A Macular Hole in a Female Adult with Bilateral Coats Disease

Purpose:To report a case of a macular hole in a female adult with bilateral Coats disease.Methods:The fundus photograph, fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) were performed in two eyes, and observed theirs characters.Results:Fundus photograph showed massive yellowish-white exudation in the temporal midperiphery of both eyes, but the degree was slighter in the right eye. There was 1/3 DD macular hole in left eye. FFA revealed general dilatation of capillaries, multiple aneurysms, and tortuous and closure of vessels in superotemporal midperiphery in both eyes, but the degree was slighter in the right eye. There was a one-third DD round transmitted fluorescence according the macula hole. ICGA revealed that hyperfluorescence of aneurysms in superotemporal midperiphery, the images of aneurysms were more clearly than in FFA. There was a 2/3 DD hypoflurescence of macula in the late phase of angiography.Conclusions: FFA and ICGA have respective advantage in revealing vas     

Characteristics of Indocyanine Green Angiography in Exudative Age—related Macular Degeneration

Objective: To observe the characteristics of indocyanine green angiography (ICGA) in exudative age-related macular degeneration (AMD).Methods: Thirty-one cases (39 eyes) were diagnosed as exudative AMD by ocular examination, fundus color photography, fundus fluorescein angiography (FFA) and ICGA. Their ages ranged from 50 to 82 years and visual acuities from FC/30cm to 0. 7. We analyzed and compared the characteristics of ICGA and FFA in these patients. Results: Of 26 eyes with occult choroidal neovascularization (CNV) by FFA, 15 (57. 7% ) had classic CNV by ICGA. Of 4 eyes with serous retinal pigment epithelial detachment (FED) without CNV by FFA, 1 had serous FED with classic CNV by ICGA. The hyperfluorescence of the scar staining was detecfed by ICGA. Conclusion ? ICGA adds clinically useful information and is an important adjunct in the evaluation, classification, and laser treatment of patients with occult CNV in AMD. Eye Science 1999; 15: 156 - 161.     

维替泊芬光动力疗法治疗息肉状脉络膜血管病变的随访观察

目的 观察维替泊芬光动力疗法(photodynamic therapy,PDT)对息肉状脉络膜血管病变(polypoidal choroidal vasculopathy,PCV)的1年治疗效果.方法 9例(10只眼)经眼底彩照、荧光素眼底血管造影(fundus fluorescein angiography,FFA)和吲哚青绿血管造影(indocyanine green angiography,ICGA)确诊的PCV患者,进行常规的PDT治疗,治疗后随访第2周、1月、3月、6月、1年,观察治疗前后的视力、眼底彩照、FFA和(或)ICGA.结果 PDT治疗后1年视力提高3只眼,视力稳定6只眼,1只眼PDT治疗后出血吸收第2月复发黄斑区出血视力下降;1只眼治疗后第2周出现严重视网膜下出血,随访后渐吸收,其余患眼底出血、渗出均吸收消失.第3个月造影检查渗漏停止7只眼,3只眼轻微渗漏,末次随访3只眼仍轻微渗漏.PDT治疗过程无一例出现严重全身并发症.结论 PDT是一种安全有效的PCV治疗方法,可以短期内减轻或封闭异常血管的渗漏,促进出血、渗出吸收,稳定或提高患者视力,个别患者治疗后出现严重网膜下出血能自行吸收.

Abstract：

Objective To observe prospectively one-year's effect of photodynamic therapy (PDT)with verteporfin in polypoidal choroidal vasculopathy (PCV). Methods Nine patients (10 eyes) diagnosed as PCV according to fundus color, fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) were performed PDT. Visual acuity, Fundus appearance, FFA and/or ICGA were compared before PDT, and then at 2 weeks, 1 month, 3 months, 6 months and 12 months afier PDT.Results One year after the PDT, visual acuity was improved in 3 eyes and stabilized in 6 eyes. Visual acuity in one eye decreased again because of recurred macular bleeding. Massive subretinal hemorthage in one eye appeared two weeks after PDT and absorbed during the period of follow-up. The bleeding and exudates in the last 8 eyes were absorbed during the follow-up. At the 3 months, FFA and/or ICGA showed no Ieakage in 7 eyes, slight leakage in 3 eyes and still leakage at the final follow-up. No systemic adverse effect was found during and after PDT. Conclusions PDT offers an effective and safe way of treating PCV. PDT may relieve or stop vascular leakage, promote the elimination of the retinal hemorrhage and exudates, improve or stable the visual acuity. Massive retinal hemorrhage after PDT appears and absorbs in individual patients.     

