Apparent Extension of the Atrioventricular Interval Due to Sensor-Based Algorithm Against Supraventricuiar Tachyarrhythmias

Rapid ventricular tracking response to supraventricular tachyarrhythmia is one major limitation to DDD pacing. In a DDDR pacemaker, sensor-based algorithms have been used to control these arrhythmias. These include the use of an interim rate limit (conditional ventricular tracking limit) or a separate maximum tracking and sensor rate limits (discrepant upper rate). These algorithms limit inappropriate ventricular pacing rate during tracking of pathological supraventricuiar tachyarrhythmia and atrial flutter by Wenckebach-like prolongation of the AV interval. We observed that this may cause an unexpected extension of the AV interval in patients with high atrial rate and intact AV nodal conduction. This was due to P wave rate above the conditional ventricular tracking limit or maximum tracking limit, but AV paced interval prolongation was avoided by the occurrence of intrinsic conduction, albeit at an AV interval longer than the programmed AV interval. This might appear as failure of ventricular pacing on the ECG. This phenomenon is a modified form of "upper rate" behavior occurring in the AV interval, and should be recognized as a normal behavior rather than pacemaker malfunction.     

Behavior of the Ventricular Triggering Period of DDD Pacemakers

Fifty-seven patients with implanted DDD pulse generators (23 Intermedics Cosmos and 34 Medtronic Symbios) were studied to characterize the behavior of the so-called ventricular safety pace period or nonphysiologic AV delay (ventricular triggering period) in a variety of circumstances. The pulse generators were programmed to various combinations of upper rate, lower rate, and atrioventricular (AV) intervals. We then evaluated the response of the pulse generators to a variety of signals sensed by the ventricular channel during the ventricular triggering period (VTP). In the Cosmos DDD pulse generators, the VTP lengthened from its nominal value (100 ms) whenever the sum of the atrial escape (pacemaker VA) interval and the nominal value of the VTP was shorter than the upper rate limit interval. Extension of the VTP reflected the necessary delay required to maintain constancy of the (ventricular) upper rate limit interval. In contrast, the Medtronic Symbios DDD pulse generators exhibited constancy of the VTP even when the sum of the atrial escape (pacemaker VA) interval and the duration of the nonprogrammable VTP (110 ms) was shorter than the upper rate limit interval. This response was observed only with a programmed lower rate of 90 ppm, upper rate of 100 ppm, and AV interval of 250 ms. Under these circumstances, in the presence of crosstalk or myopotentials sensed in the VTP, the Symbios DDD pulse generator violated its ventricular upper rate limit interval, but remained faithful to its separate (but equal) atrial upper rate limit interval by omitting the succeeding atrial stimulus. The behavior of the VTP of DDD pulse generators, particularly its relation to the upper rate response, must be known for the proper interpretation of pacemaker function.     

Diagnosis of Atrial Undersensing in Dual Chamber Pacemakers: Impact of Autodiagnostic Features

Atrial undersensing occurs in a considerable number of patients, both with single lead VDD pacemakers and with DDD devices. The aim of this study was to investigate the diagnostic efficacy of electrocardiographic methods and autodiagnostic pacemaker features to detect atrial sensing dysfunction. Two hundred and thirty-one patients with AV block received single lead VDD pacemakers or DDD devices. Atrial sensitivity was programmed to 0.1 or 0.18 in VDD devices and to 0.5 mV in DDD devices; the rate limits were set to 40 and 160 beats/min. Twelve-lead ECG recording for 1 minute during deep respiration and change of body position, 24-hour Holter ECG recording, and treadmill exercise were performed 2 weeks and 15 months after pacemaker implantation. AV synchrony and, if available, P wave amplitude histogram were sampled by autodiagnostic pacemaker features and compared to electrocardiographic findings. Atrial undersensing was assumed, if AV synchrony was below 100% or if minimal P wave amplitude (PWA) was equal to the programmed atrial sensitivity. Intermittent atrial undersensing occurred in 20.7% of patients. The diagnostic sensitivities of the various methods used to detect atrial sensing failures were: 24-hour Holter monitoring 97.5%, P wave amplitude histogram 90.0%, stored AV synchrony 68.0% without significant difference between the various devices, treadmill exercise testing 58.8%, and 12-lead ECG recording 21.3%. In one patient, atrial undersensing was exclusively detected by exercise testing. In conclusion, autodiagnostic pacemaker features facilitate the evaluation of atrial sensing performance. However, to exclude intermittent atrial malsensing, routine Holter monitoring and treadmill exercise are still needed .     

