厚朴生姜半夏甘草人参汤治疗胃癌术后早期倾倒综合征52例

目的:观察厚朴生姜半夏甘草人参汤治疗胃癌术后早期倾倒综合征的临床疗效。方法:选取胃癌术后早期倾倒综合征患者102例,随机分为治疗组52例和对照组50例。治疗组给予厚朴生姜半夏甘草人参汤加减治疗,对照组给予多潘立酮治疗。结果:两组临床疗效比较,治疗组有效率90.38%,对照组有效率66.00%,治疗组优于对照组(P0.05);两组中医证候疗效比较,治疗组有效率94.23%,对照组有效率68.00%,治疗组优于对照组(P0.05)。结论:厚朴生姜半夏甘草人参汤治疗胃癌术后倾倒综合征疗效显著。     

厚朴生姜半夏甘草人参汤联合西药治疗功能性腹胀

目的观察厚朴生姜半夏甘草人参汤联合奥替溴铵片治疗功能性腹胀的临床疗效。方法 60例患者,随机分为对照组和治疗组,每组30例,对照组给予奥替溴铵口服,治疗组给予中药厚朴生姜半夏甘草人参汤联合奥替溴铵治疗。结果治疗后,2组症状积分与治疗前比较均有明显降低(P0.05)。症状积分治疗组低于对照组(P0.05),治疗组总有效率优于对照组(P0.05),有显著性差异。结论厚朴生姜半夏甘草人参汤联合奥替溴铵对于功能性腹胀具有良好的疗效。     

厚朴生姜甘草半夏人参汤治疗脾胃气虚型功能性腹胀65例

目的:观察厚朴生姜甘草半夏人参汤治疗脾胃气虚型功能性腹胀的疗效.方法:将95例脾胃气虚型功能性腹胀患者随机分为治疗组和对照组,治疗组予厚朴生姜甘草半夏人参汤治疗,疗程为4周,对照组予莫沙必利片5mg,每天3次,疗程为4周.2组分别进行治疗前后对比观察,判定疗效,并进行统计学分析.结果:治疗组临床疗效优于对照组(P＜0.05).结论:厚朴生姜甘草半夏人参汤治疗脾胃气虚型功能性腹胀有较好疗效.     

厚朴生姜半夏甘草人参汤治疗糖尿病胃轻瘫45例

目的:观察厚朴生姜半夏甘草人参汤治疗糖尿病胃轻瘫(DGP)的临床疗效.方法:对45例患者采用厚朴生姜半夏甘草人参汤加减治疗.结果:显效33例,有效9例,无效3例,总有效率为93.3%.结论:厚朴生姜半夏甘草人参汤治疗DGP疗效满意.     

中西医结合治疗功能性腹胀40例临床观察

目的:观察中西医结合治疗功能性腹胀的临床疗效。方法:将80例功能性腹胀患者随机分治疗组和对照组各40例。对照组采用复方阿嗪米特肠溶片治疗,治疗组在对照组治疗基础上加用厚朴生姜甘草半夏人参汤治疗。2组均治疗6周后统计疗效。结果:总有效率治疗组为90.0%,对照组为72.5%,2组比较,差异有统计学意义(P0.05);2组症状积分治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P0.05);2组复发率比较,差异有统计学意义(P0.05)。结论:复方阿嗪米特肠溶片联合厚朴生姜甘草半夏人参汤加减治疗功能性腹胀有较好疗效。     

厚朴生姜半夏甘草人参汤治疗胃痞60例临床观察

应用厚朴生姜半夏甘草人参汤治疗胃痞 60例 ,并与吗叮啉对照组进行对比观察。结果显示治疗组总有效率为 95 % ,对照组总有效率为 90 .3 % ,两组治疗均有效 ,两组之间疗效无显著性差异 (P >0 .0 5)。结论 :厚朴生姜半夏甘草人参汤对胃痞有较好疗效     

五磨饮治疗脾虚气滞型功能性消化不良疗效研究

目的:观察五磨饮治疗脾虚气滞型功能性消化不良的临床疗效及其安全性。方法:确诊为脾虚气滞型功能性消化不良患者120例,随机分为治疗组和对照组各60例,治疗组给予五磨饮治疗,对照组给予多潘立酮治疗,两组疗程均为4周。采用PAGI-SYM症状量表、中医证侯量表及饮水负荷试验观察患者临床症状和胃感觉功能的变化情况,并观察不良事件。结果:治疗组和对照组总有效率分别为93.3%和83.3%,组间临床疗效比较,差异有统计学意义(P0.05)。治疗组中医证侯各项指标治疗前后组内差异性有统计学意义(P0.05);对照组胃脘胀满、嗳气吞酸积分治疗前后组内差异有统计学意义(P0.05)。组间治疗后比较,胃脘胀满、胃脘疼痛、嗳气泛酸、饮食减少及善太息积分差异有统计学意义(P0.05)。两组治疗期间均未发生不良事件。结论:五磨饮能显著缓解脾虚气滞型功能性消化不良患者的临床症状和胃感觉功能,且安全性较好。     

