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1.
Thirteen patients with a diagnosis of “hyperlucent lung”, 9 women and 4 men ranging in age from 19 to 68, are reviewed. Four patients had congenital absence of the pulmonary artery, and 9 had what we believe should be termed acquired hypoperfusion of a lung.In patients with acquired hypoperfusion, the pathophysiology is determined by recurrent pulmonary infection with resultant decrease in lung volume and function, decreased pulmonary artery flow, and increased bronchial circulation. Recurrent infection may lead to severe hemoptysis. Pulmonary resection was carried out in 1 of those with congenital absence of the pulmonary artery and in 5 with acquired lesions.  相似文献   

2.

Background

Liver hypertrophy induced by partial portal vein occlusion (PVL) is accelerated by adding simultaneous parenchymal transection (“ALPPS procedure”). This preclinical experimental study in pigs tests the hypothesis that simultaneous ligation of portal and hepatic veins of the liver also accelerates regeneration by abrogation of porto-portal collaterals without need for operative transection.

Methods

A pig model of portal vein occlusion was compared with the novel model of simultaneous portal and hepatic vein occlusion, where major hepatic veins draining the portal vein–deprived lobe were identified with intraoperative ultrasonography and ligated using pledgeted transparenchymal sutures. Kinetic growth was compared, and the portal vein system was then studied after 7 days using epoxy casts of the portal circulation. Portal vein flow and portal pressure were measured, and Ki-67 staining was used to evaluate the proliferative response.

Results

Pigs were randomly assigned to portal vein occlusion (n?=?8) or simultaneous portal and hepatic vein occlusion (n?=?6). Simultaneous portal and hepatic vein occlusion was well tolerated and led to mild cytolysis, with no necrosis in the outflow vein–deprived liver sectors. The portal vein–supplied sector increased by 90 ± 22% (mean ± standard deviation) after simultaneous portal and hepatic vein occlusion compared with 29 ± 18% after PVL (P < .001). Collaterals to the deportalized liver developed after 7 days in both procedures but were markedly reduced in simultaneous portal and hepatic vein occlusion. Ki-67 staining at 7 days was comparable.

Conclusion

This study in pigs found that simultaneous portal and hepatic vein occlusion led to rapid hypertrophy without necrosis of the deportalized liver. The findings suggest that the use of simultaneous portal and hepatic vein occlusion accelerates liver hypertrophy for extended liver resections and should be evaluated further.  相似文献   

3.
Isolated macrodactyly in the ulnar nerve distribution is extremely rare. A case associated with cubital tunnel syndrome is reported.  相似文献   

4.

Background

Surgical enteral access prior to multimodality treatment for esophageal cancer is controversial as dysphagia is often used for feeding tube referral. We hypothesized that enteral access before neoadjuvant chemoradiation for esophageal cancer provides no benefit compared to that placed during definitive esophagectomy.

Methods

Patients undergoing esophagectomy for esophageal malignancy from 2007???2014 were retrospectively identified. Clinicopathologic factors were recorded including preoperative enteral access, weight change, nutritional laboratory works, and perioperative complications.

Results

Of 156 identified patients, 99 (63.5%) received neoadjuvant chemoradiation and comprised the study cohort. Fifty (50.5%) underwent enteral access (gastrostomy [14], jejunostomy [32], other [4]; “Access Group”) prior to chemoradiation followed by esophagectomy and were compared to 49 “No-Access” patients who underwent enteral access during esophagectomy. Clinicopathologic variables were similar between cohorts. The Access and No-Access cohorts had similar reported dysphagia (86% vs 75.5%, respectively; P?=?.2) and mean preesophagectomy serum albumin (3.9 vs 4 gm/dL, respectively; P?=?.2). Weight loss?±?6-month periesophagectomy was similar between access versus No-Access cohorts (?11.2% vs ?15.4%, respectively; P?=?.1). Weight loss during this period was likewise similar for patients with dysphagia in the Access (?11%) versus No-Access group (?15.2%, P?=?.1). No difference in complication rates was noted between Access (64%) and No-Access groups (51%, P?=?.2).

