共查询到20条相似文献，搜索用时 15 毫秒
1.
Signe T. Andersen Kasper Grosen Hatice Tankisi Morten Charles Niels T. Andersen Henning Andersen Ioannis N. Petropoulos Rayaz A. Malik Troels S. Jensen Pall Karlsson 《Journal of diabetes and its complications》2018,32(12):1153-1159
Aims
In this cross-sectional study, we explored the utility of corneal confocal microscopy (CCM) measures for detecting diabetic polyneuropathy (DPN) and their association with clinical variables, in a cohort with type 2 diabetes.Methods
CCM, nerve conduction studies, and assessment of symptoms and clinical deficits of DPN were undertaken in 144 participants with type 2 diabetes and 25 controls. DPN was defined according to the Toronto criteria for confirmed DPN.Results
Corneal nerve fiber density (CNFD) was lower both in participants with confirmed DPN (n?=?27) and in participants without confirmed DPN (n?=?117) compared with controls (P?=?0.04 and P?=?0.01, respectively). No differences were observed for CNFD (P?=?0.98) between participants with and without DPN. There were no differences in CNFL and CNBD between groups (P?=?0.06 and P?=?0.29, respectively). CNFD was associated with age, height, total- and LDL cholesterol.Conclusions
CCM could not distinguish patients with and without neuropathy, but CNFD was lower in patients with type 2 diabetes compared to controls. Age may influence the level of CCM measures. 相似文献2.
Jingchuan Guo Rachel G. Miller Tina Costacou William P. Follansbee Trevor J. Orchard 《Journal of diabetes and its complications》2018,32(3):298-304
Objectives
We aimed to assess association between abnormal LVEF, in the absence of coronary artery disease (CAD), and 25-year incidence of major outcomes of diabetes (MOD) in a cardiology substudy of the Pittsburgh Epidemiology of Diabetes Complications cohort of childhood-onset type 1 diabetes.Methods
115 normotensive type 1 diabetes individuals without known CAD, underwent a baseline exercise radionuclide ventriculography. Abnormal LVEF was defined as a resting ejection fraction <50% or a failure to increase ejection fraction with exercise by >5% (men) or a fall in ejection fraction with exercise (women). Cox proportional hazards models were used to predict the composite endpoint of MOD (first instance of major CAD, stroke, end-stage renal disease, blindness, amputation or diabetes-related death).Results
Mean baseline age was 28 and diabetes duration 19?years. In a mean follow-up of 19?years, 50 MOD events were identified. Allowing for established risk factors at baseline, abnormal LVEF (n?=?22) independently predicted MOD incidence (HR?=?2.12, 95% CI: 1.12–4.00, p?=?0.022) but not major CAD (HR?=?1.33, 95% CI: 0.53–3.33, p?=?0.539).Conclusions
An abnormal LVEF may identify diabetic cardiomyopathy and predict long term risk of MOD (but not CAD alone) in type 1 diabetes individuals, consistent with it reflecting microvascular disease. 相似文献3.
Amena Keshawarz Andrew R. Piropato Talia L. Brown Lindsey M. Duca Rachel M. Sippl R. Paul Wadwa Janet K. Snell-Bergeon 《Journal of diabetes and its complications》2018,32(11):975-981
Aims
Compare physical activity (PA) levels in adults with and without type 1 diabetes and identify diabetes-specific barriers to PA.Methods
Forty-four individuals with type 1 diabetes and 77 non-diabetic controls in the Coronary Artery Calcification in Type 1 Diabetes study wore an accelerometer for 2?weeks. Moderate-to-vigorous physical activity (MVPA) was compared by diabetes status using multiple linear regression. The Barriers to Physical Activity in Type 1 Diabetes questionnaire measured diabetes-specific barriers to PA, and the Clarke hypoglycemia awareness questionnaire measured hypoglycemia frequency.Results
Individuals with type 1 diabetes engaged in less MVPA, fewer bouts of MVPA, and spent less time in MVPA bouts per week than individuals without diabetes (all p?<?0.05), despite no difference in self-reported PA (p?>?0.05). The most common diabetes-specific barrier to PA was risk of hypoglycemia. Individuals with diabetes reporting barriers spent less time in MVPA bouts per week than those not reporting barriers (p?=?0.047).Conclusions
Individuals with type 1 diabetes engage in less MVPA than those without diabetes despite similar self-reported levels, with the main barrier being perceived risk of hypoglycemia. Adults with type 1 diabetes require guidance to meet current PA guidelines and reduce cardiovascular risk. 相似文献4.
