STUDY ON SERUM CERULOPLASMIN LEVELS IN VARIOUS CONDITIONS AND TYPES OF LEUKEMIA

Serum ceruloplasmin (CP) was determined by electroimmunodiffusion method in 89 normal persons and 92 leukemic patients. It was found that the serum CP of acute and chronic leukemia was very significantly higher than normal (P<0.01). There were no signifcant difference in elevation of serum CP between various types of leukemia. During remission oJ acute or chronic leukemia, the serum CP decreased significantly (P<0.05), but still higher than normal (P<0.01). In the case of long-term remission, serum CP decreased to normal level. During relapse of acute leukemia or acute blast crisis of chronic leukemia, serum CP raised again significantly (P<0.05). Infection enabled the leukemic patient to further increase serum CP (P<0.01). In acute leukemia, serum CP level correlated positively with the percentage of blast cells in bone marrow (P<0.05).     

STUDY ON VARIOUS OPERATIONS AND PROGNOSIS OF EXTRAHEPATIC BILE DUCT CANCER

ＳＴＵＤＹＯＮＶＡＲＩＯＵＳＯＰＥＲＡＴＩＯＮＳＡＮＤＰＲＯＧＮＯＳＩＳＯＦＥＸＴＲＡＨＥＰＡＴＩＣＢＩＬＥＤＵＣＴＣＡＮＣＥＲ［ＦａｎＹｕｅｚｕ，ＷａｎｇＢａｏｃｈａｎｇ，ＣａｉＴｏｎｇｎｉａｎｅｔａｌ．ＣｈｉｎａＮａｔ１ＪＮｅｗＧａｓｔｒｏｅｎｔ...     

A RAPID AND SENSITIVE METHOD FOR DETECTION OF ARYLSULFATASE ACTIVITIES

Conventional colorimetric methods for determination of arylsulfatase activities are insensitive for microassays. In this study a rapid and sensitive fluorogenic technique was used with issues of the normal levels of arylsulfatase A and B activities in leukocytes. In addition, 2 cases of genetic lysosomal storage diseases were confirmatively diagnosed, one as MLD, the other as MLS, and a third case highly suspected clinically as MLS was finally excluded by this method.     

A CLINICAL STUDY ON ACUPUNCTURE FOR PREVENTION AND TREATMENT OF TOXIC SIDEEFFECTS DURING RADIOTHERAPY AND CHEMOTHERAPY

Radiotherapy and chemotherapy arecommonly used in the treatment of tumors.However,such toxic side-effects as leukopenia,gastrointestinal or systemic reactions occurredin the treatment are so serious that somepatients can not tolerate it and even abandonthe treatment.Recently,some doctors have     

A PRELIMINARY STUDY ON SERUM TRACE ELEMENTS IN“YIN-DEFICIENCY”AND“YANG-DEFICIENCY”PATIENTS APPLICATION OF THE PIXE ANALYSIS IN MEDICAL SCIENCE

1.The results show that PIXE analysiscan be used advantageously in trace elementanalysis of biomedical samples.The normalvalues of trace elements in serum obtainedin our work agree with values reported byOther researchers.2.Changes of trace elements in serumwere found in“Yin-deficiency”aNd“Yang-deficiency”as diagnosed in traditional Chi-nese medicine.In addition to the significantdifferences of the concentration of Cu andthe ratio of Zn/Cu between“deficiencysyndrome”patients and normal SUbjects,there also appeared to be significant dif-ference between“Yin-deficiency”and“Yang-deficiency”patients.     

A PRELIMINARY STUDY ON IUD WITH RATE-LIMITING MEMBRANE CONTROLLING DELIVERY OF INDOMETHACIN AND p-AMINOMETHYL BENZOIC ACID

Enhancement of endometrial rrihrinolysis activity and increaseng of PGs release are the main factors that cause uterus abnormal bleeding, which might be prevented by antifribrinolytic agents and PG synthesis and release inhibitors. In the present study,     

