Early operation for fulminant acute pancreatitis: a possible way to decrease mortality

Background Although the indication and the timing for surgery in fulminant acute pancreatitis (FAP) are still controversial, our experience of surgical treatment for fulminant acute pancreaUtis may help improve the outcome for patients.Methods The clinical data of twenty-six patients with FAP from January 1, 2001 to October 1,2005 were analyzed. The diagnostic criteria fitted the 2007 Guidelines for the Management of Severe Acute Pancreatitis by the Chinese Medical Association.Results Twenty-six patients with FAP received surgical debridement, with a mortality rate of 42.3% (11/26). The postoperative mortalities in the ＞72 hour operation group and the <72 hour operation group were highly significantly different (7/8 vs 22.2% (4/18), respectively).Conclusions Early surgery may reduce the intraabdominal pressure and prevent the deterioration of FAP. An operation within 72 hours from the onset of symptoms might decrease the mortality of the disease.     

Early operation for fulminant acute pancreatitis: a possible way to decrease mortality

Background Although the indication and the timing for surgery in fulminant acute pancreatitis (FAP) are still controversial, our experience of surgical treatment for fulminant acute pancreaUtis may help improve the outcome for patients.Methods The clinical data of twenty-six patients with FAP from January 1, 2001 to October 1,2005 were analyzed. The diagnostic criteria fitted the 2007 Guidelines for the Management of Severe Acute Pancreatitis by the Chinese Medical Association.Results Twenty-six patients with FAP received surgical debridement, with a mortality rate of 42.3% (11/26). The postoperative mortalities in the ＞72 hour operation group and the <72 hour operation group were highly significantly different (7/8 vs 22.2% (4/18), respectively).Conclusions Early surgery may reduce the intraabdominal pressure and prevent the deterioration of FAP. An operation within 72 hours from the onset of symptoms might decrease the mortality of the disease.     

Early operation for fulminant acute pancreatitis: a possible way to decrease mortality

Background Although the indication and the timing for surgery in fulminant acute pancreatitis (FAP) are still controversial, our experience of surgical treatment for fulminant acute pancreaUtis may help improve the outcome for patients.Methods The clinical data of twenty-six patients with FAP from January 1, 2001 to October 1,2005 were analyzed. The diagnostic criteria fitted the 2007 Guidelines for the Management of Severe Acute Pancreatitis by the Chinese Medical Association.Results Twenty-six patients with FAP received surgical debridement, with a mortality rate of 42.3% (11/26). The postoperative mortalities in the ＞72 hour operation group and the <72 hour operation group were highly significantly different (7/8 vs 22.2% (4/18), respectively).Conclusions Early surgery may reduce the intraabdominal pressure and prevent the deterioration of FAP. An operation within 72 hours from the onset of symptoms might decrease the mortality of the disease.     

Early operation for fulminant acute pancreatitis: a possible way to decrease mortality

Background Although the indication and the timing for surgery in fulminant acute pancreatitis (FAP) are still controversial, our experience of surgical treatment for fulminant acute pancreaUtis may help improve the outcome for patients.Methods The clinical data of twenty-six patients with FAP from January 1, 2001 to October 1,2005 were analyzed. The diagnostic criteria fitted the 2007 Guidelines for the Management of Severe Acute Pancreatitis by the Chinese Medical Association.Results Twenty-six patients with FAP received surgical debridement, with a mortality rate of 42.3% (11/26). The postoperative mortalities in the ＞72 hour operation group and the <72 hour operation group were highly significantly different (7/8 vs 22.2% (4/18), respectively).Conclusions Early surgery may reduce the intraabdominal pressure and prevent the deterioration of FAP. An operation within 72 hours from the onset of symptoms might decrease the mortality of the disease.     

Early operation for fulminant acute pancreatitis: a possible way to decrease mortality

Background Although the indication and the timing for surgery in fulminant acute pancreatitis (FAP) are still controversial, our experience of surgical treatment for fulminant acute pancreaUtis may help improve the outcome for patients.Methods The clinical data of twenty-six patients with FAP from January 1, 2001 to October 1,2005 were analyzed. The diagnostic criteria fitted the 2007 Guidelines for the Management of Severe Acute Pancreatitis by the Chinese Medical Association.Results Twenty-six patients with FAP received surgical debridement, with a mortality rate of 42.3% (11/26). The postoperative mortalities in the ＞72 hour operation group and the <72 hour operation group were highly significantly different (7/8 vs 22.2% (4/18), respectively).Conclusions Early surgery may reduce the intraabdominal pressure and prevent the deterioration of FAP. An operation within 72 hours from the onset of symptoms might decrease the mortality of the disease.     