Unusual Wenckebach Upper Rate Response of an Atrial-Based DDD Pacemaker

We describe in this report an unusual form of Wenckebach upper rate response produced by a DDD pulse generator with atrial-based lower rate timing. The pacemaker maintained the programmed upper and lower rate intervals at the expense of a prolonged atrial paced-ventricular paced AV interval. This form of upper rate behavior eliminated the longer cycle (containing the unsensed P wave) that occurs at the end of the pacemaker Wenckebach sequence during traditional DDD pacing with ventricular-based lower rate timing.     

Irregular Ventricular Stimulation in the DDI Mode of a Dual Chamber Pacemaker With Atrial-Based Lower Rate Timing

This report describes two patients with atrial fibrillation in whom an implanted CHORUS DDD pacemaker programmed to the DDI mode produced an irregular ventricular stimulation rate. The lower rate timing of these devices is atrial-based only when an atrial event opens an AV interval shorter than the programmed AV delay. In the DDI mode, if Api represents the time when an atrial paced event (Ap) would have occurred if it had not been inhibited by a previous atrial sensed event (As), then Api-Vp constitutes the implied AV interval where Vp is a paced ventricular event. Although the As-Vp interval (As-Api+Api-Vp) generates an atrial refractory period during its entire duration, the pacemaker can sense an atrial event (A r ) during the implied AV interval. A r cannot start another AV delay, but it can initiate the atrial-based lower rate interval. This timing mechanism can cause irregular prolongation of Vp-Vp intervals to a value longer than the programmed lower interval with a maximal extension equal to the programmed AV delay. Such behavior of the CHORUS pacemaker should not be interpreted as malfunction.     

Prediction of Wenckebach Behavior and Block Response in DDD Pacemakers

At higher atrial rates, the behavior of a DDD pulse generator will depend on the atrial rate or spontaneous atrial interval (SAI) and the settings of the pacemaker: upper rate interval (URI), atrioventricular interval (AVI), and atrial refractory interval (ARI). An algorithm was developed enabling the prediction of the degree of Wenckebach block using the parameters mentioned above. In the absence of the programmed settings of the pacemaker, these parameters can be determined by noninvasive methods. AVI can be measured by application of a magnet over the pulse generator, while URI and ARI can be estimated during chest wall stimulation by progressively increasing the frequency of the external extrastimuli. The use of the formula in combination with chest wall stimulation allows the evaluation of the proper functioning of any DDD pacemaker during exercise and in patients with atrial rhythm disturbances, even when no information about the pacemaker settings is available.     

Sustained inhibition of a DDD pacemaker at rates below the programmed lower rate during automatic PVARP extension

A patient with a Pacesetter Paragon III DDD pacemaker exhibited sustained pacemaker inhibition at rates below the programmed lower rate during sinus rhythm with marked first degree AV block. In this device, a pacemaker defined ventricular extrasystole initiates automatic extension of the postventricular atrial refractory period to 480 ms and the atrial escape interval to 830 ms regardless of the programmed lower rate. Sustained pacemaker inhibition at rates below the programmed lower rate occurred because the P wave fell continually in the extended postventricular atrial refractory period, and the conducted QRS complex initiated a pacemaker ventricular extrasystole response with atrial escape interval extension. This process continued as long as the P wave stayed within the extended postventricular atrial refractory period, no ventricular extrasystole disrupted the sequence, and the R-R interval of spontaneous beats was shorter than the extended atrial escape interval. Such a pacemaker response should not be misinterpreted as device malfunction.     

