体外与非体外循环冠状动脉旁路移植术对左主干病变患者桥血管的影响

目的 比较不同手术方式对左主干病变桥血管的影响.方法 选取我院2010年1月-2011年12月因冠心病左主干病变而接受手术治疗的患者132例,男性98例,女性34例,平均年龄(63.5±8.6)岁.按手术方法分为:体外循环组(on-pump coronary artery bypass grafting,CCABG)及非体外循环组(off-pump coronary artery bypass grafting,OPCAB).CCABG组70例,共搭桥219支,乳内动脉(left internal mammary artery,LIMA)桥70支,大隐静脉(saphenous vein,SV)桥149支.OPCAB组62例,共搭桥181支,乳内动脉桥62支,大隐静脉桥119支.术中应用即时血流仪(transit-time flow meter,TTFM)测量桥血管血流量、搏动指数(pulsatility index,PI)及血流波形.结果 两组患者术前一般资料差异无统计学意义.术中桥血流测量:乳内动脉-前降支桥血流量CCABG组为(27.3±16.5)ml/min,OPCAB 组为(27.7±18.7)ml/min(P=0.812);两组PI值分别为3.1±1.6及3.0±1.8(P=0.312),差异均无统计学意义.大隐静脉-回旋支桥血流量CCABG组为(37.3±3.4)ml/min,OPCAB组为(35.0±5.6)ml/min(P=0.086);两组PI值分别为2.9±1.5及3.0±1.7(P=0.675),差异无统计学意义.结论 对于左主干病变的患者,不论行CCABG或OPCAB,对桥血管及吻合口的质量无影响,均可达到满意的再血管化.     

非体外循环法冠状动脉搭桥术15例报道

目的报告15例用"Octopus方法"行冠状动脉搭桥术(Off-Pump coronary artery bypass,OPCAB).方法正中切口非体外循环下"Octopus方法"的冠状动脉搭桥术.1例搭桥1根,1例搭桥2根,搭桥3根以上13例.移植血管:左乳内动脉12根,大隐静脉33根.移植部位:前降支15根,对角支6根,回旋支9根,右冠脉11根,后降支4根. 结果无手术死亡,无术中中转体外循环,术后心绞痛消失,MRI提示桥血管通畅. 结论OPCAB"Octopus方法"适用于多支血管病变,几乎包括所有靶血管,手术效果好,并发症少.     

非体外循环法冠状动脉搭桥术15例报道

目的 报告15例用“Octopus方法”行冠状动脉塔桥术（Off-Pump coronary artery bypass,OPCAB)。方法 正中切口非体外循环下“Octopus方法”的冠状动脉搭桥术。1例搭桥1根，1例搭桥2根，搭桥3根以上13例。移植血管：左乳内动脉12根，大隐静脉33根。移植部位：前降支15根，对角支6根，回旋支9根，右冠脉11根，后降支4根。结果 无手术死亡，无术中中转体外循环，术后心绞痛消失，MRI提示桥血管通畅。结论 OPCAB“Octopus方法”适用于多支血管病变，几乎包括所有靶血管，手术效果好，并发症少。     

体外与非体外循环下冠状动脉搭桥治疗冠状动脉三支病变的对比研究

目的:对比研究体外与非体外循环下冠状动脉搭桥治疗冠状动脉三支病变的临床效果。方法:300例单纯冠状动脉多支搭桥患者分别进入常规体外循环下冠状动脉搭桥组(CCABG组,n=150例)和非体外循环冠状动脉搭桥组(OPCAB组,n=150例)。两组患者在心绞痛程度、合并慢性阻塞性肺病(COPD)、心肌梗死史和糖尿病、急诊手术和左主干(LM)病变等方面无显著性差异,但OPCAB组手术前有脑梗死史和肾功能异常患者的比例明显多于CCABG组(P均<0.05)。所有患者均采用胸骨正中切口。CCABG组在常规CPB心脏停跳下进行,OPCAB组用单根心包深吊线,引入一纱条,帮助暴露各冠状动脉分支,采用心脏局部固定器,辅以腔内分流栓,完成远端吻合。所有患者术终行桥血流定量测定。结果:OPCAB组无1例需转成CCABG。所有患者均在心脏侧壁和后壁区域搭桥。两组人均冠状动脉远端吻合数(OPCAB组:3.84±1.06,CCABG组:3.75±0.94)和再血管化指数相似;手术后呼吸支持时间、胸腔引流量和输血量OPCAB组明显少于CCABG组(P<0.05,P<0.01);OPCAB组呼吸功能不全和肾功能异常发生率低于CCABG(P均<0.05);两组围手术期心肌梗死、脑卒中、房颤发生率和手术病死率无统计学差异。结论:对比研究结果显示,OPCAB可用于冠状动脉三支血管病变,能达到与常规CCABG相似的完全性再血     