A CLINICAL STUDY ON TCM DIFFERENTIATION OF SYMPTOMS AND SIGNS IN PREGNANCY HYPERTENSION SYNDROME

An epidemiological investigation was made into the diagnostic types of 457 cases of pregnancy classified according to differentiation of symptoms and signs by traditional Chinese medicine (TCM) with the aim of finding out its relationship with pregnancy hypertension syndrome (PHS). The total occurrence rate of PHS was 36.8%. In early pregnancy, 65.9% of patients with deficiency of yin of the liver had a high rate of developing PHS, while in the intermediate stage, 61.6% of patients with deficiency of the spleen and exuberance of the liver were most liable to develop it. In 50 cases diagnosed and treated on the basis of TCM differentiation of symptoms and signs the incidence was reduced to be 20%. The changes of such biochemical indices as ACh, AChE, cholic acid and gastrin in different diagnostic types during pregnancy, as well as the effect of spleen-invigorating therapy on these indices in pregnancy with deficiency of the spleen were also observed.     

MOLECULAR EPIDEMIOLOGY OF AND CLINICAL STUDY ON ADENOVIRUS 3 AND 7 IN CHINA

<正> In this paper, we reported a study on viral DNA restrictionendonuclease cleavage maps of 244 strains of Ad3 and Ad7 during 13 years (1976-1989) in Changchun, Shenyang, Beijing, Shanghai and Nanjing, and their relationship to the clinic.The results showed that three genomes 3I,3II and 3 III of Ad3 and two genomes -7b and 7 d of Ad 7 were identified in China.It was apparent that 3 I and 7d were the dominant genomes of Ad 3 and Ad 7 in recent years in China.Diseases caused by different genomes showed different virulence,pathogenicity and geographical distribution. Different genomes might cause not only different diseases, but even the same disease caused by them were quite different in clinical manifestations. In this study, we are just making a start to disclose the epidemiological characteristics of Ad p, and Ad 7 , and their relationship to different clinical manifestations on the molecular level.     

EFFECT OF GOSSYPOL ACETIC ACID ON CHROMOSOME ABERRATIONS AND ANEUPLOIDIES IN OOCYTES AND ZYGOTES OF MICE

It was reported that gossypol acetic acid could effectively inhibit th~ implantation in ratA. This finding indicated that gossypol acet/c acid might also be used as a female contraceptive. The Present study further investigated the genetic effect of gossypol acetic     

A PRELIMINARY STUDY ON THE MECHANISM OF EAR-ACUPUNCTURE FOR WITHDRAWAL OF SMOKING

The changes of smoking taste and short termeffectiveness for stopping smoking by usingcar-acupuncture in 28 heavy smokers wereobserved.Matched comparative study was per-formed between 16 heavy smokers and 16non-smokers.Four primary sensations of taste,pain tolerance threshold,plasma cortisol and plasmaleucine-enkephalin(PLEK)were measured beforeand after smoking and measured again after smokingsubsequent to ear-acupuncture.Double blind andrandomized tests between two sets of ear-acupointsand ear non-acupoints were employed in this study.The results showed:(1)The threshold for tastes tosour and sweet of smokers have become more sensi-tive after ear-acupuncture.(2)The increased PLEKlike substance(PLELS)induced by smoking couldbe inhibited by ear-acupuncture.(3).The change ofprimary sensations of taste to smoking was correlatedto the change of PLELS.(4)No obvious differencesbetween ear-acupoints and ear non-acupoints foreither parameters mentioned above or short termtherapeutic effect were found.It is suggested thatthe change of primary sensations of taste after car-acupuncture seemed to be one of the reasons forwithdrawal of cigarette smoking;PLELS might playan important role in the development and sustenanceof smoking habit,ear-acupuncture could modulatePLELS accordingly,the cortical response to endogen-ous opium-like substance,and mimicked to the effec-tiveness of naloxone for reducing cigarette smoking.     