Ventriculoatrial Conduction: A Cause of Atrial Malpacing in AV Universal Pacemakers. A Report of Two Cases

Retrograde atrial activation during ventricular pacing has often been a cause of intermittent or persistent arrhythmias (pacemaker-mediated tachycardia) in AV universal pacemakers. We recently encountered two cases in which VA conduction was responsible for atrial malpacing in patients with an implanted AV universal pacemaker, one programmed in DDD and one in DVI mode. Atrial malpacing was induced by the atrial refractoriness due to retrograde activation. In the first patient, it was observed when the pacemaker was programmed to a rate of 110 ppm (lower rate) and an AV interval of 200 ms in order to check crosstalk. In the second patient, it was observed after ventricular premature contractions.     

Method of atrioventricular programming in atrial flutter in patients with biventricular pacemaker

BACKGROUND: Atrial flutter is a common cause of exacerbation of congestive heart failure (CHF). Typically, during atrial tachycardia, pacemakers, both dual and biventricular, are programmed to ignore atrial tracking. Virtually all current pacemakers and defibrillators use a programmable mode switch algorithm to switch between atrial tracking modes (DDD, DDDR) to nontracking modes (DDIR, DDI, VVI) during episodes of atrial tachycardia. METHODS: In this report, we describe a novel method of atrioventricular (AV) pacemaker programming in four patients with atrial flutter and CHF who remained symptomatic postbiventricular pacemaker implantation. All patients had chronic atrial flutter upon interrogation; adjustment of AV delay and postventricular atrial refractory period (PVARP) was performed to enable sensing of every second to fourth atrial flutter beat by the atrial lead. Mode switch was turned "OFF" in all points, and lower and upper rate limits were set to 50 and 100 bpm. Once sequential early and late diastolic filling was seen on mitral inflow pulsed-wave (PW) Doppler, further adjustment of AV delay and PVARP was performed until the highest and broadest atrial velocity occurred on mitral inflow PW Doppler. RESULTS: All patients developed improvement in aortic ejection duration and peak ejection velocity during AV optimization. Repeat ECG in these patients at 8 months, 7 days, 2 days, and 2 months postoptimization showed no change in P and QRS relationship. All patients developed improvement in CHF symptoms postbiv pacemaker optimization. CONCLUSION: In symptomatic patients with CHF and stable atrial flutter who have a biventricular pacemaker, atrial mechanical contribution to cardiac output can be achieved by adjusting PVARP and AV delay during echo-guided pacemaker programming.     

Importance of Heart Rate Response During Exercise in Patients Using Atrioventricular Synchronous and Ventricular Pacemakers

Atrioventricular synchronous pacing offers advantages over fixed-rate ventricular (VVI) pacing both at rest and during exercise. This study compared the hemodynamic effects at rest and exercise of ventricular pacing at a rate of 70 beats/min, ventricular pacing where the rate was increased during exercise and dual chamber pacing. Ten patients, age 63 +/- 8 years, with multiprogrammable DDD pacemakers were studied using supine bicycle radionuclide ventriculography. Radionuclide data during dual chamber pacing was acquired at rest and during a submaximal workload of 200-400 kpm/min. The pacemakers were then programmed to VVI pacing at a rate of 70 beats/min, and 1 week later, studies were repeated in the VVI mode at rest, during exercise at a rate of 70 beats/min, and during exercise with the VVI pacemaker programmed to a rate adapted to the DDD pacing exercise rate. At rest, the cardiac output was lower in the VVI compared with the AV sequential mode (4.1 +/- 1.1 vs 5.7 +/- 1.1 1/min, P less than 0.01). During exercise, the cardiac output increased from resting values in the DDD and VVI pacing modes, however cardiac output in the rate-adapted VVI mode was higher than in the VVI mode with the rate maintained at 70 beats/min (8.1 +/- 1.5 vs 6.3 +/- 1.1 1/min, P = 0.02). Three patients completed lower workloads with VVI pacing at 70 beats/min compared with AV synchronous pacing. At rest, AV sequential pacing was superior to VVI pacing, suggesting the importance of the atrial contribution to ventricular filling. With VVI pacing during exercise, cardiac output was improved with an increased pacemaker rate, suggesting that the heart rate response during exercise was the major determinant of the higher cardiac output.     

