Bioactivities and Pharmaceutical Effects of 1-Aminocyclopro- panecarboxylic Acid

作 者：

ZHU Qin-wei    KRAEMER Alexander    ZHU Xu-xiang  

作者单位：

Faculty of Public Health,Bielefeld University,Bielefeld 33615,Germany 

期 刊：

中草药（英文版）    

Journal：

CHINESE HERBAL MEDICINES  

年,卷(期)：

2010, 02(2) 

分类号：

R2 

Keywords：

1-aminocyclopropanecarboxylic acid    bioactivities    cerebro- and cardiovascular    neurological protection    non-protein acid    pharmaceutical effects   

机标分类号：

R96 R97 

机标关键词：

neuroprotective effectscardiovascular systemlearning and memorydetermination ofclinical trialsstudiesnervous systemsignificanceamino acidglutamatedifferentcountriesAbstractsresearcharticlesvarietyResultsnaturalMedlinemedical 

基金项目：

 

DOI：

10.3969/j.issn.1674-6384.2010.02.001 

参考文献(98条)

1. Ethylene in Plant Biology 1973
2. Ethylene biosynthesis:Identification of 1-aminocyclopropane-1-carboxylic acid as an intermediate in the conversion of methionine to ethylene 1979(1)
3. A clinical trial of the effects of dietary patterns on blood pressure 1997
4. Rat middle cerebral artery occlusion:Evaluation of the model and development of a neurologic examination 1986(3)
5. Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures 1993
6. Lipid peroxidation forms ethylene from 1-aminocyclopropane-1-carboxylic acid and may operate in leaf senescence 1984
7. Chronic administration of a glycine partial agonist alters the expression of N-methyl-D-aspartate receptor subunit mRNAs 1997(3)
8. Protection from hypoxic injury in cultured hepatocytes by glycine,alanine,and serine 1994
9. 1-Aminocyclopropane-1-carboxylic acid:A new amino-acid in perry pears and cider apples 1957(4555)
10. The free amino acid of certain British fruits 1960
11. Buffer GW.Peterson PJ Uptake and metabolism of inorganic forms of seleniurn-75 by Spirodela oligorrhiza 1967
12. Cameron AC.Fenton CAL.Yu Y.Adams DO Yang SF Increased production of ethylene by plant tissues treated with 1-aminocyclopropane-1-carboxylic acid 1979(2)
13. Castro-Puyana M.Crego AL.Marina ML.Garcia-Ruiz C CE methods for the determination of non-protein amino acids in foods 2007(22)
14. Cherkofsky SC 1-aminocyclopropanecarboxylic acid:Mouse to man interspecies pharmacokinetic comparisons and allometric relationships 1995(10)
15. Choi DW Glutamate neurotoxicity and diseases of the nervous system 1988(8)
16. Cowie DB.Cohen GN Biosynthesis by Escherichia coli of active altered proteins containing selenium instead of sulfur 1957(2)
17. DeGraba TJ.Pettigrew LC Why do neuroproteetive drugs work in animals but not humans 2000(2)
18. Ding CM.Zhu XX.Zhang ZM Test report of ACPC feeding table poultry 2004(2)
19. Dirnagl U.Iadecola C.Moskowitz MA Pathobiology of ischaemic stroke:An integrated view 1999(9)
20. Elliott P.Stamler J.Dyer AR.Appel L,Dennis B,Kesteloot H,Ueshima H,Okayama A,Chart Q,Garside DB,Zhou B Association between protein intake and blood pressure:The INTERMAP Study 2006(1)
21. Faden AI.Jacobs TP Dynorphin-related peptides cause motor dysfunction in the rat through a non-opiate mechanism 1984
22. Fleisch JM M(O)glichkeiten der Blutdrucksenkung dutch operantes Konditionieren unter Einsatz einer neuen BiofeedbackAnordnung 1996
23. Fossom LH.Basile AS.Skolnick P Sustained exposure to 1-aminocyclopropanecarboxylic acid,a glycine partial agonist,alters N-methyl-D-aspartate receptor function and subunit composition 1995(6)
24. Fossom LH.Von Lubitz DK.Lin RC.Skolnick P Neuroprotective actions of 1-aminocyclopropanecarboxylic acid(ACPC):A partial agonist at strychnine-insensitive glycine sites 1995(4)
