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1.
The terms “body weight” and “body composition” are by no means synonymous, and attention is increasingly being focused on body composition. A measurement of relative fatness is a better criterion of caloric overnutrition than is body weight.

The simple technique of skinfold measurement using established standard methods is the most practical for use in the field to obtain an estimate of fatness or caloric overnutrition. The current need is for the establishment of “norms” for skinfolds for population groups of all ages and both sexes. When these are established, excellent simple criteria for overnutrition will be available.

Prior to the establishment of norms, more work is needed to indicate which skinfolds for each age group and for each sex best reflect total body fatness. Body fatness may then be studied in relation to body weight and both may be related to morbidity, mortality and longevity. Finally, the answer may be obtained to the question whether it is overweight per se or overfatness that is related to excess morbidity and mortality.

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2.
Human serum albumin labelled with iodine-133 or technetium-99m was injected by the lumbar or cisternal route into patients suspected of having communicating hydrocephalus, and scintigrams were performed up to 24 hours after injection.

The CSF isotope studies were shown to be a valuable adjunct to clinical examination and pneumoencephalography in the diagnosis of hydrocephalus. This was especially true in suspected cases of “normal”-pressure hydrocephalus where there may be considerable uncertainty as to which patients with normal pressure and enlarged ventricles will benefit from a shunting procedure. The CSF isotope study provides useful information to the clinician in differentiating patients with symptomatic hydrocephalus from the larger group with dementia, cerebral atrophy and hydrocephalus ex vacuo.

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3.
The Probability of Death Following a Fracture of the Hip   总被引:3,自引:0,他引:3       下载免费PDF全文
All patients 45 years of age and over admitted with fractures of the hip to hospitals in the Atlantic Health Region of Nova Scotia were followed up over a two-year period. Actuarial methods were used to estimate survivorship from the date of fracture in 202 patients.

Over-all, it was estimated that only 63.8% would be alive by one year post-fracture. This is 70% of the survival rate expected in the general population of corresponding age and sex. The period of greatest mortality was within the first 12 weeks. Patients surviving to one year could be considered “cured”, for after that their survivorship was at least as favourable as that of the “normal” population.

Mortality was greatest in males in those 75 years of age and over and especially in patients who were relatively immobilized prior to their fracture. In this “dependent” group the relative survival ratio at one year was only 38%.

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4.
The normal variations in the paper electrophoretic lipoprotein patterns in 240 healthy Canadian males and females, aged 10 to 59 years, have been described and compared with serum cholesterol and triglyceride levels.

The incidence of abnormal chylomicra, beta and pre-beta lipoproteins was similar in both sexes and increased with age in both sexes.

Chylomicron bands and/or pre-beta trails from the origin occurred in 4% of subjects, pre-beta bands in 27% and “abnormally” dense beta bands in 28%.

Five per cent of subjects were considered to have definite hyperlipoproteinemia, another 19% had slight and 21% had questionable hyperlipoproteinemia. Fifty-five per cent were normal.

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5.
A knowledge of the prevalence of ventricular septal defect in different age groups is basic to the estimation of all complications of this disease. The Cardiac Registry in the City of Toronto has provided this information for elementary school children. Clinical diagnosis of ventricular septal defect was made if the child had a pansystolic murmur in the 3rd or 4th left intercostal space with a palpable thrill and/or electrocardiographic evidence of ventricular hypertrophy and/or radiologic evidence of pulmonary plethora at one or more examinations. When possible, the diagnosis was confirmed by cardiac catheterization. Children with the same murmur, no thrill and normal electrocardiogram and radiograph were labelled “probable” and presumed to have a minute or disappearing defect.

The prevalence rate of ventricular septal defect in elementary school children varied betwen 0.44 and 0.48 per 1000 in four successive years of study. The rate of “probable” ventricular septal defect varied between 0.27 and 0.37 per 1000 children.

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6.
A “radioactive renogram” using o-iodohippurate sodium (Hippuran)-I131 was performed in 57 patients who had either hypertension or various renal diseases. In longstanding essential hypertension, the initial uptake and secretory phases are often reduced below normal. In five hypertensive patients who were shown to have unilateral renal disease, the renogram showed significantly abnormal tracings on the affected side. In three patients suffering from ureteral obstruction, the excretory phase was significantly prolonged.