体外循环与非体外循环冠状动脉旁路移植术输血情况的对比研究

目的对比研究常规冠状动脉旁路移植术（conventional coronary artery bypass grafting,CCABG）与非体外循环冠状动脉旁路移植术（off-pump coronary artery bypass,OPCAB）患者术中及术后输血量及输血费用的不同。方法对345例行CABG的患者进行了术中、术后输血量及输血费用的统计,所有患者分为CCABG组135例,OP-CAB组210例。分别统计两组患者术中及术后输红细胞量、血浆量、血小板量、输血总量以及各自相关费用。结果CCABG组输血率显著高于OPCAB组（分别为82.2%和46.7%,P〈0.05）,输红细胞量、输红细胞费用、输血浆量、输血浆费用、输血总量及输血总费用CCABG组均显著高于OPCAB组（P〈0.05）,而输血小板量及输血小板费用两组之间无显著性差异（P〉0.05）。结论与CCABG相比,OPCAB患者术中、术后输血量及输血费用显著减少,OPCAB对患者恢复有利,并能减轻患者经济费用。     

非体外循环冠状动脉旁路移植术216例

随着心肌保护技术的发展、体外循环设备的不断改良等,常规体外循环下冠状动脉旁路移植术(conventional coronary artery bypass grafting,CCABG)技术已相当成熟,但体外循环(CPB)本身导致的并发症如全身炎症反应等仍不可避免[1].非体外循环冠状动脉旁路移植术(off-pump coronary bypass grafting,OPCAB)避免了体外循环,减轻了心肌缺血-再灌注损伤,为有体外循环高危因素或者不能耐受体外循环的患者,提供了一种治疗可能,成为现代微创冠脉外科的重要术式[2,3].2000年3月至2006年3月,本院完成OPCAB216例,现就OPCAB手术方法和围术期处理等报道如下.     

冠脉旁路移植术后康复1018例

1临床资料 1997-01／2004-12我院共完成冠脉旁路移植术(coronary artery bypass graft,CABG)1018(男888,女130)例,60岁以上582例(57．1％),70岁以上217例(21．3％),最大年龄86岁;非体外循环冠状动脉旁路移植术(OPCAB)510例,体外循环下冠状动脉旁路移植术(CCABG)508例;不稳定性心绞痛852例,术前同时合并其他疾病784例(77．1％),高血压病500例,     

左胸廓内动脉联合桡动脉行冠状动脉旁路移植术早期临床疗效

目的 探讨体外循环与非体外循环下左胸廓内动脉(left internal thoracic artery, LITA)联合桡动脉(radial artery, RA)行全动脉化冠状动脉旁路移植术(total arterialized coronary artery bypass grafting, TA-CABG)的早期临床效果。方法 回顾性分析山东省千佛山医院心脏外科2020年1月至2022年6月接受全动脉化冠状动脉搭桥术105例患者临床资料,其中不停跳冠状动脉旁路移植术(off-pump coronary artery bypass grafting, OPCAB)患者59例,为OPCAB组,体外循环下冠状动脉旁路移植术(on-pump coronary artery bypass grafting, ONCAB)患者46例,为ONCAB组。分析包括术前资料、术中桥血管获取及吻合方式、术后并发症及处理措施,所有患者术后12个月复查冠状动脉CT血管造影(computed tomography angiography, CTA),并评估桥血管通畅率及不良心血管事件发生率。结果 ONCA...     