中医治疗脾虚气滞型功能性消化不良临床研究

目的:观察和胃贴敷脐配合运胃汤口服治疗脾虚气滞型功能性消化不良患者的临床疗效。方法:将符合纳入标准的100例患者随机分为观察组与对照组各50例,治疗组患者给予和胃贴敷脐配合运胃汤口服治疗,对照组患者给予多潘立酮片、兰索拉唑口服治疗。治疗6周后,观察比较两组患者的临床疗效。结果:经治疗,观察组患者治疗总有效率为90.0%,明显高于对照组的78.0%,差异具有统计学意义(P0.05)。结论:和胃贴敷脐配合运胃汤治疗脾虚气滞型功能性消化不良患者疗效确切,值得临床推广应用。     

中西医结合治疗功能性消化不良脾虚气滞型临床观察

目的:观察白术健脾汤联合多潘立酮治疗功能性消化不良脾虚气滞型的临床疗效。方法:40例随机分为对照组和观察组各20例,两组均给予多潘立酮片口服,观察组加用白术健脾汤口服,比较两组治疗前后的症状评分及生活质量评分。结果:总有效率观察组高于对照组(P0.05)。观察组治疗后的唾液淀粉酶活性和d—木糖排泄率优于治疗前(P0.05),与对照组治疗后比较差异有统计学意义(P0.05)。结论:白术健脾汤联合多潘立酮治疗功能性消化不良脾虚气滞型可有效改善临床症状,效果较好。     

中药加西沙比利治疗功能性消化不良70例

目的:观察补气散结、降气消食类中药加西沙比利治疗功能消化不良的疗效。方法:对130例经胃镜检查确诊病例随机分组,分别给予厚朴生姜半夏甘草人参汤加味(厚朴、党参、生姜、半夏、甘草等药)和西沙比利(观察组),西沙比利(对照组)治疗。结果:两组治疗前后比较有显著性差异(P<0.01),观察组明显优于对照组。提示:中药加西沙比利治疗功能性消化不良疗效明显,不良反应少,无病情反跳现象。     

Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots

Intraperitoneal injection of an aqueous extract of the crude drug "shigoka" (Siberian ginseng), Eleutherococcus senticosus roots, remarkably diminished plasma-sugar level in mice. Fractionation of the extract by monitoring the activity yielded seven glycans, eleutherans A, B, C, D, E, F, and G, which exerted marked hypoglycemic effects in normal and alloxan-induced hyperglycemic mice.     

Phytochemistry, Metabolism, and Metabolomics of Ginseng

Ginseng, as a medicinal plant, has been used for thousands of years in China, Korea, and Japan, and the study on ginseng is a hotspot in the research field as evidenced by about 7000 scientific papers in PUBMED. In recent decades, many ginseng studies focused on the metabolism and metabolomics of ginseng or its active ingredients using modern bioanalytical technologies. To date, more than 200 ginsenosides and non-saponin constituents have been isolated and identified. In the past decades, rapid development of analytical technologies has facilitated the advancement of ginseng research in many ways. In this review, we focus on the advances of ginseng research in chemistry, pharmacology, and metabolomics. We also provide the comments on the significance as well as challenges of metabolomics-based ginseng studies.     

Correlation of Metabolism, Metabolomics, and Metabonomics

<正>In this issue,CHM published two reviews on drug metabolism of Chinese herbal medicines.Three key words have been found,they are metabolism,metabolomics,and metabonomics.As we known,drug metabolism is the biochemical modification of pharmaceutical substances respectively by living organisms through specialized enzymatic systems,the rate of metabolism determines the duration and intensity of pharmacological responses     

Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Galium mexicanum

Ethnopharmacological relevance

To study the potential benefit of the traditional Mexican medicinal plant Galium mexicanum Kunth (Rubiaceae). Hexane, chloroform, and methanol extracts as well as various fractions from these extracts were tested to determine antibacterial, antifungal, antiparasitic or anti-inflammatory activities in vitro.

