硫酸羟氯喹治疗扁平苔藓41例疗效观察

采用羟氯喹200mg，每日2次，连用8周而后200mg每日1次，维持4周，治疗41例扁平苔藓（LP），12周后疗效为：痊愈率26．8％，总有效率70．2％，对泛发性，慢性局限性或者LP并发粘膜损害者疗效好，副作用轻。     

羟氯喹联合糖皮质激素治疗皮肌炎临床观察

临床上对于无肿瘤的皮肌炎患者首选糖皮质激素治疗，治疗无效或不能耐受的患者可加用免疫抑制剂治疗。为了减少单纯应用糖皮质激素引起的不良反应，我们采用羟氯喹联合糖皮质激素治疗皮肌炎取得了一定的临床效果，现报告如下：     

羟氯喹并平消胶囊治愈急性泛发性扁平苔藓一例

患者男，45岁，手足发疹，增厚伴瘙痒4月余，于2003年4月16日就诊，患者4个月前，偶然发现掌，跖发生小片皮疹，偶感痒而搔抓，不久皮损增多，扩大。并互相融合为角化斑块，1个月后觉口唇发厚，麻木；颊黏膜上下齿咬合处感粗糙，先后在多家医院诊治，并作病理切片，诊断为扁平苔藓，用过维A酸，氯喹及外用糖皮质激素软膏和维A酸软膏治疗无效，     

硫酸羟氯喹治疗口腔扁平苔藓临床疗效观察

为观察硫酸羟氯喹治疗口腔扁平苔藓（OLP），对52例OLP患者用硫酸羟氯喹治疗，观察临床疗效。结果：痊愈40．4％，显效51．9％，无效率7．7％，有效率为92．3％。     

硫酸羟氯喹等治疗面部糖皮质激素依赖性皮炎41例

我们于2004年1-10月采用硫酸羟氯喹口服等治疗面部糖皮质激素依赖性皮炎41例,取得满意疗效,现总结如下。     

泛发性扁平苔藓1例

报告1例泛发性扁平苔藓患者。患者男,73岁。躯干四肢皮损伴瘙痒2个月。皮疹为红色斑丘疹,泛发于全身,以手背、双上肢伸侧、颈背部、足背为主,日光照射后皮损加重。左手背皮损组织病理检查示典型扁平苔藓病理表现。诊断:泛发性扁平苔藓。     

泛发性扁平苔藓1例

扁平苔藓是一种原因不明的慢性或亚急性炎症性皮肤病,治疗效果不满意,现将笔者诊治的1例泛发性扁平苔藓报告如下。     

多形性日光疹伴急性泛发型扁平苔藓1例

患者，男，52岁。颜而、双手斑丘疹6年，全身泛发丘疹3月。患者于1995年3月面部日晒后起红斑，瘙痒，在附近医院以“脂溢性皮炎”进行治疗，症状反复。半年后，双颞部口晒后出现红色丘疹，绿夏至黄豆大小，剧痒，持续在市皮防所治疗无效，于1997年4月存广东省皮防所诊断为“多形性口光疹”，给予氯喹，小剂量泼尼松11服，症状明显好转。8月停药后复发，此后     

羟氯喹联合外用糖皮质激素治疗儿童泛发型环状肉芽肿一例并文献复习

报道1例羟氯喹联合外用糖皮质激素治疗儿童泛发型环状肉芽肿并对相关文献进行复习。患儿,男,8岁。躯干、四肢泛发性环状斑片2个月。组织病理检查：真皮内见上皮样肉芽肿,中央胶原纤维变性、坏死,肉芽肿周围组织细胞、淋巴细胞浸润,胶原纤维增生,胶原间散在单一核细胞浸润。诊断：泛发型环状肉芽肿。给予硫酸羟氯喹片0.1 g/d口服,皮损外用复方丙酸氯倍他索软膏,1个月后复诊明显好转。继续治疗并随访。     