个体化全动脉冠状动脉旁路移植术的临床应用

目的：总结非体外循环下个体化全动脉冠状动脉旁路移植术（coronary artery bypass grafting,CABG）的近期结果和手术经验。方法：2016年1月—2018年11月,55例冠脉多支病变患者接受了非体外循环下个体化全动脉CABG术。26例采用原位左乳内动脉和左桡动脉（47.3%）作为移植血管材料,16例采用原位左乳内动脉和双桡动脉（29.1%）,11例使用原位左乳内动脉、游离右乳内动脉和左桡动脉（20.0%）,余2例使用原位双乳内动脉和左桡动脉（3.6%）。观察患者围手术期并发症,随访移植血管通畅率,考察患者的生存质量。结果：有2例患者术后置入主动脉内球囊反搏（intra?aortic balloon pump,IABP）治疗,2例切口延迟愈合,1例急性肾衰,经积极治疗后均好转,围术期和随访过程中无死亡,无主要心脑血管不良事件发生,心绞痛症状全部消失,随访的移植血管全部通畅,无再次血运重建手术需要。结论：非体外循环下全动脉CABG近期临床疗效满意,基于个体靶血管解剖特点的个体化全动脉策略可实现完全再血管化,近期桥血管通畅率满意。     

非体外循环下左主干病变冠脉旁路移植术的疗效分析

目的探讨非体外循环下冠状动脉旁路移植术(off-pump coronary artery bypass grafting,OPCAB)治疗左主干病变的安全性和可行性。方法选择2008年3月～2012年6月冠脉旁路移植术患者450例,分为两组,左主干病变组215例,非左主干病变组235例,所有病例由同一团队施行OPCAB,回顾性分析两组病例术后各项指标及早期死亡率。结果左主干病变组4例因术中搬动心脏出现血流动力学极度不稳定转为体外循环(cardiopulmonary bypass,CPB)下手术,两组人均搭桥数为3.02支,人均搭桥数左主干组较非左主干组高,主要集中在左冠状动脉(前降支和回旋支),差异均有统计学意义(均P<0.05)。用血量、术后重症监护室(ICU)治疗时间、主动脉内球囊反搏(IABP)使用率、术中转CPB手术比例左主干组高,乳内动脉使用率非左主干组高,差异均有统计学意义(均P<0.05)。两组在术后各种并发症及死亡率上差异无统计学意义(P>0.05)。结论 OPCAB治疗左主干病变是安全可行的,但是术前需要做好充分的应急准备,包括IABP和CPB,有条件的医疗单位可以推广应用。     

Graft patency in off-pump and conventional coronary artery bypass grafting for treatment of triple vessel coronary disease

Inanattempttoavoidthedeleteriouseffectsofcardiopulmonarybypass (CPB) ,off pumpcoronarybypasssurgeryhasrecentlybeenrediscoveredandrefined Overthepastdecade ,theuseofoff pumporbeating heartcoronaryarterybypass (OPCAB)surgeryhassincebecomemorepopularandwidelyused Intriplevesseldisease ,accesstothelateralandposteriorwallvesselstofacilitatecompleterevascularizationevolved ,accompaniedbytechnicaladvancesintheinstrumentationforstabilizationoftheheart Multiplepreviousauthorshavereportedaseriesofoff…     

Comparative study of graft flow between on-pump and off-pump coronary bypass surgery for patients with multivessel coronary artery disease

Objective： To Comparatively study grafts flow between on-pump and off-pump coronary bypass surgery for patients with triple coronary artery disease. Methods ： The grafts flow was studied in 100 patients of OPCAB and compared with 100 cases of CCABG by means of Medi-Stim Butterfly Flowmeter measurement intraoperatively. Results： The mean number of the distal anastomosis was 3.78＋ 1.11 in CCABG group, and 3.83 ＋ 0.93 in OPCAB group. The index of completeness of revascularization in CCABG group was 1.01 ＋ 0.08, and 1.10＋ 0.09 in OPCAB group. The flow of grafts was satisfied in all patients. The PI values were all under 5. There was no significant difference in the mean graft flow and PI value between two groups. Conclusion： OPCAB can provide the same grafts flow and similar completeness of revascularization when compared with CCABG which indicates the similar anastomosis quality of grafts in OPCAB and CCABG groups.     

