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Hepatitis B virus mother‐to‐child transmission among HIV‐infected women receiving lamivudine‐containing antiretroviral regimens during pregnancy and breastfeeding
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M. F. Pirillo P. Scarcella M. Andreotti H. Jere E. Buonomo J.‐B. Sagno R. Amici M. G. Mancini P. Leone S. Ceffa S. Mancinelli M. C. Marazzi S. Vella L. Palombi M. Giuliano 《Journal of viral hepatitis》2015,22(3):289-296
The study included 309 HIV‐infected pregnant women receiving a lamivudine‐containing antiretroviral regimen from week 25 of gestational age until 6 months postpartum, during breastfeeding. Twenty‐seven of them (8.7%) were hepatitis B virus surface antigen (HBsAg) positive; at baseline, hepatitis B virus (HBV) DNA levels >3 log10 IU/mL (with a median level of 6.2 log10 IU/mL) were found in 10 women, who at one, three and six months postpartum had median levels of 5.2 log10 IU/mL, 4.5 log10 IU/mL and 2.8 log10 IU/mL, respectively. Twenty‐four of the 30 breast milk samples evaluated had undetectable HBV DNA and the other six had values between 15 and 155 IU/mL. Median lamivudine concentrations were 1070 ng/mL in serum and 684 ng/mL in breast milk. Among the 24 HBV‐exposed children with available samples, 16 always tested negative, four had a transient infection, one had an undetermined status and three (12.5%) first tested positive at Month 12 or Month 24. Among the children born to the HBV‐uninfected mothers of the same cohort, the rate of HBsAg positivity at 12–24 months was 2% (4/196). Our finding of the absence of significative levels of HBV DNA in the breast milk of co‐infected mothers supports the present recommendations for breastfeeding in HBV‐infected women. Horizontal transmission can be hypothesized for the infections detected in children at 12–24 months. Children born to HBV‐positive mothers remained at higher risk of postnatal HBV acquisition compared to those born to HBV‐negative women. 相似文献
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Anaemia in HIV‐infected pregnant women receiving triple antiretroviral combination therapy for prevention of mother‐to‐child transmission: a secondary analysis of the Kisumu breastfeeding study (KiBS)
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Collins Odhiambo Clement Zeh Frank Angira Valarie Opollo Brenda Akinyi Rose Masaba John M. Williamson Juliana Otieno Lisa A. Mills Shirley Lee Lecher Timothy K. Thomas 《Tropical medicine & international health : TM & IH》2016,21(3):373-384
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Uptake and performance of prevention of mother‐to‐child transmission and early infant diagnosis in pregnant HIV‐infected women and their exposed infants at seven health centres in Addis Ababa,Ethiopia
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Marshet Girma Rahel Wendaferash Hailu Shibru Yemane Berhane Michael Hoelscher Arne Kroidl 《Tropical medicine & international health : TM & IH》2017,22(6):765-775
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Excessive mortality and loss to follow‐up among HIV‐infected children in Guinea‐Bissau,West Africa: a retrospective follow‐up study
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Ditte Steiniche Sanne Jespersen Candida Medina Fatima Corona Sanha Christian Wejse Bo Langhoff Hønge the Bissau HIV Cohort Study Group 《Tropical medicine & international health : TM & IH》2018,23(10):1148-1156
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The cascade of care to prevent mother‐to‐child transmission in Rio de Janeiro,Brazil, 1996–2013: improving but still some way to go
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Cristina Barroso Hofer Matthias Egger Mary‐Ann Davies Ana Cristina Cisne Frota Ricardo Hugo de Oliveira Thalita Fernandes Abreu Lúcia Evangelista Araújo Bernardo Bastos Witthlin Alice Weber Carvalho Janaína Rivas Cordeiro Giulia Pasqualini Lima Olivia Keiser 《Tropical medicine & international health : TM & IH》2017,22(10):1266-1274
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Differential effects of sex in a West African cohort of HIV‐1, HIV‐2 and HIV‐1/2 dually infected patients: men are worse off
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Sanne Jespersen Bo Langhoff Hønge Joakim Esbjörnsson Candida Medina David da Silva Té Faustino Gomes Correira Alex Lund Laursen Lars Østergaard Andreas Andersen Peter Aaby Christian Erikstrup Christian Wejse the Bissau HIV Cohort study group 《Tropical medicine & international health : TM & IH》2016,21(2):253-262
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