灯盏细辛注射液治疗老年冠心病心肌缺血疗效评价

目的评价灯盏细辛注射液治疗老年冠心病心肌缺血的疗效及安全性.方法将患者 81例随机分为两组,均予硝酸异山梨酯与阿斯匹林,治疗组加用灯盏细辛注射液静滴;观察两组治疗前后血脂、血液流变学指标与动态心电图结果.结果治疗组疗效及相关观察指标的改善优于对照组,治疗中未见明显不良反应.结论灯盏细辛注射液有降脂与改善血液流变性作用,是治疗冠心病心肌缺血有效而安全的药物.     

灯盏细辛注射液治疗冠心病心绞痛临床观察

目的:观察灯盏细辛注射液治疗冠心病心绞痛的临床疗效。方法:将100例冠心病心绞痛患者随机分为治疗组和对照组,治疗组予灯盏细辛注射液,对照组用丹参注射液。结果:治疗组临床疗效及心电图、血液流变学改变明显优于对照组。结论:灯盏细辛注射液能显著改善冠心病心绞痛临床症状及心肌供血,改善微循环。     

灯盏细辛注射液联合金黄散加铁箍散治疗血栓性浅静脉炎临床观察

目的观察灯盏细辛注射液治疗血栓性浅静脉炎的临床疗效。方法将34例患者随机分为两组,治疗组予灯盏细辛注射液静滴,对照组予丹参注射液静滴,两组均于患处外敷金黄散及铁箍散,14d为1疗程;比较两组临床疗效及治疗后血液流变学指标改善情况。结果治疗组临床疗效明显优于对照组;两组治疗后血液流变学指标均有改善,而治疗组明显优于对照组。结论灯盏细辛注射液联合金黄散加铁箍散外用治疗血栓性浅静脉炎疗效满意。     

灯盏细辛注射液治疗糖尿病周围神经病变52例临床观察

目的观察灯盏细辛注射液治疗糖尿病周围神经病变(DPN)的疗效。方法应用灯盏细辛注射液治疗DPN52例,并与使用西药弥可保的对照组53例作对照;观察两组临床症状、体征、神经传导速度及血液流变学指标变化。结果两组神经传导速度均有显著改善;治疗组在改善临床症状、体征方面疗效优于对照组,血液流变学指标的改善亦优于对照组。结论灯盏细辛注射液治疗DPN可改善周围神经血供,修复受损神经,恢复其正常功能,对DPN具有较好的治疗作用。     

灯盏细辛注射液对脑梗死患者认知功能的影响

为了观察灯盏细辛注射液对脑梗死患者认知功能的影响,选择44例有认知损害但未达痴呆诊断的脑梗死患者,随机分为灯盏细辛注射液组和复方丹参注射液组静脉滴入,每组各22例,观察对血液流变学指标和认知功能的影响。结果,治疗后灯盏细辛注射液组不仅明显改善血液流变学指标,而且认知功能较治疗前也有明显改善(P<0.01),但复方丹参注射液组较治疗前无明显改善,仅对血小板聚集率有影响(P<0.05)。说明灯盏细辛注射液可改善脑梗死患者的脑部血液循环,可能有助于提高患者的认知功能。     

灯盏细辛注射液治疗急性脑梗死疗效观察

目的观察灯盏细辛注射液对急性脑梗死的疗效。方法将100例患者随机分为两组,治疗组50例予灯盏细辛注射液静滴,对照组50例用复方丹参注射液静滴。结果治疗组总有效率为86.00%,明显高于对照组之72.00%,并具有降低血液黏度、改善血液流变学等作用。结论灯盏细辛注射液治疗急性脑梗死疗效显著,安全可靠。     

灯盏细辛注射液治疗椎-基底动脉缺血性眩晕临床观察

目的观察灯盏细辛注射液对椎-基底动脉缺血性眩晕的临床疗效。方法将80例患者随机分为治疗组50例和对照组30例,治疗组予灯盏细辛注射液、对照组予维脑路通注射液治疗,疗程均为10d;观察两组治疗前后中医证候积分、椎-基底动脉血液平均流速及血液流变学指标的变化。结果治疗组临床证候疗效优于对照组(P<0.05),在改善椎-基底动脉血液平均流速及血液流变学指标等方面治疗组亦优于对照组(P<0.05)。结论灯盏细辛注射液治疗椎-基底动脉缺血性眩晕有明显疗效。     