Yang Xiao Xiaoyu Xiao Aimin Xu Xiaoyan Chen Weili Tang Zhiguang Zhou 《Journal of diabetes and its complications》2018,32(12):1100-1104
Objective
The aim of this study was to investigate the prospective association of circulating adipocyte fatty acid-binding protein (A-FABP) levels with the development of subclinical atherosclerosis in patients with type 2 diabetes in an 8-year prospective study.Methods
A total of 170 patients with newly diagnosed type 2 diabetes were recruited in the study and 133 patients completed the follow-up of 8?years. Baseline plasma A-FABP levels were measured with enzyme-linked immunosorbent assays. The role of A-FABP in predicting the development of subclinical atherosclerosis over 8?years was analyzed using multiple logistic regression.Results
Of the 133 patients without subclinical atherosclerosis at baseline, a total of 100 had progressed to subclinical atherosclerosis over 8?years. Baseline A-FABP level was significantly higher in patients who had progressed to subclinical atherosclerosis at year 8 compared with ones who had not developed subclinical atherosclerosis after adjustment for sex (15.3 [12.1–23.2] versus 13.3 [10.0–18.9] ng/ml, P?=?0.021). High baseline A-FABP level was an independent predictor for the development of subclinical atherosclerosis in patients with type 2 diabetes (odds ratio: 16.24, P?=?0.022).Conclusions
Circulating A-FABP levels predict the development of subclinical atherosclerosis in type 2 diabetes patients. 相似文献5.
Kristi Reynolds Sharon H. Saydah Scott Isom Jasmin Divers Jean M. Lawrence Dana Dabelea Elizabeth J. Mayer-Davis Giuseppina Imperatore Ronny A. Bell Richard F. Hamman 《Journal of diabetes and its complications》2018,32(6):545-549
Aims
To estimate short-term mortality rates for individuals with type 1 or type 2 diabetes diagnosed before age 20?years from the SEARCH for Diabetes in Youth study.Methods
We included 8358 individuals newly-diagnosed with type 1 (n?=?6840) or type 2 (n?=?1518) diabetes from 1/1/2002–12/31/2008. We searched the National Death Index through 12/31/2010. We calculated standardized mortality ratios (SMRs) based on age, sex, and race for the comparable US population in the geographic areas of the SEARCH study.Results
During 44,893?person-years (PY) of observation (median follow-up?=?5.3?years), 41 individuals died (91.3 deaths/100,000?PY); 26 with type 1 (70.6 deaths/100,000?PY) and 15 with type 2 (185.6 deaths/100,000?PY) diabetes. The expected mortality rate was 70.9 deaths/100,000?PY. The overall SMR (95% CI) was 1.3 (1.0, 1.8) and was high among individuals with type 2 diabetes 2.4 (1.3, 3.9), females 2.2 (1.3, 3.3), 15–19?year olds 2.7 (1.7,4.0), and non-Hispanic blacks 2.1 (1.2, 3.4).Conclusions
Compared to the state populations of similar age, sex, and race, our results show excess mortality in individuals with type 2 diabetes, females, older youth, and non-Hispanic blacks. We did not observe excess short-term mortality in individuals with type 1 diabetes. 相似文献6.
Agnieszka Szypowska Lidia Groele Marta Wysocka-Mincewicz Artur Mazur Lucyna Lisowicz Iwona Ben-Skowronek Joanna Sieniawska Bożenna Klonowska Dorota Charemska Jolanta Nawrotek Irena Jałowiec Artur Bossowski Klaudyna Noiszewska Beata Pyrżak Izabela Rogozińska Mieczysław Szalecki 《Journal of diabetes and its complications》2018,32(6):570-574
Aims
The level of C-peptide can identify individuals most likely to respond to immune interventions carried out to prevent pancreatic β-cell damage.The aim of the study was to evaluate factors associated with C-peptide levels at type 1 diabetes (T1D) diagnosis.Methods
This study included 1098 children aged 2-17 with newly recognized T1D. Data were collected from seven Polish hospitals. The following variables were analyzed: date of birth, fasting C-peptide, HbA1c, sex, weight, height, pH at diabetes onset.Results
A correlation was observed between fasting C-peptide level and BMI-SDS (p?=?0.0001), age (p?=?0.0001), and HbA1c (p?=?0.0001). The logistic regression model revealed that fasting C-peptide ≥0.7 ng/ml at diabetes diagnosis was dependent on weight, HbA1c, pH and sex (p?<?0.0001).Overweight and obese children (n?=?124) had higher fasting C-peptide (p?=?0.0001) and lower HbA1c (p?=?0.0008) levels than other subjects. Girls had higher fasting C-peptide (p?=?0.036) and higher HbA1c (p?=?0.026) levels than boys.Conclusion
Obese and overweight children are diagnosed with diabetes at an early stage with largely preserved C-peptide levels. Increased awareness of T1D symptoms as well as improved screening and diagnostic tools are important to preserve C-peptide levels. There are noticeable gender differences in the course of diabetes already at T1D diagnosis. 相似文献7.