Atrial Natriuretic Factor Release During Exercise in Patients Successively Paced in DDD and Rate Matched Ventricular Pacing

Dual chamber pacemakers were implanted in nine patients with permanent second or third degree AV block feight had complete retrograde block). Two identical exercise tests were performed after at least 1 month after implantation. During the first test (T₁) the pacemaker was programmed to the DDD mode and heart rates were recorded every 15 to 30 seconds during exercise and 30 minutes after exercise. Following 30 minutes of rest, the implanted pacemaker was programmed to the VVT mode and driven by an external pacemaker via a skin electrode. The second exercise test (T₂) was then performed and the rate of the external pacemaker was progressively changed to reproduce exactly the rate observed during T₁ at the same exercise stress. Atrial natriuretic factor (ANF) levels were determined at rest, at regular intervals during exercise, and 30 minutes after exercise. ANF levels and release were statistically higher during rate matched ventricular, than DDD pacing. It is concluded that preservation of AV synchrony reduces ANF release induced by heart rate acceleration during exercise.     

Dual Chamber Pacemakers: Upper Rate Behavior

Upper rate management of a dual chamber pacemaker requires sensing of the atrium and limitation of ventricular response to desired levels. Limitation of ventricular rate response is accomplished by setting atrial channel refractoriness which consists of two separate and continuous intervals, the atrioventricular interval (AV interval) and the atrial refractory interval, after the ventricular pace or sense event (AR interval). A P-wave that falls within the total atrial refractory interval (TARI) remains unsensed and one that falls beyond the TARI is sensed. If the upper rate limit interval (URI) is programmed to equal the TARI, the upper rate limit will occur by development of sudden AV block. If the URI is of greater duration (lower allowed rate) than the TARI, the difference in interval between the two is the Wenckebach interval (WI) and is the duration of a response plateau, when the atrial coupling interval is less than the upper rate interval. All dual chamber timing cycles can be interpreted in terms of atrial refractoriness and upper rate limitation with consideration of the lower rate interval, and the ventricular refractory and blanking intervals.     

Initial Experience with Mode Switching in a Dual Sensor, Dual Chamher Pacemaker in Patients with Paroxysmal Atrial Tachyarrhythmias