On the basis of comparative albumin and iodohippurate renograms, the initial uptake can no longer be considered as a vascular phase, as previously believed.

The iodohippurate-I131 renogram is a useful adjunct in the investigation of hypertension and renal disease, providing information about each kidney not so readily obtained by other means. Nevertheless, the test does not supplant any other investigative procedure and should not be depended upon as a screening procedure.

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7.
Unilateral decrease in renal vascularity is demonstrated by a new technique for studying the renal vascular parenchyma on the “excretory” urogram.

Renal vascularity, decreased on the side of acute ureteral obstruction, returns to normal with the relief of the obstruction.

The use of the vascular nephrogram as a screening test for renovascular hypertension is illustrated and discussed.

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8.
为了解健康青少年骨矿物质含量和确定正常值范围,本文以武汉地区幼儿园、中小学校、技校学生作整群调查对象,对3555名5~19岁青少年进行了骨矿物质含量硷测。测定部位为主力臂桡骨中下1/3处和远端15%处,使用国产 FT-647型单光子骨密度仪。结果显示:(1)青少年骨矿含量男性高于女性。(2)骨矿物质含量呈增龄性增加,增加的速度与年龄、性别、发育期有关,12岁前,两性增加均缓慢,12岁以后男性增加较女性快。(3)青少年骨矿物质含量与身高、体重、年龄呈正相关。根据以上结果,在制订青少年骨矿物质含量正常值时应以性别、每岁龄分组来确定正常值范围。骨矿物质低为异常,故只需计算 P_s 值,按此标准,调查中发现男、女性不同部位骨矿物质含量异常的人数为3.8%~4.99%。由此可见,青春期骨矿物质含量的检测对保护青少年的发育和健康至关重要,同时还有利于预防各年龄原发性和继发性骨质疏松症的发生。  相似文献   

9.
Delirium is not a clinical entity but a symptom-complex of manifold etiology. Its presence signifies acute cerebral insufficiency and often represents a medical and/or psychiatric emergency.

Though some forms of delirium have distinctive features, the fundamental phenomena are common to all, with clouding of consciousness the sine qua non. The condition has two major components: (1) the basic “acute brain syndrome” and (2) associated release phenomena.

Clinicians must first make the vital differentiation between delirium and “functional” mental disorder, then proceed with the elucidation of the underlying diagnosis and the concurrent organization of symptomatic and etiologic treatment.

Proper treatment combines management of the acute brain syndrome with general and specific procedures for control of the underlying condition. Dealing with the symptom-complex itself involves the principles and practice of sedation, hydration, and nutrition, nursing care and supportive measures. Provided the basic organic condition is treatable, the prognosis today is usually good.

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10.
A Survey of Hemoglobin Values in Canada   总被引:3,自引:3,他引:0       下载免费PDF全文
A compilation of hemoglobin values has been made from submissions from laboratories in Canada using the cyanmethemoglobin standard prepared and distributed by the Canadian Communicable Disease Centre (formerly the Laboratory of Hygiene). From 84 participating laboratories 21,580 values were analyzed statistically by age and sex. “Medical referrals”, exclusive of blood dyscrasias, were included but were documented separately from “well persons”. In most age groupings no significant difference in these two categories was found.

Values for boys and girls were similar up to 12 years of age. For adult women from 18 to 84 years the mean value was 13.0 g. per 100 ml. (95% confidence limits 10.8-15.2 g.); for pregnant women 19 to 44 years the mean value was 12.2 g. per 100 ml. (9.7-14.6 g.). For men aged 17 to 24 years the mean value was 15.0 g. per 100 ml. (12.8-17.3 g.); 25-49 years 14.6 g. per 100 ml. (12.4-16.9 g.); 50-69 years 14.3 g. per 100 ml. (11.8-16.8 g.). It is noteworthy that for the most part the mean values were slightly lower than those frequently quoted as “normal” and that the mean values, particularly for the male, were lower with increasing age.