眼底血管样条纹临床及荧光造影表现

目的 分析眼底血管样条纹(angioidstreaks,AS)的临床特征与眼底荧光血管造影(fundus fluorescein angiography,FFA)及吲哚青绿血管造影(fundus indocyanine green Angiography,ICG)表现.方法 对7例(14只眼)血管样条纹患者行眼科常规检查,眼底照相.其中6例(12只眼)患者行FFA及ICG检查.结果 眼底表现:14只眼眼底见视盘周围血管样放射状条纹,7只眼黄斑区视网膜下出血,黄白色硬性渗出,大小不一的灰黄色病灶(50.00%),3只眼见黄斑区萎缩瘢痕灶(21.43%);FFA表现:血管样条纹10眼表现为透见荧光(83.33%),2只眼表现为中央低荧光,两侧高荧光(16.67%),7只眼在黄斑区出现脉络膜新生血管(choroidalneovascularization,CNV)的强荧光(58.33%),3只眼黄斑区萎缩瘢痕灶晚期荧光着染(25.00%);ICG表现:12只眼血管样条纹表现为早期不显影,中期呈强荧光,7只眼CNV表现为强荧光,3只眼黄斑区萎缩瘢痕灶中2只眼见边界不清斑状CNV.结论 眼底血管样条纹患者的眼底较典型,FFA及ICG能进一步明确诊断,对疾病治疗有指导意义.

Abstract：

Objective To investigate the clinical manifestations, features of fundus fluorescein angiography(FFA)and fundus indocyanine green angiography(ICG)with angioid streaks. Methods Seven patients(14 eyes)with bilateral angioid streaks were examined by the routine ophthalmological examination, FFA and ICG. Colorfundus photographs were also taken. Results Fundus findings: angioid streaks were visualized in the posterior pole of 14 eyes and the macular areas of 7 eyes,(50.00%)had subretinal hemorrhages with neovascularization. FFA: streaks were hyperfluorescent in 10 eyes(83.33%), hypofluorescentareas between hyperfluorescent edges in 2 of the 12 eyes(16.67%), hyperfluorescent were seen in choroidal neovascularization (CNV)of macular in 7 eyes(58.33%). ICG: the result of streaks in 12 eyes showed hypofluorescence at the early phase and hyperfluorescence at the late phase, hyperfluorescent were seen in CNV of macular in 7 eyes, 2 eyes presented occult CNV. Conclusion In all eyes, angioid streaks are well visualized. FFA and ICG results may contribute to the diagnosis and treatment for patients with angioid streaks.     

Indocyanine Green Angiographic and Multifocal Electroretinographic Features in the Diffuse and Regional Form of Bietti‘s Crystalline Retinopathy

Purpose:To observe different features of indocyanine green angiography(ICGA) and multifocal electroretinography(ERG)in the diffuse and regional type of Bieti‘s crystalline retinopathy(BCR).MEthods:ICGA and the multifocal ERG were performed in two cases of the diffuse and regional type of BCR respectively.These data were compared with fluorescein angiography(FA),Standard Ganzfeld ERG,and visual field testing.Results:In the regional case,ICGA revealed reduced perfusion of the choroidal circulation in the early phase and multiple hypofluorescent spots in the posterior pole in the late phase,due to choriocapillaris filling defect;the extent of choroiocapillaris loss was shown in early phase of ICGA and there were multifocal hyperfluorescent dots surrounding hypofluorescent spots in late phase in the diffuse case.The multifocal ERG showed that the central responses were markedly depressed,corresponding to the visual field defects,while the findings of Ganzfeld ERG were normal in the regional BCR;However,both the multifocal ERG and Ganzfeld ERG were severely subnormal in the diffuse case.Conclusions:The features of ICGA and multifocal ERG are different between the diffuse and regional BCR.In the meantime,the two tools are also useful to differentiate the type and assess the extent of evolution in BCR.     