急性泛发性扁平苔藓1例

1病历摘要患者男,42岁。因全身丘疹伴瘙痒1个月,于1999年6月8日至我科就诊。患者1个月前双上肢出现红色丘疹,伴剧烈瘙痒,尤以夜间为甚。1周内皮损波及整个躯干及四肢。2周前自觉口腔双颊部黏膜感觉异常,口唇轻度瘙痒、干燥、脱屑。患者既往体健,无肝炎及自身免疫性疾病史。体格检查:各系统检查未见异常。皮肤科检查:全身可见紫红至褐色扁平丘疹,以腰部及四肢屈侧为著(图1A、B)。多数皮损表面有较厚的鳞屑,鳞屑不易去除,其上可见Wickham纹。部分皮损平行排列,部分皮损呈线状或条索状。颊黏膜可见网状白色条纹,未见糜烂。口唇干燥,略肿胀,呈…     

类天疱疮样扁平苔藓1例

目的：报告和分析一例少见的类天疱疮样扁平苔藓病例。方法：取患背部皮损活检组织部分行组织病理和免疫病理检查。结果：活检组织切片,HE染色示：表皮角化过度伴角化不全,颗粒层不规则增厚,基底细胞液化严重已融合成表皮下大疱,无大疱区域表皮和真皮分界不清。有较多淋巴细胞在此区域以及血管周浸润,可见“色素失禁”现象。直接免疫荧光显示基底膜有IgG、C3、IgM呈线状沉积。符合类天疱疮样扁平苔藓。经治疗后痊愈,随访一年未见复发。结论：类天疱疮样扁平苔藓临床表现和病理结果不同于大疱性扁平苔藓和大疱性类天疱疮,是一个独立的疾病。可采用灰黄霉素、四环素和烟酰胺治疗。     

色素性扁平苔藓1例

患者男,27岁。全身皮肤起褐色皮疹3月余。查体见四肢、躯干散在米粒至绿豆大小圆形或椭圆形紫褐色斑,界清,中央略凹陷,表面有蜡样光泽,可见wickham纹。皮损组织病理:表皮角化过度,基底层及真皮浅层色素增多,基底细胞灶性液化变性,真皮浅层水肿,真皮浅层及血管周围淋巴细胞呈带状浸润。诊断:色素性扁平苔藓。     

类天疱疮样扁平苔藓1例

本文报道1例类天疱疮样扁平苔藓（LPP）。通过免疫荧光和免疫印迹技术比较了LPP与类天疱疮（BP）抗原在一些免疫特性方面的区别。LPP抗原存在于BMZ的部位相似于BP,在PBS溶液处理的标本中发现LPP抗原稳定性强于BP抗原,而且免疫印迹检测发现此例病人血清能与200kD蛋白结合,这与BP经典抗原是不同的。结合上述分析,认为LPP抗原与BP抗原不同。     

A Case of Lichen Planus Pigmentosus-inversus in a Korean Patient

Lichen planus pigmentosus-inversus is a rare variant of lichen planus pigmentosus. The eruption of lichen planus pigmentosus-inversus occurs mainly in the flexural regions and presents with brownish macules and patches. Here we describe the case of a 31-year-old Korean woman who presented with hyperpigmented lesions over her antecubital and popliteal area and groin. Physical examination revealed multiple brownish macules and patches on the intertriginous area without pruritis, and histologic findings showed a regressive pattern of lichen planus. These clinical and histological findings were consistent with a diagnosis of lichen planus pigmentosus-inversus.     

