基于TPM硬件的移动Agent安全模型研究

主要讨论了安全强度较高的基于硬件的移动Agent安全方案.将可信计算技术与平台引入移动Agent的安全机制,基于可信硬件TPM所提供的相关安全服务实现移动Agent的主动保护机制.设计了在可信硬件平台上的移动Agent安全框架模型并进行了详细分析.     

基于Multi-Agent的电子商务中的恶意Agent研究

描述并讨论了以Agent为中介的电子商务中的恶意Agent问题.恶意Agent是一种带有不良意图,能够攻击标准代理,扰乱交易,欺骗用户,盗窃机密信息,浪费资源和破坏市场等的软件实体,在某些方面它们比PC病毒更有危害.为此提出了SCAAM,并且用一些策略来具体描述这种模型的工作过程.     

基于生物实体分布感知的E-service工作流突现研究

基于生物网络平台,提出了一种E-service工作流突现方法.生物实体(具有免疫行为的移动Agent)代理E-service,构成一个自治的单元,通过分布感知确认服务关系,生物实体协商和演化完成了E-service工作流组合.采用服务相对质量的矩阵,准确地描述服务和工作流关系和E-service相对质量,最优E-service工作流组合的建立转化为带约束的最优化问题,并给出不带参数的罚函数动态演化算法解决方案.仿真表明,这种方法提高了适应性和性能.     

多Agent信息系统知识发现研究

本文根据信息系统的定义,提出了采用集合方法描述的多Agent信息系统,研究了在多Agent交互中规则的形成过程.对规则表示和存储方法进行了研究.鉴于各Agent的规则可存储在数据库中,采用ID3算法对这些规则进行挖掘是可行的.对该方法用实例进行了验证.     

Agent-based P2P环境下开放式服务体系架构研究

将Agent的概念引入P2P服务体系架构中,会对整个架构的灵活性和自适应性产生重要的影响.在深入讨论和研究Agent-based P2P环境独特的技术特点的基础上,设计并提出了Agent-based P2P环境下开放式服务体系架构模型,即OSA-ABP.模型架构由5层分层模型和多Agent交互模型构成,与同类架构比较,在架构的开放性、异构Agent兼容性、资源统一描述发布等方面具有较高的技术优势.     

基于多Agent协同的快速入侵检测系统

在多Agent协同入侵检测系统中,不同检测Agent并行地检测网络包中不同的入侵特征,以提高系统的检测效率.使用消息、自定义通信协议等作为系统的协同通信机制,有效地避免了系统中的单点故障,并且,该机制使得各个Agent的检测结果可以有效融合.在分析了入侵的类型、特征后,使用4个检测Agent仿真了入侵检测的过程,并在检测精度、检测误差影响很小的情况下,使检测每条记录的时间大幅度减少.     

面向业务过程管理的Agent平台的设计及实现

业务过程管理能够支持企业业务流程优化运行,因而日益成为学术界和工业界研究和开发的重点.目前绝大多数的业务过程管理系统都是在传统的工作流管理系统基础上的扩展,因而具有适应性能力不强等缺点.介绍了一个面向业务过程管理的Agent平台,它包含了Agent的建模工具和运行环境.对该Agent的模型、相关工具和环境的实现方法进行了说明.该平台能够方便地支持面向业务过程管理的Agent的构造,并提供了求解业务问题的能力.     

Agent技术在Web服务中的应用探讨

Web服务是一组采用面向服务的体系架构的基于标准的Web协议的软件构件,而Agent是一种在某个环境中自主行动以实现其设计目标的智能化软件实体.Web服务与多Agent系统(MAS,Multi-Agent System)在架构、范例和技术方法等方面具有很大的相似性.Web服务的可信性是未来计算机软件发展关键的问题,实现Web服务在分布式环境下的协同式测试具有一定的挑战性.本文在探讨Web服务与Agent技术的共性的基础上,分析并总结了Agent技术在Web服务中的应用.针对Web服务测试的开放性、协同性、动态性和不确定性等特点,结合Agent系统的自主性、反应性、适应性和社会性,本文提出了一种基于MAS的Web服务测试框架(MAST,Multi-Agent-based Service Testing),并对其关键技术进行了探讨.     

基于DFL的Agent推理模型

推理是Agent研究的核心问题之一.根据Agent的推理特性,引用DFL理论提出基于动态模糊逻辑(DFL)的Agent推理模型,实现了范例验证系统,即基于动态模糊逻辑(DFL)的Agent推理模型的叮当漫画书城系统.     

高校教育资源浪费现象探析

现阶段我国高校存在着严重的人力、物力、财力和土地等教育资源浪费现象 ,成为制约高校教学质量和办学效益的重要因素。文章对教育资源浪费概念的表述及其内涵的理解作了阐述 ,分析了目前高校内部教育资源浪费的现状及原因 ,并对如何减少教育资源浪费提出对策与措施。     

药理学课程中的人文教育

人文教育是培养人文精神的教育,药理学是为临床合理用药、防治疾病提供基本理论的医（药）学专业基础学科。在药理学专业课程中通过回顾辉煌历史、介绍药物来源、坚持医德教育、介绍新药发现、实验课实践等途径渗透、实施人文教育,从而全面发展医（药）学学生的素质。     

Mobile apps for chemistry in the world of drug discovery

Mobile hardware and software technology continues to evolve very rapidly and presents drug discovery scientists with new platforms for accessing data and performing data analysis. Smartphones and tablet computers can now be used to perform many of the operations previously addressed by laptops or desktop computers. Although the smaller screen sizes and requirements for touch-screen manipulation can present user-interface design challenges, especially with chemistry-related applications, these limitations are driving innovative solutions. In this early review of the topic, we collectively present our diverse experiences as software developer, chemistry database expert and na?ve user, in terms of what mobile platforms could provide to the drug discovery chemist in the way of applications in the future as this disruptive technology takes off.     