肝病患者347例血清总胆汁酸检测及其临床意义探讨

目的 :探讨肝病患者血清总胆汁酸检测及其临床意义。方法 :用酶比色法检测 347例肝病患者的血清总胆汁酸浓度。结果 :急性肝炎、慢性乙肝中度、慢性乙肝重度、肝硬化、肝癌的TBA、ALT明显高于正常对照组 (P<0 0 1) ,慢性乙肝轻度与正常对照组对比差异无统计学意义 (P >0 0 5 )。各肝病间比较 ,肝硬化与肝癌差异无统计学意义 (P >0 0 5 ) ,慢性乙肝重度与肝硬化间差异有统计学意义 (P <0 0 5 ) ,其余各肝病间差异均有统计学意义(P <0 0 1)。结论 :胆汁酸水平是反映肝实质性损伤的一项灵敏指标。     

血清总胆汁酸测定在肝病诊断中的临床意义

目的：探讨血清总胆汁酸（TBA）测定在各种肝病诊断中的临床应用价值。方法：采用循环酶法测定168例肝病患者的空腹血TBA水平。结果：血清TBA水平在急性肝炎、慢性活动性肝炎、重症肝炎、肝硬化、肝癌、脂肪肝、酒精性肝炎患者中明显升高,其阳性率分别为90．9％、89．2％、100％、100％、100％、41．7％、47．4％。升高的程度与肝病的严重程度相一致。结论：血清TBA的测定可以作为反映急慢性肝病、肝硬化严重程度和预后的指标。     

新生儿黄疸血清胆汁酸的变化研究

目的　 探讨新生儿母乳性及病理性黄疸时胆汁淤积情况。方法　 用酶法比色自动生化分析仪检测母乳性黄疸组 2 8例 ,病理性黄疸组 88例 (早产因素组 30例 ,围产因素组 30例 ,感染因素组 2 8例 ) ,对照组 30例血清总胆汁酸 (TBA)水平 ,并进行对照分析。结果　 对照组TBA为 (9.30±4 .79) μmol/L ;母乳性黄疸组为 (17.72± 10 .6 8) μmol/L ;病理性黄疸组中 ,早产因素组为 (2 7.71±13.2 3) μmol/L ;围产因素组为 (33.6 6± 17.6 0 ) μmol/L ;感染因素组为 (40 .6 4± 2 5 .5 6 ) μmol/L。对照组TBA水平与母乳性黄疸组及病理性黄疸组中的各因素组比较 ,差异均具有显著性 (P <0 .0 1,P <0 .0 1。而病理性黄疸组中的各因素组TBA比较无统计学意义 (P >0 .0 5 ) ,但以感染因素组最高 ,围产因素组次之 ,早产因素组最低。而母乳因素组TBA均比病理性黄疸组中的各因素组低 ,差异具有显著性 (P <0 .0 1。结论　 病理性黄疸及母乳性黄疸患儿均存在胆汁淤积 ,其程度以感染因素组最重 ,而母乳因素组最轻。测定血TBA诊断胆汁淤积 ,比测定胆红素更准确     

胃液、胃粘膜组织总胆汁酸测定对胆汁返流性胃炎的诊断价值

目的 :探讨空腹胃液、胃粘膜组织总胆汁酸 (TAB)的含量对胆汁返流性胃炎的诊断价值。方法 :对 47例胆汁返流性胃炎 (RG)组 ,15例消化性溃疡 (PU)组 ,2 0例慢性浅表性胃炎 (CSG)组及 12例正常对照组在胃镜检查的同时 ,抽取胃液 ,钳取胃粘膜组织作 TBA含量测定。胃粘膜组织同时作 HP及病理组织学检查。结果 :胆汁返流性胃炎组胃液及胃粘膜组织 TBA含量分别为 (315 .85 5 0± 35 .946 8)μm ol/ L ;(0 .2 10 7± 0 .0 810 )μmol/ g。明显高于 PU、 CSG及正常对照组 (P <0 .0 0 1)。胃粘膜组织 TBA含量与胃液 TBA含量呈明显正相关 ,rs=0 .82 8,P <0 .0 0 1。胃粘膜的炎症程度也随 TBA含量的增加而加重。χ2 =15 .6 37,P <0 .0 0 5。随着 TBA含量的增加 ,HP的检出率下降 ,χ2 =9.42 ,P <0 .0 1。结论 :胃液、胃粘膜组织 TBA含量对胆汁返流性胃炎有诊断价值。而胃粘膜组织 TBA含量更有价值。     

