共查询到20条相似文献,搜索用时 250 毫秒
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在《中国药典》2000年版中,当测定颗粒剂的【干燥失重】时规定:“除另有规定外,照干燥失重测定法测定,含糖颗粒剂宜在80℃真空干燥,减失重量不得超过2.0%”。但附录“干燥失重测定法”中并未规定干燥温度。为消除此缺陷,2005年版药典在颗粒剂【干燥失重】测定中增加了温度的规定:“…于105℃干燥至恒重”。[第一段] 相似文献
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目的采用干燥失重法建立以PEG6000为载体辅料制备的熊果酸固体分散体的水分测定方法。方法先将样品在较低的温度(52℃)下干燥至大部分水分除去后,然后逐渐升温至105℃干燥至恒重。另应用甲苯法测定样品的水分。结果在低温(52℃)下可以将70%以上的大部分水分除去,在105℃极易恒重。测定结果同甲苯法无显著性差异。结论干燥失重法不需要特殊设备,简单易行、重复性好,可用于该制剂水分的测定。 相似文献
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微波干燥与灭菌方法与传统方法效果比较 总被引:1,自引:0,他引:1
目的:研究微波干燥灭菌技术的特点和优点。方法:选用同种白一丸成品,运用微波和传统方法从时间、温度等方面考察干燥灭菌效果。结果:微波干燥灭菌方法效果明显优于传统方法。结论:微波干燥灭菌,不仅干燥速度快,能源利用率高,干燥灭菌效果好,成品质量高。 相似文献
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The freezing of antibiotic admixtures has been proposed as a potentially useful method by which the efficiency of admixture services might be improved. The time involved in thawing, however, has discouraged the implementation of this practice. This study describes a technique of thawing frozen antibiotic admixtures contained in minibags in commercially available microwave ovens. A quantitative microbiological agar gel diffusion assay was employed to determine the effect of such treatment on the antibiotic activity of the admixture. Admixtures containing cephalothin sodium, cefazolin sodium, cefamandole nafate, cefoxitin sodium, penicillin G potassium, ampicillin sodium, oxacillin sodium, carbenicillin disodium, and gentamicin sulfate in dextrose 5% solution were frozen at -20 degrees C for 30 days. The admixtures were assayed immediately before freezing, and again after either thawing technique: that is, upon exposure of the minibags to room temperature air or to microwave radiation. Assays were also performed 8 and 24 hours after thawing in order to assess antibiotic stability following each freeze-thaw treatment. It was discovered that, with the exception of ampicillin sodium, each of the antibiotics studied could be frozen and thawed as described without significant loss of activity, and were stable for 24 hours after thawing. The application of a freeze microwave-thaw technique to central admixture services can be seen as a cost-effective method of circumventing many of the problems associated with existing programs. 相似文献
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Caroline Buschmüller Wolfgang Wiedey Claas Dscher Jochen Dressler Jrg Breitkreutz 《European journal of pharmaceutics and biopharmaceutics》2008,69(1):380-387
This is the first report on in-line moisture measurement of pharmaceutical products by microwave resonance technology. In order to meet the FDA’s PAT approach, a microwave resonance sensor appropriate for pharmaceutical use was developed and implemented into two different fluidized-bed dryers. The novel sensor enables a continuous moisture measurement independent from the product density. Hence, for the first time precise real time determination of the moisture in pharmaceutical granules becomes possible. The qualification of the newly developed sensor was performed by drying placebo granules under experimental conditions and the validation using drug loaded granules under real process conditions. The results of the investigations show good correlations between water content of the granules determined by the microwave resonance sensor and both reference methods, loss on drying by infrared light exposure and Karl Fischer titration. Furthermore, a considerable time saving in the drying process was achieved through monitoring the residual water content continuously by microwave resonance technology instead of the formerly used discontinuous methods. 相似文献
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Young-Joon Park Dong-Sung Ryu Dong Xun Li Qi Zhe Quan Dong Hoon Oh Jong Oh Kim Youn Gee Seo Young-Im Lee Chul Soon Yong Jong Soo Woo Han-Gon Choi 《Archives of pharmacal research》2009,32(6):893-898
To develop a novel tacrolimus-loaded solid dispersion with improved solubility, various solid dispersions were prepared with
various ratios of water, sodium lauryl sulfate, citric acid and carboxylmethylcellulose-Na using spray drying technique. The
physicochemical properties of solid dispersions were investigated using scanning electron microscopy, differential scanning
calorimetery and powder X-ray diffraction. Furthermore, their solubility and dissolution were evaluated compared to drug powder.
The solid dispersion at the tacrolimus/CMC-Na/sodium lauryl sulfate/citric acid ratio of 3/24/3/0.2 significantly improved
the drug solubility and dissolution compared to powder. The scanning electron microscopy result suggested that carriers might
be attached to the surface of drug in this solid dispersion. Unlike traditional solid dispersion systems, the crystal form
of drug in this solid dispersion could not be converted to amorphous form, which was confirmed by the analysis of DSC and
powder X-ray diffraction. Thus, the solid dispersion system with water, sodium lauryl sulfate, citric acid and CMC-Na should
be a potential candidate for delivering a poorly water-soluble tacrolimus with enhanced solubility and no convertible crystalline. 相似文献
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目的:对不同生产工艺哌拉西林钠的质量进行对比研究及评价。方法:运用水分、水活度、酸度、有关物质等方法测定不同工艺产品,同时进行加速试验,并将测定结果进行多因素相关分析,综合评价不同工艺产品的质量。结果:冷冻干燥样品的水分、水活度、有关物质测定结果明显低于喷雾干燥样品,pH高于喷雾干燥样品,且产品的稳定性较喷雾干燥样品好。结果表明,水分与产品质量密切相关。结论:控制水分是保证本品质量的关键环节;应对现行标准部分项目控制指标予以修改;研究表明冷冻干燥工艺生产的原料质量较好,且不易受环境因素的影响,应当引导企业主动使用该原料。 相似文献
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Hinz DC 《Journal of pharmaceutical and biomedical analysis》2007,43(2):779-783
The water content of six different substances was determined by means of five different methods. The methods used were loss on drying, thermogravimetry (coupled with DSC), a new phosphorous-pentoxide method, direct Karl-Fischer titration and the Karl-Fischer oven. A combination of direct Karl-Fischer titration and the KF-oven method was found to be the optimal technique for water determination of substances of unidentified chemical and thermal behaviour based on detailed considerations about selectivity, type of water binding, sample properties and efficiency. 相似文献
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The poor solubility of astaxanthin in water can cause problems during dissolution tests of dosage forms because they are usually performed in water-based media. The aim of this study was the development of a convenient dissolution medium and a method for a spectrophotometric determination of astaxanthin in an aqueous solution. Three surfactants in different concentrations were tested as solubility-improving substances: sodium lauryl sulfate (SLS), polysorbate 80 (PS 80) and macrogolglycerol hydroxystearate (Cremophor RH 40, CR 40). Optimal conditions were determined. The dissolution of astaxanthin from solid dosage form is performed into 1000 g of a solution of sodium lauryl sulfate with the concentration 1.0% (w/w) at 37 degrees C by paddle method, 100 rotations per minute, dissolution time 30 minutes. The procedure is convenient for solid dosage forms with a content of 4 to 12 mg of astaxanthin. The spectrophotometric determination of astaxanthin in aqueous solution from the dissolution test is measured at 486 nm. The specific absorbance A(1%) 1cm for astaxanthin in water is 2000, a sodium lauryl sulfate solution (1%) was used as a blank. 相似文献