.7%) patients received voriconazole. In total, 52.2% of patients died; of the deaths, 33.0% were attributed to CAPA. We found that the cumulative incidence of CAPA in the ICU ranged from 1.0% to 39.1%. 相似文献
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Angiezel Merced-Morales Peter Daly Anwar Isa Abd Elal Noreen Ajayi Ekow Annan Alicia Budd John Barnes Arielle Colon Charisse N. Cummings A. Danielle Iuliano Juliana DaSilva Nick Dempster Shikha Garg Larisa Gubareva Daneisha Hawkins Amanda Howa Stacy Huang Marie Kirby Krista Kniss Rebecca Kondor Jimma Liddell Shunte Moon Ha T. Nguyen Alissa OHalloran Catherine Smith Thomas Stark Katie Tastad Dawud Ujamaa Dave E. Wentworth Alicia M. Fry Vivien G. Dugan Lynnette Brammer 《MMWR. Morbidity and mortality weekly report》2022,71(29):913
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Hiroshi JONAI Mariko ONO Koichi HIRACHI Michihiro TANAKA Hiroshi SOHARA Yukihiro UMEMURA 《Industrial health》2021,59(5):298
Increased variety and use of chemicals and the number of chemical disasters have changed chemical management. Europe and the United States have adopted self-regulation in chemical management; furthermore, countries worldwide must comply with the relevant United Nations recommendations and international standards for chemical management. Japan has experienced numerous pollution incidents and occupational disasters, resulting in the development of laws and regulations on chemical management; however, these policies are inconsistent with international trends. In particular, the shift from a compliance approach to self-regulation and measures for small businesses remain as challenges. This paper discusses the current situation and issues in chemical management in Japan, focusing on international trends. 相似文献