Development of a semi-automated chemical stability system to analyze solution based formulations in support of discovery candidate selection

A semi-automated chemical stability system was developed, validated, and implemented to assess the chemical and physical stability (24 h) of intravenous and oral solution based formulations in support of preliminary in vivo drug discovery studies. The system utilizes a single Agilent 1100 LC and Xterra column with multiple UV wavelength monitoring. Mobile phase selection, either basic or acidic, is selected base upon on the physico-chemical properties of the test compound. The system was validated against 14 new chemical entities across multiple therapeutic areas. The results indicated that drug discovery compounds could be accurately quantified (<2% R.S.D.) in a wide range of formulation vehicles in greater than 90% of the test cases. This method can be used as a quantitative tool for triaging formulation variables and packaging configurations to quickly develop stable solutions for dosing.     

Balancing the risks and the benefits

Pharmaceutical research organizations can benefit from outsourcing discovery activities that are not core competencies of the organization. The core competencies for a discovery operation are the expertise and systems that give the organization an advantage over its competition. Successful outsourcing ventures result in cost reduction, increased operation efficiency and optimization of resource allocation. While there are pitfalls to outsourcing, including poor partner selection and inadequate implementation, outsourcing can be a powerful tool for enhancing drug discovery operations.     

Potential of phage-displayed peptide library technology to identify functional targeting peptides

Combinatorial peptide library technology is a valuable resource for drug discovery and development. Several peptide drugs developed through phage-displayed peptide library technology are presently in clinical trials and the authors envision that phage-displayed peptide library technology will assist in the discovery and development of many more. This review attempts to compile and summarize recent literature on targeting peptides developed through peptide library technology, with special emphasis on novel peptides with targeting capacity evaluated in vivo.     

Are Vietnamese food exports contaminated with dioxin from Agent Orange?

In this study the levels of dioxins and dioxinlike compounds, dibenzofurans, and polychlorinated biphenyls (PCBs) were measured in food exported from Vietnam to the United States. In the past, some Vietnamese fish was found to be contaminated with dioxin, 2,3,7,8-TCDD, or TCDD, from Agent Orange. U.S. commercial catfish farmers recently claimed that exported Vietnamese food, especially catfish, was contaminated with dioxin from Agent Orange and was thus a matter of concern to the U.S. Congress. In 2001, twenty-two exported Vietnamese food samples (mostly fish) were purchased in the United States and Laos to evaluate possible contamination with dioxin from Agent Orange. Dioxin, dibenzofuran, and coplanar PCB congeners were measured by high-resolution gas chromatography-high-resolution mass spectrometry by laboratories in Germany and Canada certified for dioxin analysis by the World Health Organization (WHO). In the current study, only low levels of dioxins and dioxinlike compounds were present in all exported Vietnamese food analyzed, despite recent findings of elevated levels of one dioxin, 2,3,7,8-TCDD, from Agent Orange exposure in some Vietnamese individuals, presumably due to food consumption. It appears unlikely that exported Vietnamese food is, in general, contaminated with large amounts of dioxin (TCDD) from Agent Orange or other sources. Further food sampling from areas of heavy Agent Orange spraying in Vietnam is warranted to map out where the source of TCDD contamination of food may be originating.     

Development of antibiotics and the future of marine microorganisms to stem the tide of antibiotic resistance

Antibiotics remain essential tools in the control of infectious diseases. With the emergence of new diseases, resistant forms of diseases such as tuberculosis and malaria, as well as the emergence of multidrug-resistant bacteria, it has become essential to develop novel antibiotics. Development of the existing antibiotics involved three strategies, including discovery of new target sites, modification of existing antibiotic structures, and the identification of new resources for novel antibiotics. Marine microorganisms have clearly become an essential new resource in the discovery of new antibiotic leads.     

Dioxin, dibenzofuran, and coplanar PCB levels in Laotian blood and milk from agent orange-sprayed and nonsprayed areas, 2001

Agent Orange, a phenoxyherbicide contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), was used by American military forces during the United States-Vietnam war between 1962 and 1971 primarily as a defoliant to destroy forests where enemy troops might find cover. Agent Orange was used mainly in Vietnam, but also to a lesser extent in Laos and Cambodia. In Laos, there have been no prior studies of TCDD contamination from Agent Orange, despite known defoliation and documented records of Agent Orange spraying. This article presents findings of TCDD in human blood and milk from two geographic areas in Laos: Vientiane, a nonsprayed area, and Sepone, an Agent Orange-sprayed area. German and Canadian laboratories used high-resolution gas chromatography-mass spectrometry to measure 7 dioxin, 10 dibenzofuran, and 4 non-ortho or coplanar polychlorinated biphenyls in Laotian blood and milk samples. Most subjects tested in this Laos Ministry of Health Study showed low dioxin and dibenzofuran levels, consistent with what would be expected in a primarily rural nonindustrial country. These findings are consistent with relatively low dioxin and dibenzofuran levels recently found in food from these same areas. The chemically and toxicologically related non-ortho PCBs were measured but were found at low levels compared to specimens from other countries, presumably because of less industrialization and industrial pollution in Laos.     

高校后勤社会化改革中的人力资源管理研究

人力资源是现代企业的战略性资源,也是企业发展的关键因素。人力资源管理已成为现代企业的管理核心。通过对高校后勤社会化进程中人力资源管理现状及其存在的问题进行分析研究,提出加强高校后勤人力资源管理的对策和建议。