新生儿败血症血清总胆汁酸的变化及其临床意义

为探讨新生儿败血症时血清总胆汁酸（TBA）的改变，以及与常规肝功能检测指标的关系，采用病例对照研究方法，对77例确诊为新生儿败血症的患儿进行血清TBA、谷丙转氨酶（ALT）、总胆红素（TB）、γ-谷丙酰转肽酶（γ-GT）的测定，并对血清TBA增高的患儿作恢复期复查。结果：败血症非休克组和败血症休克组血清TBA增高，与对照组比较差异有极显著性意义（P均＜0．01）；败血症休克组血清TBA明显高于非休克组（P＜0．05）；败血症经有效治疗后血清TBA显著下降（P＜0．01）。但血清TBA与ALT、TB、γ－GT之间无相关性（P均＞0．05）。提示：新生儿败血症血清TBA水平明显增高，恢复期迅速下降。血清TBA升高的程度与病情密切相关。     

病毒性肝炎患者血清总胆汁酸测定及其意义

目的：探讨各型病毒性肝炎血清总胆汁酸（TBA）水平及其临床意义。方法：检测210例病毒性肝炎患者空腹血清TBA水平并与常规肝功能酶学指标ALT、AST、ALP、GGT作对比分析。结果：各型病毒性肝炎患者血清TBA与对照组比较均有显著性差异（P ＜ 0．01）;慢性肝炎轻、中、重度及肝炎后肝硬化患者血清TBA异常率与ALT、AST、ALP、GGT异常率比较有显著性差异（P ＜ 0．01）。结论：病毒性肝炎患者血清TBA水平对反映肝功能受损程度有较高灵敏性,对判断病情活动程度及预后有一定临床价值。     

HBV感染者血清总胆汁酸含量的测定及其临床意义

目的：通过检测乙型肝炎病毒（ＨＢＶ）感染血清总胆汁酸（ＴＢＡ）的含量,探讨该指标在乙型肝炎诊治中的意义。方法：采用全自动酶法分析技术对６００份ＨＢＶ感染及１１０份正常对照组血清进行空腹总汁酸测定,同时对其他肝功能相关项目进行测定。结果：“１３５”、“１４５”、“２４５”、“５”模式组血清ＴＢＡ含量与正常对照组相比,差异显（Ｐ〈０．０１,Ｐ〈０．０５）。“２５”、“４５”模式组血清ＴＢＡ含量与正常对照组相比,差异显（Ｐ〉０．０５）。结论：ＴＢＡ是一项比较灵敏的肝功能指标,它不仅可以帮助医生及早发现ＨＢＶ携带肝脏损伤的情况,而且有助于监测乙型肝炎患的治疗效果。     

妊娠期肝内胆汁淤积症孕妇肝功能变化与母儿预后关系的探讨

目的：探讨妊娠期肝内胆汁淤积症（ICP）孕妇肝功能变化与母儿预后的关系。方法：对我院2005～2010年确诊为ICP的140例孕妇临床资料进行回顾性分析。结果：血清谷丙转氨酶（ALT）〉40U／L、总胆红素（TBIL）〉28umol／L的孕妇,产后出血及早产、胎儿窘迫的发生率增高,且ALT水平越高,其发生率越高。结论：ICP孕妇肝功能的变化可预测母儿预后,ALT及TBIL水平升高者胎儿预后不佳,必须高度重视,严密监护,适时终止妊娠。     

氯乙烯作业工人血清甘胆酸含量的测定

检测了125例氯乙烯作业工人血清甘胆酸(CG)含量,结果为13.7±14.8mg/L。对照组164例。CO 含量为8.3±6.8mg/L。两组比较差异有显著意义。其异常率相比,差异有高度显著性(X~2=7.71,P<0.01)。在氯乙烯作业工人中有15例诊断为慢性氯乙烯中毒观察对象,其 CG 异常与常规肝功比较,差异有非常显著意义,表明 CG 可作为氯乙烯中毒肝脏损害的早期敏感指标。     

梗阻性黄疸胆汁体外引流术前后血清结合胆酸动态变化的观察

本文通过对25名肝外梗阻黄疸血清结合胆酸放免测定,观察引流后不同时间血清结合胆酸的变化,发现结合胆酸下降的幅度大于胆红素,其下降速度也提前于胆红素。从而提出应把血清结合胆酸列为观察减黄效果的主要指标。