Médicaments et performance de la fonction d'équilibration

Introduction – Balance control in some sports discipline can be the aim of the action, and its breaking off can expose to severe trauma.Synthesis of facts – Some drugs' adverse effects can induce lower equilibrium performance, in relation for example with vigilance drop or vestibular ototoxicity. The drug effect site can concern one or more links in the chain (peripheral or central impact). Individual sensitivity is variable, as well as speed of reversibility.Conclusion – Symptoms induced by pathology for which therapy is prescribed are sometimes difficult to distinguish from those induced by therapy itself.     

Protéines et acides aminés dans la récupération post-effort

Recent data. – Recent evidence suggests an interest for the intake of nitrogenous substances during the anabolic post-exercise phase. Modest amounts of indispensable amino acids stimulate net protein gain and might contribute to long term training adaptations in muscle. Proteins play a subsidiary but limited role in glycogen resynthesis. Regarding other functions theoretically susceptible to be modulated by specific amino acids, for instance cysteine and glutamine, no quantitative evidence exists today demonstrating that amino acid-specific supplements would benefit healthy athletes.     

Les bases génétiques et moléculaires de la performance et de l'adaptation à l'exercice physique

Objectives – This paper reviews the state of our knowledge on the genetic and molecular bases of performance and the response to exercise training, the theme of the inaugural conference of the XIXth annual meeting of the Société Française de Médecine du Sport held in Rennes in October 1999.Topics – The studies on the genetic bases of performance performed over the past 20 years suggest that 25 to 50% of interindividual differences observed in maximal and sub-maximal oxygen consumption as well as in other indicators of aerobic performance could be explained by genetic factors. For metabolic and histochemical properties of skeletal muscle, heritabilities ranging from 40 to 70% have been reported. Considerable interindividual differences are also observed in the cardiorespiratory, metabolic and morphologic adaptations to exercise training and results from twin and family studies suggest that these differences are also determined by genetic factors. Unlike many other complex traits such as hypertension or obesity, the search for candidate genes of performance is in its infancy. Only a few studies with candidate genes such as the angiotensin converting enzyme (ACE), the muscle specific creatine kinase (CKMM) or genes of mitochondrial DNA have reported positive results with indicators of aerobic performance.Conclusion – More studies are needed before any conclusion could be made about the role of these genes in performance and adaptation to exercise training. Although the molecular dissection of performance and adaptation to regular exercise is a complex task, considerable progress will probably be achieved in the next decade in our understanding of the molecular basis of these complex phenotypes.     

Infections ORL,immunodépression et stress liés à la pratique des activités physiques et sportives

Objectives – Understand the pathophysiology of upper respiratory tract infections (URTI), the most common ailment of elite athletes.Actualities – URTI likely develop as a consequence of local or systemic immunosuppression. Such a lowered protection may result both from training and from the stress associated to competitive sports. This literature review summarises the physiology of the immune system associated to the upper respiratory tract, then presents evidence supporting the impact of stress and training respectively on the immune system.Perspective – Better knowledge of the impact of high-level sport on the immune system may allow to adapt training and competition in order to avoid or limit the immunosuppression leading to an increased susceptibility to infections.     

Réponses du cortisol et de la testostérone salivaires au cours de la récupération post-compétitive en rugby

Aim. – In order to evaluate the biological repercussions of the post-competitive tiredness state, we measured the progress of the salivary cortisol and testosterone levels in the players of a rugby-team during the week following an international match.Results. – The results reveal a fall of the cortisol levels during the first 4 days following the competition, compared to the values measured at the same hour of a resting day. Conversely, the testosterone levels present an increase during the same period. Consequently, 5 days of recovery are needed for these two biological variables chosen as tiredness markers to return to their basic values.     

Dopage et sport : connaissances et attitudes des pharmaciens de la ville de Yaoundé

Introduction – Fourty-one retail pharmacists (23 females and 18 males) out of 70 that Yaoundé town counts, participated to this study aimed at determining their attitudes towards and knowledge in doping. They answered a questionnaire concerning their knowledge of doping agents, how they face doping and the role of pharmacists in doping prevention.Synthesis – Results suggest that pharmacists (54%) have been confronted to doping, less than once a month for 27% of them and at least once a month for the rest. Six pharmacists (15%) have been offered to provide doping agents to sport men. 51% (mainly females) consider that the use of food supplements could induce consumption of forbidden drugs. The majority (83%) of pharmacists (mainly females) consider that doping is a public health problem. They agree (88%) that pharmacists have a part to play in doping prevention but also agree (58%; mainly females) that they are poorly or very poorly informed to that effect.Conclusion – The requests made to pharmacists suggest the consumption of doping agents by sport men in our region. It is therefore necessary to carry out an epidemiologic study on prevalence and consumption patterns.