结外恶性淋巴瘤48例临床分析

1974～1987年,我们收治结外恶性淋巴瘤48例。患者年龄9～73岁,平均37.6岁;病程1.5～29个月,均经组织病理学确诊。其中低度恶性1例,中度恶性19例,高度恶性25例,不能分类2例。混合细胞型何杰金氏病1例。病变首发部位在鼻腔11例,回盲部7例。小肠5例,胃和睾丸各4例,乳腺3例,脑、眼眶、结缔组织各2例,直肠、股骨、牙龈、     

原发性结外恶性淋巴瘤50例临床分析

目的　探讨原发性结外恶性淋巴瘤的临床特点、病理类型、易误诊的原因,总结其诊断和治疗的经验。方法　回顾性分析广东省佛山市第一医院1996-01 ~2000 -12经病理确诊的原发于结外的恶性淋巴瘤共50例。结果　发生于胃肠道者25例,咽淋巴环9例,中枢神经系统4例,脾淋巴瘤5例,甲状腺4例,乳腺1例,骨2例。均为非霍奇金淋巴瘤(NHL)。免疫组化分析以B细胞型为主。临床表现复杂,多易误诊。术后进行化疗和放疗的效果好。结论　原发性结外恶性淋巴瘤临床表现因病变部位不同而异。对疑诊病例应尽早手术,术后放疗和化疗可以取得较好的疗效。     

结外淋巴瘤

结外淋巴瘤主要指非霍奇金淋巴瘤（ＮＨＬ）,其发生率为３０％～５０％,而发生于霍奇金淋巴瘤（ＨＤ）者十分罕见。Ｄｏｗｓｏｎ曾对此提出诊断条件：①首发部位必须在淋巴结外的器官及淋巴组织;②必须经手术或活检病理证实,排除其它恶性肿瘤;③肝脾不肿大;④白细胞...     

乳腺恶性淋巴瘤超声表现1例

乳腺恶性淋巴瘤少见,复恩大学附属华山医院发现1例,现报告如下： 1．临床资料 患者,女,61岁,体检发现右乳肿块而就诊。查体：双乳对称,无乳头凹陷、溢液、溢血。右乳晕外上象限可扪及一大小约50mm×35mm×18mm质硬肿块,表面不光滑,活动可,无皮肤粘连,元明显触痛,左乳触诊未及明显异常。     

恶性淋巴瘤的胸部表现16例

目的 恶性淋巴瘤常累及胸部。74例恶性淋巴瘤中，16例出现胸部病变，发生率为21．6％。霍奇金淋巴瘤38例中有7例，非霍奇金淋巴瘤36例中有9例。恶性淋巴瘤常常侵犯纵隔、肺及胸膜，主要表现为纵隔或肺门淋巴结肿大，肺野均匀一致性浸润及胸腔积液等。经联合化疗与放疗，伴随淋巴瘤的缓解，胸部病变消退。     

老年人结外恶性淋巴瘤外周血免疫指标测定分析

目的检测老年人结外恶性淋巴瘤(PENL)患者外周血T淋巴细胞亚群比例和免疫球蛋白(Ig)水平的变化。方法76例恶性淋巴瘤患者分成2组原发性结外淋巴瘤(结外组)36例,原发性结性淋巴瘤(结性组)40例,另取非淋巴瘤(炎性组)20例作为对照组。分别应用流式细胞术(FCM)和免疫速率比浊法测定T淋巴细胞亚群比例免疫球蛋白(Ig)和Ig以及C3、C4含量。结果结外组CD3 、CD4 和CD8 明显降低(P<0.01),原发性结性恶性淋巴瘤(结性组)CD4 /CD8 比值和NK细胞较其他2组差异有显著性(P<0.01);结外组、结性组中CD3 、CD4 和NK细胞与IgA、IgG、C3有显著的相关性(P<0.01)。结论PENL患者免疫功能的改变,可以作为病情进展的免疫学指标。     

肺部结外NK/T细胞淋巴瘤1例并文献复习

<正>结外NK/T 细胞淋巴瘤(extranodal NK/T-cell lymphoma, ENKTL)是非霍奇金淋巴瘤的一种亚型,临床很罕见,且恶性程度高,进展快,预后很差。可累及鼻腔、上呼吸道、皮肤、胃肠道、大脑、睾丸等结外部位,累及肺部的ENKTL更为少见。肺部ENKTL临床及影像学表现缺乏特异性,在早期很容易被误诊为肺炎。本文报道2020年10月在我院确诊的一例肺部ENKTL,并对其临床表现、胸部CT特点、病理特征和预后进行了描述。     

原发性结外淋巴瘤25例误诊分析

原发性结外淋巴瘤２５例误诊分析四川省人民医院血液科（６１００７２）王晓冬，张晋琳，缪世锟原发性结外淋巴瘤是一种除病变部位（非淋巴结组织）外，一般无邻近淋巴结肿大及肝脾病变．并且血象正常．经病理活检证实为淋巴瘤的疾患．现将我院１９８９年８月至１９９５年...     

