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1.
The interaural time difference (ITD) is an important cue to localize sound sources. Sensitivity to ITD was measured in eight
users of a cochlear implant (CI) in the one ear and a hearing aid (HA) in the other severely impaired ear. The stimulus consisted
of an electric pulse train of 100 pps and an acoustic filtered click train. Just-noticeable differences (JNDs) in ITD were
measured using a lateralization paradigm. Four subjects exhibited median JNDs in ITD of 156, 341, 254, and 91 μs; the other
subjects could not lateralize the stimuli consistently. Only the subjects who could lateralize had average acoustic hearing
thresholds at 1,000 and 2,000 Hz better than 100-dB SPL. The electric signal had to be delayed by 1.5 ms to achieve synchronous
stimulation at the auditory nerves.
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2.
A simple, biophysically specified cell model is used to predict responses of binaurally sensitive neurons to patterns of input
spikes that represent stimulation by acoustic and electric waveforms. Specifically, the effects of changes in parameters of
input spike trains on model responses to interaural time difference (ITD) were studied for low-frequency periodic stimuli,
with or without amplitude modulation. Simulations were limited to purely excitatory, bilaterally driven cell models with basic
ionic currents and multiple input fibers. Parameters explored include average firing rate, synchrony index, modulation frequency,
and latency dispersion of the input trains as well as the excitatory conductance and time constant of individual synapses
in the cell model. Results are compared to physiological recordings from the inferior colliculus (IC) and discussed in terms
of ITD-discrimination abilities of listeners with cochlear implants. Several empirically observed aspects of ITD sensitivity
were simulated without evoking complex neural processing. Specifically, our results show saturation effects in rate–ITD curves,
the absence of sustained responses to high-rate unmodulated pulse trains, the renewal of sensitivity to ITD in high-rate trains
when inputs are amplitude-modulated, and interactions between envelope and fine-structure delays for some modulation frequencies. 相似文献
3.
Objective: To determine speech perception in quiet and noise of adult cochlear implant listeners retaining a hearing aid contralaterally. Second, to investigate the influence of contralateral hearing thresholds and speech perception on bimodal hearing. Patients and methods: Sentence recognition with hearing aid alone, cochlear implant alone and bimodally at 6 months after cochlear implantation were assessed in 148 postlingually deafened adults. Data were analyzed for bimodal summation using measures of speech perception in quiet and in noise. Results: Most of the subjects showed improved sentence recognition in quiet and in noise in the bimodal condition compared to the hearing aid-only or cochlear implant-only mode. The large variability of bimodal benefit in quiet can be partially explained by the degree of pure tone loss. Also, subjects with better hearing on the acoustic side experience significant benefit from the additional electrical input. Conclusions: Bimodal summation shows different characteristics in quiet and noise. Bimodal benefit in quiet depends on hearing thresholds at higher frequencies as well as in the lower- and middle-frequency ranges. For the bimodal benefit in noise, no correlation with hearing threshold in any frequency range was found. 相似文献
6.
Objectives: To investigate if the interaural time difference (ITD) ability is dependent of stimulation strategy. To examine the correlation between ITD, interaural level differences (ILD) and the ability to localize different sounds. Methods: Thirty subjects aged 8–13 who were implanted bilaterally before 3 years of age were tested. Twenty of the subjects used processors programmed with fine structure (FS) strategy on both sides. ITD and ILD just noticeable difference (JND) of a 250?Hz pure tone was measured using their clinical processors. Furthermore, their ability to localize sound in the horizontal plane was measured using eye tracking. Results: Ten of the 20 subjects with FS obtained an ITD threshold compared to none in the group without FS (0/10). ILD JND was correlated to localization ability of the broadband (BB) sound. Mean absolute error of the localization of a low-frequency (LF) sound was larger than that of a BB sound. Conclusions: The ability to detect ITD was present only when the cochlear implant stimulation had FS. The LF sound was more difficult to localize than the BB sound and ITD ability of FS strategies did not affect the localization ability of either sound. A low ILD seems necessary to improve the localization ability. 相似文献
7.
The mammalian cochlea has two types of sensory cells; inner hair cells, which receive auditory-nerve afferent innervation,
and outer hair cells, innervated by efferent axons of the medial olivocochlear (MOC) system. The role of the MOC system in
hearing is still controversial. Recently, by recording cochlear potentials in behaving chinchillas, we suggested that one
of the possible functions of the efferent system is to reduce cochlear sensitivity during attention to other sensory modalities
(Delano et al. in J Neurosci 27:4146–4153, 2007). However, in spite of these compelling results, the physiological effects of electrical MOC activation on cochlear potentials
have not been described in detail in chinchillas. The main objective of the present work was to describe these efferent effects
in the chinchilla, comparing them with those in other species and in behavioral experiments. We activated the MOC efferent
axons in chinchillas with sectioned middle-ear muscles by applying current pulses at the fourth-ventricle floor. Auditory-nerve
compound action potentials (CAP) and cochlear microphonics (CM) were acquired in response to clicks and tones of several frequencies,
using a round-window electrode. Electrical efferent stimulation produced CAP amplitude suppressions reaching up to 11 dB.
They were higher for low to moderate sound levels. Additionally, CM amplitude increments were found, the largest (≤ 2.5 dB)
for low intensity tones. CAP suppression was present at all stimulus frequencies, but was greatest for 2 kHz. CM increments
were highest for low-frequency tones, and almost absent at high frequencies. We conclude that the effect obtained in chinchilla
is similar to but smaller than that observed in cats, and that the effects seen in awake chinchillas, albeit different in
magnitude, are consistent with the activation of efferent fibers. 相似文献
9.