Dagfinn Aune Tingting Feng Sabrina Schlesinger Imre Janszky Teresa Norat Elio Riboli 《Journal of diabetes and its complications》2018,32(5):501-511
Background
Diabetes and elevated blood glucose have been associated with increased risk of atrial fibrillation in a number of epidemiological studies, however, the findings have not been entirely consistent. We conducted a systematic review and meta-analysis to clarify the association.Material and methods
We searched the PubMed and Embase databases for studies of diabetes and blood glucose and atrial fibrillation up to July 18th 2017. Cohort studies were included if they reported relative risk (RR) estimates and 95% confidence intervals (CIs) of atrial fibrillation associated with a diabetes diagnosis, prediabetes or blood glucose. Summary RRs were estimated using a random effects model.Results
Thirty four studies were included in the meta-analysis of diabetes, pre-diabetes or blood glucose and atrial fibrillation. Thirty two cohort studies (464,229 cases, >10,244,043 participants) were included in the analysis of diabetes mellitus and atrial fibrillation. The summary RR for patients with diabetes mellitus versus patients without diabetes was 1.30 (95% CIs: 1.03–1.66), however, there was extreme heterogeneity, I2?= 99.9%) and evidence of publication bias with Begg's test, p?<?0.0001. After excluding a very large and outlying study the summary RR was 1.28 (95% CI: 1.22–1.35, I2?=?90%, n?=?31, 249,772 cases, 10,244,043 participants). The heterogeneity was mainly due to differences in the size of the association between studies and the results persisted in a number of subgroup and sensitivity analyses. The summary RR was 1.20 (95% CI: 1.03–1.39, I2?=?30%, n?=?4, 2392 cases, 58,547 participants) for the association between prediabetes and atrial fibrillation. The summary RR was 1.11 (95% CI: 1.04–1.18, I2?=?61%, n?=?4) per 20?mg/dl increase of blood glucose in relation to atrial fibrillation (3385 cases, 247,447 participants) and there was no evidence of nonlinearity, pnonlinearity?= 0.34.Conclusions
This meta-analysis suggest that prediabetes and diabetes increase the risk of atrial fibrillation by 20% and 28%, respectively, and there is a dose-response relationship between increasing blood glucose and atrial fibrillation. Any further studies should clarify whether the association between diabetes and blood glucose and atrial fibrillation is independent of adiposity. 相似文献8.
Igor Akushevich Arseniy P. Yashkin Julia Kravchenko Fang Fang Konstantin Arbeev Frank Sloan Anatoliy I. Yashin 《Journal of diabetes and its complications》2018,32(4):362-367
Aims
To identify how efforts to control the diabetes epidemic and the resulting changes in diabetes mellitus, type II (T2D) incidence and survival have affected the time-trend of T2D prevalence.Methods
A newly developed method of trend decomposition was applied to a 5% sample of Medicare administrative claims filed between 1991 and 2012.Results
Age-adjusted prevalence of T2D for adults age 65+ increased at an average annual percentage change of 2.31% between 1992 and 2012. Primary contributors to this trend were (in order of magnitude): improved survival at all ages, increased prevalence of T2D prior to age of Medicare eligibility, decreased incidence of T2D after age of Medicare eligibility.Conclusions
Health services supported by the Medicare system, coupled with improvements in medical technology and T2D awareness efforts provide effective care for individuals age 65 and older. However, policy maker attention should be shifted to the prevention of T2D in younger age groups to control the increase in prevalence observed prior to Medicare eligibility. 相似文献9.
