Recent advances in the treatment of hyponatremia

Hyponatremia is a common and potentially serious electrolyte disorder, most often caused by excessive arginine vasopressin (AVP) secretion. Conventional management of hyponatremia is based on graded steps starting from water restriction in mild cases to administration of saline in symptomatic cases, which may not be effective. A major new approach in the treatment of hyponatremia is the development of AVP receptor antagonists that directly inhibit the effect of increased AVP which results in the excretion of electrolyte free water. This review summarizes pathophysiology, conventional treatment and future directions in the treatment of hyponatremia.     

Recent advances in the treatment of hyponatremia

Hyponatremia is a common and potentially serious electrolyte disorder, most often caused by excessive arginine vasopressin (AVP) secretion. Conventional management of hyponatremia is based on graded steps starting from water restriction in mild cases to administration of saline in symptomatic cases, which may not be effective. A major new approach in the treatment of hyponatremia is the development of AVP receptor antagonists that directly inhibit the effect of increased AVP which results in the excretion of electrolyte free water. This review summarizes pathophysiology, conventional treatment and future directions in the treatment of hyponatremia.     

Recent advances in the treatment of psoriatic arthritis

This article provides an overview of recent developments in the treatment of psoriatic arthritis with an emphasis on patent literature for the period January 1998 to December 2002. The main pathogenic pathways thought to be operative in psoriatic arthritis are highlighted and some novel compounds that can potentially interfere with such pathways at different levels are discussed. Among the new agents proposed, the inhibitors of cytokine signaling, angiogenesis, and extracellular matrix degradation appear to be of particular interest for the treatment of psoriatic arthritis resistant to conventional therapies. Finally, new formulations of existing drugs and natural remedies claimed to be useful for the treatment of psoriatic arthritis are reviewed.     

Recent advances in the treatment of gastric cancer

Gastric cancer is one of the most common cancers in the world. The prognosis of the disease is poor, with only 40% of patients eligible to undergo potentially curative surgery. Even for those patients who undergo a complete resection, the rate of recurrence is very high. Extensive studies of multidisciplinary adjuvant treatment have been conducted seeking to improve the cure rates in the past two decades. The benefit of D2 dissection is still controversial and is undergoing prospective evaluation. Preliminary results from the United States Gastrointestinal Intergroup study, a well designed trial, have shown overall survival benefit of postoperative chemoradiation therapy. Neoadjuvant chemotherapy or chemoradiation is under active study in order to increase the number of patients to undergo potential curative surgery. Although many chemotherapy regimens have been developed recently, only modest clinical efficacy has been demonstrated for advanced metastatic disease. So far, there is no single regimen considered to be standard.     

Recent advances in the treatment of L-DOPA-induced dyskinesia

Parkinson's disease (PD) is a degenerative movement disorder resulting from the loss of dopaminergic neurons in the substantia nigra pars compacta. The most widely used treatment for PD is administration of the dopamine precursor L-DOPA, although this eventually results in uncontrolled involuntary movements (dyskinesia) that can be more debilitating than the underlying disease itself. The causes of L-DOPA-induced dyskinesia are unclear, but probably involve non-physiological pulsatile stimulation of dopamine receptors or non-physiological dopamine release (eg, from serotonergic nerve terminals) in the striatum. In any case, this signaling leads to an imbalance in the activity of two basal ganglia pathways, the 'direct' and 'indirect' striatal output pathways, that are characterized by distinct neurochemical architectures. The wide range of neurotransmitter and neuromodulatory receptors present on these two striatal output pathways offers a huge range of potential therapeutic targets. Two main strategies for the treatment of dyskinesia exist: the use of drugs that can be given as an adjunct to L-DOPA, reducing the occurrence of dyskinesia without impairing its antiparkinsonian effect, or therapies with equal antiparkinsonian action as L-DOPA that do not elicit dyskinesia. Novel treatments for dyskinesia in clinical/preclinical development include A(2alpha) receptor antagonists, alpha(2) adrenoceptor antagonists, mu-opioid receptor antagonists and subtype-selective NMDA antagonists. Future research strategies are likely to focus on the molecular mechanisms underlying the emergence of dyskinesia and may lead to the development of agents that can prevent or reverse the cellular changes underlying this phenomenon.     

Recent advances in the treatment of gestational diabetes

Despite four decades of research there is a lack of international consensus on the screening, diagnosis, treatment and follow up of gestational diabetes mellitus (GDM). Currently, GDM is managed by diet modification, exercise and exogenous human insulin. During the last decade, several insulin analogues and oral antihyperglycaemic drugs have revolutionised the management of diabetes mellitus in non-pregnant women. Most of these recent drugs still remain investigational in GDM due to concerns about their safety in pregnancy. This review will focus primarily on the pharmacological treatment of GDM. It will objectively assess the value of these exciting new drugs in pregnancy as they could potentially benefit every woman with GDM.     

