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尿道结构异常与泌尿系感染临床治疗探讨 总被引:1,自引:0,他引:1
本文报道了16以复泌尿系感染患者,经外科检查大都伴有不同程度的尿道结构异常,指出对于反复泌尿系统感染患者应进行尿道结构的外科检查并给予必要的外科手术治疗才能彻底治愈。 相似文献
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目的探讨四维彩色多普勒超声诊断胎儿结构性异常畸形的价值。方法利用四维彩色多普勒超声诊断仪对1 313例孕妇进行检查,分析四维彩色多普勒超声在诊断胎儿结构性异常畸形的准确性和直观性。结果本组结构性异常38例,四维彩色多普勒超声漏诊1例,诊断符合率97.37%,漏诊率2.63%;胎儿结构性异常主要包括无脑儿、脊柱裂、唇腭裂、心脏畸形、泌尿系统、隔离肺、耳廓异常、肢体异常等。结论四维彩色多普勒超声对胎儿结构性异常畸形能够准确、直观地显示且图像清晰,具有较高的临床应用价值和发展前景。 相似文献
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目的分析矩阵四维超声产前诊断胎儿心内大血管发育异常的临床价值。方法收集我院2012年12月至2013年12月诊治的中晚期产妇600例作为研究对象,所有产妇均经矩阵四维超声产前诊断,采用回顾性的方式分析产妇的临床资料,观察诊断结果。结果研究结果显示,本组600例胎儿心脏均获得四维图像,诊断显示,有12例胎儿存在心内大血管发育异常,包括1例右室双出口,2例完全性大动脉转位,1例心内膜垫缺损,3例共同动脉干,1例肺动脉狭窄,3例主动脉狭窄,另外1例右肺动脉异常起源于升主动脉,而左肺动脉仍与主肺动脉延续(P<0.05)。结论矩阵四维超声能够非常迅速的对胎儿心脏容积成像,其诊断结果不会受到胎儿运动的影响,大大降低了胎儿心脏检查中对操作者技巧的依赖性,并且获得的图像非常清晰直观,为疾病的诊断提供了重要依据,该方式可作为产前诊断胎儿心内大血管发育异常的首选诊断技术,值得在临床上推广应用。 相似文献
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目的探讨鼻腔镜手术治疗鼻腔内解剖结构异常所导致头痛的临床效果。方法选取本院收治的42例因鼻腔结构异常而导致头痛患者,均采用鼻腔镜手术治疗,根据患者鼻内解剖结构变异情况采用不同的手术方式,观察其临床治疗效果。结果治愈29例,显效9例,治愈率为69.05%,有效率达90.48%。术后VAS评分明显低于术前,差异有统计学意义(P〈0.05)。结论鼻腔镜手术术野明亮,能够准确彻底地切除病灶,有效改善鼻腔和鼻窦的通气引流功能,避免误伤周围组织,并可降低手术并发症的发生率。 相似文献
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目的 探讨变应性鼻炎合并鼻腔结构异常的手术治疗方法及效果。方法 对48例变应性鼻炎合并鼻中隔偏曲、钩突肥大、泡状中鼻甲等鼻腔结构异常的患者行鼻内镜下微创手术矫正治疗,术后换药清理鼻腔。观察变应性鼻炎症状体征变化。结果 术后变应性鼻炎的症状体征逐渐得到改善,随访观察半年至2年,其中显效18例,有效23例,无效7例。总有效率85.4%。结论 鼻腔结构异常是变应性鼻炎发病及症状加重的原因之一,鼻内镜下微创手术矫正鼻腔异常结构,重建生理性呼吸通道,同时手术及鼻腔填等也降低了冲经兴奋性.经随访观察疗效是肯定的。 相似文献
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目的:应用三维超声对32例由于先天发育或后天疾病导致宫腔内结构发生异常的病例进行诊断,方法:所用仪器为VOLUSON530D MT三维彩超诊断系统,探头为三维容积探头(SVAM-3-5),频率范围1-8.5MHZ,重建模式选用表面成像模式,混合性模式;结果:观察表明三维表面成像模式和混合性模式可良好地显示宫腔内结构的异常变化。结论:临床实际应用中,三维超声可为临床提供较二维超声更丰富的诊断信息,在妇产科疾病的诊断中将起着举足轻重的作用。 相似文献
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卡铂的空间结构类似物丙二酸银(I)的合成及其抗活性 总被引:1,自引:0,他引:1
合成了三种与卡铂空间结构类似的丙二酸银(I)的化合物:〔Ag2(CH2(XO2)2)〕n(1)〔Ag2{(CH2)4C(CO2)2)}n(2)和〔Ag2{CH3CHCH2C(CO2)2}〕n(3),并评价了它们对几种人类肿瘤细胞株的体外细胞毒性。所合成的合化物对实验用的几种肿瘤细胞株有强烈的毒性作用,而对正常人肝细胞的毒性作用则较弱,与肿瘤细胞株对比差异显著(P<0.05)。虽然其作用机理还不清楚,但参照对铂类抗肿瘤药物的研究,本实验结果提示银的化合物也可能成为有希望的抗癌药物先导物。 相似文献
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《Clinical Research and Regulatory Affairs》2013,30(2):99-112
AbstractThe doctrine of informed consent is fundamental to all medical personnel involved in investigational research. Informed consent arose from the Helsinki declaration that stated, “concern for the interests of the subject must always prevail over the interests of science and society.” (6) As clinical research is a part of medical practice, it is reasonable to assume that exceptions to fully informed consent that are defendable in medical practice can be applied to clinical research as well. The exceptions to fully informed consent are waiver, incompetence, therapeutic priviledge, emergency, or proxy. 相似文献
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《实用医药杂志(山东)》2017,(11)
目的建立完善的胃舒康颗粒的质量标准。方法采用TLC对胃舒康颗粒处方中的药材成分黄芪、原儿茶醛、黄连、红花、川芎和当归进行定性鉴别,并用HPLC对胃舒康颗粒中的有效成分丹参素钠的含量进行测定。结果胃舒康颗粒中黄芪、原儿茶醛、黄连、红花、川芎和当归的供试品薄层色谱中,在与对照品色谱相应的位置上,显相同颜色的斑点;丹参素钠含量在10.17~162.77μg/ml范围内线性关系良好(r=0.9999),平均回收率102.2%(n=6),精密度RSD=0.15%。结论该方法简单,结果准确、重现性好,可作为该制剂的质量控制方法 。 相似文献
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鉴别实验作为药品质量标准的重要组成部分,是对药品真假判定的关键依据,因此鉴别实验的可操作性以及适用性对于检验工作,尤其是快速检验工作具有重要意义。而由于一些品种的特殊性,即使是一些质量合格的药品,如果按照药典标准严格操作的话,有的鉴别实验也难成正反应或者不符合规定,从而造成结果的误判,甚至引发不必要的纠纷。本文就2010年版枟中国药典枠二部中苯妥英钠片中的“紫外鉴别”与葡萄糖氯化钠注射液中的“钠盐鉴别”进行分析并给出一些修改建议。 相似文献
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Suzuki T Uchida H Tanaka KF Nomura K Takano H Tanabe A Watanabe K Yagi G Kashima H 《The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)》2004,7(2):133-142