Takahiro Yajima Kumiko Yajima Hiroshi Takahashi Keigo Yasuda 《Journal of diabetes and its complications》2018,32(8):759-763
Aims
To evaluate the effect of dulaglutide on body composition in type 2 diabetes mellitus (T2DM) patients undergoing hemodialysis (HD).Methods
Twenty-one T2DM patients on HD, who had been treated with insulin and newly added teneligliptin (N?=?10) or dulaglutide (N?=?11), were enrolled. Body composition changes, such as fat mass (FM) and skeletal muscle mass (SMM), glycated albumin (GA), and insulin doses were compared before and after six months of treatment with teneligliptin or dulaglutide.Results
The percentage changes of GA and insulin doses were comparable between the teneliglipin and dulaglutide groups. Conversely, although FM and SMM did not change in the teneligliptin group (from 15.7?kg to 14.1?kg, P?=?0.63 and 18.6?kg to 18.9?kg, P?=?0.16, respectively), those in the dulaglutide group significantly decreased (from 21.9?kg to 18.9?kg, P?=?0.037 and 21.0?kg to 20.2?kg, P?=?0.011, respectively).Conclusions
Six months of dulaglutide treatment significantly reduced not only FM but also SMM, although changes in GA and insulin doses were comparable with those in the teneligliptin group. Dulaglutide may have the effect of promoting sarcopenia; therefore, it may be carefully used in T2DM patients on HD. 相似文献10.
Using routine HbA1c measurements in stroke and the associations of dysglycaemia with stroke outcomes
Jeremy Lew Vincent Thijs Leonid Churilov Geoffrey Donnan Warwick Park Raymond Robbins Graeme K. Hart Christopher Bladin Kaylyn Khoo Lik-Hui Lau Alanna Tan Que Lam Douglas Johnson Jeffrey D. Zajac Elif I. Ekinci 《Journal of diabetes and its complications》2018,32(11):1056-1061
Aims
Diabetes is a major risk factor for stroke. We aimed to investigate the prevalence of diabetes and pre-diabetes within a stroke cohort and examine the association of glycaemia status with mortality and morbidity.Methods
Inpatients aged ≥54 who presented with a diagnosis of stroke had a routine HbA1c measurement as part of the Austin Health Diabetes Discovery Initiative. Additional data were attained from hospital databases and Australian Stroke Clinical Registry. Outcomes included diabetes and pre-diabetes prevalence, length of stay, 6-month and in-hospital mortality, 28-day readmission rates, and 3-month modified Rankin scale score.Results
Between July 2013 and December 2015, 610 patients were studied. Of these, 31% had diabetes while 40% had pre-diabetes. Using multivariable regression analyses, the presence of diabetes was associated with higher odds of 6-month mortality (OR?=?1.90, p?=?0.022) and higher expected length of stay (IRR?=?1.29, p?=?0.004). Similarly, a higher HbA1c was associated with higher odds of 6-month mortality (OR?=?1.27, p?=?0.005) and higher expected length of stay (IRR?=?1.08, p?=?0.010).Conclusions
71% of this cohort had diabetes or pre-diabetes. Presence of diabetes and higher HbA1c were associated with higher 6-month mortality and length of stay. Further research is necessary to determine if improved glycaemic control may improve stroke outcomes. 相似文献11.
Aladeen Alloubani Abdulmoneam Saleh Ibrahim Abdelhafiz 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(4):577-584
Background
Stroke is becoming a major challenge in healthcare systems, and this has necessitated the study of the various risk factors. As the number of people with hypertension, diabetes mellitus and obesity increases, the problem is expected to worsen. This review paper evaluates what can be done to eliminate or reduce the risk of stroke.Objective
The aim of the research is to evaluate the risk factors for stroke. The paper also aims to understand how these risks can be handled to avoid incidences of stroke.Method
Published clinical trials of stroke risk factors studies were recognised by a search of EMBASE and MEDLINE databases with keywords hypertension, blood pressure, diabetes mellitus, stroke or cardiovascular disease, or prospective study, and meta-analysis.Results
The findings of this review are that the prevention of stroke starts with identifying risk factors for stroke, most of the patients diagnosed with stroke have various risk factors. Consequently, it is a very significant to identify all the risk factors for stroke as well as to teach the patient how to dominate them.Conclusion
after summarising all the studies mentioned in the paper, it can be established that hypertension and diabetes mellitus are a stroke risk factors and correlated in patients with atherosclerosis. 相似文献12.