Recent advances in the pharmacological treatment of tinnitus

Tinnitus is an extremely prevalent condition that impinges on the lives of sufferers to varying degrees. In some people, it is a fairly minor irritation but, for many, the tinnitus intrudes to such a degree that it affects their ability to lead a normal life, and in some very extreme cases has resulted in suicide. Insomnia, inability to concentrate and depression are commonly reported to accompany the condition. Relief can be reliably obtained using intravenous lignocaine, which indicates that pharmacology can provide a route for effective alleviation of the condition. In this article, Julie Simpson and Ewart Davies review the potential pharmacological therapies, and emphasize that clinical research has been hampered by the absence of a reliable objective assessment of the tinnitus and by the variable nature of the complaint.     

Recent advances in the treatment of gestational diabetes

Despite four decades of research there is a lack of international consensus on the screening, diagnosis, treatment and follow up of gestational diabetes mellitus (GDM). Currently, GDM is managed by diet modification, exercise and exogenous human insulin. During the last decade, several insulin analogues and oral antihyperglycaemic drugs have revolutionised the management of diabetes mellitus in non-pregnant women. Most of these recent drugs still remain investigational in GDM due to concerns about their safety in pregnancy. This review will focus primarily on the pharmacological treatment of GDM. It will objectively assess the value of these exciting new drugs in pregnancy as they could potentially benefit every woman with GDM.     

川崎病治疗新进展

川崎病又称皮肤黏膜淋巴结综合征,是一种以全身性中、小动脉炎性病变为主要病理改变的热性发疹性疾病。急性期联合应用丙种球蛋白和阿司匹林是川崎病的首选治疗方案。对于糖皮质激素的使用临床尚有争议。恢复期治疗以抗凝,溶栓为主。严重冠状动脉病变可采用外科及介入治疗。     

强直性脊柱炎治疗新进展

强直脊柱炎的药物治疗一直为风湿病学家所关注,本文综述了近年来新的药物,包括皮质类固醇激素、COX-2特异性抑制剂、甲氨蝶呤、帕米膦酸盐、沙利度胺（反应停）、TNF单克隆抗体及阿米替林的治疗方案、疗效、作用机制和不良反应等。     

隐球菌脑膜炎治疗新进展

<正> 隐球菌脑膜炎(隐脑)是隐球菌属中某些种类或变种侵犯中枢神经系统引起的一种深部真菌感染,其病情重,治疗困难,病死率高。近年来隐脑的发病率呈明显上升趋势,突出表现在艾滋病(AIDS)人群中,据统计,美国约有5％～10％的AIDS患者发生隐脑;我国以散发、非AIDS人群为主,但也有     

Recent advances in the pharmacological treatment of colorectal cancer

Recent advances in the treatment of colorectal cancer have lead to significant gains in response rates and survival. The combination of newer agents such as irinotecan and oxaliplatin with 5-fluorouracil/leucovorin using various dosing schedules in the metastatic setting has resulted in a steady improvement in the outcome of patients with colorectal cancer. Experimental therapies such as epidermal growth factor receptor inhibitors, vascular endothelial growth factor inhibitors and cyclooxygenase-2 inhibitors, have shown promise in early clinical trials and have acceptable toxicity profiles. Efforts towards improving risk-stratification of stage II colorectal cancer patients and optimising therapy in patients with advanced disease, have focused on molecular and genetic markers. It is hoped that the addition of new therapies to existing drug combinations, as well as further advances in the understanding of colorectal cancer biology, will lead to further improvement in survival and quality of life for patients.     

Recent advances in the treatment of polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disorder that presents a challenge for clinical investigators. It is the most common endocrine disorder of reproductive-aged women, yet the optimal therapeutic approach is unknown because the pathophysiological and molecular basis of the syndrome is not fully understood. Currently, the treatment is targeted to the patient's primary complaint. Treatment strategies focus on the reduction of clinical manifestations of hyperandrogenism (e.g., hirsutism), restoration of regular menses and achieving pregnancy. Pharmacological agents available for the treatment of hirsutism include androgen suppressors and peripheral androgen blockers. Combined oral contraceptive pills are the most commonly used androgen suppressor and the treatment of choice for menstrual dysfunction in PCOS patients who do not desire pregnancy. The first-line treatment for infertility in PCOS is clomiphene-citrate, whereas parenteral gonadotropins are commonly used in clomiphene-resistant patients. The benefits of insulin-sensitising agents for PCOS patients have become increasingly clear over the last decade. Metabolic disturbances associated with PCOS appear to have important long-term health implications and require further attention. This review summarises the current and emerging therapeutic strategies for the management of PCOS.     

Recent advances in the pharmacological treatment of colorectal cancer

Recent advances in the treatment of colorectal cancer have lead to significant gains in response rates and survival. The combination of newer agents such as irinotecan and oxaliplatin with 5-fluorouracil/leucovorin using various dosing schedules in the metastatic setting has resulted in a steady improvement in the outcome of patients with colorectal cancer. Experimental therapies such as epidermal growth factor receptor inhibitors, vascular endothelial growth factor inhibitors and cyclooxygenase-2 inhibitors, have shown promise in early clinical trials and have acceptable toxicity profiles. Efforts towards improving risk-stratification of stage II colorectal cancer patients and optimising therapy in patients with advanced disease, have focused on molecular and genetic markers. It is hoped that the addition of new therapies to existing drug combinations, as well as further advances in the understanding of colorectal cancer biology, will lead to further improvement in survival and quality of life for patients.     