25. Gao M.Kondo F.Murakami T.Xu JW,Ma N,Zhu XX,Mod K,Ishida T 1-Aminocyclopropanecarboxylic acid,an antagonist of N-methyl-D-aspartate receptors,causes hypotensive and antioxidant effects with upregulation of heme oxygenase-1 in stroke-prone spontaneously hypertensive rots 2007(3)
26. Grant KA.Valverius P.Hudspith M.Tabakoff B Ethanol withdrawal seizures and the NMDA receptor complex 1990(3)
27. Haque MM.Nasreen SA Epidemiological study of risk factors of stroke and its immediate consequence 2008(2)
28. Herman BH.Goldstein A Antinoeiception and paralysis induced by intrathecal dynorphin A 1985(1)
29. Heyman S.Spokes K.Rosen S.Epstein FH Mechanism of glycine protection in hypoxic injury:Anologies with glycine receptor 1992(1)
30. Howell SE.Miller SR.McCallister JD.Cherkofsky SC Patrick KS Gas chromatographic-mass spectrometric determination of urinary 1-aminocyclopropanecarboxylic acid in mice using a deuterated internal standard 1995(1)
31. Jia M.Dong Z.Zhu Y.Guan YB Molecular targets of Chinese used in treatment of stroke 2006(12)
32. Kolesnikov YA.Maccechini ML.Pastemak GW 1-Aminocyclopropane carboxylic acid(ACPC)prevents mu and delta opioid tolerance 1994(18)
33. Kunz C.Linn T.Gortner L.Bretzel RG Ern(a)hrungsprobleme bei Kindern und Erwachsenen 2003
34. Layer RT.Bland LR.Skolnick P MK-801,but not drugs acting at strychnine-insensitive glycine receptors,attenuate methamphetamine nigrostriatal toxicity 1993(1)
35. Lea PJ.Norris RD The use of amino acid analogues in studies of plant metabolism 1976
36. Levy SB Multidrug resistance-a sign of the times 1998(19)
37. Liang ZH.Wei EQ.Zhu CY.Zhang SH,Xu HM An improved imaging analysis for quantitative 2003(6)
38. Lin JC.Tsao WL.Wang Y Cardiovascular effects of NMDA in the RVLM of spontaneously hypertensive rats 1995(3)
39. Lin Y.Fossom LH.Skolnick P.Long JB Sustained exposure to a glycine receptor partial agonist differentially alters NMDA receptor agonist and antagonist potencies in cultured spinal cord neurons 1998
40. Long JB.Petras JM.Mobley WC.Holaday JW Neurological dysfunction after intrathecal injection of dynorphin A(1-13)in the rat.Ⅱ.Non-opioid mechanisms mediate loss of motor,sensory,and autonomic function 1988(3)
41. Long JB.Rigamonti DD.Oleshansky MA.Wingfield CP Martinez-Arizala A Dynorphin A-reduced rat spinal cord.injury:Evidence for excitatory amino acid involvement in a pharmacological model of ischemic spinal cord injury 1994(1)
42. Long JB.Skolnick P 1-Aminocyclopropanecarboxylic acid protects against dynorphin A-induced spinal injury 1994(3)
43. Longa EZ.Weinstein PR.Carlson S.Cummins R Reversible middle cerebral artery occlusion without craniectomy in rats 1989(1)
44. Lopes T.Neubauer P.Boje KM Chronic administration of NMDA glycine partial agonists induces tolerance in the Porsolt swim test 1997(4)
45. Lundy EF.Solik BS.Frank RS.Lacy PS Combs DJ Zelenock GB D'Alecy LG Morphometric evaluation of brain infarcts in rats and gerbils 1986(3)
46. Lürssen K.Naumann K.Schrt(o)der R 1-Aminocyclopropane-1-carboxylic acid-An intermediate of ethylene biosynthesis in higher plants 1979
47. MacMahon S.Peto R.Cutler J.Collins R,Sofrlie P,Neaton J,Abbott R,Godwin J,Dye Blood pressure,stroke and coronary heart disease.Part 1:Prolonged differences in blood pressure.Prospective observational studies corrected for the regression dilution bias 1990
48. Manev H.Costa E.Wroblewski JT.Guidotti A Abusive stimulation of excitatory amino acid receptors:A strategy to limit neurotoxicity 1990(10)
