分析儿童牙颌畸形的预防措施和早期治疗效果

目的分析儿童牙颌畸形的预防措施和早期治疗效果。方法选取2015年1月份-2016年1月份我院门诊收治的儿童患者80例,所有患者中开牙合10例,牙间隙宽6例,深覆牙合18例,下颌后缩16例,前牙反牙合12例,前牙拥挤18例,针对不同的畸形,制定不同的治疗矫正方案。结果选取的80例患者,临床效果均理想,满意度为100%,随访1年表示无并发症和其他明显异常畸形;矫正前磨牙位移(5.86±0.78),矫正后为(3.74±0.32),患儿磨牙位移明显缩小;切牙凸距减小量明显增大,干预前(2.53±0.81),干预后为(4.01±1.63),差异有统计学意义(P0.05)。结论加大力度治疗牙颌畸形,可维持儿童口腔健康水平。     

留守儿童牙牙颌畸形主要原因及诊治

目的探讨分析留守儿童牙颌畸形的主要原因，以及有效的诊治方法。方法回顾性分析2008年3月至2010年12月未我院治疗的牙颌畸形儿童中，属于留守范围的儿童牙镛畸形的的治疗方法，治疗效果，心及临床上对该类疾病的发生的原因分析。结果2008年3月至2010年12月来我院口腔科治疗并诊断为牙领畸形儿童294例，其中属于留守儿童的患儿109例，占总数的37．07％。造成留守儿童牙颌畸形的主要原因为口腔不良习惯所致，9l例（83．49％），其次分别为遗传因素（16．52％）、乳牙滞留（7．34％），齡齿（5．51％）、慢性丧病（1．83％）．其他（1．83％）。在治疗方面，109例患者均采用一般矫正治疗，其中53倒采用固定矫正器治疗，56倒采用活动矫正器治疗。均取得满意治疗效果。结论留守儿童惠有牙领畸形的发生率比正常家庭儿童患病的概率要高，主要是由于藏子在发育的关键时期不能接受到良好的习惯教养所致。对于儿童时期发现的牙颌畸形在治疗效果方面比成年人畸形治疗更容易，因为此时儿童的发育还没有停止，及时进行矫正效果更好。因此，儿童牙颌畸形一定要早治疗，更要早预防。     

儿童错颌畸形早期矫治的体会

目的:探析对儿童错颌畸形患儿早期进行矫治的临床效果.方法:选取该院2013年9月至2016年9月收治的53例儿童错颌畸形患儿,对其临床资料作回顾性分析,分析错颌畸形的临床表现,给予针对性治疗,分析治疗的结果.结果:53例患儿中,乳前牙反颌4例,第一乳磨牙早失5例,第二乳磨牙早失13例,埋伏牙3例,个别牙扭转10例、牙间隙宽5例、前牙拥挤5例、深覆合4例、开颌4例,其发生时间多为6-12岁.经2-18个月的矫治,53例患儿前牙覆合、覆盖关系,上下颌发育导向均恢复正常,对于口腔习惯不良者得到破处,均达到了Ⅰ类骨面型.结论:对儿童错颌畸形患儿早期进行矫治,十分必要,不仅帮助患儿恢复口腔正常的发育环境,阻断引起牙颌畸形的不良因素,恢复牙颌的发育导向,同时,促进儿童心理健康发展.     

粘接式夹板(牙合)垫加前牵引矫正替牙期骨性前牙反(牙合)的疗效观察

目的 探讨粘接式上颌夹板牙合垫加前方牵引,矫正替牙期骨性前牙反牙合的治疗方法 及治疗前后牙颌结构的变化.方法 选择替牙期骨性反牙 合14例,年龄(6～10岁),患者均为前牙反牙合,上颌相对下颌后缩,采用自凝塑料制作上颌夹板式牙合垫的口内矫治器,和口外前方牵引器结合,矫正前牙反牙 合.结果 粘接式上颌夹板式牙合垫口内矫治器固位良好,作用力适度,和口外前方牵引器结合,治疗替牙期骨性前牙反牙合治疗后前牙反牙 合解除,磨牙关系由近中转变为中性,前牙覆盖关系达到正常,面型改善.SNA角平均增大3.22°,ANB角平均增大4.52°.上切牙唇倾,下切牙舌倾.结论 粘接式夹板牙合垫加前牵引,矫正替牙期骨性Ⅲ类错牙合效果明显,利于Ⅲ类骨骼畸形的改善.     