Stefano Bortolotti Lisa Zarantonello Ambra Uliana Nicola Vitturi Sami Schiff Patrizia Bisiacchi Angelo Avogaro Piero Amodio Alberto Maran 《Journal of diabetes and its complications》2018,32(11):1040-1045
Aims
To detect whether adults with type 1 diabetes mellitus (T1DM) have lower cognitive performance than healthy individuals and to detect risk factors for low cognitive performance.Methods
Twenty-six adults with T1DM and twenty-six healthy subjects matched for age, gender and educational level were compared for cognitive performance by a chronometric computerized test measuring visuo-spatial working memory (N-Back) and by two validated neuropsychological tests (Mini Mental State Examination, Animal Naming Test). Clinical data about diabetes duration, average daily insulin dosage, glycated haemoglobin, retinopathy, urine albumin-creatinine ratio, previous hypoglycaemic coma and awareness of hypoglycaemia were obtained from medical records. Basal pre-test glycemia and blood pressure were measured for each patient.Results
No differences were found between patients (n?=?26) and healthy controls (n?=?26) in neuropsychological tests. Within diabetic patients, those with impaired awareness of hypoglycaemia (n?=?7) or history of coma in the recent 1–3?years (n?=?5) had psychomotor slowing at the N-Back test (592?±?35 vs. 452?±?21?ms and 619?±?40 vs. 462?±?19?ms, respectively; both p?<?0.01). The variables related to diabetic severity did not show a relationship with reaction times of the N-Back test.Conclusion
Psychomotor speed slowing is detectable in patients with T1DM who have a history of previous hypoglycaemic episodes or coma. 相似文献13.
Objective
Ascending aortic aneurysm (AAA) is one of the major causes of ventricular diastolic dysfunction. Diastolic dysfunction can induce ventricular repolarization dispersion. Nevertheless, myocardial repolarization dispersion is not yet to be fully evaluated in patients with AAA. We aimed to evaluate ventricular repolarization using QT and Tp-Te interval and corrected (c) Tp-Te/QT ratio in patients with AAA.Methods
One hundred-four patients with AAA without coronary artery disease (CAD) served as the aneurysm group and 82 patients having a normal aortic diameter as the control group. All patients underwent transthoracic echocardiography (TTE) for measurements of LV diastolic function and underwent electrocardiography (ECG) to calculate RR, QT, Tp-Te intervals and QT dispersion. Bazett's formula was used to calculate QTc and cTp-Te intervals. cTp-Te/QT ratio was also calculated.Results
The groups were similar according to basal characteristics. We found left ventricular diastolic properties were impaired and QT dispersion, QTc interval, and both of Tp-Te and cTp-Te intervals were significantly prolonged in the aneurysm group than the control group. There were also significant correlations between TTE and ECG parameters. On multivariate linear regression analysis, indexed ascending aortic dimension (AAoD), LA diameter and E/e′ ratio were independent predictors of ventricular repolarization dispersion in AAA patients.Conclusions
Our study results showed that patients with AAA may have an increased risk for ventricular arrhythmogenesis because of deteriorated the left ventricular diastolic function. 相似文献14.
Jin Ook Chung Seon-Young Park Ji Hyun Han Dong Hyeok Cho Dong Jin Chung Min Young Chung 《Journal of diabetes and its complications》2018,32(4):357-361
Objective
To evaluate the relationship between levels of serum apolipoproteins and the prevalence of cardiovascular autonomic neuropathy (CAN) in type 2 diabetes.Methods
In total, 3199 individuals with type 2 diabetes were investigated in a cross-sectional study. The diagnosis of CAN was made based on the results of a cardiovascular reflex test. Serum apolipoprotein A-I (apoA-I) and apolipoprotein B (apoB) levels were measured.Results
Serum apoA-1 levels were significantly low in individuals with CAN, but there was no significant association between serum apoB levels and CAN. According to the degree of cardiovascular autonomic dysfunction, the average apoA-I levels were significantly different after adjusting for other covariates (normal, 1.32?g/l, 95% confidence interval [CI] 1.30–1.35; early, 1.29?g/l, 95% CI 1.27–1.31; definite, 1.27?g/l, 95% CI 1.25–1.30; P for trend?=?0.010). In the multivariable analysis, the statistically significant association between apoA-I and CAN remained after adjusting for the risk factors (odds ratio per standard deviation increase in the log-transformed value, 0.65; 95% CI, 0.43–0.97, P?=?0.036). Additional adjustments for serum high-sensitivity C-reactive protein (or fibrinogen) concentrations eliminated this relationship.Conclusions
Serum apoA-I levels are inversely associated with the prevalence of CAN in individuals with type 2 diabetes. Our data also suggest that a putatively increased risk of CAN associated with decreased apoA-I levels might be mediated by correlated increases in the levels of inflammatory markers. 相似文献15.