Conclusion

Despite healthcare provider bias, there seems to be no nutritional or perioperative benefit for enteral access before neoadjuvant chemoradiation for esophageal malignancy. Patients with esophageal malignancy should therefore proceed to appropriate neoadjuvant and surgical therapy with enteral access performed during definitive resection or reserved for those with frank obstruction on endoscopy.  相似文献   

5.
本文报告对19例急性坏死性胰腺炎早期手术(24小时内)治疗的结果,存活率达100%。就早期手术的理论依据、早期手术的指征、手术时机和手术方式进行了讨论。作者认为,早期手术的成功取决于充分的胰腺减压、彻底的坏死组织清除和有效的引流及冲洗。  相似文献   

6.
During a 1-yr period an increased incidence of hypertrophic PS was noted in a closed referral population. These patients demonstrated a temporal relationship between the ingestion of EE and the development of PS. A sequence of events from pylorospasm to pyloric tumors was suggested from the data.  相似文献   

7.
Tan HL  Liew QY  Loo S  Hawkins R 《Anaesthesia》2002,57(5):478-483
Sodium phosphate is widely used as an effective bowel preparation agent. It is used in smaller volumes, leading to improved patient tolerance. Although it is generally safe, cases of severe hyperphosphataemia following sodium phosphate administration have been reported in the literature. The common risk factors identified are advanced age, impaired renal function, impaired colonic motility and multiple doses. However, many doctors remain unaware of the dangers associated with this agent. We report six cases of severe electrolyte and metabolic derangement due to sodium phosphate bowel preparation: two patients had delayed awakening from general anaesthesia, and four patients suffered life-threatening consequences.  相似文献   

8.
The recognized late complications of necrotizing enterocolitis are intestinal stenosis and internal fistulae. Malabsorption is a possible complication but has not yet been reported. The case of necrotizing enterocolitis reported in this paper survived severe septicemia and later developed extensive proximal and distal colonic strictures and an intervening enterocyst.Intestinal stenosis in the newborn or the infant may follow such causes as necrotizing enterocolitis or exchange transfusion, but it is suggested that, whatever the immediate precipitating factor, a common pathogenesis exists, namely, intestinal ischemia resulting in necrosis of the bowel wall, followed by healing with fibrosis and consequent stenosis.  相似文献   

9.

Background

Red blood cell-derived microparticles are biologically active, submicron vesicles shed by erythrocytes during storage. Recent clinical studies have linked the duration of red blood cell storage with thromboembolic events in critically ill transfusion recipients. In the present study, we hypothesized that microparticles from aged packed red blood cell units promote a hypercoagulable state in a murine model of transfusion.

Methods

Microparticles were isolated from aged, murine packed red blood cell units via serial centrifugation. Healthy male C57BL/6 mice were transfused with microparticles or an equivalent volume of vehicle, and whole blood was harvested for analysis via rotational thromboelastometry. Serum was harvested from a separate set of mice after microparticles or saline injection, and analyzed for fibrinogen levels. Red blood cell-derived microparticles were analyzed for their ability to convert prothrombin to thrombin. Finally, mice were transfused with either red blood cell microparticles or saline vehicle, and a tail bleeding time assay was performed after an equilibration period of 2, 6, 12, or 24 hours.

Results

Mice injected with red blood cell-derived microparticles demonstrated an accelerated clot formation time (109.3?±?26.9 vs 141.6?±?28.2?sec) and increased α angle (68.8?±?5.0 degrees vs 62.8?±?4.7 degrees) compared with control (each P?<?.05). Clotting time and maximum clot firmness were not significantly different between the 2 groups. Red blood cell-derived microparticles exhibited a hundredfold greater conversion of prothrombin substrate to its active thrombin form (66.60?±?0.03 vs 0.70?±?0.01 peak OD; P?<?.0001). Additionally, serum fibrinogen levels were lower in microparticles-injected mice compared with saline vehicle, suggesting thrombin-mediated conversion to insoluble fibrin (14.0 vs 16.5?µg/mL, P?<?.05). In the tail bleeding time model, there was a more rapid cessation of bleeding at 2 hours posttransfusion (90.6 vs 123.7?sec) and 6 hours posttransfusion (87.1 vs 141.4?sec) in microparticles-injected mice as compared with saline vehicle (each P?<?.05). There was no difference in tail bleeding time at 12 or 24 hours.