原发性结外淋巴瘤43例临床分析

原发性结外淋巴瘤是指原发于淋巴结以外淋巴组织或非淋巴组织的恶性肿瘤。其临床特点与发病部位有关，临床表现复杂多样，且缺乏特异性症状和体征，极易发生误诊、漏诊，直接影响到早期诊断及治疗。现将我院6年来收治的43例原发性结外淋巴瘤的临床特点、误诊情况报告如下。     

原发性结外淋巴瘤62例临床分析

恶性淋巴瘤(ML)是原发于淋巴结和结外淋巴组织的恶性肿瘤,其中10％～44％原发于淋巴网状组织与器官,称为原发性结外淋巴瘤(PENL),发生于粘膜上皮组织者称为粘膜相关淋巴组织(MALT)淋巴瘤。现将我院1998年1月～2001年4月间收住并经病理学检查确诊的PENL患者62例作一临床分析,供临床参考。     

老年人恶性淋巴瘤的临床特点与转归(附30例报告)

1966年至1987年收治的老年人恶性淋巴瘤30例,占同期恶性淋巴瘤住院病人的14.5%;男25例,女5例,年龄为60～75岁。淋巴瘤分类:HD7例,NHL23例;60%的患者起病缓慢,临床表现常不典型,症状隐袭,随病情发展可出现高热、局部或/和全身淋巴结肿大、消瘦和衰竭等症状,早期易致误诊。并发症以呼吸道感染最多(占16.7%),其次为败血症及合并白血病,预后严重。老年患者具有对化疗疗效差,缓解率低,病死率高(本组达50%)的特点。     

中青年与老年淋巴瘤患者248例

<正>淋巴瘤是一类原发于淋巴结和(或)结外淋巴组织的恶性肿瘤,可发生于任何年龄,病理可见分化、成熟程度不一的肿瘤性淋巴细胞大量增生,侵犯全身各个部位或组织。本文回顾性分析我院收治的248例淋巴瘤患者的临床资料,总结并比较老年与中青年淋巴瘤患者的临床特点及疗效。1资料与方法1.1一般资料收集2009年3月至2013年9月我院收治的淋巴瘤患者248例,男159例,女89例,年龄18～87岁,平均     

304例原发性结外淋巴瘤临床病理分析

目的:探讨原发性结外型淋巴瘤(PENL)的临床和病理特征。方法:回顾性分析304例PENL的病例资料,从性别、发病年龄、病理类型、起病部位等方面进行总结分析。结果:①304例PENL中位年龄51岁(3~91岁),41~70岁为高发年龄段;男女比为1.2∶1.0,原发于小肠和腮腺的好发于男性,甲状腺、扁桃体和脾则表现为女性明显多于男性。②本组PENL占同期淋巴瘤的53.0%(304/574),以非霍奇金淋巴瘤(NHL)为主,占95.1%;霍奇金淋巴瘤(HL)占4.9%。结外NHL占同期NHL的58.1%(289/497),结外HL占同期HL的19.5%(15/77)。③原发部位广泛,常见于胃肠道(25.0%)、鼻腔(12.2%)、纵膈(9.9%)、扁桃体(9.5%)。④原发于胃肠道、扁桃体、中枢神经系统、骨、乳腺、甲状腺、睾丸、子宫、卵巢、脾、肺、肾等部位的PENL病理类型,以弥漫性大B细胞淋巴瘤常见;原发于鼻腔的PENL病理类型,以结外NK/T细胞淋巴瘤常见。临床分期以Ⅰ期、Ⅱ期为主。结论:PENL发病率较高,发病部位广泛,临床表现多样且无特异性,临床中对各组织器官疾病进行诊断时应警惕淋巴瘤的可能性,尽早行组织病理学检查,避免漏诊和误诊。     

35例原发性恶性胃淋巴瘤临床特点分析

原发性恶性胃淋巴瘤（PMGL）临床表现缺乏特异性，内镜和上消化道钡餐检查确诊率低。目的：了解PMGL的临床特点，以期早期诊断，早期治疗，改善预后。方法：回顾性分析上海仁济医院2000年9月～2006年2月收治的PMGL病例的病史资料。结果：共35例PMGL患者人选。主要消化道症状为上腹痛，伴全身症状者较少。内镜下溃疡型、弥漫浸润型和结节肿块型病变分别占67．7％、22．6％和9．7％，病变主要位于胃窦和胃体。内镜活检病理检查确诊率为54．5％。35例PMGL术后病理诊断均为B细胞性非霍奇金淋巴瘤，其中黏膜相关淋巴组织（MALT）淋巴瘤5例，弥漫性大B细胞淋巴瘤（DLBCL）26例，DLBCL合并MALT淋巴瘤（DLBCML）4例。患者预后与肿瘤病理类型、临床分期和血清乳酸脱氢酶（LDH）水平有关（P〈0．05）。术后3年生存率为81．8％。结论：PMGL患者局部表现严重而全身状况良好。内镜下病变大、范围广且多部位侵犯。多点取材或“挖洞式”活检可提高内镜诊断率。治疗方案的选择应根据肿瘤病理类型、临床分期和是否存在幽门螺杆菌感染而定。     