Mode switching algorithms have been developed to avoid tracking of atrial fibrillation (AF) or flutter (AFL) during DDD(R) pacing. Upon recognition of AF or AFL, the mode is switched to a nontracking, sensor driven mode. The Vitatron Diamond model 800 pacemaker does this on a beat-to-beat basis. Atrial events occurring within a “physiological range” (± 15 beats/min) calculated from a running average of the atrial rate are tracked. When atrial events are not tracked the escape interval is either determined by the sensor(s) or by a fallback algorithm thereby preventing large increases in V-V interval during mode switching. Loss of atrioventricular (AV) synchrony by atrial premature beats and after an episode of AF or AFL is prevented by atrial synchronization pulses (ASP), which are delivered after a safe interval (timed out from the sensed premature atrial event) has expired and before delivery of the next ventricular stimulus. We implanted 26 such devices in 18 men and 8 women with symptomatic second- or third-degree AV block and paroxysmal AF or AFL. Their ages ranged from 18–84 years (mean 60), and the follow-up ranged from 2–13 months (mean 8). During pacemaker check-up, exercise testing or 24-hour Holter monitoring one or more episodes of mode switching was documented in 8 patients. In these 8 patients a smooth transition (ventricular rate) from sinus rhythm to AF or AFL was documented on one or more occasions, without inappropriate increase in ventricular rate in the DDDR mode. None of the patients complained of palpitations. Appropriate rate response was seen in all patients during Holter monitoring and exercise. Restoration of AV synchrony with ASP was documented many times. In 2 patients the DDIR mode was programmed due to intermittent synchronization of ventricular stimuli to near incessant supraventricular tachycardia, which sometimes gave rise to asymptomatic slightly irregular ventricular paced rhythms below WO beats/min. Recognition of AF or AFL was reliable. No inappropriate increases in ventricular pacing rate were seen at the onset of or during AF or AFL. ASP is an effective method of maintaining AV synchrony and avoiding competitive atrial pacing.     

Limitations to Activation of the Antitachycardia Burst Pacing Function of the Symbios 7008 Pacemaker in the Universal (DDD) Mode

The Symbios 7008 antitachycardia pacemaker was implanted in five patients for control of supraventricular tachycardia. Shortly after implantation in the first two patients, it was noted that the burst pacing sequence was not automatically activated by tachycardia when the pacemaker was in the DDD mode. Data from these two and the subsequent three patients were evaluated to explain this observation. The problem was primarily related to the operation of the device during the postventricular atrial refractory period. In all patients, the atrial electrogram encroached upon the programmed postventricular atrial refractory period because VA conduction during SVT was less than the lowest programmable interval (155 ms). Atrial events occurring during this interval will not trigger the tachycardia termination sequence. In all five patients, the size of the atrial electrogram decreased substantially (48 +/- 10%; mean +/- SD) during supraventricular tachycardia compared to sinus rhythm. In at least two of the five patients, decreased atrial size during supraventricular tachycardia may also have resulted in intermittent failure of atrial sensing during tachycardia, even at the most sensitive setting (0.6 mV). The latter may remain a problem even if the technical fault in SVT detection in the DDD mode were corrected. Two related problems were noted in the DDD mode: ventricular events during rapid SVT do not reset the low rate interval, resulting in random low rate pacing; and, automatic prolongation of atrial refractory period by two successive ventricular events without an intervening atrial sensed event compounds problems of atrial sensing. All of these problems were easily circumvented in all patients by noninvasive reprogramming to the DVI mode in which supraventricular tachycardia detection is based on ventricular sensing. These findings have implications for the future design of such devices.     

Paradoxical AV Delay Shortening of a Pacemaker

Barold, S.S., et al. : Paradoxical AV Delay Shortening of a Pacemaker. Paradoxical shortening of the paced AV delay (atrial paced-ventricular paced or Ap-Vp interval) was observed at rest in the DDD and DDDR modes in three patients with implanted CPI Vigor DR pacemakers programmed with a long AV delay and a relatively narrow difference between the lower and upper rates. This behavior is related to the VA extension algorithm designed to prevent the sensor-driven atrial pacing rate from exceeding the programmed upper rate whenever a sensed conducted QRS complex continually follows an atrial stimulus. We found that this algorithm also becomes manifest at rest and may cause shortening of the Ap-Vp intervals. The VA extension algorithm is best conceptualized in terms of a separate atrial upper rate that functions on exercise and at rest. The atrial and ventricular upper rates are equal but the atrial upper rate is initiated by an atrial-paced or sensed event and the ventricular upper rate is initiated by a paced or sensed ventricular event. Under certain circumstances delay in the release of the atrial stimulus Ap to conform to the atrial upper rate interval produces variable abbreviation of the paced AV (Ap-Vp) delays with resultant variation in the duration of the atrial escape intervals despite fundamental ventricular-based lower rate timing.     