灯盏细辛注射液治疗急性脑梗死的研究

目的探讨灯盏细辛注射液治疗急性脑梗死的临床疗效。方法将60例急性脑梗死患者随机分为对照组和治疗组,治疗组在对症支持的基础上加用灯盏细辛注射液治疗,14d后判定临床疗效,并检测血液流变学的改变。结果治疗组治疗后临床疗效与对照组比较有显著性差异(P<0.05);2组血液流变学的比较有非常显著性差异(P<0.01)。结论灯盏细辛注射液治疗急性脑梗死可降低全血黏度和全血还原黏度,改善微循环,提高临床疗效。     

灯盏细辛注射液加高氧液治疗椎-基底动脉供血不足临床观察

目的观察灯盏细辛注射液加高氧液治疗椎-基底动脉供血不足的临床疗效.方法将患者 115例随机分为两组,治疗组 58例予灯盏细辛注射液加高氧液,对照组 57例予氟桂利嗪;观察两组治疗效果及其它相关指标的变化.结果治疗组临床疗效及血液流变学指标、椎-基底动脉血流的改善均优于对照组.结论 灯盏细辛注射液加高氧液治疗椎-基底动脉供血不足疗效满意.     

黄芪-灯盏细辛注射液联用改善大鼠气虚血瘀证的作用研究

目的:通过联用益气活血药黄芪注射液与灯盏细辛注射液,探讨两种药物联用对气虚血瘀证的改善效果。方法:将60只雄性SD大鼠留8只作为正常组,其余大鼠在寒冷、潮湿、劳累、饥饿等多因素条件下导致大鼠气虚,腹腔注射0.6ml/kg肾上腺素注射液导致血瘀,按照临床使用总量不变原则换算剂量,将气虚血瘀证大鼠随机分为黄芪注射液∶灯盏细辛注射液为0∶10(即黄芪注射液0ml/kg;灯盏细辛注射液2ml/kg)组、2∶8(即黄芪注射液0.4ml/kg;灯盏细辛注射液1.6ml/kg)组、4∶6(即黄芪注射液0.8ml/kg;灯盏细辛注射液1.2ml/kg)组、6∶4(即黄芪注射液1.2ml/kg;灯盏细辛注射液0.8ml/kg)组、8∶2(即黄芪注射液1.6ml/kg;灯盏细辛注射液0.4ml/kg)组、10∶0(即黄芪注射液2ml/kg;灯盏细辛注射液0ml/kg)组与模型组,由于灯盏细辛本身作为缺血性脑卒中的治疗药,因此,将其设置成阳性对照。每组8只,腹腔注射药物至体内,每天1次。给药3天后,观察大鼠体征、记录大鼠体重变化、摄食量及游泳时间;测定凝血时间并取各组血清按照测试盒方法测总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇等含量,并取各组全血测量其血液粘度。结果:各给药组均可明显降低气虚血瘀大鼠的全血粘度;能明显降低大鼠凝血时间,也都有一定程度的降低其血清总胆固醇含量,其中黄芪注射液∶灯盏细辛注射液=8∶2(即黄芪注射液1.6ml/kg;灯盏细辛注射液0.4ml/kg)时降低效果最明显;各组均有较好的降低其血清低密度脂蛋白胆固醇的含量作用,其中黄芪注射液∶灯盏细辛注射液=4∶6(即黄芪注射液0.8ml/kg;灯盏细辛注射液1.2ml/kg)最为明显;各组均能升高血清高密度脂蛋白胆固醇的含量。结论:黄芪注射液与灯盏细辛注射液联用对大鼠气虚血瘀症状有所改善,其改善效果较好,初步得出联用比例在黄芪注射液∶灯盏细辛注射液=4∶6到8∶2的范围内效果较好。     

基于HIS灯盏细辛注射液真实世界临床用药特点分析

目的:了解灯盏细辛注射液的临床应用情况,为规范临床合理用药及前瞻性研究提供思路与指导。方法:选取全国20家三甲综合医院使用灯盏细辛注射液的住院患者信息,运用基本数据描述方法及关联规则进行分析。结果:在21 498例患者中,用药患者多为45岁以上老年人;主要用于脑梗死(中医诊断为中风)、冠心病、高血压病、糖尿病的治疗;用法以静脉注射为主,单次用药剂量多集中在30～40 mL;用药疗程多为14 d左右。结论:灯盏细辛注射液临床使用基本符合药品说明书;患者多为老年患者,且多合并有糖尿病和高血压病。     