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11.
Ways of obtaining “two-donor” fibrinogen, as described in an earlier communication,1 with an optimal and more constant amount of Factor VIII activity were investigated. Four modifications of the method as originally described by Nitschmann et al. are described. This freshly prepared modified “two-donor” fibrinogen was used in the treatment of severe or moderately severe hemorrhage in 20 hemophiliacs. Comparison of the results with those obtained by intermittent transfusions of fresh plasma or fresh blood indicated that the modified “two-donor” fibrinogen was definitely the preferable preparation.  相似文献   

12.
Long-term bone calcium metabolism was measured using a whole body counter apparatus and the radioisotopes calcium-47 and strontium-85. Strontium was given with calcium in a single intravenous injection in order to estimate long-term retention of calcium. Calcium-47, with a short radio-active half-life, was measured directly for 20 days, and then indirectly from strontium retention for periods up to 200 days.

The standard parameters of calcium transport were measured and, as well, a new parameter, calcium accretion to the fixed bone pool. These studies were carried out on 13 subjects, six of whom were selected “normals” and seven were patients with osteoporosis. Calcium accretion to the fixed bone pool, the new index of bone formation, varied from 100 to 210 mg. of calcium daily in normal subjects and from 70 to 340 mg./day in patients with osteoporosis. These values are one-third of those for the accretion to the total bone pool, the previously reported bone formation rate.

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13.
Five university centres in Canada and the United States have collaborated in a study of a test for carcinoembryonic antigen, with the Montreal General Hospital laboratory acting as the reference laboratory, examining duplicate halves of specimens from patients examined in local laboratories.

Between June 1971 and April 1972, 503 patients were admitted to the study, 146 with cancer of the colon or rectum. Discrimination between colo-rectal cancer and “other” diagnoses was good at 2.5 ng./ml. or more, such a result being obtained in 66% of the patients with colo-rectal cancer in the local laboratories and 62% in the reference laboratory compared with 39% and 33% respectively of patients with “other” diagnoses. Patients with Duke's C lesions of the colon or rectum were more likely to have raised CEA levels than patients with more localized lesions. CEA was also more commonly found in patients with other cancers and in patients with liver disease than in patients with other (benign) diagnoses.

It is concluded that the test can be reproduced in other laboratories and that it or another simplified technique could become an important diagnostic aid for colo-rectal cancer.

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14.
The results of x-ray pelvimetry performed on 66 pregnant women, with a view to predicting the outcome of pregnancy, were reviewed. It was concluded that such pelvimetry was most valuable in cases in which it indicated a normal pelvis or gross bony disproportion. It was least effective in those with a “borderline” pelvis, in which the correct management of the patient requires an adequate trial of labour. The authors believe that pelvimetry in the later stages of pregnancy has no ill effects on the unborn baby or the mother.

Indications for use of x-ray pelvimetry in obstetrics, the technique employed, the various types of female pelvis and the relation of these to the course of labour are considered. Pelvimetry findings are compared with the eventual outcome of labour in women with suspected cephalopelvic disproportion. It is emphasized that the pelvic assessment should be made jointly by the radiologist and obstetrician.

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15.
A consecutive series of 1530 patients with carcinoma of the breast has been reviewed to study the influence of age and marital status on the disease.

The risk of developing breast cancer increases with age, though a peak may be reached at 75 years. The risk of developing a tumour of advanced clinical stage at presentation apparently increases with age. Local recurrence rates and mortality rates are similar at all ages. It is concluded that the therapy required is similar in all age groups.

The increased risk of developing breast cancer in “never married” women is in the postmenopausal period. Survival rates and the distribution of the various presenting clinical stages are similar in both single and married patients.

Though ageing and marital status have an initiating effect on breast cancer, they do not have a continuing effect on the established disease.

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16.
Competitive inhibition of binding between radioiodine-labelled encephalitogenic basic protein from human myelin (125I-HEProt) and normal human alpha-2 macroglobulin and between 125I-HEProt and rabbit antiHEProt serum was used to study concentrated cerebrospinal fluid (CSF) under “blind” control for cross-reactivity with HEProt. Samples of CSF from patients meeting the standard criteria for definite MS and possible MS, and from patients with optic neuritis and “other” diagnoses were studied. CSF from patients in all four groups was shown to have an inhibitor cross-reactive with HEProt when studied by the 125I-HEProt/alpha-2 macroglobulin test, but the amount was significantly greater in the definite MS group than in the “other” group. Results of the two tests on CSF from MS patients correlated, suggesting that the tests were identifying the same inhibitor. It was concluded that CSF contains an inhibitor similar to HEProt and that the amount present in CSF could be a useful diagnostic marker of MS.  相似文献   