Daniel Restifo Joni S. Williams Emma Garacci Rebekah J. Walker Mukoso N. Ozieh Leonard E. Egede 《Journal of diabetes and its complications》2018,32(9):819-823
Background
Diabetes has been identified as a risk factor for developing colorectal cancer (CRC); however, the literature identifying groups most at risk is sparse. This study aims to understand the relationship between CRC and diabetes by age and race/ethnicity.Methods
This is a cross-sectional study of data from the 2001–2014 National Health and Nutrition Examination Survey (unweighted n?=?37,173; weighted n?=?214,363,348). Individuals were categorized as having CRC if diagnosed with colon or rectal cancer and as having diabetes if told by a doctor they had diabetes, were taking insulin, or had an HbA1c?≥?6.5%. Covariates included gender, age, race, marital status, educational level and income as a ratio of the poverty line. Multivariable logistic regression was used to assess the relationship between CRC and diabetes overall and stratified by age and by race.Results
24.32% of the sample with CRC also had diabetes. After adjusting for covariates, individuals with diabetes had a 47% greater probability of having CRC (p?=?0.03). While significance did not persist after stratification for those ≥65?years (OR?=?1.06, p?=?0.74), those <65?years with diabetes had nearly 5-times higher odds of having CRC (OR?=?4.78, p?<?0.001). When stratified by race, both groups had statistically higher odds of having CRC; however, the odds for non-whites (OR?=?1.87, p?=?0.04) were higher compared to whites (OR?=?1.54, p?=?0.03).Conclusion
Individuals younger than 65 and racial/ethnic minorities have higher odds of CRC when also diagnosed with diabetes. Targeted interventions for these populations, especially regarding screening recommendations, may result in earlier detection of CRC and improved health outcomes. 相似文献16.
Takahiro Yajima Kumiko Yajima Makoto Hayashi Hiroshi Takahashi Keigo Yasuda 《Journal of diabetes and its complications》2018,32(3):310-315
Aims
To evaluate the efficacy and safety of adding once-weekly dulaglutide to insulin therapy in type 2 diabetes mellitus (T2DM) patients on hemodialysis.Methods
Fifteen insulin-treated T2DM patients on hemodialysis were enrolled. Continuous glucose monitoring was performed before (1st hospitalization) and after the fifth dulaglutide administration (2nd hospitalization). The insulin dose was reduced after the first administration of dulaglutide (1st hospitalization day 6). Parameters of glycemic control were compared on 1st hospitalization days 4–5, 2nd hospitalization days 3–4, and days 6–7.Results
The median total daily insulin dose was reduced significantly from 12 (12–25) to 0 (0?12) U (p?<?0.0001) after treatment with dulaglutide. Mean glucose level on 2nd hospitalization days 3–4 significantly decreased and that on days 6–7 tended to decrease compared with that on 1st hospitalization days 4–5 (median, 8.2 to 6.7?mmol/L, P?=?0.006 and 8.2 to 6.9?mmol/L, P?=?0.053, respectively). %CV of glucose levels decreased significantly after dulaglutide administration (28.1 to 19.8, P?=?0.003 and 28.1 to 21.0, P?=?0.019). However, the incidence of hypoglycemia remained unchanged.Conclusions
Dulaglutide may improve glycemic control and excursion and allow total daily insulin to be reduced without increasing the risk of hypoglycemia in T2DM patients on hemodialysis. 相似文献17.