49. Marvizón JC.Lewin AH.Skolnick P 1-Aminocyclopropane carboxylic acid:A potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate receptor complex 1989(3)
50. Meyer BU.Schneider W.Elstner EF Peroxide-dependent amino acid oxidation and chemiluminescence catalysed by magnesium-pyridoxal phosphate-glutamate complex 1992(3)
51. Mills E.Minson J.Drolet G.Chalmers J Effect of intrathecal amino acid receptor antagonists on basal blood pressure and pressor responses to brainstem stimulation in normotensive and hypertensive rats 1990(6)
52. Muir KW.Lees KR Clinical experience with excitatory amino acid antagonist drugs 1995(3)
53. Nagasawa H Effect of ACC,a component of Coprinus comafus,on fertility of male mice 1995
54. Nahum-Levy R.Fossom LH.Skolnick P.Benveniste M Putative partial agonist 1-aminocyclopropanecarboxylic acid acts concurrently as a glycine-site agonist and a glutamate-site antagonist at N-methyl-D-aspartate receptors 1999(6)
55. Nowak G.Li Y.Paul IA Chronic glycine treatment desensitizes the behavioral response to 1-aminocyclopropanecarboxylic acid(ACPC),a partial agonist at the strychnine-insensitive glycine site of the NMDA receptor complex 2000(2)
56. Olney JW.Labruyere J.Wang G.Wozniak DF Price MT Sesma MA NMDA antagonist neurotoxicity:Mechanism and prevention 1991(5037)
57. Papp M.Gruca P.Willner P Selective blockade of druginduced place preference conditioning by ACPC,a functional NDMA-receptor antagonist 2002(5)
58. Papp M.Moryl E Antidepressant-like effects of 1-aminocyclopropanecarboxylic acid and D-cycloserine in an animal model of depression 1996(2-3)
59. Patat A.Molinier P.Hergueta T.Brohier S,Zieleniuk I,Danjou P,Warot D,Puech A Lack of amnestic,psychotomimetic or impairing effect on psychomotor performance of eliprodil,a new NMDA antagonist 1994(3)
60. Peterson SL Infusion of NMDA antagonists into the nucleus reticularis pontis oralis inhibits the maximal electroshock seizure response 1995(1-2)
61. Peterson SL.Purvis RS.Griffith JW Differential neuroprotective effects of the NMDA receptor-associated glycine site partial agonists l-aminocyclopropanecarboxylic acid(ACPC)and D-cycloserine in lithium-pilocarpine status epilepticus 2004(5)
62. Popik P.Rygielaka Z A partial agonist at strychnine-insensitive glycine sites facilitates spatial learning in aged rats 1999(1)
63. Priestley T.Home AL.McKeman RM.Kemp JA The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures 1990(1-2)
64. Przegali(n)ski E.Tatarczy(n)ska E.Dere(n)-Wesolek A.ChojnackaWójcik E Anticonfiict effects of a competitive NMDA receptor antagonist and a partial agonist at strychnine-insensitive glycine receptors 1996(1)
65. Przegali(n)ski E.Tatarczy(n)ska E.Dere(n)-Wesolek A.ChojnackaWojcik E Antidepressant-like effects of a partial agonist at strychnine-insensitive glycine receptors and a competitive NMDA receptor antagonist 1997(1)
66. Przegali(n)ski E.Tatarczy(n)ska E.Klodzi(n)ska A.Chojnacka-Wójcik E Tolerance to anxiolytic-and antidepressant-like effects of a partial agonist of glycineB receptors 1999(3)
67. Rogawski MA Low affinity channel blocking(uncompatitive)NMDA receptor antagonists as therapeutic agents-toward an understanding of their favorable tolerability 2000(1)
68. Rubenstein E Methods for the use of nonprotein amino acids as therapeutic agents 2001
69. Schneider W Der hypocholesterin(a)mische und antiatherosklerotische EinfluB yon Magnesium-Pyridoxal-5'-phosphatGlutamat im Serum,in der Leber und der Aorta hypercholesterin(a)mischer Ratten und Kaninchen" 1987
