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G蛋白偶联雌激素受体在雌激素相关肿瘤发生中的作用 总被引:1,自引:0,他引:1
《中国药理学通报》2014,(8)
在经典的雌激素核受体α和β之外,雌激素或雌激素样物质也可以经过膜受体,即G蛋白偶联雌激素受体(GPER)发挥功能。G蛋白偶联雌激素受体是雌激素非基因通路信号转导过程的重要介导因子,在雌激素相关肿瘤细胞的发生和治疗中具有重要的意义。现针对G蛋白偶联雌激素受体在雌激素相关肿瘤细胞中介导的效应及有关机制的研究进展进行综述。 相似文献
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雌激素受体及与雌激素相关疾病的研究进展 总被引:1,自引:0,他引:1
雌激素是一种由雌激素受体基因表达的重要类固醇激素,在体内靶组织众多,具有广泛的生物学活性。雌激素受体是类固醇激素受体超家族成员之一,由于其分布的广泛性及生物效应的复杂性,因而受到广泛关注。该文就雌激素受体及与雌激素不同途径的生物效应相关的疾病研究进展情况进行阐述,旨在进一步认识其广泛性作用,为临床雌激素相关性疾病的预防和治疗提供借鉴。 相似文献
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雌激素膜受体GPR30的研究进展 总被引:1,自引:0,他引:1
雌激素膜受体GPR30作为一个独立的雌激素受体,介导了雌激素众多的生理功能,该文就GPR30的结构、定位、信号通路和生物学效应作一综述。 相似文献
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目的 观察雌激素与雌激素受体在大鼠肝脏缺血再灌注损伤中的作用.方法 用Pringle's大鼠全肝缺血再灌注损伤模型,选取健康清洁级雄性SD大鼠120只,随机分成假手术组、肝缺血再灌注组和雌激素干预组(预处理+肝缺血再灌注组)3组,每组各40只;检测血清谷丙转氨酶(ALT)水平,HE染色观察肝脏组织形态学变化,ELISA法测定血清肿瘤坏死因子-a(TNF-a)水平,免疫组化方法检测肝脏组织核转录因子(NF-KB)和雌激素受体(ER)的表达情况.结果 假手术组,血清ALT,TNF-a水平升高不明显,ER,NF-KB表达无明显变化,肝脏组织形态学改变不明显;缺血再灌组、雌激素干预组的ALT,TNF-a水平与ER,NF-KB表达显著升高;但雌激素干预组ER表达明显高于缺血再灌组,缺血再灌组的NF-KB表达明显高于雌激素干预组,缺血再灌组的肝脏组织损伤程度显著高于雌激素干预组.结论 雌激素能刺激雌激素受体表达,进而降低TNF-a水平、抑制NF-KB表达,来减轻肝脏缺血再灌注损伤. 相似文献
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选择性雌激素受体调节剂 总被引:2,自引:0,他引:2
对选择性雌激素受体调节剂(SERM)的定义、作用机制及其临床研究应用进行了概述,介绍了SERM在不同的靶组织可以表现为雌激素激动剂和(或)拮抗剂的作用,雌激素的作用模型及其与SERM的不同作用靶位,各类SERM的临床应用情况和发展前景。 相似文献
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目的研究雌激素、雌激素受体与乳腺癌的关系。方法收集2006至2010年天津西青医院病理科47例乳腺癌病例,用免疫组织化学染色进行雌激素受体检测。结果 32例乳腺癌患者雌激素受体阳性,15例阴性。结论雌激素、雌激素受体与乳腺癌三者之间的关系密切。 相似文献
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H. Timmerman 《Pharmacy World & Science》1989,11(5):146-150
The role of histamine in brain function is discussed. A brief review is presented on the three types of histamine receptors with regard to their biochemistry and functions, as well as on specific ligands, both agonists and antagonists. It is concluded that several aspects of the pharmacology of histamine in the central nervous system are still a matter of empirism and speculations. The recent publications on the brain-penetrating H2 antagonist zolantidine and the selective H3 agonists and antagonists are expected to contribute to the knowledge of the histaminergic pathways in the brain. Therapeutical areas within the central nervous system are related to behaviour (including wake-sleep), neuroendocrinal processes, the control of muscle activity and cerebral circulation. 相似文献
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《Biochemical pharmacology》2015,98(4):512-517
Recent published findings have shown that many proteins discovered in the immune system and residing on immune cells with well established immune-related functions are also found in neurons of the central nervous system. These studies have uncovered a rich variety of neuronal functions attributed to these immune proteins. This review will focus on two key interacting protein complexes that previously were known for adaptive immune reactions, the major histocompatability complex and the T-cell receptor complex. We will review where these immune proteins are expressed in the CNS and their neuronal function. 相似文献
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目的 了解中枢神经系统感染性疾病的临床流行特征。方法 对2012—2016年间安徽医科大学第一附属医院住院诊断为中枢神经系统感染的805例病例进行回顾性资料分析。按照病种构成、年度分布、年龄分布、季节分布、性别差异、城乡分布和病死率等特征进行临床流行病学统计分析。结果 主要病种构成依次为:病毒性脑炎73.4%,化脓性脑膜炎13.2%、结核性脑膜炎8.0%、隐球菌脑膜炎4.2%、脑寄生虫病1.2%。病毒性脑炎发病年龄以10岁以内儿童感染为主,化脓性脑膜炎10岁以内和60岁以上年龄段感染者较多,结核性脑膜炎发病集中在10岁以后且有老龄化趋势,隐球菌脑膜炎以青壮年发病较多。病毒性脑炎和结核性脑膜炎的发病季节主要是春季。5种中枢神经系统感染性疾病中,男女构成比均差异无统计学意义(P>0.05)。除脑寄生虫病10例均发生于农村,其他四种城乡差异无统计学意义(P>0.05)。中枢神经系统感染性疾病的总病死率为8.8%,病死率前3位者为隐球菌脑膜炎、结核性脑膜炎、化脓性脑膜炎。化脓性脑膜炎病原菌以肺炎链球菌、大肠埃希菌、脑膜炎双球菌为主。引起病毒性脑炎的病毒主要为肠道病毒及疱疹病毒。结论 安徽地区中枢神经系统感染的病种构成依次为:病毒性脑炎>化脓性脑膜炎>结核性脑膜炎。儿童病毒性脑炎和化脓性脑膜炎多见,老年人化脓性脑膜炎和结核性脑膜炎多见,HIV合并隐球菌脑膜炎有所增加。中枢神经系统感染病死率较高。 相似文献
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Five neuroleptics: penfluridol, haloperidol, chlorpromazine, pimozide and oxypertine, and two benzodiazepine minor tranquilizers; chlordiazepoxide and diazepam, were studied in mice and rats. When the drugs were injected i.p. in mice, all neuroleptics increased the brain homovanillic acid (HVA) concentration but two benzodiazepines did not change it. Of the drugs tested, only pimozide increased the brain level of 5-hydroxyindoleacetic acid. Penfluridol accelerated the turnover rate of brain dopamine (DA), wheras haloperidol accelerated both DA and noradrenaline turnover rates. In rats, oral administration of penfluridol caused an increase in the striatal HVA and 3,4-dihydroxyphenylacetic acid which persisted longer than that following haloperidol. The concentration of brain 3-methoxy-4-hydroxyphenylethylene glycol, however, was not affected by penfluridol even when the drug was administered at a high dose. Based on these and earlier findings, it is concluded that the effect of penfluridol on DA metabolism resembles that of typical neuroleptic compounds and penfluridol acts only on DA neurons as a long-acting DA receptor blocker. 相似文献
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