A Case of Linear Lichen Planus Pigmentosus

Lichen planus pigmentosus (LPP) is chronic pigmentary disorder that shows diffuse or reticulated hyperpigmented, dark brown macules on the sun-exposed areas such as the face, neck and other flexural folds. Clinically, it is different from classical lichen planus because LPP has a longer clinical course and it manifests with dark brown macules. In case of LPP, involvement of the scalp, nail or mucosal area is rare. The histopathological findings of the lesions show an atrophic epidermis, the presence of melanophages and a vacuolar alteration of the basal cell layer with a sparse lymphohistiocytic lichenoid infiltration. Although there have been a few reports of LPP, there have only 3 cases of linear LPP along the lines of Blaschko in the Korean dermatologic literature. Our patient had lesions on the neck and chin with a linear pattern. In this report, we describe a very rare case of LPP with a linear distribution related to Blaschko''s lines on the neck and chin areas.     

Childhood Lichen Planus with Palmoplantar Involvement

Lichen planus (LP) commonly involves the flexor aspects of the wrists, legs, and oral and genital mucous membranes. But it rarely occurs on the palms and/or soles. It mainly affects people in the age range 30~60 years. Childhood LP is reported to constitute only 1~4% of total cases of LP. In the literature, a few cases of LP on the palms and soles of pediatric patients have been reported. Here we report an interesting case of childhood LP with palmoplantar involvement. The patient was a 7-year-old boy who for 6 months had variously sized and shaped, pruritic, violaceous, polygonal papules and plaques on the whole body. The skin biopsy specimens taken from four sites of the patient (dorsum of the hand and foot, sole and chest) showed typical features of LP on histopathology. A diagnosis of generalized LP with palmoplantar involvement was made.     

有表皮下水疱形成的急性泛发性扁平苔藓1例

患者男,49岁。全身起紫红色丘疹和丘疱疹3月余,伴瘙痒。皮肤科情况:躯干及四肢可见泛发性紫红色扁平丘疹及丘疱疹,粟粒至黄豆大小,以腰背部及双下肢受累为著,部分融合成斑块,上附少量白色鳞屑,不易刮除,可见Wickham纹。腰部皮损组织病理示:表皮角化过度,颗粒层局灶性增厚,棘层肥厚,基底细胞严重液化变性,表皮下水疱,真皮浅层单一核细胞带状浸润。诊断:急性泛发性扁平苔藓。     

Two Cases of Lichen Planus Pigmentosus-inversus Arising from Long-standing Lichen Planus-inversus

Lichen planus pigmentosus-inversus (LPP-inversus) is an extremely rare variant of lichen planus (LP), and only a few cases have been reported. Its course is characterized by exacerbations and remissions, and it is known to be more chronic than classical LP is. We report two cases of LPP-inversus and offer the suggestion that LPP-inversus may originate from LP of flexural areas.     

色素性扁平苔藓并发皮革样胃癌伴转移1例

患者男,68岁,维吾尔族。全身起黑褐色皮疹伴瘙痒1年。查体见躯干及四肢近端散在分布米粒至手掌大黑褐色扁平丘疹和斑块,界清,表面有蜡样光泽,可见wickham纹。消化道钡透示:瀑布型胃,胃腔缩小,黏膜粗乱—皮革胃样改变。皮损组织病理示:表皮轻度角化过度,色素增多,灶状基底细胞液化变性,真皮浅层较多淋巴组织细胞浸润,可见较多嗜色素细胞。IHC:HMB-45阴性,CK5/6表皮阳性,LCA阴性,S-100阴性,Ki-67阴性。诊断:色素性扁平苔藓;皮革样胃癌(胃小弯处淋巴结转移)。     

扁平苔藓外周血T细胞及亚群的研究

对３２例皮肤扁平苔藓患者以抗人Ｔ细胞单克隆抗体碱性磷酸酶－抗碱性磷酸酶法检测外周血Ｔ淋巴细胞及其亚群，并与２６名健康志愿者进行对照。结果表明，扁平苔藓患者存在着ＣＤ及ＣＤ细胞升高，降低，与健康对照组比较，有统计学意义。其中泛发型患者此种改变更为明显，支持扁平苔藓的发病与异常细胞介导的免疫反应有关。