70. Schroeder R.Luerssen K Mittel zur Regulierung des Pflanzenwachstums 1980
71. Simberkoff MS Drug-resistant pneumococcal infections in the United States.A problem for clinicians,laboratories,and public health 1994(23)
72. Skolnick P.Marvizón JC.Jackson BW.Monn JA Rice KC Lewin AH Blockade of N-methyl-D-aspartate induced convulsions by 1-aminocyclopropanecarboxylates 1989(18)
73. Skolnick P.Miller R.Young A.Boje K,Trullas R Chronic treatment with 1-aminocyclopropanecarboxylic acid desensitizes behavioral responses to compounds acting at the N-methylD-aspartate receptor complex 1992(4)
74. Stevens CW.Yaksh TL Dynorphin A and related peptides administered intrathecally in the rat:A search for putative kappa opiate receptor activity 1986(3)
75. Stromberg MF.Volpicelli JR.O'Brien CP.Mackler SA The NMDA receptor partial agonist,1-aminocyclopropanecarboxylic acid(ACPC),reduces ethanol consumption in the rat 1999(3)
76. Swain T Secondary compounds as protective agents 1977
77. Trullas R.Folio T.Young A.Miller R,Boje K,Skolnick P 1-aminocyclopropanecarboxylates exhibit antidepressant and anxiolytic actions in animal models 1991(3)
78. Trullas R.Skolnick P Functional antagonists at the NMDA receptor complex exhibit antidepressant actions 1990(1)
79. V(a)h(a)talo ML.Virtanen AI Cyclic α-aminocarboxylic acid in berries ofcowberry 1957
80. Viu E.Zapata A.Capdevila J.Skolnick P,Trullas R Glycine(B)receptor antagonists and partial agonists prevent memory deficits in inhibitory avoidance learning 2000(2)
81. Von Lubitz DK.Lin RC.McKenzie RJ.Devlin TM McCabe RT Skolnick P A novel treatment of global cerebral ischemia with a glycine partial agonist 1992(1)
82. Wang FR.Jiang YS.Xiao WW.Zhang SM Mice focal cerebral ischemia-reperfusion model established by internal carotid artery suture method 2003(2)
83. Weinberg JM.Venkatachalam MA.Roeser NF.Davis JA Varani J Johnson KJ Amino acid protection of cultured kidney tubule cells against calcium ionophore-induced lethal cell injury 1991(6)
84. Yang SF The formation of ethylene from l-aminocyclopropane-l-carboxylic acid 1984
85. Yang SF A bit in the research on ethylene biosynthesis 1998
86. Yang SF.Hoffman NE Ethylene biosynthesis and its regulation in higher plants 1984
87. Yao JF.Zhang ZM.Xu GP.Xu FQ,Zhou HC,Wang XH,Deng B Feeding test report of ACC on poultry 2001
88. Ye CL.Li BH Protective effects of clonidine on cerebral ischemia in mice and cats 1993(1)
89. Yu YB.Adams DO.Yang SF l-Aminocyclopropanecarboxylate Synthase,a Key Enzyme in Ethylene Biosynthesis 1979(1)
90. Zapata A.Capdevila JL.Viu E.Tmllas R 1-Aminocyclopropane-carboxylic acid reduces NMDA-induced hippocampal neurodegeneration in vivo 1996(2)
91. Zhang J.Xu JL.Zhu XX Nonprotein amino acid ACC regulates and controls the growing development of silkworm 1990(4)
92. Zhao ZR Protection of ACC on brain neurological impairment induced by ischemia 2005
93. Zhao ZR.Zhu QW.Zhu XX Protection of 1-aminocyclopropanecarboxylic acid against brain neurological impairment by ischemia 2005(10)
94. Zhu XX The Regulating Effects of ACC on the Rice.Advances in plant growth substance and herbicide research and application(1) 1998
95. Zhu XX New feed additive ACPC.New Feed Certificate No.[2003]02 2003
96. Zhu XX 1-Aminocylopropanecarboxylic Acid(ACC)on Cardiocerebrovascular Diseases 2005(26)
97. Zhu XX Application of ACPC in preparation of medicine against cardiovascular diseases 2007
98. Zhu XX.Xu JL Physiological actions of nonprotein amino acid ACC of animals 1991(4)