Clinical Features and Differential Diagnosis of Acute Idio-pathic Blind Spot Enlargement Syndrome

Purpose： To study the clinical manifestations and the diag- nostic and differential diagnostic characteristics of acute idio- pathic blind spot enlargement syndrome （AIBSES）. Methods： Six patients diagnosed with AIBSES underwent complete eye examinations including fundus photography, fundus fluorescein angiography（FFA）, indocyanine green an- giography （ICGA）, optical coherence tomography （OCT）, electroretinogram （ERG）, and visual field examinations. Results： All patients had enlarged blind spots of variable sizes and densities. Three eyes had mild swelling of the optic disc and one eye had peripapillary scarring that corresponded to the permanent field defect. Two patients who underwent FFA had fluorescein leakage of blood vessels around the optic disc and ICGA highlighted diffuse, small hypofluorescent spots scatter- ing throughout the posterior pole. OCT showed that the inner and outer segment （IS/OS） line were absent in five patients and the middle cone outer segment tip line was absent in the nasal macular area in one eye.     

眼底血管造影联合频域光相干断层扫描同步检查法对渗出性老年性黄斑变性脉络膜新生血管的诊断价值

Objective To evaluate the diagnostic value of Heidelberg retinal angiography(HRA) combined with optical coherence tomography (OCT) to detect neovascularization (CNV) in exudative age-related macular degeneration (AMD) patients. Methods This is a cross-sectional study of a series of clinical cases. AMD diagnosis was established by international standard vision chart, Slit lamp microscope, direct or indirect ophthalmoscope examination. A total of 50 eyes (42 cases) of exudative AMD received HRA and frequency domain OCT scan. All 50 eyes received fundus fluorescein angiography (FFA) and frequency-domain OCT simultaneously, and among them 15 eyes also received indocyanine green angiography (ICGA) at the same time. FFA and ICGA were carried out by conventional methods, CNV was localized by real-time Localization technology of frequency domain OCT. In the radial and grid-like section from the areas with strong fluorescence, image acquisition settings are 7 μm fault for each frame, 30° intervals for radialsection, 10 vertical and 10 horizontal scan lines for grid-like section. CNV can be divided into 4 types (typical CNV, partial typical CNV, occult CNV, CNV scarring) according to their boundaries demonstrated in FFA. Based on the features of the OCT images, there were 3 types of integrated image (sub-RPE type, sub-retinal type and mixed type). Results CNV was detected in all 50 eyes. There were 4 eyes (8%) of typical CNV, 11 eyes (22%) of partial typical CNV, 32 eyes (64 %, including 27 eyes of RPE detachment and 5 eyes of passive late leakage) of occult CNV and 3 eyes (6%) of CNV scarring. There were 4 eyes (8%) of sub-RPE type (CNV under the RPE light band) , 16 eyes (32%) of sub-retinal type(interrupted light band of RPE and choroid capillary layer) and 30 eyes (60%) of mixed type of integrated image. Conclusion The image integration technology of the HRA and frequency domain OCT system provide a valuable tool to classify and measure CNV, which will benefit the clinical treatment of AMD patients.     