Conclusion

Red blood cell-derived microparticles induce a transient hypercoagulable state through accelerated activation of clotting factors.  相似文献   

10.
11.
Permanent atrial pacing provides an important approach to refractory supraventricular and selected ventricular arrhythmias. This report reviews current techniques for instituting atrial pacing; namely, epicardial electrode implantation and transvenous coronary sinus placement. An improved method of atrial epicardial electrode implantation is described. Representative cases are reviewed to illustrate clinical settings in which permanent atrial pacing has controlled previously refractory arrhythmias.  相似文献   

12.
An experimental study was undertaken to determine the effect of cardiac tamponade on peak jugular venous flow velocity (JVFV). Tamponade was produced in seven dogs by incremental infusion of saline into the pericardial cavity while right atrial pressure, right ventricular pressure, pericardial pressure, aortic pressure, electrocardiogram cardiac output, respiration and directional jugular venous flow velocity was monitored. The development of tamponade was associated with an increase in venous and pericardial pressure. Aortic pressure and cardiac output declined progressively. The control JVFV averaged 14 cm/sec and declined markedly during tamponade before other hemodynamic parameters had changed significantly. A 10% decline in mean aortic pressure was associated with a decrease in JVFV to 53% of control. Jugular venous flow velocity had decreased markedly before pericardial pressure or venous pressure had risen into a range suggestive of tamponade. This study documents the marked reduction in JVFV early in the course of cardiac tamponade which can be easily monitored with a directional Doppler velocity detector.  相似文献   

13.
14.
The diagnosis of superior sulcus tumor was established in 35 patients at the University of Michigan Medical Center over the sixteen-year period from 1955 through 1970. Twelve patients underwent preoperative irradiation with cobalt 60 followed by radical en bloc excision of the chest wall. None of these patients survived five years. Twenty-three patients received radiation therapy with cobalt 60 only. Three of these patients survived five years free of disease. The absolute five-year survival in the entire group of patients was 8.6%. This study raises the question of the role of radical chest wall excision in the treatment of superior sulcus tumor.  相似文献   

15.
16.
A statewide survey of pediatric surgery was sponsored by the Connecticut Society of American Board Surgeons to determine the general surgeons attitudes about performing routine and complex pediatric surgery, the absolute volume of index pediatric surgical conditions in the state, and the proportion treated by pediatric and nonpediatric surgeons. The incidence of index conditions studied was very similar to those previously reported. Approximately one half of all index cases were treated by nonpediatric surgeons, indicating that the number of pediatric surgeons could be increased, and possibly doubled, if all index procedures were performed by pediatric surgeons. Two-thirds of responding surgeons recognized the need for a regional neonatal surgical center. Regional or statewise surveys of index surgical conditions are recommended to determine regional manpower needs.  相似文献   

17.
小儿肾积水Anderson-Hynes手术后并发症及其治疗   总被引:1,自引:0,他引:1  
对52例(54侧)先天性肾盂输尿管连接部梗阻性肾积水患者行Anderson-Hynes手术,对其手术的并发症进行分析,主要并发症为吻合口梗阻(39%)和泌尿系感染(28%).经腹进行手术,肠梗阻发生率为13%(3/23).患儿手术时年龄与手术后并发症发生率无显著性意义.  相似文献   

18.
19.
目的:探讨先天性胆总管囊肿应用胆总管空肠KOUS-Y型手术的应用价值和手术方法。方法:回顾性分析我院1991年~1997年收治的11例手术病例。结果:全组无手术死亡,随访5~10年,生活质量好,无并发症发生。结论:胆总管空肠KOUX-Y型手术是治疗先天性胆总管囊肿的理想术式。  相似文献   

20.
气管隆突切除及重建术治疗中心型支气管肺癌   总被引:2,自引:0,他引:2  
本文报告10例侵及气管隆突或距隆突0.3cm以内的中心型支气管肺癌行气管隆突切除及重建术,其中右上叶及隆突切除重建术3例,右全肺及隆突切除2例,左全肺及隆突切除4例,左上叶及隆突切除重建术1例,加部分左心房切除术3例。本组根治切除9例。姑息切除1例。术后并发症3例(30%)。术后无癌生存6年1例,3年1例,2年10月1例,2年6月3例,1年2例,半年1例;另1例于术后8月死于脑转移。重点讨论了手术适应证、手术方法、围手术期监护和处理。  相似文献   

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