Recent advances in the treatment of systemic fungal infections

Systemic fungal infections are life-threatening diseases that are occurring with increasing frequency, especially in immunocompromised patients. Advances in the treatment of systemic fungal infections have been achieved through better understanding of two classic antifungal drugs, amphotericin B and flucytosine, and through the recent development of several antifungal azole derivatives. The purpose of this paper is to review the recent advances in pharmacology, toxicology, formulation and clinical trials of antifungal agents for the treatment of systemic mycoses.     

Recent advances in the treatment of epithelial ovarian cancer

Ovarian cancer leads to more fatalities than any other form of gynaecological cancer in North America and Europe. Over the last 30 years survival figures have improved somewhat due to improvements in diagnosis, surgery and chemotherapy. Despite these advances, the majority of patients will die from their disease, with the overall 5-year survival being just 30%. The majority of patients with this disease will require treatment with cytotoxic chemotherapy. It is now well established that the platinum agents (cisplatin or carboplatin) are the most important drugs to be included in first-line regimens. More recently, randomised trials have confirmed the benefit of the addition of taxanes to platinum-containing regimens and the standard of care has become the combination of carboplatin and paclitaxel. Several unanswered questions remain regarding the optimal schedule, the optimum duration of treatment, possible benefits to be gained from the addition of other drugs and whether paclitaxel the best taxane. Despite high response rates to first line chemotherapy, the majority of patients with advanced ovarian cancer will relapse and will be candidates for further chemotherapy, which can palliate symptoms and improve survival even in recurrent disease. For a patient relapsing within six months of first-line treatment, studies have shown that there is little point in rechallenge with the same drugs. However, for patients who have a longer treatment-free interval the response rates to rechallenge with platinum is significant. A number of drugs have been shown to have activity in platinum- and taxane-refractory disease and are approved for this and/or other applications. These include topotecan, etoposide, pegylated liposomal doxorubicin, epirubicin, gemcitabine, altretamine, oxaliplatin and vinorelbine. Anti-oestrogens such as tamoxifen have a small but significant response rate. Recurrent ovarian cancer is a good setting to test investigational agents and compounds with promising activity including new platinums and taxoids, as well as a range of new compounds. Non-cytotoxic approaches that are showing promise include therapies designed to overcome drug resistance, signal transduction inhibitors, immunotherapy and gene therapy.     

Recent advances in the treatment of chronic hepatitis B

Introduction: At present, two strategies exist for the treatment of chronic hepatitis B (CHB): i) standard or pegylated interferon alpha (IFN) with mainly immune modulatory effects; and ii) nucleos(t)ide analogues (NA) with direct antiviral effects. The optimal treatment for an individual patient remains controversial. Areas covered: The treatment efficacy and prediction of response to antiviral agents for chronic hepatitis B are reviewed and discussed. Expert opinion: The rates of hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) loss or seroconversion are continuously increasing in CHB patients after stopping a finite course of IFN, whereas long-term NA therapy is usually required to improve the adverse outcomes of CHB. Lower baseline HBV DNA level is a strong predictor for both sustained viral suppression and HBeAg seroconversion in patients receiving IFN-based as well as NAs therapy. In addition, HBeAg-positive patients with genotype A or B infection have better responses to IFN-based therapy than those with genotypes C or D infection. Furthermore, on-treatment predictors such as declines of serum HBV DNA, HBsAg and HBeAg levels may be helpful in making decisions of subsequent therapy. Regarding the association of host genetic factors with responses to antiviral therapy, current evidence is limited.     

Recent advances in the treatment of polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disorder that presents a challenge for clinical investigators. It is the most common endocrine disorder of reproductive-aged women, yet the optimal therapeutic approach is unknown because the pathophysiological and molecular basis of the syndrome is not fully understood. Currently, the treatment is targeted to the patient’s primary complaint. Treatment strategies focus on the reduction of clinical manifestations of hyperandrogenism (e.g., hirsutism), restoration of regular menses and achieving pregnancy. Pharmacological agents available for the treatment of hirsutism include androgen suppressors and peripheral androgen blockers. Combined oral contraceptive pills are the most commonly used androgen suppressor and the treatment of choice for menstrual dysfunction in PCOS patients who do not desire pregnancy. The first-line treatment for infertility in PCOS is clomiphene-citrate, whereas parenteral gonadotropins are commonly used in clomiphene-resistant patients. The benefits of insulin-sensitising agents for PCOS patients have become increasingly clear over the last decade. Metabolic disturbances associated with PCOS appear to have important long-term health implications and require further attention. This review summarises the current and emerging therapeutic strategies for the management of PCOS.