眼底血管造影联合频域光相干断层扫描同步检查法对渗出性老年性黄斑变性脉络膜新生血管的诊断价值

Objective To evaluate the diagnostic value of Heidelberg retinal angiography(HRA) combined with optical coherence tomography (OCT) to detect neovascularization (CNV) in exudative age-related macular degeneration (AMD) patients. Methods This is a cross-sectional study of a series of clinical cases. AMD diagnosis was established by international standard vision chart, Slit lamp microscope, direct or indirect ophthalmoscope examination. A total of 50 eyes (42 cases) of exudative AMD received HRA and frequency domain OCT scan. All 50 eyes received fundus fluorescein angiography (FFA) and frequency-domain OCT simultaneously, and among them 15 eyes also received indocyanine green angiography (ICGA) at the same time. FFA and ICGA were carried out by conventional methods, CNV was localized by real-time Localization technology of frequency domain OCT. In the radial and grid-like section from the areas with strong fluorescence, image acquisition settings are 7 μm fault for each frame, 30° intervals for radialsection, 10 vertical and 10 horizontal scan lines for grid-like section. CNV can be divided into 4 types (typical CNV, partial typical CNV, occult CNV, CNV scarring) according to their boundaries demonstrated in FFA. Based on the features of the OCT images, there were 3 types of integrated image (sub-RPE type, sub-retinal type and mixed type). Results CNV was detected in all 50 eyes. There were 4 eyes (8%) of typical CNV, 11 eyes (22%) of partial typical CNV, 32 eyes (64 %, including 27 eyes of RPE detachment and 5 eyes of passive late leakage) of occult CNV and 3 eyes (6%) of CNV scarring. There were 4 eyes (8%) of sub-RPE type (CNV under the RPE light band) , 16 eyes (32%) of sub-retinal type(interrupted light band of RPE and choroid capillary layer) and 30 eyes (60%) of mixed type of integrated image. Conclusion The image integration technology of the HRA and frequency domain OCT system provide a valuable tool to classify and measure CNV, which will benefit the clinical treatment of AMD patients.     

眼底血管造影联合频域光相干断层扫描同步检查法对渗出性老年性黄斑变性脉络膜新生血管的诊断价值

Objective To evaluate the diagnostic value of Heidelberg retinal angiography(HRA) combined with optical coherence tomography (OCT) to detect neovascularization (CNV) in exudative age-related macular degeneration (AMD) patients. Methods This is a cross-sectional study of a series of clinical cases. AMD diagnosis was established by international standard vision chart, Slit lamp microscope, direct or indirect ophthalmoscope examination. A total of 50 eyes (42 cases) of exudative AMD received HRA and frequency domain OCT scan. All 50 eyes received fundus fluorescein angiography (FFA) and frequency-domain OCT simultaneously, and among them 15 eyes also received indocyanine green angiography (ICGA) at the same time. FFA and ICGA were carried out by conventional methods, CNV was localized by real-time Localization technology of frequency domain OCT. In the radial and grid-like section from the areas with strong fluorescence, image acquisition settings are 7 μm fault for each frame, 30° intervals for radialsection, 10 vertical and 10 horizontal scan lines for grid-like section. CNV can be divided into 4 types (typical CNV, partial typical CNV, occult CNV, CNV scarring) according to their boundaries demonstrated in FFA. Based on the features of the OCT images, there were 3 types of integrated image (sub-RPE type, sub-retinal type and mixed type). Results CNV was detected in all 50 eyes. There were 4 eyes (8%) of typical CNV, 11 eyes (22%) of partial typical CNV, 32 eyes (64 %, including 27 eyes of RPE detachment and 5 eyes of passive late leakage) of occult CNV and 3 eyes (6%) of CNV scarring. There were 4 eyes (8%) of sub-RPE type (CNV under the RPE light band) , 16 eyes (32%) of sub-retinal type(interrupted light band of RPE and choroid capillary layer) and 30 eyes (60%) of mixed type of integrated image. Conclusion The image integration technology of the HRA and frequency domain OCT system provide a valuable tool to classify and measure CNV, which will benefit the clinical treatment of AMD patients.     