Giuseppe d&#x;Annunzio Andrea Beccaria Angela Pistorio Enrico Verrina Nicola Minuto Roberto Pontremoli Alberto La Valle Mohamad Maghnie 《Journal of diabetes and its complications》2018,32(10):955-960
Aims
Diabetic Nephropathy (DN) is rarely encountered in childhood, otherwise early subclinical abnormalities are detectable few years after diabetes diagnosis. Our aim was to evaluate the incidence rate of microalbuminuria in childhood onset type 1 diabetes (DM1) patients. Secondary aim was to examine which variables could influence the development of DN.Methods
We longitudinally evaluated 137 young patients with DM1 from diagnosis (1994–2004) for a median of 11.8?years (1st–3rd q: 9.7–15.0). Overnight albumin excretion rate, degree of metabolic control, presence of microangiopathic complications and autoimmune co-morbidities were retrospectively collected.Results
DN was observed in 16/137 cases (11.7%), with an incidence rate of 10.0 per 1000?person-years. Young T1D patients with persistent micro/macro-albuminuria were more likely to have higher HbA1c concentrations over the last four years (P?=?0.04), and were more likely to have retinopathy (P?=?0.011) and subclinical peripheral neuropathy (P?=?0.003).Conclusions
DN predictors were age at DM1 diagnosis and mean HbA1c levels. Even if DN incidence is lower than reported, periodical screening is mandatory. Moreover, borderline microalbuminuria as additional risk factor deserves attention. 相似文献18.
Hadii M. Mamudu Pooja Subedi Timir Paul Ali E. Alamin Arsham Alamian Liang Wang David Stewart Antwan Jones Sam Harirforoosh Gerald Blackwell Matthew Budoff 《Journal of diabetes and its complications》2018,32(10):900-905
Aim
To examine the risk factor of coronary artery calcium (CAC) in individuals with diabetes and those without diabetes in Central Appalachia.Methods
Study population included 2479 asymptomatic participants who underwent CAC screening between August 2012 and November 2016. CAC score was classified into four categories [0 (no plaque), 1–99 (mild plaque), 100–399 (moderate plaque), and ≥400 (severe plaque)]. Multinomial logistic regression analyses were conducted to test the association between CAC and cardiovascular disease (CVD) risk factors among participants with diabetes, age and gender matched controls, and randomly selected controls.Results
13.6% of total participants had diabetes. Around 69%, 59.8%, and 57.7% of the participants with diabetes, matched controls, and randomly selected controls had CAC score ≥1, respectively. Participants with diabetes had higher prevalence of all CVD risk factors than controls. Among participants with diabetes, hypertension and physical inactivity increased the odds of CAC?=?100–399, while among those without diabetes, hypertension and hypercholesteremia increased the odds of having CAC?=?1–99 and CAC?≥?400.Conclusion
Half of study participants had subclinical atherosclerosis (i.e., CAC), and individuals with diabetes had higher CAC scores. This study suggests that individuals with diabetes in Central Appalachia might benefit from screening for CAC. 相似文献19.
Jhen-Hao Jhan Hsin-Chih Yeh Yu-Han Chang Shiao-Jin Guu Wen-Jeng Wu Yii-Her Chou Ching-Chia Li 《Journal of diabetes and its complications》2018,32(7):688-692
Introduction
Androgen-deprivation therapy (ADT) is important in the treatment of prostate cancer. However, the relationship between ADT and the risk of diabetes remains unclear, and the association between duration and types of ADT has not been fully investigated.Aim
To examine the risk of developing type 2 diabetes mellitus (T2DM) in men who underwent ADT for prostate cancer.Methods
Data were collected retrospectively from the Longitudinal Health Insurance Database of Taiwan. In total, 4604 prostate cancer patients ≥40?years old who underwent ADT were included in the study cohort, and 4604 prostate cancer patients without ADT were included as controls, after adjusting for age and other comorbidities.Results
During the four-year follow-up period, the incidence of new-onset T2DM was 27.49 and 11.13 per 1000 person-years in the ADT and ADT-never cohorts, respectively. The ADT cohort was 2.19 times more likely to develop T2DM than the control group (95% CI 1.90–2.53, P?<?0.001). Furthermore, the association was particularly striking in the subgroup of patients receiving complete androgen blockade (adjusted HR 2.33, 95% CI 1.96–2.78, P?<?0.001).Conclusions
Men with prostate cancer who received ADT are at risk for developing diabetes. 相似文献20.
Nuray Kahraman Ay Asim Enhos Yasin Ay Nijad Bakhshaliyev Aydin Nadir Erdem Karacop Ilke Celikkale Mahmut Uluganyan Razaman Ozdemir Omer Goktekin 《Journal of electrocardiology》2018,51(6):923-927