关节镜下膝关节多发韧带损伤修复与重建患者术后康复护理的临床效果

目的探讨关节镜下膝关节多发韧带损伤修复与重建患者术后康复护理的临床效果。方法抽取30例膝关节多发韧带损伤修复病人给予探讨,随机分组,对照组采取一般护理措施,研究组采取术后康复护理。结果通过比较,研究组好于对照组,差异明显,具有统计学意义。结论针对膝关节多发韧带损伤病人开展术后康复护理,增强膝关节功能,提升生活质量,有助于疾病恢复,具有良好的临床作用。     

前交叉韧带重建术后运动康复临床研究

目的 探讨前交叉韧带重建术后康复方法的安全性和有效性,力求确定一种有指导价值的康复方案.方法 选取前交叉韧带重建术后患者60例为研究对象.按照术后是否严格完成康复计划分为2组:康复训练组(40例)和对照组(20例).随访至术后1年,比较2组膝关节活动度、Lysholm评分、大腿肌肉放松和收缩状态、关节功能及稳定性等指标变化情况.结果 2组在住院时间、手术时间、关节腔穿刺治疗率等方面差异无统计学意义(P＞0.05);术后1年康复组在膝关节活动度、大腿肌肉放松和收缩状态、Lysholm评分均明显优于对照组,差异有统计学意义(P＜0.05).结论 本康复方案对于前交叉韧带损伤术后功能的恢复安全有效,建议前交叉韧带损伤重建患者选用.     

前交叉韧带重建术后早期应用中医推拿手法的康复疗效

目的探讨前交叉韧带重建术后早期应用中医推拿手法的康复疗效。方法自2018年1月我院收治行单纯前交叉韧带重建术的患者30例随机分成两组,对照组15例行标准前交叉韧带重建术后康复治疗,包括肌肉锻炼与活动度练习;中医推拿组15例在标准的前交叉韧带重建术后康复治疗的基础上增加中医推拿手法,推拿手法自术后1周开始,持续四周;分别于术后1、3、6个月测量患肢膝关节活动度与大腿周径,术前与术后6个月采用Lysholm评分标准对患者膝关节功能进行评估,并对结果进行统计学分析。结果两组患者术前术后Lysholm评分均有明显提升(P0.05),但二组之间无明显统计学差异(P0.05);中医推拿组术后1个月的患肢膝关节活动度与大腿周径均比对照组高,有明显统计学差异(P0.05),术后3、6个月患肢膝关节活动度与大腿周径无明显统计学差异(P0.05)。结论前交叉韧带重建术后早期应用中医推拿手法可以有效的降低膝关节粘连的发生率,提升肌肉力量,加速前交叉韧带重建术后的康复过程。     

两种屈膝角度固定移植物对前交叉韧带重建术后膝关节功能的影响

目的：探讨两种屈膝角度固定移植物对前交叉韧带（ ACL）重建术后膝关节功能的影响。方法：选取ACL损伤患者20例,分为实验组和对照组,使用LARS人工韧带重建ACL,实验组在屈膝90°拧入钛螺钉固定胫骨侧韧带,对照组在屈膝70°拧入钛螺钉固定胫骨侧韧带;比较两组患者膝关节功能评分（ Lysholm评分和IK-DC的主观评分）、大腿周径差值和膝关节最大屈曲角度。结果：术后6月内,实验组Lysholm评分、IKDC主观评分高于对照组,膝关节最大屈曲角度大于对照组,差异有统计学意义（ P＜0.05）;术后1～6月,实验组患者大腿周径差值小于对照组,差异有统计学意义（ P＜0.05）;两组大腿周径差值和膝关节最大屈曲角度随术后恢复时间的延长而逐渐缩小,至术后12个月,实验组膝关节最大屈曲角度仍大于对照组（ P＜0.05）。结论：屈膝90°固定移植物比屈膝70°对ACL重建术后膝关节的疗效好。     

骨创伤患者术后康复功能锻炼和护理干预方案探析

目的：探讨骨创伤患者进行术后康复功能锻炼和对其进行护理干预的有效方案。方法：将2011年3月至2013年3月我院收治120例进行手术治疗的骨创伤患者按照随机数表的方法分为观察组和对照组，每组各60例患者。为对照组患者在术后进行常规骨科护理干预，为观察组患者在进行常规护理干预的基础上让其有针对性地进行综合康复功能锻炼，对比分析两组患者在接受相应护理干预后关节功能恢复的情况、术后疼痛改善的情况及住院时间等指标。结果：观察组患者患肢功能康复的优良率明显高于对照组患者，差异显著（P＜0.05），有统计学意义；其住院时间明显短于对照组患者，差异显著（P＜0.05），有统计学意义；其术后疼痛的改善程度明显优于对照组患者，差异显著（P＜0.05），有统计学意义。结论：让骨创伤患者进行有针对性的术后功能锻炼和对其进行护理干预可取得显著的临床效果，改善其预后，促使其更快痊愈。     