Early operation for fulminant acute pancreatitis: a possible way to decrease mortality

Background Although the indication and the timing for surgery in fulminant acute pancreatitis (FAP) are still controversial, our experience of surgical treatment for fulminant acute pancreaUtis may help improve the outcome for patients.Methods The clinical data of twenty-six patients with FAP from January 1, 2001 to October 1,2005 were analyzed. The diagnostic criteria fitted the 2007 Guidelines for the Management of Severe Acute Pancreatitis by the Chinese Medical Association.Results Twenty-six patients with FAP received surgical debridement, with a mortality rate of 42.3% (11/26). The postoperative mortalities in the ＞72 hour operation group and the <72 hour operation group were highly significantly different (7/8 vs 22.2% (4/18), respectively).Conclusions Early surgery may reduce the intraabdominal pressure and prevent the deterioration of FAP. An operation within 72 hours from the onset of symptoms might decrease the mortality of the disease.     

Early operation for fulminant acute pancreatitis: a possible way to decrease mortality

Background Although the indication and the timing for surgery in fulminant acute pancreatitis (FAP) are still controversial, our experience of surgical treatment for fulminant acute pancreaUtis may help improve the outcome for patients.Methods The clinical data of twenty-six patients with FAP from January 1, 2001 to October 1,2005 were analyzed. The diagnostic criteria fitted the 2007 Guidelines for the Management of Severe Acute Pancreatitis by the Chinese Medical Association.Results Twenty-six patients with FAP received surgical debridement, with a mortality rate of 42.3% (11/26). The postoperative mortalities in the ＞72 hour operation group and the <72 hour operation group were highly significantly different (7/8 vs 22.2% (4/18), respectively).Conclusions Early surgery may reduce the intraabdominal pressure and prevent the deterioration of FAP. An operation within 72 hours from the onset of symptoms might decrease the mortality of the disease.     

Early operation for fulminant acute pancreatitis: a possible way to decrease mortality

Background Although the indication and the timing for surgery in fulminant acute pancreatitis (FAP) are still controversial, our experience of surgical treatment for fulminant acute pancreaUtis may help improve the outcome for patients.Methods The clinical data of twenty-six patients with FAP from January 1, 2001 to October 1,2005 were analyzed. The diagnostic criteria fitted the 2007 Guidelines for the Management of Severe Acute Pancreatitis by the Chinese Medical Association.Results Twenty-six patients with FAP received surgical debridement, with a mortality rate of 42.3% (11/26). The postoperative mortalities in the ＞72 hour operation group and the <72 hour operation group were highly significantly different (7/8 vs 22.2% (4/18), respectively).Conclusions Early surgery may reduce the intraabdominal pressure and prevent the deterioration of FAP. An operation within 72 hours from the onset of symptoms might decrease the mortality of the disease.     

Early operation for fulminant acute pancreatitis: a possible way to decrease mortality

Background Although the indication and the timing for surgery in fulminant acute pancreatitis (FAP) are still controversial, our experience of surgical treatment for fulminant acute pancreaUtis may help improve the outcome for patients.Methods The clinical data of twenty-six patients with FAP from January 1, 2001 to October 1,2005 were analyzed. The diagnostic criteria fitted the 2007 Guidelines for the Management of Severe Acute Pancreatitis by the Chinese Medical Association.Results Twenty-six patients with FAP received surgical debridement, with a mortality rate of 42.3% (11/26). The postoperative mortalities in the ＞72 hour operation group and the <72 hour operation group were highly significantly different (7/8 vs 22.2% (4/18), respectively).Conclusions Early surgery may reduce the intraabdominal pressure and prevent the deterioration of FAP. An operation within 72 hours from the onset of symptoms might decrease the mortality of the disease.     