眼底血管造影联合频域光相干断层扫描同步检查法对渗出性老年性黄斑变性脉络膜新生血管的诊断价值

Objective To evaluate the diagnostic value of Heidelberg retinal angiography(HRA) combined with optical coherence tomography (OCT) to detect neovascularization (CNV) in exudative age-related macular degeneration (AMD) patients. Methods This is a cross-sectional study of a series of clinical cases. AMD diagnosis was established by international standard vision chart, Slit lamp microscope, direct or indirect ophthalmoscope examination. A total of 50 eyes (42 cases) of exudative AMD received HRA and frequency domain OCT scan. All 50 eyes received fundus fluorescein angiography (FFA) and frequency-domain OCT simultaneously, and among them 15 eyes also received indocyanine green angiography (ICGA) at the same time. FFA and ICGA were carried out by conventional methods, CNV was localized by real-time Localization technology of frequency domain OCT. In the radial and grid-like section from the areas with strong fluorescence, image acquisition settings are 7 μm fault for each frame, 30° intervals for radialsection, 10 vertical and 10 horizontal scan lines for grid-like section. CNV can be divided into 4 types (typical CNV, partial typical CNV, occult CNV, CNV scarring) according to their boundaries demonstrated in FFA. Based on the features of the OCT images, there were 3 types of integrated image (sub-RPE type, sub-retinal type and mixed type). Results CNV was detected in all 50 eyes. There were 4 eyes (8%) of typical CNV, 11 eyes (22%) of partial typical CNV, 32 eyes (64 %, including 27 eyes of RPE detachment and 5 eyes of passive late leakage) of occult CNV and 3 eyes (6%) of CNV scarring. There were 4 eyes (8%) of sub-RPE type (CNV under the RPE light band) , 16 eyes (32%) of sub-retinal type(interrupted light band of RPE and choroid capillary layer) and 30 eyes (60%) of mixed type of integrated image. Conclusion The image integration technology of the HRA and frequency domain OCT system provide a valuable tool to classify and measure CNV, which will benefit the clinical treatment of AMD patients.     

原田病的吲哚青绿血管造影特征

目的 探讨原田(Harada)病的吲哚青绿血管造影(indocyanine green angiography,ICGA)特征。 方法 对26例经荧光素眼底血管造影(fundus fluorescien angiography,FFA)确诊的Harada病患者26例52只眼同时进行ICGA检查。 结果 Harada病的主要ICGA表现为：①早期异常暗的背景荧光5例8只眼；②脉络膜灌注不良12例18只眼；③脉络膜血管及涡静脉扩张20例34只眼；④晚期斑片状强荧光8例12只眼；⑤中周及后极部斑点状弱荧光4例5只眼。 结论 Harada病ICGA特征：早期异常暗的背景荧光，脉络膜灌注不良，脉络膜血管及涡静脉扩张，中周及后极部斑片状弱荧光，晚期可见斑片状强荧光。(中华眼底病杂志,2000,16:12-13)     

多发性后极部色素上皮病变的吲哚青绿和荧光素眼底血管造影

目的 研究多发性后极部色素上皮病变(multifocal posterior pigment epitheliopathy,MPPE)的视网膜和脉络膜循环特点,探讨该病的发病机制及其与中心性浆液性脉络膜视网膜病变(central serouschorioretinopathy,CSC)之间的关系。 方法 对6例MPPE患者的7只眼吲哚青绿血管造影(indocyanine green angiography,ICGA)和荧光素眼底血管造影(fundus fluorescein angiography,FFA)检查结果进行对比分析。 结果 5例5只眼FFA检查为活动期,其中4只眼在ICGA造影早期有脉络膜充盈延迟,占80%。FFA显示有渗漏处,ICGA均有相应的渗漏灶。在渗漏灶的周围及后极部尚有弥漫性相对强荧光。病变恢复期,FFA已无明显渗漏,ICGA仍显示脉络膜荧光渗漏。 结论 MPPE与CSC有着相同的ICGA改变,但前者病变范围更加广泛。MPPE为CSC的较严重型,为原发于脉络膜病变的疾病。(中华眼底病杂志,2000,16：6-8)     

多灶性脉络膜炎眼底血管造影的改变

目的 探讨多灶性脉络膜炎(multifocal choroiditis)患者的临床表现及吲哚青绿血管造影(ICGA)和荧光素眼底血管造影(FFA)的特点。 方法 收集多灶性脉络膜炎患者8例10只眼，分别对其临床特征和眼底血管造影图像进行分析。 结果 8例患者均表现为眼底后极部和周边部的多灶性脉 络膜病变；ICGA显示病灶区呈弱荧光，提示为脉络膜灌注不良；非活动性病灶表现为荧光染色和透见荧光，萎缩处可见脉络膜大血管。FFA显示病灶区呈弱荧光，活动性病灶晚期有渗漏，非活动性病灶呈透见荧光。 结论 原发于脉络膜的多灶性脉络膜炎的临床表现随病程长短、病变部位的不同和病灶多少而各异，ICGA和FFA可清晰地显示病变发展的过程，并可用于指导临床治疗。 （中华眼底病杂志，2004，20：87-89）     