基于关节镜下ACL损伤重建术应用快速康复的疗效观察

目的观察快速康复及传统康复两种方案对前交叉韧带重建术后患者膝关节功能康复的效果差异。方法将28例行前交叉韧带重建术后的患者分为对照组及研究组,各14例,分别给予传统康复方案及快速康复方案。术后1个月、3个月、6个月时分别采用VAS视觉评分表、膝关节Lysholm评分表、测量大腿周径及被动关节活动度以评估患者膝关节功能恢复情况。结果术后1个月、3个月、6个月对患者进行膝关节功能评分,术后1个月、3个月时研究组评分明显高于对照组,差异具有显著统计学意义(P0.05)。结论通过快速康复方案进行系统康复治疗可使膝关节前交叉韧带重建术后的患者缩短康复时间,并能在较短时间内达到运动水平。     

膝关节镜下自体肌腱移植前交叉韧带重建的康复护理

目的 探讨关节镜下自体肌腱移植重建前交叉韧带的系统康复护理效果。方法47例患者在关节镜下行自体肌腱移植重建前交叉韧带,术前术后实施系统康复护理,指导患者功能训炼,比较米前术后膝关节功能。尘青果全部患者均获得随访,随访时间1-2年,平均18月。术后膝关节Lysholm评分优良,所有患者膝关节功能良好,可正常工作和生活。结论关节镜下自体肌腱移植重建前交叉韧带术前术后配合实施系统康复护理,对提高手术成功率及恢复膝关节功能有积极的作用。     

护理干预对关节镜下前交叉韧带重建术后功能恢复的研究

目的探讨护理干预对关节镜下前交叉韧带重建术后功能恢复的应用价值。方法选择2009年1月至2013年1月在我院收治的60例前交叉韧带损伤在关节镜下行韧带重建的患者,随机分成研究组(30例)与对照组(30例)。对研究组患者进行护理干预,在手术前制定科学、系统的康复计划,并给予心理护理以及康复知识的宣教,同时在关节镜下行韧带重建术后指导病人做功能恢复锻炼。对对照组患者进行骨科常规治疗的护理。结果术后平均随访6个月,研究组患者的膝关节功能优良率为93.33%,对照组患者的膝关节功能优良率为66.67%,研究组患者的膝关节功能恢复的有效率高于对照组(P<0.05)。结论早期对关节镜下行前交叉韧带重建手术患者进行护理干预,有益于其膝关节功能的康复。     

微型骨锚治疗手部肌腱韧带止点撕脱损伤的疗效观察

目的 探讨微型骨锚治疗手部肌腱韧带止点撕脱损伤的疗效.方法 15例手部肌腱韧带止点撕脱损伤患者采用2mm微型骨锚固定,并进行随访,采用Dargan功能评定法对患手功能进行评价.结果 15例患者手术切口均Ⅰ类甲等愈合,术后2周拆线.本组均获得随访,随访时间6～30个月,平均18个月,受伤关节活动时无疼痛,日常生活自理,恢复受伤前劳动能力.术后患指功能优9例,良4例,可2例,优良率86.67％.结论 采用微型骨锚治疗手部肌腱韧带止点撕脱损伤应严格把握适应证,术中仔细操作,术后系统康复锻炼,患者伤手的功能可以明显的改善.     

自体腘绳肌腱重建前交叉韧带术后两种康复方案效果的比较

目的：观察自体腘绳肌腱重建前交叉韧带术后两种不同康复方案的临床效果,为前交叉韧带重建术后康复方案的选择提供理论依据。方法：收集单侧自体腘绳肌腱重建膝关节前交叉韧带手术的患者32例,其中,车祸20例,运动损伤12例。采用保守康复方案16例,采用积极康复方案16例。术后6个月时比较关节活动度、髌上10em处双侧大腿周径差值、Lysholm评分、IKDC评分、关节稳定性。结果：两组术后6个月比较,膝关节活动度存在明显差异;髌上10em处双侧大腿周径差值无明显差异;Lysholm评分存在明显差异;IKDC评分有明显差异;关节稳定性检查均为阴性。结论：自体腘绳肌腱重建膝关节前交叉韧带术后早期积极康复可以明显改善膝关节功能,增加关节活动度．缩短康复时间．但远期效果还有待研究。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.