Exercise Induced Sympathetic Influences Do Not Change Interatrial Conduction Times in VDD and DDD Pacing

Using telemetry, right atrial electrogram (RA), and marker channel of atrial sense events (M_A) in combination with the left atrial electrogram (LA), recorded by a filtered bipolar esophageal lead, interatrial conduction during submaximal exercise and at rest was examined in 46 DDD pacemaker patients. The RA-LA and M_A-LA conduction times measured in the presence of atrial sensing (VDD) as well as the conduction time S_A-LA from atrial stimulus (S_A) to LA, determined during atrial pacing (DDD) were found to be individual constants independent of exercise induced sympathetic influences. Thus, having determined an optima! mechanical interval (LA-LV)_mech/opt from left atrium to ventricle by other methods, the optimal AV delay for DDD as well as for VDD operation can be calculated by the sum of the appropriate interatrial conduction time (S_A-LA, respectively M_A-LA) and the (LA-LV)_mech/opt interval. Due to the constant S_A-LA and M_A-LA, the difference between these two values (AV delay correction interval) is a constant as well, which remains unchanged during exercise. Therefore, in selecting the rate responsive AV delay, only hemodynamic and not electrophysiologica] measurements need to be considered.     

Superior Cardiac Hemodynamics of Atrioventricular Synchrony Over Rate Responsive Pacing at Submaximal Exercise: Observations in Activity Sensing DDDR Pacemakers

LAU, C.-P., ET AL.: Superior Cardiac Hemodynamics of Atrioventricular Synchrony Over Rate Responsive Pacing at Submaximal Exercise: Observations in Activity Sensing DDDR Pacemakers. The relative hemodynamic profile between dual chamber pacing (DDD) and activity sensing rate responsive pacing (VVIR) was compared in ten patients with dual chamber rate responsive pacemakers (Synergist 11). With a double blind, randomized exercise protocol, DDDR pacemakers were programmed into VVI, VVIR, and DDD (AV interval 150 msec) modes and in seven patients the test in the DDD mode was repeated with the AV interval programmed at 75 msec. A treadmill exercise test of 6-minutes duration (2 stages, Stage 1 at 2 mph, 0% gradient and Stage II at 2 mph, 15% gradient) was performed at each of the programmed settings, with a rest period of 30 minutes in between tests. Cardiac output was assessed using continuous-wave Doppler sampling ascending aortic flow and expressed as a percentage of the value achieved during VVI pacing. During exercise, pacing rate between DDD and VVIR pacing was similar but was higher with DDD at the first minute of recovery (91 ± 4vs 81 ± 3 beat/min, respectively). Cardiac output was significantly higher at rest, during low level exercise, and recovery with DDD pacing compared with VVIR pacing (resting: 21 ± 14 vs -2 ± 7%; Stage I: 36 ± 6 vs 16 ± 7%; Stage II: 25 ± 15 vs 10 ± 8%; recovery: 26 ± 12 vs 4 ± 9%; p < 0.05 in all cases). Systolic blood pressure was significantly higher during low level of exercise in the DDD mode. Shortening of the AV interval to 75 msec did not significantly affect cardiac output during exercise, but cardiac output after exercise was reduced (2 ± 6 vs 23 ± 6% at an AV interval of 150 msec, p < 0.02). By enhancing the stroke volume, DDD pacing improves cardiac hemodynamics at rest, during low level exercise, and early postexercise recovery.     