伏格特小柳原田综合征的吲哚青绿眼底血管造影观察

目的 探讨利用吲哚青绿血管造影(indocyanine green angiography,ICGA)检查作为伏格特小柳原田(Vogt-Koyanagi-Harada,VKH)综合征临床观察指标的意义。 方法 对26例VKH患者荧光素眼底血管造影(fundus fluorescein angiography,FFA)和ICGA检查资料进行分析。 结果 FFA表现为色素上皮水平多数针尖状渗漏,快速形成多湖状荧光积存。治疗后上述改变很快消失。葡萄膜炎期ICGA表现：①66.7%的患眼为多数灶状弱荧光区域和脉络膜大、中血管荧光影像减少;②70.8%的患眼脉络膜血管扩张;③79.2%的患眼为造影后期显示灶状强荧光区。在病变恢复期,与FFA检查比较,ICGA的异常发现恢复缓慢。 结论 ICGA 可较好提供VKH的脉络膜循环损害的信息,并在评价疗效上有意义。(中华眼底病杂志,2000,16:9-11)     

多灶性脉络膜炎临床前期眼底血管与吲哚青绿血管造影分析

目的 探讨临床前期多灶性脉络膜炎(Multifocal choroiditis,MC)荧光素眼底血管造影(fundus fluorescein angiography,FFA)和吲哚青绿血管造影(Indocyanine green angiography,,ICGA)同步检查的影像学特征及其临床意义.方法 回顾分析10例确诊为MC患者的临床资料,分别对其FFA和ICGA对比分析.结果 10例患者17只眼中只有一例MC复发患者双眼后极部发现3～5个边界清楚的萎缩灶,其余15只眼眼底均未发现异常,3例患者玻璃体发现轻度的炎症细胞存在,17只眼FFA未发现活动期炎症病灶的存在;ICGA早期及中期无异常改变,而后期在后极部或视盘周围则出现圆形或椭圆形低荧光斑,成簇状分布,有的融合在一起.结论 临床前期的多灶性脉络膜炎眼底及FFA无明显改变,易误诊为其他疾病,ICGA有助于确诊,为指导治疗、挽救患者的视力以及缩短患者的病程提供了很大的帮助.     

多灶性脉络膜炎临床前期眼底血管与吲哚青绿血管造影分析

目的 探讨临床前期多灶性脉络膜炎(Multifocal choroiditis,MC)荧光素眼底血管造影(fundus fluorescein angiography,FFA)和吲哚青绿血管造影(Indocyanine green angiography,,ICGA)同步检查的影像学特征及其临床意义.方法 回顾分析10例确诊为MC患者的临床资料,分别对其FFA和ICGA对比分析.结果 10例患者17只眼中只有一例MC复发患者双眼后极部发现3～5个边界清楚的萎缩灶,其余15只眼眼底均未发现异常,3例患者玻璃体发现轻度的炎症细胞存在,17只眼FFA未发现活动期炎症病灶的存在;ICGA早期及中期无异常改变,而后期在后极部或视盘周围则出现圆形或椭圆形低荧光斑,成簇状分布,有的融合在一起.结论 临床前期的多灶性脉络膜炎眼底及FFA无明显改变,易误诊为其他疾病,ICGA有助于确诊,为指导治疗、挽救患者的视力以及缩短患者的病程提供了很大的帮助.     

多灶性脉络膜炎临床前期眼底血管与吲哚青绿血管造影分析

目的 探讨临床前期多灶性脉络膜炎(Multifocal choroiditis,MC)荧光素眼底血管造影(fundus fluorescein angiography,FFA)和吲哚青绿血管造影(Indocyanine green angiography,,ICGA)同步检查的影像学特征及其临床意义.方法 回顾分析10例确诊为MC患者的临床资料,分别对其FFA和ICGA对比分析.结果 10例患者17只眼中只有一例MC复发患者双眼后极部发现3～5个边界清楚的萎缩灶,其余15只眼眼底均未发现异常,3例患者玻璃体发现轻度的炎症细胞存在,17只眼FFA未发现活动期炎症病灶的存在;ICGA早期及中期无异常改变,而后期在后极部或视盘周围则出现圆形或椭圆形低荧光斑,成簇状分布,有的融合在一起.结论 临床前期的多灶性脉络膜炎眼底及FFA无明显改变,易误诊为其他疾病,ICGA有助于确诊,为指导治疗、挽救患者的视力以及缩短患者的病程提供了很大的帮助.     