17.
Applicants to Canadian Medical Schools for 1966-67   总被引:2,自引:2,他引:0       下载免费PDF全文
An examination of applicants to Canadian medical schools for 1966-67 revealed that 4534 applications were received for the approximately 974 available places. The number of Canadian applications was 2866 and these were made by 1815 individual applicants, an increase of 48 over 1965-66. United States applicants declined from 1143 to 1013.

Evaluations made by the schools concerning the acceptability of the Canadian applicants disclosed that 55 applicants who rated as “acceptable” by one or more schools failed to gain admission to any medical school in 1966-67 (as compared to 36 in 1965-66). However, of those applicants who did find a place 76 were evaluated as “marginal” or “unacceptable”, while another 126 were rated as “acceptable” by one school but “marginal” and/or “acceptable” by one or more other schools.

These results were interpreted to imply that the Canadian medical schools were still experiencing difficulty in attracting well-qualified applicants for study in medicine.

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18.
Tuberculosis: A Challenge to the General Practitioner   总被引:1,自引:1,他引:0       下载免费PDF全文
Of 157 patients dying of tuberculosis in Ontario (1960) 132 (87.4%) suffered from the pulmonary form of the disease (incidence 2.6 per 100,000). In the same year, 1632 of 1847, or 88.3%, active new cases reported had the pulmonary type and 183 additional cases were reported without details as to type of disease. Thus, in 1960, a total of 2030 new cases of tuberculosis were reported in Ontario.

Of 1367 patients with pulmonary tuberculosis (reinfection type), 357 (26.1%) had “far advanced” disease and 613 (44.8%) had “moderately advanced” disease.

This high percentage of patients with “moderately advanced” to “far advanced” disease at the time of diagnosis constitutes the real challenge to physicians in private practice, who made the diagnosis in 45% of cases.

Emergence of resistant strains of bacteria increases the urgency of prompt diagnosis and treatment. The most vulnerable population segment is the 15-30 year age-group, many of whom are negative intracutaneous reactors. A high index of suspicion is necessary, particularly in certain segments of the population with a high incidence of infection, combined with a careful history, meticulous physical examination, intracutaneous tests, chest and other radiographs, and appropriate bacteriological studies.

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19.
Seventy-seven hospitalized children from whom respiratory syncytial virus was subsequently isolated were studied in retrospect. This demonstrated the association of host invasion by this agent with an acute respiratory disease requiring hospitalization for approximately one week.

Boys considerably outnumbered girls, the average age was 7.5 months, and in 56% the admission diagnosis was “bronchiolitis”. Cough and difficulty in breathing were the most common presenting complaints and “pneumonia” the most common radiological diagnosis. Nearly half the patients also harboured accepted disease-causing bacterial pathogens. All the patients recovered and have remained well.

The appearance of the virus in Montreal was seasonal, beginning in late autumn and terminating in early spring.

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20.

Background

Behaviour problems in children still needs precise definition, explicit criterion and assessment on multiple paradigms.

Methods

Fifty children of the age group 6-14 years, from paediatric outpatient department, selected after randomisation were assessed for behaviour problems with the child behaviour checklist. The data collected was analysed using appropriate statistical tests.

Results

40% children were above cutoff score. Mean child behaviour check list (CBCL) score was 40.6. Total of 72% children were from armed forces background of whom 9% were siblings of officers. 30.6% children from the armed forces background were above the cutoff score. There was no significant difference in the behaviour problems between different age groups and sex. There was no significant difference in behaviour problems between children of officers, other ranks or various income groups. Female children had behaviour problems like “too concerned with neatness or cleanliness”, “feels has to be perfect” and “argues a lot” where as male children had behaviour problems like “Does not feel guilty after misbehaving”, “argues a lot” and “restless”.

Conclusion

Behaviour problems in the subjects were externalizing ones. No specific trend was found in children of defence personnel vis-a-vis children of civilian population.Key Words: Child behaviour problems, Child behaviour checklist  相似文献   

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