灯盏细辛注射液不良反应个案文献计量学分析

目的:探讨灯盏细辛注射液所致不良反应的一般规律及特点,指导临床合理用药。方法:通过检索1979—2012年国内公开发表的医学期刊报道应用灯盏细辛注射液致不良反应案例,并进行文献计量学分析。结果:共检索到灯盏细辛注射液不良反应个案报道15篇涉及25例,其不良反应与性别、年龄、溶媒、剂量、联合用药有相关性,临床主要表现为过敏反应,严重者可出现过敏性休克及多器官功能损害。结论:临床医师及药师应了解灯盏细辛注射液所致不良反应的规律和特点,规范合理用药,加强应用监测,减少不良反应的发生。     

灯盏细辛注射液联用西药治疗不稳定心绞痛的Meta分析

目的:评价灯盏细辛联合西药常规治疗不稳定型心绞痛临床疗效和安全性。方法:计算机检索Cochrane图书馆,Medline,EMbase,CBM,CNKI,VIP和万方数据库,由2位研究者独立筛选和提取资料,根据Cochrane Reviewer’s Handbook5.0评价标准和工具评价纳入文献质量,用RevMan 5.1软件进行数据分析。结果:共纳入17个随机对照试验,共计1 644名患者。仅2个研究采用恰当的随机分配方法,1个研究提及采用单盲,其余所有研究均未提及随机方法、分配隐藏、盲法及失访。Meta分析结果显示:灯盏细辛注射液加用常规治疗组治疗不稳定心绞痛有效率(OR=3.54,95%CI[2.60,4.82])和心电图疗效(OR=2.36,95%CI[1.88,2.96])优于单用常规治疗组。本组纳入17篇研究报道的不良反应表现轻微,使用安全。研究可能存在发表偏倚。结论:目前证据证实灯盏细辛注射液联合常规疗法治疗不稳定性心绞痛比西医常规治疗更具有优势。但基于研究的局限,建议进行更多大样本、多中心,随访时间更长的随机对照研究加以证实。     

Pharmacological studies on coleonol,a hypotensive diterpene from Coleus forskohlii

Coleus spp. have been used in Aurvedic medicine for heart diseases, spasmodic pain, painful micturition and convulsions. The pharmacological properties of coleonol, a diterpene, isolated from Coleus forskohlii were investigated. Its predominant effect is to lower the blood pressure of anaesthetised cat and rat as well as of the spontaneously hypertensive rat due to relaxation of the vascular smooth muscle. In small doses it has a positive inotropic effect on isolated rabbit heart as well as on cat heart in vivo. Coleonol also exhibits nonspecific spasmolytic activity on smooth muscle of the gastrointestinal tract in various species but not on bronchial musculature of guinea pig. Large doses of coleonol have a depressant action on the central nervous system. These results provide the rationale for the use of this plant in Aurvedic medicine.     

Postmarketing evaluation on the safety and effectiveness of Dengzhanxixin injection made from Dengzhanxixin(Herba Erigerontis Breviscapi)

OBJECTIVE: To assess the safety and effectiveness of Dengzhanxixin injection(DZI) extracted from Dengzhanxixin(Herba Erigerontis Breviscapi) and identify its potential risks.METHODS: A series of studies were conducted on the production process, quality standards, and pharmacology. Postmarketing clinical studies and literature reviews including adverse reactions(ADR),adverse events(ADE), case analysis and systematic reviews were also conducted. Data from the hospital information system and spontaneous reporting system were analyzed.RESULTS: The acute toxicity test indicated that the Lethal Dose 50 test( LD 50) dosage was 250 times more than the clinical maximum daily dosage(6mg/kg). In long-term toxicity tests, rats experi-enced renal tubular damage at 480 mg/kg. However, the dose of 120 mg/kg is safe and non-toxic,which is 40 times above the clinical daily maximum. Beagles had increased serum creatinine at160 mg/kg. In a prospective study, 15 962 cases experienced 16 ADR/ADE. The rate of ADR/ADE was0.1002%. ADR symptoms included rash(16.00%),chills(16.00%), and fever(16.00%).CONCLUSION: There is significant evidence that DZI is safe and effective in a clinical setting.     