冠状动脉旁路移植术出入液量的对比分析

目的分析非体外循环下冠状动脉旁路移植术(OPCAB)和体外循环下冠状动脉旁路移植术(CCABG)术式出入液量的变化,总结术后处理经验。方法回顾性分析并比较解放军总医院2005年6月至2005年10月连续44例OPCAB及17例CCABG手术临床资料,以同期28例体外循环(extracorporeal c ircu lation,ECC)下成人心脏手术作对照,重点统计手术后出入液量的变化。结果OPCAB组术中出血量明显少于CCABG组,与ECC组相当;术后引流液量与CCABG无明显差别;OPCAB组术后输血率明显少于CCABG组。OPCAB组术中入液量明显少于CCABG组及ECC组,而术后当天及第一天入液量均多于CCABG组及ECC组。OPCAB组术中、术后当天出液量明显少于CCABG组及ECC组,而术后第1、2、3天出液量与CCABG组相当,而多于ECC组。各组手术均无死亡病例,无严重并发症。结论OPCABG与CCABG相比,减少了术中出血,降低了术后输血率,从而避免了异体输血的风险;同时术后不需要刻意利尿及补液,在出入液量管理方面有着不同于CCABG的特点。     

Comparative study of on-pump and off-pump coronary bypass surgery in patients with triple-vessel coronary artery disease

Background Studies on selected patients undergoing off-pump versus on-pump coronary artery bypass surgery have produced inconsistent results, especially in patients with multiple coronary artery disease. This study compared the clinical results of on-pump and off-pump coronary bypass surgery in patients with triple-vessel disease.Methods A total of 300 consecutive isolated, multiple coronary artery bypass grafting (CABG) patients were assigned to the off-pump coronary artery bypass (OPCAB, n=150) or CABG with cardiopulmonary bypass (CCABG, n=150) groups. There were no significant differences regarding degree of angina, history of myocardial infarction or diabetes, and presence of left main coronary artery disease between the two groups. Ejection fraction in the OPCAB group before surgery was lower than in the CCABG group (P&lt;0.01). In addition, more patients had a history of stroke and abnormal renal function preoperatively in the OPCAB group（P&lt; 0.01）. In OPCAB patients, single deep pericardial stay suture with a sling snared down was used to expose the target vessels, along with a stabilizer and a coronary shunt. A Medi-Stim Butterfly Flowmeter was used to measure blood flow through grafts in both groups.Results No OPCAB patient was converted to the CCABG group. The average numbers of distal anastomoses and the indexes of completeness of revascularization (ICR) were similar in both groups. Postoperative respiratory support time and the volumes of chest tube drainage and of blood transfusions were less in the OPCAB group than in the CCABG group (both P&lt;0.01). The postoperative incidences of pulmonary dysfunction and renal insufficiency were lower in the OPCAB group than in the CCABG group （both P&lt;0.05）. There were no significant differences between the two groups in mortality and other causes of morbidity (periopetative myocardial infarction, stroke, atrial fibrillation). Conclusions OPCAB can be applied to patients with triple-vessel coronary artery disease and can achieve similar completeness of revascularization and similar early surgical results, with shorter respiratory support, reduced transfusion requirement, and fewer cases of pulmonary dysfunction and abnormal renal function.     