>>更多...     

英文摘要

查看全文 下载全文     

英文摘要

查看全文 下载全文     

英文摘要

查看全文 下载全文     

英文摘要

查看全文 下载全文     

英文摘要

查看全文 下载全文     

英文摘要

查看全文 下载全文     

英文摘要

查看全文 下载全文     

英文摘要

查看全文 下载全文     

中西医结合治疗大肠癌的研究进展

本文从中西医结合在大肠癌术后辅助、联合化疗、晚期姑息等环节的应用等方面,总结近年来中西医治疗大肠癌的现状,探讨中西医结合治疗大肠癌的进展及存在的问题.     

博尔宁胶囊对大肠癌P21ras基因和mtp53基因蛋白含量干预的临床观察

目的:中药制剂博尔宁胶囊在临床应用中对癌症基因的表达的影响方面还较少有相关的临床观察数据。在细胞分子水平层次和采用基因芯片为代表的先进技术,多方位、多层次地揭示中医中药防治大肠癌的机制,比较、重组和筛选防治大肠癌的治法方药,成为进一步深入研究中医药防治大肠癌的迫切需要,所以采用此队列研究,对博尔宁胶囊联合FOLFOX4方案(奥沙利铂、亚叶酸钙、氟尿嘧啶)治疗结肠癌进行临床观察。方法:随机分组中药制剂博尔宁胶囊联合FOLFOX4方案治疗大肠癌术后患者30例,单纯FOLFOX4方案治疗大肠癌术后患者30例,从治疗前后大肠癌P21ras和mtp53基因含量变化方面进行比较分析。结果:中药制剂博尔宁胶囊在大肠癌进展期或术后复发治疗中对抑癌基因有干预作用。大肠癌术后患者经博尔宁胶囊治疗后血清mtp53基因蛋白含量较治疗前明显降低(配对T检验,P <0.05)。血清P21ras基因蛋白含量较治疗前非常明显降低(配对t检验,P <0.01)。结论:研究证实博尔宁胶囊治疗大肠癌有提高肿瘤治疗的近期与远期疗效作用,对于大肠癌术后抗转移复发及延长生存期都有着明显的改善。具有提高机体免疫力,减轻化疗的消化道不良反应,提高患者化疗耐受程度。认为博尔宁胶囊能对大肠癌化疗耐药基因具有一定的逆转作用。     

大肠癌的中医研究现况

近些年来大肠癌的发病率与死亡率高居不下,成为危害国民生命健康的主要恶性肿瘤之一,虽然目前大肠癌的治疗以手术治疗并辅以放化疗、靶向治疗等手段为主,但仍存在一些不可避免的问题导致大肠癌治疗始终无法理想化.中医药在大肠癌治疗的作用日益凸显,有效弥补了现代医学治疗中的不足,因此本文通过筛选并分析近些年来的相关文献,从大肠癌的病...     