Antipsychotic polypharmacy has been empirically used and a recent trend in favour of that mode of therapy has been suggested for the treatment of schizophrenia. The clinical efficacy, however, still remains to be clarified. In order to critically evaluate the usefulness of such kind of psychopharmacotherapy, antipsychotic combination regimen (polypharmacy) was switched to a treatment with the single main antipsychotic (monotherapy) in cross-tapered fashion, while approximately maintaining the total amount, for patients with chronic schizophrenia. Patients had been treated with an average of three antipsychotics and maintained with the same antipsychotic polypharmacy regimen for more than 6 months before the entry. They were followed up with an antipsychotic monopharmacy and evaluated at 24 wk after completion of switching. Forty-seven patients were recruited for this study. Of 44 patients for whom evaluation was possible, 24 (54.5%) remained stable, while 10 (22.7%) showed improvement and the same number of patients ended in a deleterious status. Twenty-two patients were converted to antipsychotic monotherapy, while another 12 needed minimal dosing of low-potency agents. Overall, social functioning, evaluated by the Global Assessment of Functioning and the Clinical Global Impression, remained unchanged. Eighteen of 34 successful patients showed adverse effects of the main antipsychotic medication, which necessitated a significant dose reduction. Nine out of 10 deteriorating patients had been treated with a combination of low- and high-potency antipsychotics. It is suggested that many instances of antipsychotic polypharmacy is avoidable. The result is compatible with the current treatment recommendations, which dictate the use of a single antipsychotic agent. 相似文献
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Wenqing Li Andrea Maes Michelle Quinlan Suraj Anand 《Journal of biopharmaceutical statistics》2013,23(1):82-97
Thorough QT/QTc (TQT) trials are conducted to assess a drug's risk potential for prolonging the QT interval. In a randomized crossover, multiple postdose electrocardiograph (ECG) readings are collected over time, within each period leading to a repeated-measures scenario. Additionally, baseline readings at single or multiple time points are collected prior to treatment. Two active, yet seemingly separate, areas of statistical research for TQT crossover studies concern the method of baseline correction and the specified covariance structure for repeated measures analysis. Due to interdependence of the covariance structure of baseline-corrected QTc values and the definition of baseline, these two research areas cannot be considered separately. We illustrate how the covariance structure for baseline-corrected QTc values differs under various definitions of baseline and provide recommendations on the choice of baseline: Time-matched baseline averaged over periods and time-matched baseline from the first period only are preferable in terms of efficiency; in case a period-specific correction is required to account for the treatment carryover effect, period-specific time-averaged baseline with multiple measurements taken predose in each period offers greater efficiency than a single predose baseline. This research on the interdependence of baseline correction method and covariance structure enables statisticians to use observed data from previous TQT studies to plan design and analysis for future studies. 相似文献
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原子吸收光谱法亦称原子吸收分光光度法,简称为原子吸收法。在药品检验领域,原子吸收法的应用近年明显加强。胶囊的铬超标事件后,原子吸收法更是引起全国药检人的高度重视。但是由于原子吸收法在药检行业普及的时间还不够长,而微量分析的技术要求又比较高,现实应用中有很多问题需要解决,所以有必要在2015年版《中国药典》中修订原子吸收法的相关内容。借《中国药典》2015年版编制之际,对原子吸收法相关内容提出一些建议,望与同行专家商榷。 相似文献
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The Method of Self-Consistent Regression for the Quantitative Analysis of Relationships Between Structure and Properties of Chemicals 总被引:1,自引:0,他引:1
Pharmaceutical Chemistry Journal - 相似文献