Early operation for fulminant acute pancreatitis: a possible way to decrease mortality

Background Although the indication controversial, our experience of surgical patients. and the timing for surgery in fulminant treatment for fulminant acute pancreatitis acute pancreatitis （FAP） are still may help improve the outcome for Methods The clinical data of twenty-six patients with FAP from January 1, 2001 to October 1, 2005 were analyzed. The diagnostic criteria fitted the 2007 Guidelines for the Management of Severe Acute Pancreatitis by the Chinese Medical Association. Results Twenty-six patients with FAP received surgical debridement, with a mortality rate of 42.3% （11/26）. The postoperative mortalities in the 〉72 hour operation group and the 〈72 hour operation group were highly significantly different （7/8 vs 22.2% （4/18）, respectively）. Conclusions Early surgery may reduce the intraabdominal pressure and prevent the deterioration of FAP. An operation within 72 hours from the onset of symptoms might decrease the mortality of the disease.     

暴发性急性胰腺炎早期感染特点分析

目的 探讨暴发性急性胰腺炎（FAP）患者早期感染的临床和细菌学特点.方法 回顾性分析82例外科重症监护病房收治的FAP患者的病史资料,比较发病14 d内继发感染患者（早期感染组,n=51）与非感染患者（非感染组,n=31）感染相关因素和28 d病死率,分析早期感染组患者的感染与细菌学特点.结果 早期感染组机械通气比例和早期手术比例显著高于非感染组（P＜0.05）,两组其他感染相关因素和28 d病死率差异无统计学意义（P〉0.05）.早期感染组共检出68株病原菌,分别为革兰阳性菌22株（32.4%）,革兰阴性菌29株（42.6%）,真菌17株（25.0%）;早期感染组胆道感染11例（21.6%）,肺部感染24例（47.1%）,胰腺与胰周感染8例（15.7%）,血流性感染3例（5.9%）,创面感染7例（13.7%）,尿路感染4例（7.8%）.结论 FAP患者早期感染发生率较高,机械通气和早期手术可能与早期感染的发生相关;革兰阴性菌为主要病原菌,革兰阳性菌和真菌也占据一定比例.     

暴发性急性胰腺炎早期感染特点分析

目的 探讨暴发性急性胰腺炎（FAP）患者早期感染的临床和细菌学特点。方法 回顾性分析82例外科重症监护病房收治的FAP患者的病史资料，比较发病14 d内继发感染患者（早期感染组，n=51）与非感染患者（非感染组，n=31）感染相关因素和28 d病死率，分析早期感染组患者的感染与细菌学特点。结果 早期感染组机械通气比例和早期手术比例显著高于非感染组（P＜0.05），两组其他感染相关因素和28 d病死率差异无统计学意义（P>0.05）。早期感染组共检出68株病原菌，分别为革兰阳性菌22株（32.4%），革兰阴性菌29株(42.6%)，真菌17株(25.0%)；早期感染组胆道感染11例（21.6%），肺部感染24例（47.1%），胰腺与胰周感染8例（15.7%），血流性感染3例（5.9%），创面感染7例（13.7%），尿路感染4例（7.8%）。结论 FAP患者早期感染发生率较高，机械通气和早期手术可能与早期感染的发生相关；革兰阴性菌为主要病原菌，革兰阳性菌和真菌也占据一定比例。     

急性胰腺炎手术治疗的探讨

目的 :探讨提高急性胰腺炎的治愈率 ,减少并发症和死亡率。方法 :沿胰腺纵轴和与纵轴斜行切开胰腺包膜 ,腺体松动 ,小网膜腔置管灌洗引流。结果 :本组 3 6例均经CT、B超和手术证实 ,急性出血坏死性胰腺炎 3 4例 ,急性水肿型胰腺炎 2例 ,经本方法治疗均在两周后痊愈出院。结论 :本手术方法是能提高急性胰腺炎治愈率 ,减少并发症和死亡率的一种较简单安全的有效方法     

超声监测在急性暴发型心肌炎PCPS治疗中的应用(附1例报告)