体外和非体外循环对冠状动脉搭桥术疗效的影响

目的对比分析99例非体外循环下冠状动脉搭桥术(OPCAB)和87例常规体外循环下冠状动脉搭桥术(CCABG)的疗效。方法对186例冠状动脉搭桥术的疗效进行回顾性分析。结果CCABG死亡1例,OPCAB组无手术死亡;OPCAB组在ICU时间、呼吸机辅助呼吸时间、术后住院时间方面优于CCABG组;但两组在死亡率、输血量、术后引流量和肺部感染等方面差异无统计学意义。结论OPCAB和CCABG均安全可行,疗效确实;OPCAB与CCABG相比,在术后恢复上有一定优势,但还不能取代CCABG。     

中高危冠心病患者并行体外循环下冠状动脉旁路移植术临床效果分析

目的:分析并行体外循环下冠状动脉旁路移植术(on-pump beating heart coronary artery bypass grafting,On-Pump BHCABG)对中高危冠心病患者的治疗效果。方法:随机选择20例并行体外循环下冠状动脉旁路移植术患者(观察组)与20例体外循环停跳冠状动脉旁路移植术患者(对照组),评价两种手术方式治疗效果。结果:两组患者移植血管数、红细胞输注量、血浆冷沉淀输注量、血小板输注量、IABP置入率、死亡率、不良心血管事件发生率比较,差异均无统计学意义(P>0.05)。与对照组相比,观察组体外循环时间、术后ICU停留时间、呼吸机辅助通气时间均明显缩短,新鲜冰冻血浆输注量较少,住院总费用较低,差异均有统计学意义(P<0.05)。结论:并行体外循环冠状动脉旁路移植术可以缩短中高危冠心病患者体外循环时间,减少术后监护和住院时间,减少患者住院费用。对于不适于采用非体外循环冠状动脉旁路移植术治疗的中高危患者,建议优先考虑并行体外循环下冠状动脉旁路移植术。     

两种冠状动脉旁路移植术的临床效果及餐后血压和心率的比较

为了比较非体外循环冠状动脉旁路移植术(OCABG)和体外循环冠状动脉旁路移植术(CABG)术后患者的临床疗效及餐后血压和心率,回顾分析行冠状动脉旁路移植术患者181例的临床资料,其中,106例为非体外循环冠状动脉旁路移植术患者(OCABG组),75例为体外循环冠状动脉旁路移植术患者(CABG组)。结果显示,与CABG组比较,OCABG组总有效率显著增高(82.67% vs 95.28%); 与餐前相比,两组收缩压(SBP)、舒张压(DBP)和心率(HR)在餐后均有不同程度变化。结果说明,采用非体外循环冠状动脉旁路移植术治疗冠心病的临床效果更加显著,有利于维持患者餐后血压及心率的稳定。     

Is the use of cardiopulmonary bypass for isolated coronary artery bypass an independent predictor of mortality and morbidity in patients with severe left ventricular dysfunction?

Background Patients presenting with severe left ventricular dysfunction （SLVD） undergoing conventional coronary artery bypass grafting （CCABG） are at an increased risk of perioperative mortality and morbidity. The aim of this study was to assess the risk factors responsible for mortality and morbidity among patients with SLVD by comparing CCABG and oft-pump coronary artery bypass surgery （OPCAB）.
Methods We retrospectively evaluated 186 consecutive patients with SLVD who underwent coronary artery bypass grafting （CABG）, including 102 by CCABG and 84 by OPCAB. Registry database, medical notes, and charts were studied for preoperative and postoperative data of the patients. Different variables and risk factors （preoperative, intraoperative, and postoperative） were evaluated and compared. The morbidity and mortality outcomes were compared in the two groups. The follow-up results and quality of life were assessed after surgery.
Results The two groups had similar percentage of patients with preoperative high-risk profiles and no significant differences were found between groups in baseline variables such as age or comorbidities. There was a significant difference in the number of grafts used between the two groups. CCABG patients received （3.6±0.5） grafts per patient, while OPCAB patients had （2.7±0.6） grafts （P 〈0.05）. Completeness of revascularization was also significantly different between the two groups （CCABG 91.1% vs OPCAB 73.8%, P 〈0.05）. The hospital mortality was similar in the two groups （4.8% in OPCAB vs 5.9% in CCABG）. The risk-adjusted mortality, according to the calculated propensity score, did not reach statistical significance in the two groups. In this study, OPCAB seemed to have a beneficial effect on reducing reoperation for bleeding, blood transfusion requirement, and the length of stay at ICU. But the incidence of perioperative myocardial infarction was more common in the off-pump group （P 〈0.05）. The degree of improvement in angina and qual