郁证发微(三十七)——郁证痛经论

探讨郁证性痛经的因机证治。七情内伤可致气血失运、经络瘀滞而引发痛经。肝郁肝火为郁证痛经之因;诸痛属心,五志感心,心主血脉功能异常可致气血失调而引发痛经。痛经临床表现常伴有情绪障碍和(或)一系列躯体症状。治疗郁证性痛经的原则为急则治标止痛,缓则治本解郁。与不通则痛、通则不痛,不荣则痛、荣则不痛一样,郁滞则痛、郁解痛消。治疗郁证性痛经防重于治。     

穴位注射对下肢动脉硬化闭塞症镇痛作用的临床观察

目的：观察穴位注射当归注射液治疗以疼痛为主要表现的下肢动脉闭塞症的疗效.方法：50例患者随机分为治疗组和对照组,治疗组在常规治疗基础上给予穴位注射当归注射液,对照组给予改善循环、扩血管药物治疗,于治疗前及治疗后第1、2周末对周静息痛发作频次、持续时间、疼痛程度和踝肱指数进行测评.结果：治疗组在减少周静息痛发作频次、缩短每次发作持续时间、减轻疼痛程度、改善踝肱指数方面,均明显优于对照组.结论：穴位注射对以静息痛为主诉的下肢动脉硬化闭塞症有较好效果,且不良反应少.     

胃脘痛源流考

胃脘痛历代病名有:胃脘痛、脘痛、胃心痛、心痛、心中痛、心腹痛、心下痛、心脾痛、胃痛、脾心痛等;唐宋以前,"胃脘痛"多与心痛相混,金元以后才逐渐将胃脘痛与心痛区分开来,并逐渐发展完善;历代医家认为其病因病机多为禀赋不足,中焦无权,饮食劳倦,损伤脾胃,情志不遂,气机失和,血络瘀滞,不通而痛,外感六淫,阻遏胃气,虫聚于内,痛引胃腑;对胃脘痛的治疗,有中药治疗:滋补脾胃法、养阴柔肝法、理气和胃法、攘外安内法、温中散寒法、温化水饮法、消食导滞法、祛痰清热法、化瘀攻下法、安蛔止痛法等,还有针灸疗法、养生食疗法。以上历代医家的认识,不仅确定中医药防治胃脘痛的理论基础,至今仍影响我们对该病的治疗理念,对临床实践起着重要启迪与昭示作用。     

Analgesic Effect of Intrathecal Melissa officinalis in the Rat Model of Hot-Water and Formalin-Induced Pain

Melissa officinalis (MO) is one of the oldest herbal medicines commonly used in traditional medicine, which some studies have investigated for its analgesic effect. This study is an attempt to investigate the effects of intrathecal administration of Melissa officinalis on the pain induced by heat and formalin.In this experimental study, 70 male Wistar rats with an average weight of 270-320 g were randomly divided into five groups: control; sham that received 25 μl of saline through the spinal catheter; and three experimental groups that received 5, 10 or 20 mg/kg M. officinalis via the spinal catheter respectively. Five days after catheterization of the spinal cord from the lumbar region under anesthesia, the effects of Intrathecal administration of M. officinalis on heat- and formalin-induced pain were evaluated. Data were analyzed by using one-way ANOVA. Intrathecal injection of M. officinalis blocked heat-induced pain compared to sham group (p = 0.001). Maximum analgesia was observed 30 min after the injection. Furthermore, intrathecal administration of MO alleviated both acute (p = 0.007) and chronic (p = 0.001) phases of formalin-induced pain. Motor block was not observed in any of the above mentioned groups. The results showed that intrathecal administration of MO could significantly improve hot-water and formalin-induced pain in male Wistar rats.     

祛痰化瘀兼益气健脾法治疗胸痹心痛研究简况

"夫脉当取太过不及,阳微阴弦,即胸痹而痛;所以然者,责其极虚也,今阳虚知在上焦,所以胸痹心痛者,以其阴弦也"。痰浊血瘀,心脉痹阻不通为基本病机,新病多以邪实为主,久病多由实转虚,或虚实夹杂。实证有痰阻心脉、气滞心胸、心血瘀阻证、寒凝心脉证;虚证包括心气亏虚、心阴不足、心肾阳虚证,以痰浊血瘀为主,并伴有阳虚。方剂治疗有归脾汤、袁氏镇心痛、邓氏冠心胶囊、调脾护心法等。