目的 动态观察急性暴发型心肌炎的心脏超声心动图表现及在经皮心肺支持系统(PCPS)治疗术中的应用价值。方法 应用彩色多普勒超声心动图诊断仪动态观察1例急性暴发型心肌炎患者在PCPS治疗术前后房室腔大小、室壁厚度、搏动幅度以及心功能指标,床旁实时监测术中导管位置。结果 超声心动图监测表现为PCPS术前后室壁运动功能明显改善,心脏射血分数与室壁短轴缩短率改善。结论 急性暴发型心肌炎患者超声表现为室壁运动明显减弱,心脏射血分数明显减低,左室腔内径增大,少量心包积液。彩色多普勒超声诊断在心脏急症的救治中能起到重要作用。     

重症急性胰腺炎非手术治疗方法的探讨

目的探讨急性重症胰腺炎的非手术治疗方法。方法回顾性分析2001年～2004年50例急性重症胰腺炎患者非手术治疗的临床资料。结果急性重症胰腺炎(SAP)是一病情凶险、并发症多的急腹症,非手术疗法可纠正SAP引起的一系列早期病理生理改变,并取得满意治疗效果。结论对SAP不再是针对清除胰周及胰腺坏死组织的手术治疗,而主要是应用积极、有效、综合的非手术治疗,处理胰腺感染等并发症。可取得满意的治疗效果。     

重症急性胰腺炎非手术治疗方法的探讨

目的 探讨急性重症胰腺炎的非手术治疗方法。方法 回顾性分析2001年一2004年50例急性重症胰腺炎患者非手术治疗的临床资料。结果 急性重症胰腺炎（sAP）是一病情凶险、并发症多的急腹症，非手术疗法可纠正SAP引起的一系列早期病理生理改变，并取得满意治疗效果。结论 对SAP不再是针对清除胰周及胰腺坏死组织的手术治疗，而主要是应用积极、有效、综合的非手术治疗，处理胰腺感染等并发症。可取得满意的治疗效果。     

重症急性胰腺炎早期目标指导的液体治疗

目的探讨重症急性胰腺炎(severe acute pancreatitis,SAP)早期2种不同液体治疗策略对患者预后的影响。方法回顾性分析首都医科大学宣武医院2000年1月至2010年1月期间收治的80例SAP患者,2000年1月至2004年12月期间收治的患者采用传统液体治疗方法(简称传统治疗组,n=34),2005年1月至2010年1月期间收治的患者采取早期目标指导的液体治疗策略(简称早期目标治疗组,n=46),比较2组间急性生理与慢性健康状况评分(APACHEⅡ)、器官功能不全评分(Marshall)、多器官功能不全综合征(multiple organ dysfunction syndrome,MODS)发生率、胰腺感染率和病死率的差异。结果与传统治疗组相比,早期目标治疗组患者液体治疗第3天的APACHEⅡ和Marshall评分有显著降低(分别为APACHEⅡ:8.22±3.89 vs 11.35±4.27,P=0.017;Marshall:4.48±2.21 vs 6.82±3.15,P=0.021)。另外,早期目标治疗组患者入院1周内MODS发生率、胰腺感染率和住院病死率也较传统治疗组有所降低(分别为MODS:52%vs 62%,P=0.393;胰腺感染率:37%vs 44%,P=0.653;病死率:17%vs 24%,P=0.576),但其差异无统计学意义。结论本研究有限的病例结果提示,早期目标指导的液体治疗可在一定程度上缓解SAP病情,但能否改善SAP患者预后有待临床进行前瞻性随机对照研究。     

重症急性胰腺炎Ⅰ、Ⅱ级胰腺坏死特点和早期手术指征的探讨

目的：探讨重症急性胰腺炎（ＳＡＰ）Ⅰ、Ⅱ级的胰腺坏死特点及早期手术指征。方法：回顾分析我院１９８０年１月至２０００年５月ＳＡＰ１８２例的手术病理所见、临床表现、治疗方案和死亡原因。结果：ＳＡＰⅠ级中５９．２％为胰腺局灶型坏死,其中有２４．４％进展为广泛坏死,另４０．８％为广泛坏死;ＳＡＰⅡ级１００％为广泛坏死。广泛坏死在强化非手术治疗前提下适时早期手术能提高治愈率。结论：ＳＡＰⅡ级早期非手术治疗无效时应适时手术治疗。     