基于信息协作平台的结直肠癌中西医结合三级防治体系的研究初探

结直肠癌(CRC)是常见的消化道恶性肿瘤,近年来结直肠癌的发病率在世界范围内呈攀升状态。大量证据表明,筛查有助于CRC的早期诊断,可降低患者死亡率。因此探讨建立从预防筛查癌前病变和早期癌到早期治疗的有效防治体系有着非常重要的实际意义。中医药早期介入对于结直肠癌的防治有着重要作用,及时加入中医药干预,形成中西医结合的优化方案可明显提高结直肠癌防治水平。建立包括集结直肠癌筛查注册、结直肠癌中西医结合临床路径、"诊疗标准"库、"循证"知识库及资源共享于一体的更加切合临床实用、功能更为强大的结直肠癌信息协作平台可大大增强结直肠癌监测与管理水平,提高工作效率,力争降低结直肠癌的发病率和死亡率。     

结直肠癌中医药研究进展与思考

目的:综述与评价结直肠癌的中医药诊疗研究进展。方法:中医药目前是我国结直肠癌多学科治疗中的重要组成部分,本文从辨证规律研究、治疗进展、疗效评价研究等方面,对近年来中医药治疗结直肠癌临床研究进行综述。结果:辨证治疗结直肠癌的客观化研究成为热点,中医药治疗结直肠癌的疗效得到进一步肯定,但仍缺乏统一的辨证标准和适用于中医药的疗效评价标准,仍然缺乏大样本、多中心的高质量随机对照试验结果。结论:中医药治疗结直肠癌研究取得了可喜进展,但仍需进一步的多单位协作研究。     

中医药治疗大肠癌的切入点和优势

本文以大肠癌高危人群预防和治疗癌前病变、大肠癌术后预防复发转移、晚期大肠癌患者延长生存,改善生活质量、中药治疗年老体弱多病的晚期肠癌患者、大肠癌相关并发症的防治、中药对手术及放化疗的减毒增效研究等为切入点,论述了中医药治疗大肠癌的优势、困难及发展机遇,旨在为中医药防治大肠癌的临床应用和今后的研究提供参考。     

大肠癌手术后中西医结合治疗研究进展

大肠癌的综合治疗在近年内取得了飞快发展,中医药治疗在大肠癌根治术后的治疗中发挥着积极的作用,本文通过对大肠癌术后中西医综合治疗的进展进行综述,为中西医结合治疗术后大肠癌的研究方向提供依据。     

大肠癌术后中西医治疗研究进展

大肠癌的术后辅助治疗在近年内取得了飞快发展,中医药治疗在大肠癌根治术后的治疗中发挥着积极的作用,本文通过对大肠癌术后中西医辅助治疗的进展进行综述,为中西医治疗术后大肠癌的研究提供依据。     

中医药治疗晚期结直肠癌的临床研究进展

中医药治疗方法在晚期结直肠癌的综合治疗中占有重要地位。中医药可以改善晚期结直肠癌患者临床症状、生存质量及免疫状态;可以对放化疗起减毒增效效应;可以预防肿瘤复发和转移,使患者在延长生存期、提高生存率方面获益。中医药参与临床治疗主要有单纯中医药治疗法、中西医结合治疗法以及直肠直接给药法。本文从生存期、生存率的角度,回顾中医中药治疗晚期结直肠癌的临床研究进展。     

健脾法在治疗大肠癌中的应用

从病因病机、临床施治、临床研究综述了健脾法在治疗大肠癌中的应用。指出:脾虚湿毒瘀阻是大肠癌最主要的发病机理,脾虚在大肠癌的发病中尤为重要。大肠癌以正虚为本,湿热蕴毒为标。宜首重健脾益气,扶正培本,调整机体的免疫功能,使正胜邪却。