Use of a Dual Chamber Pacemaker with a Novel Fallback Algorithm as an Effective Treatment for Sick Sinus Syndrome Associated with Transient Supraventricular Tachyarrhythmia

A dual chamber pacemaker having a fallback (FB) mode was utilized in nine patients with sick sinus syndrome (SSS) associated with transient supraventricular tachyarrhythmia (atrial fibrillation [Af] in three patients, atrial flutter [AF] in two, and paroxysmal atrial tachyarrhythmia [PAT] in four). Various degrees of abnormality of atrioventricular (AV) conduction were observed at the time of pacemaker implantation in five patients. In this pacemaker, a DDD mode was active during sinus rhythm, but the mode changed, through a given cycle of high rale tracking at an upper rate limit (VRL), to VDI only during intrinsic atrial rate increases that were either normally or abnormally above the URL. The VDI mode automatically returned to DDD when the atrial rate fell below the URL. At follow-up periods of 7–12 months, this pacemaker appeared to be especially effective in those SSS patients with transient Af or AF. In the SSS patients with PAT, however, the FB mode was not active because the PAT rhythm was conducted to the ventricle without block (1:1 conduction) and thus the given cycles of ventricular tracking at the URL did not occur. From the repetitive FB starting tests that were performed during an Af period in one patient with transient Af, a 2:1 point setting of a given URL plus 30–50 ppm was required to quickly start the FB algorithm. Moreover, an atrial sensitivity setting that was less than half of the P wave amplitude was desirable. These results suggest that, when properly set, the DDD plus FB mode is useful in a SSS patient with transient supraventricular tachyarrhythmia when a significant degree of AV block is present.     

Changes in QT and Q-aT Intervals Induced by Mental and Physical Stress with Fixed Rate and Atrial Triggered Ventricular Inhibited Cardiac Pacing

We have investigated the influence of mental stress and physical stress, i.e., exercise, on the QT and Q-aT intervals (measured from the pacemaker stimulus to the end or the apex, respectively, of the T wave). The study was made on ten patients with high degree atrioventricular block treated with AV universal (DDD) pacemakers. These were programmed to a fixed rate ventricular (VVI) or an atrial triggered (VDD) function for different parts of the study. An arithmetic mental stress test and a bicycle exercise test were performed with each mode of pacing. In the VVI pacing mode, the atrial rate increased by 11% during mental stress and by 46% during exercise. There was a significant shortening of QT and Q-aT intervals with both types of stress. With VDD pacing, mental stress induced a 12% increase in rate and a significant shortening of QT and Q-aT. The paced rate increased by 50% during the exercise test. This increase in ventricular rate was associated with the most marked changes in QT and Q-aT intervals. Thus, both types of stress cause a significant shortening of the QT and Q-aT interval even in the absence of a simultaneous increase in ventricular rate. When the latter is allowed to increase during VDD pacing, both intervals shorten considerably more. There was a marked inter-individual variability in the response to both types of stress. These findings are of importance with regard to the QT sensing rate responsive pacemaker which can be expected to respond to mental stress in most patients, but that response might be unpredictable in the individual.     

The Use of Exercise Testing in Children to Evaluate Abnormalities of Pacemaker Function not Apparent at Rest

The purpose of this study was to evaluate the use of exercise testing in identifying abnormalities of pacemaker function and in confirming set parameters not apparent at rest in children with implanted atrial synchronous physiologic pacemakers. Maximal exercise tests were performed on 24 children (15 boys, 9 girls) from 4.5 to 18 years of age (median = 15) with physiologic pacemakers. The lower rate limit was observed before or following testing in 19 of 24 cases. In each case this correlated with the set lower rate limit. The upper rate limit was reached in 10 of 24 cases and was found to be lower than that programmed in one case in which a long atrial refractory period had limited the upper rate limit. Six children reached the maximum upper rate limit to which their pacemaker could be programmed. No abnormalities of atrial capture or ventricular capture occurred during exercise testing. Ventricular sensing was normal in each case. Atrial sensing was observed to be normal in 15 of the 24 cases. Two patients had decreased atrial sensing with exercise. Reversion to the "noise rate" due to myopotential inhibition was found in seven other cases. Subsequent tests on two of these children showed normal sensing.(ABSTRACT TRUNCATED AT 250 WORDS)