原发性大肠恶性淋巴瘤的内镜表现

原发性大肠恶性淋巴瘤指原发于大肠的结外型淋巴瘤, 组织学类型一般为非霍奇金淋巴瘤,包括黏膜相关性淋巴瘤和肠病相关性淋巴瘤。中低度恶性的多为黏膜相关性淋巴瘤,细胞类型为B淋巴细胞型,此类淋巴瘤中部分可能分化较好,组织学上可见     

不同淋巴细胞起源的原发性结直肠恶性淋巴瘤临床特点差异分析

Objective To investigate the difference of clinical features between primary colorectal malignant T cell lymphoma and primary colorectal malignant B cell lymphoma.Methods Forty cases diagnosed as primary eolorectal malignant lymphoma (PCML) between Jan 1999 and May 2008 were studied retrospectively.Results The average age of 40 patients with PCML was (41.0±11.2) years old.Twenty-seven cases (67.5%) were diagnosed as B-cell lymphoma.Thirteen cases (32.5%) were diagnosed as T-cell lymphoma.Patients with T-cell lymphoma in PCML had more symptoms such as fever,night sweat and hematochezia,and was easier to perforate than those with B-cell lymphoma.Protrude type and single-focus and right-colon type were common in B-cell lymphoma under colonoscopy,but ulcerative type and multi-focus and fulbcolon were common in T-cell lymphoma.B-cell lymphoma had an earlier diagnosis,and more opportunities for surgery than T-cell lymphoma.Conclusions The misdiagnostic rate for PCML was high.Protrude type and single-focus and right-colon type were common in B-cell lymphoma under eolonoscopy,but ulcerative type and multi-focus and full-colon were common in T-cell lymphoma.B-cell lymphoma could be diagnosed earlier.     

不同淋巴细胞起源的原发性结直肠恶性淋巴瘤临床特点差异分析

Objective To investigate the difference of clinical features between primary colorectal malignant T cell lymphoma and primary colorectal malignant B cell lymphoma.Methods Forty cases diagnosed as primary eolorectal malignant lymphoma (PCML) between Jan 1999 and May 2008 were studied retrospectively.Results The average age of 40 patients with PCML was (41.0±11.2) years old.Twenty-seven cases (67.5%) were diagnosed as B-cell lymphoma.Thirteen cases (32.5%) were diagnosed as T-cell lymphoma.Patients with T-cell lymphoma in PCML had more symptoms such as fever,night sweat and hematochezia,and was easier to perforate than those with B-cell lymphoma.Protrude type and single-focus and right-colon type were common in B-cell lymphoma under colonoscopy,but ulcerative type and multi-focus and fulbcolon were common in T-cell lymphoma.B-cell lymphoma had an earlier diagnosis,and more opportunities for surgery than T-cell lymphoma.Conclusions The misdiagnostic rate for PCML was high.Protrude type and single-focus and right-colon type were common in B-cell lymphoma under eolonoscopy,but ulcerative type and multi-focus and full-colon were common in T-cell lymphoma.B-cell lymphoma could be diagnosed earlier.     

不同淋巴细胞起源的原发性结直肠恶性淋巴瘤临床特点差异分析

Objective To investigate the difference of clinical features between primary colorectal malignant T cell lymphoma and primary colorectal malignant B cell lymphoma.Methods Forty cases diagnosed as primary eolorectal malignant lymphoma (PCML) between Jan 1999 and May 2008 were studied retrospectively.Results The average age of 40 patients with PCML was (41.0±11.2) years old.Twenty-seven cases (67.5%) were diagnosed as B-cell lymphoma.Thirteen cases (32.5%) were diagnosed as T-cell lymphoma.Patients with T-cell lymphoma in PCML had more symptoms such as fever,night sweat and hematochezia,and was easier to perforate than those with B-cell lymphoma.Protrude type and single-focus and right-colon type were common in B-cell lymphoma under colonoscopy,but ulcerative type and multi-focus and fulbcolon were common in T-cell lymphoma.B-cell lymphoma had an earlier diagnosis,and more opportunities for surgery than T-cell lymphoma.Conclusions The misdiagnostic rate for PCML was high.Protrude type and single-focus and right-colon type were common in B-cell lymphoma under eolonoscopy,but ulcerative type and multi-focus and full-colon were common in T-cell lymphoma.B-cell lymphoma could be diagnosed earlier.