正畸治疗完全性唇腭裂错颌畸形的效果观察

目的：分析研究正畸治疗完全性唇腭裂错颌畸形的效果。方法调查分析42例完全性唇腭裂错颌畸形患者,给予患者采用方丝弓矫治、部分配合活动矫治器,通过拍片对比治疗前后矫正效果。结果42例患者接受正畸治疗后,前牙扭转以及舌倾情况均明显改善,牙列整齐牙弓形态良好,植骨成功率为85.7%（36/42）,单侧唇腭裂鼻外形恢复优良率为76.7%,双侧唇腭裂鼻外形恢复优良率为75.0%。结论临床采用正畸治疗完全性唇腭裂错颌畸形患者,矫正效果良好。     

Twin-block矫治器与直丝弓固定矫治器矫正安氏Ⅱ类错牙合畸形的临床疗效

目的探讨Twin-block矫治器与直丝弓固定矫治器联合矫正安氏Ⅱ类错牙合畸形的临床治疗效果。方法对我科收治的26例安氏Ⅱ类错牙合畸形矫正进行回顾性分析。结果患者均完成治疗,治疗时间平均（17.2±1.9）个月,患者侧貌有明显改善,颏唇沟变浅,口内检查上下牙列整齐,前牙覆盖覆牙合基本正常,上下第一磨牙呈中性关系。X线头影测量均有明显好转,趋于正常。结论 Twin-block矫治器与直丝弓固定矫治器联合可有效诱导下颌功能前移,改善上下颌关系,改善侧面部容貌和咬合关系,有效提高患者生活和生命质量,可作为矫正安氏II类错牙合畸形的主要方法。     

下颌联冠斜面导板治疗乳前牙反

前牙反（牙合）是一种常见的牙颌畸形,因严重影响（牙合）、颌、面的正常发育,并常随年龄增大而错（牙合）而加重.因此,提倡尽早矫治.本文介绍粘固式下颌前牙联冠斜面导板,用于乳前牙反（牙合）的治疗,具有成本低、制作简单、疗程短、效果显著的优点,现将该矫治方法介绍如下：[第一段]     

传统方法与BiteTurbo治疗深覆牙合的疗效分析

目的：比较传统方法和 bite turbo 打开前牙咬牙合的疗效。方法：收集2014年10月至2016年3月40例在该院进行矫治的错牙合畸形患者并伴有前牙深覆牙合,均分为二组,第一组使用上颌平面导板打开咬牙合,第二组使用 Bite Turbo 打开咬牙合,比较临床操作时间和打开咬牙合所需时间。结果：40例深覆牙合患者均矫正,两组矫治所需时间差异无统计学意义（P>0.05）,两组临床操作时间差异具有统计学意义（P<0.05）。结论：以上二种方法打开前牙深覆牙合均能取得较满意的效果,但使用 Bite Turbo 更节约临床操作时间。     

正畸固定矫治器矫治乳前牙（合）的疗效观察

目的：探讨固定矫治器治疗乳前牙（合）的疗效。方法对2011-01～2014-03在广西壮族自治区人民医院口腔正畸科自愿选择固定矫治器进行矫治的15例牙（合）畸形病例的治疗效果进行分析。结果15例患者最长反牙（合）解除时间2个月,最短3周,平均疗程（4±0.5）个月。矫治后前牙覆牙（合）覆盖关系正常,追踪2年,13例牙性及功能性反牙（合）疗效稳定,无复发。2例有骨性反牙（合）遗传史,反牙（合）复发。结论固定矫治器治疗乳前牙反牙（合）能够减少患儿的不配合及就诊次数,并顺利地解除乳前牙反牙（合）,是一种治疗乳前牙反牙（合）的高效矫治器。     

多曲舌簧颌垫式矫正器矫正前牙畸形的临床效果观察

目的:探讨多曲舌簧颌垫式矫正器矫正前牙畸形的临床效果。方法:选取2010年9月-2014年9月本院收治的168例前牙畸形患者作为研究对象,其中前牙列患者58例,替牙列患者62例,恒牙列患者48例,按照矫治的方法不同,将不同类型患者分为对照组和研究组。对照组患者采用双曲舌簧颌垫式矫正器行矫治,研究组患者采用多曲舌簧颌垫式矫正器行矫治,比较两组患者反解除时间、复诊次数及两组矫治器固定效果。结果:在前牙列、替牙列和恒牙列方面,两组患者反解除所需平均时间比较差异均无统计学意义(P0.05),而研究组平均复诊次数均明显少于对照组,且固定成功率均明显高于对照组,差异均有统计学意义(P0.05)。结论:采用多曲舌簧颌垫式矫正器矫正前牙畸形患者,能有效减少其复诊次数,提高矫治器固定成功率,值得在临床上推广应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.