Conclusion: Differences were found between patients with stable hearing and those with progressive hearing loss in the lower frequencies with respect to the rate of progression in the contralateral ear. It is suggested that the electric acoustic stimulation (EAS) can provide improvement in hearing ability over the long-term if residual hearing might be lost to some extent. Objective: To evaluate the long-term threshold changes in the low frequency hearing of the implanted ear as compared with the non-implanted ear, and the hearing abilities with EAS along with the extent of residual hearing. Methods: Seventeen individuals were enrolled and received the EAS implant with a 24-mm FLEXeas electrode array. Hearing thresholds and speech perception were measured pre- and post-operatively for 1–5 years. Post-operative hearing preservation (HP) rates were calculated using the preservation numerical scale. Results: The average linear regression coefficient for the decline in hearing preservation score was ?6.9 for the implanted ear and the patients were subsequently categorized into two groups: those with better than average, stable hearing; and those with worse than average, progressive hearing loss. EAS showed better results than electric stimulation alone, in spite of an absence of speech perception with acoustic stimulation. 相似文献
11.
Most auditory prostheses use modulated electric pulse trains to excite the auditory nerve. There are, however, scant data
regarding the effects of pulse trains on auditory nerve fiber (ANF) responses across the duration of such stimuli. We examined
how temporal ANF properties changed with level and pulse rate across 300-ms pulse trains. Four measures were examined: (1)
first-spike latency, (2) interspike interval (ISI), (3) vector strength (VS), and (4) Fano factor (FF, an index of the temporal
variability of responsiveness). Data were obtained using 250-, 1,000-, and 5,000-pulse/s stimuli. First-spike latency decreased
with increasing spike rate, with relatively small decrements observed for 5,000-pulse/s trains, presumably reflecting integration.
ISIs to low-rate (250 pulse/s) trains were strongly locked to the stimuli, whereas ISIs evoked with 5,000-pulse/s trains were
dominated by refractory and adaptation effects. Across time, VS decreased for low-rate trains but not for 5,000-pulse/s stimuli.
At relatively high spike rates (>200 spike/s), VS values for 5,000-pulse/s trains were lower than those obtained with 250-pulse/s
stimuli (even after accounting for the smaller periods of the 5,000-pulse/s stimuli), indicating a desynchronizing effect
of high-rate stimuli. FF measures also indicated a desynchronizing effect of high-rate trains. Across a wide range of response
rates, FF underwent relatively fast increases (i.e., within 100 ms) for 5,000-pulse/s stimuli. With a few exceptions, ISI,
VS, and FF measures approached asymptotic values within the 300-ms duration of the low- and high-rate trains. These findings
may have implications for designs of cochlear implant stimulus protocols, understanding electrically evoked compound action
potentials, and interpretation of neural measures obtained at central nuclei, which depend on understanding the output of
the auditory nerve. 相似文献
12.
Conclusion: In patients with unilateral microtia and atresia after reconstruction of the auricle and external canal and fitting of a canal-type hearing aid for the operated ear, the ability to discriminate the inter-aural intensity difference (IID) was acquired in all of the patients, whereas that to discriminate inter-aural time difference (ITD) was acquired in one-half of the patients. Objective: To study the post-operative sound lateralization ability in patients with unilateral microtia and atresia after reconstruction surgery of the auricle and external canal and fitting of a canal-type hearing aid of the operated ear. Methods: Eighteen patients with unilateral microtia and atresia ranging from 13–24 years of age were recruited in this study. All of them underwent reconstruction of the auricle and external canal and were fitted a canal-type hearing aid for the operated ear. The sound lateralization test was conducted to determine IID and ITD using a self-recording apparatus. The test stimulus was a continuous narrow-band noise at 500 Hz and 50 dBHL presented to the right and left ears through the air conduction receivers. Results: IID could be measured in all of the patients, whereas ITD could be measured in only nine out of the 18 patients. Post-operative binaural hearing could be acquired in all the patients. 相似文献
13.
ObjectiveThe present study compared the speech recognition and pitch ranking abilities of normally hearing children ( n = 15) to children using a cochlear implant (CI) alone ( n = 8), bilateral hearing aids (HAs) ( n = 6), or bimodal stimulation (BMS) ( n = 9). It was hypothesised that users of BMS would score higher on tasks of speech and pitch perception than children using a CI alone, but not children using HAs. MethodsParticipants were assessed on tasks of monosyllabic word recognition in quiet, sentence recognition in quiet and noise (10 dB signal-to-noise ratio), and a pitch ranking task using pairs of sung vowels one, half, and a quarter of an octave apart. ResultsThere were no significant differences between the mean percentage-correct scores of the four participant groups for either words in quiet or sentences in quiet and noise. However, the proportion of bimodal users who scored >80% correct (80%) was significantly greater than the proportion of high-scoring unilateral CI (25%) or bilateral HA users (17%). Contrary to expectations, there was also no significant difference between the pitch ranking scores of users of BMS and users of a CI alone for all three interval sizes ( p < 0.05, RM-ANOVA). However participants using only acoustic hearing (i.e. the NH and HA groups) scored significantly higher than participants using electrical stimulation (i.e. the CI and BMS groups) on the pitch ranking task ( p < 0.05; RM-ANOVA). ConclusionsContrary to findings in postlingually deafened adults, we found no significant bimodal advantage for pitch perception in prelingually deafened children. However, the performance of children using electrical stimulation was significantly poorer than children using only acoustic stimulation. Further research is required to investigate the contribution of the non-implanted ears of users of BMS to pitch perception, and the effect of hearing loss on the development of pitch perception in children. 相似文献
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