Materials and methods

Aerial parts of the plant were extracted with various solvents and fractionated accordingly. Their antibacterial and antifungal activities were assessed on nine bacterial and four fungal strains. Leishmania donovani was used as a protozoan strain for antiparasitic activity. The anti-inflammatory activity of the compounds was investigated by measuring the secretion of interleukin-6 when macrophages were exposed to lipopolysaccharide.

Results

Various extracts and fractions obtained from this plant exhibit antibacterial, antifungal, antiparasitic, and anti-inflammatory activities. Of special interest was the hexane fraction HE 14b, which show antibacterial (ranging between 67 and 666 μg/ml) and antifungal (at concentrations of 333 μg/ml) activities. Also the hexane fraction HE 5 exhibited antiparasitic activity (at concentrations of 260 μg/ml), whereas the methanol fraction ME 13-15 showed a potent anti-inflammatory activity when compared to dexamethasone. Chemical analyses of the chloroform extract show the presence of triterpenes, saponins, flavonoids, sesquiterpene lactones, and glucosides, but no tannins were detected in the assayed extract.

Conclusions

The benefit of Galium mexicanum as a traditional medicinal plant was confirmed using antibacterial and antifungal assays in vitro. We also report for the first time, and to the best of our knowledge, antiparasitic and anti-inflammatory activities of this plant.     

Isolation and structure of homotemsirolimuses A, B, and C

Homotemsirolimuses A, B, and C (2a, 2b, 2c) were found to be minor components of a temsirolimus preparation made from rapamycin. These three temsirolimus analogues are derived from the corresponding rapamycin analogues, homorapamycins A, B, and C (1a, 1b, 1c) produced by the strain Streptomyces hygroscopicus. The structures of homotemsirolimuses A, B, and C were determined by spectroscopic methods. These compounds were tested for mTOR kinase inhibition and in two proliferation assays using LNCap prostate and MDA468 breast cancer cells. The results suggested that the mTOR inhibition and antiproliferation potencies for 2a, 2b, and 2c are comparable to those of rapamycin (1) and temsirolimus (2).     

Antimalarial activity of physalins B, D, F, and G

The antimalarial activities of physalins B, D, F, and G (1-4), isolated from Physalis angulata, were investigated. In silico analysis using the similarity ensemble approach (SEA) database predicted the antimalarial activity of each of these compounds, which were shown using an in vitro assay against Plasmodium falciparum. However, treatment of P. berghei-infected mice with 3 increased parasitemia levels and mortality, whereas treatment with 2 was protective, causing a parasitemia reduction and a delay in mortality in P. berghei-infected mice. The exacerbation of in vivo infection by treatment with 3 is probably due to its potent immunosuppressive activity, which is not evident for 2.     

酸柏栀油软胶囊对小鼠学习记忆及脑中NO、Ach的影响

目的:观察酸柏栀油软胶囊对小鼠的促学习记忆作用并初步探讨其机制。方法:采用Morris水迷宫法观察酸柏栀油软胶囊对小鼠的学习记忆影响,并测定小鼠脑内NOS、ChaE、AChE的含量。结果:酸柏栀油软胶囊1.25～5 ml/kg能缩短小鼠登台潜伏期,增加穿越原平台次数,以中剂量作用最强;且登台潜伏期随训练时间的延长,各组作用均逐渐增强,d20的作用尤为明显。酸柏栀油软胶囊尚能增加小鼠脑内NOS、ChaE活性,降低AChE活性,也以中剂量作用为佳。结论:酸柏栀油软胶囊对小鼠学习记忆有促进作用,该作用可能与其富含不饱和脂肪酸,增加脑内NO、Ach的含量有关。     

何首乌中总黄酮与微量元素含量分析及其药效机理研究

目的分析中药何首乌中总黄酮与微量元素Mg，Fe，Mn，Cu，Zn的含量。方法紫外分光光度法测定何首乌中总黄酮的含量；原子吸收分光光度法测定Mg，Fe，Mn，Cu，Zn的含量。结果总黄酮的含量27．44mg／g；Mg：952．4801&#177;10．5543μg／g；Fe：7196．7256&#177;98．8101μg；Mn：431．0929&#177;5．5698μg／g；Cu：5．5438&#177;0．1513μg；Zn：86.7915&#177;6．4781μg／g。结论实验结果为探讨中药何首乌中黄酮类化合物与微量元素的关系及研究何首乌中微量元素与药物的功效关系提供了有用的方法和依据。