Fundus fluorescein and indocyanine green angiographic study of Behcet's disease and Vogt-Koyanagi-Harada syndrome

OBJECTIVE: To study the choroidal and retinal changes in Behcet's disease and Vogt-Koyanagi-Harada syndrome (VKHS) using indocyanine green angiography (ICGA) and fundus fluorescein angiography (FFA). METHODS: Seventeen cases (27 eyes) of Behcet's disease and 18 cases (36 eyes) of VKHS were examined with FFA and ICGA. All of the patients showed an active intraocular inflammation when examined. RESULTS: FFA showed leakage from retinal vessels in patients with Behcet's disease. ICGA revealed choroidal abnormalities including dilatation and hyperpermeability of choroidal vessels in 11 eyes (40.7%). In VKHS, FFA revealed the hyperfluorescence and serous pigment epithelium detachments. Dilatation and hyperpermeability of choroidal vessels revealed by ICGA were found in 36 eyes (100%), multihypofluorescent dark dots in 32 eyes (88.9%), and choroidal filling defects in 28 eyes (77.8%). CONCLUSIONS: Although retinal vascular lesions are predominant in Behcet's disease, choroidal abnormalities evidenced by dilatation of choroidal vessels are also present in some patients. Hyperfluorescence and hypofluorescence revealed are the main findings in the patients with VKHS. A combination of FFA and ICGA is recommended for the examination of Behcet's disease and VKHS.     

Stargardt病的FFA和ICGA同步造影释义

目的：了解Stargardt病在同步进行的眼底荧光血管造影（fundus fluorescein angiography,FFA)和吲哚青绿血管造影(indocyanine green angiography,ICGA)过程中,不同时期的荧光表现。方法：使用海德堡共焦激光眼底扫描系统（Heidelberg Retina Angiography,HRA),对7例14眼典型的Stargardt病患者进行FFA和ICGA同步造影检查,对所摄取的同步图像进行同期对比分析。结果：14只眼的FFA检查均表现出明显的脉络膜湮没征（choroidal silence sign or dark choroid),ICGA则能显现脉络膜血管,但有10只眼的脉络膜血管影像比正常的暗。黄斑部病变在FFA检查中,14只眼均表现为典型的横椭圆形强烈的透见荧光,而在ICGA检查中,早期14只上均表现出比周期更强的脉络膜血管荧光,晚期(＞20分钟）有8只眼发现围绕黄斑病灶有一环形的弱荧光晕,8只眼除黄斑病灶外还伴有黄色斑点,在FFA检查中,黄色斑点大部分表现为高荧光斑,而在ICGA检查中则在大部分表现为低荧光斑,偶而有散在的高荧光点。结论：FFA和ICGA同步造影可以帮助我们了解同一病变部位,在同一时刻,不同造影的不同荧光表现,其联合应用可以加深对Stargardt病病理的认识和理解。     

脉络膜转移癌的荧光素和吲哚菁绿血管造影的影像分析

目的：比较脉络膜转移癌的荧光素眼底血管造影(FFA)及吲哚菁绿血管造影(ICGA)的影像特点,为该疾病的准确诊断提供依据。

方法：经临床诊断,有明确原发恶性肿瘤病灶的患者6例8眼,散瞳后行眼底照相,用海德堡眼底血管造影仪行FFA及ICGA同步造影,比较两种影像学检查的异同。

结果：FFA早期显示瘤体为低荧光,中期呈现针尖样或斑点样荧光,晚期表现为斑驳样强荧光,部分病例病灶边缘呈强荧光环带; ICGA显示的病灶表现为低荧光,整个造影过程中荧光强弱无明显变化,仅有1例病例在反转期出现中央及病灶周围的点状强荧光。

结论：FFA和ICGA对于脉络膜转移癌有较为特征性的表现,二者结合有助于脉络膜转移癌的诊断。