重症急性胰腺炎标准作业程序诊治流程的临床应用

目的 自拟重症急性胰腺炎（SAP）院内急救一体化标准作业程序（SOP）诊治流程,观察该SOP的临床应用效果。方法 组织上海市部分急诊重症监护病房（ICU）质量控制中心专家讨论,参阅国内外相关文献与SAP指南,并结合国内临床实际和海军军医大学（第二军医大学）长征医院"急诊-ICU"一体化建设经验,草拟SAP院内急救一体化SOP诊治流程。并将自拟的SOP方案应用于海军军医大学（第二军医大学）长征医院急救科2015年7月至2017年1月收治的42例符合SOP实施标准的SAP患者（优化组）,选择2014年1月至2015年6月收治的40例SAP患者作为常规组。比较两组患者的临床疗效,入院后72 h和1周时的白细胞计数、中性粒细胞比例、C-反应蛋白水平、降钙素原（PCT）水平、血淀粉酶水平、血糖水平、血乳酸水平、血清肌酐水平、氧合指数、改良CT严重指数（MCTSI）评分、腹腔内压力、尿中性粒细胞明胶酶相关脂质运载蛋白（NGAL）水平、急性生理和慢性健康评估Ⅱ（APACHE Ⅱ）评分等临床指标,以及相关并发症发生情况和生存情况。结果 拟定的SOP诊治流程主要参考2012年度国际SAP诊治标准,其主要变化在于患者由急诊外科医师首诊改为直接进入急诊绿色通道（抢救室）,且在综合救治方案中加入大剂量乌司他丁静脉推注、人血清白蛋白快速滴注（必要时呋噻米静脉推注）、规范化全腹芒硝外敷和生大黄灭菌溶液灌肠。优化组患者的总有效率优于常规组（P<0.05）,住院时间、自主排气时间、腹胀缓解时间、ICU停留时间、连续肾脏替代疗法治疗时间相比常规组均缩短（P均<0.05）。入院后72 h、1周时,两组患者的白细胞计数、中性粒细胞比例、C-反应蛋白水平、PCT水平、血糖水平、血乳酸水平、血清肌酐水平、氧合指数、MCTSI评分、腹腔内压力、尿NGAL水平、APACHE Ⅱ评分差异均有统计学意义（P均<0.05）,血淀粉酶水平仅在入院后72 h差异有统计学意义（P<0.01）。优化组患者急性肾衰竭、急性呼吸窘迫综合征、腹腔积液、腹腔间隔室综合征、胰腺假性囊肿和胰腺脓肿的发生率均低于常规组（P均<0.05）,生存时间长于常规组（P<0.05）,治疗2个月内的生存率高于常规组（P<0.05）。结论 拟定的院内急救一体化SOP可规范SAP诊治流程,提高SAP的救治有效率,降低病死率。     

糖皮质激素治疗重症急性胰腺炎效果的meta分析

目的 评价糖皮质激素（glucocorticoids,GC）治疗重症急性胰腺炎（severe acute pancreatitis,SAP）的疗效。 方法 根据文献纳入标准,摘录纳入文献中相关实验设计、研究对象特征、研究结果等内容。用RevMan 5.1软件进行统计。 结果 有8篇文献被纳入分析,共计361例患者,其中GC治疗组184例,对照组177例。6项试验报道了SAP患者的死亡率,显示GC组的死亡率（14/145,9.655%）明显低于对照组（28/139, 20.14%）,其差异具有统计学意义[OR=0.42, 95% CI（0.21~0.83）,P=0.01];3项试验的结果显示GC组的急性呼吸窘迫综合征（acute respiratory distress syndrome,ARDS）发生率（20/95,21.05%）较对照组（37/89, 41.57%）明显降低,差异有统计学意义[OR=0.33,95% CI（0.16~0.65）, P=0.001]。3项试验的结果显示GC治疗组中转手术率（12/87,13.79%）较对照组（26/81, 32.09%）明显降低,差异有统计学意义[OR=0.29,95% CI（0.13~0.67）, P=0.004]。4项试验的结果显示GC组平均住院时间低于对照组,差异具有统计学意义[标化均数差值-1.52, 95% CI （-2.73~-0.32）,P=0.01]; 结论 GC在降低SAP患者ARDS发生率和死亡率及缩短住院时间等方面明显优于常规治疗,GC可作为SAP的早期治疗的新选择,在临床上具有良好的应用前景。