Perceived treatment, feedback, and placebo effects in double-blind RCTs: an experimental analysis

Introduction  

In double-blind randomized placebo-controlled trials (RCT) of therapeutic interventions, the effects of the treatment may provide feedback that undermines blinding and consequently distorts measures of the effectiveness of the intervention.     

Genetic analysis of thiopurine methyltransferase polymorphism in the Jordanian population

   

This study provides the first analysis of the TPMT mutant allele frequency in a sample of the Jordanian population and indicates that TPMT*3A is the most common allele in Jordanian subjects.     

Drug utilisation on a preterm and neonatal intensive care unit in Germany: a prospective, cohort-based analysis

Purpose  

This study aims to describe the drug use on a Neonatal Intensive Care Unit (NICU) at a University Children’s Hospital in Germany, to investigate the licensing status of the drugs used and to conclude critical areas in neonatal intensive care to support prioritisation of future research.     

Taylor dispersion analysis compared to dynamic light scattering for the size analysis of therapeutic peptides and proteins and their aggregates

Purpose  

To evaluate Taylor dispersion analysis (TDA) as a novel method for determination of hydrodynamic radius of therapeutic peptides and proteins in non-stressed and stressed formulations and to compare it with dynamic light scattering (DLS).     

Pharmacokinetics,safety, and tolerability of ribavirin in hemodialysis-dependent patients

Purpose  

This study describes the pharmacokinetics, safety, and tolerability of ribavirin in hemodialysis-dependent patients.     

Eltrombopag, an oral thrombopoietin receptor agonist, has no impact on the pharmacokinetic profile of probe drugs for cytochrome P450 isoenzymes CYP3A4, CYP1A2, CYP2C9 and CYP2C19 in healthy men: a cocktail analysis

Purpose  

It is likely that the thrombopoietin receptor agonist eltrombopag will be administered concomitantly with other medications in the treatment of thrombocytopenia. Therefore the potential for eltrombopag to interact with cytochrome P450 activity was investigated.     

Development of Lidocaine-Coated Microneedle Product for Rapid, Safe, and Prolonged Local Analgesic Action

Purpose  

To demonstrate rapid (~1 min) lidocaine delivery using 3M’s solid microstructured transdermal system (sMTS) for prolonged, local analgesic action.     

Population pharmacokinetic analysis of letrozole in Japanese postmenopausal women

Purpose  

Letrozole is an orally active aromatase inhibitor for the treatment of breast cancer. The objectives of this study were to examine the pharmacokinetic profile of letrozole in Japanese subjects and to identify factors that influence variability in the pharmacokinetics of letrozole using population pharmacokinetic (PPK) analysis.     

Evaluation of Docetaxel-Loaded Intravenous Lipid Emulsion: Pharmacokinetics,Tissue Distribution,Antitumor Activity,Safety and Toxicity

Purpose  

The purpose of this study was to carry out a detailed evaluation of an intravenous lipid emulsion for docetaxel (DLE) without Tween 80 before clinical administration.     

Hepatic CYP2A6 levels and nicotine metabolism: impact of genetic, physiological, environmental, and epigenetic factors

Purpose  

We investigated the role of genetic, physiological, environmental, and epigenetic factors in regulating CYP2A6 expression and nicotine metabolism.     

Effects of acute administration of nicotine,amphetamine, diazepam,morphine, and ethanol on risky decision-making in rats

Rationale  

Most individuals can accurately assess the risks and rewards associated with choice alternatives and decide accordingly; however, drug users often display maladaptive decision-making, such that choices are biased toward excessively risky options.     

Residual effects of esmirtazapine on actual driving performance: overall findings and an exploratory analysis into the role of CYP2D6 phenotype

Introduction  

Esmirtazapine is evaluated as a novel drug for treatment of insomnia.     

Effects of personality on use of medications,alcohol, and cigarettes during pregnancy

Purpose  

The aim of the study was to examine the role of personality in a pregnant woman’s consumption of medications, cigarettes, and alcohol.     

Randomized, controlled, double-blind trial of taranabant for smoking cessation

Rationale  

It has been proposed that cannabinoid-1 receptor inverse agonists might be effective for smoking cessation. We evaluated this hypothesis with the cannabinoid-1 receptor inverse agonist taranabant.     

Organizing pneumonia: Manifestation peculiarities,causes, and outcomes

Introduction  

Organizing pneumonia (OP) is a rare disorder which may be associated with various clinical contexts and radiological patterns.     

Investigation of the Mechanism of Clearance of AMG 386, a Selective Angiopoietin-1/2 Neutralizing Peptibody,in Splenectomized,Nephrectomized, and FcRn Knockout Rodent Models

Purpose  

To investigate the mechanisms of clearance of AMG 386, an investigational recombinant peptide-Fc fusion protein (peptibody) that blocks tumor angiogenesis by neutralizing the interaction between angiopoietin-1 and -2 and the Tie2 receptor.     

A comparative analysis of the decongestive effect of oxymetazoline and xylometazoline in healthy subjects

Background  

Oxymetazoline and xylometazoline are locally effective and direct acting drugs that relieve nasal congestion. The aim of this study was to objectively determine and compare the decongestive effects of oxymetazoline and xylometazoline in healthy subjects.     

The interactions of age, sex, body mass index, genetics, and steroid weight-based doses on tacrolimus dosing requirement after adult kidney transplantation

Purpose  

The aim of this study was to evaluate the effect of different clinical covariates on tacrolimus dose requirements in adult kidney transplant patients with a specific focus on drug interactions.     

Stress in the daily lives of cocaine and heroin users: relationship to mood,craving, relapse triggers,and cocaine use

Rationale  

Quantitative real-time data on the stress experienced by drug misusers in their daily lives may provide additional insight into stress’s role in drug use.     

The effect of a novel VMAT2 inhibitor,GZ-793A,on methamphetamine reward in rats

Rationale  

Previous research suggests that the vesicular monoamine transporter-2 (VMAT2) is a novel target for the treatment of methamphetamine (METH) abuse.