眼科患儿护理干预应用效果分析

目的探讨眼科疾病患儿实施个性化护理措施的临床效果。方法对照组给予常规护理措施;研究组在常规护理基础上加入个性化护理措施,记录两组患儿护理前后心理负面情绪变化情况、并发症发生情况、患儿家属对护理工作满意度,给予统计学分析后得出结论。结果研究组患儿临床治疗总有效率（90.32%）虽略高于对照组（87.10%）,但两组对比结果并无统计学意义（P〉0.05）。研究组患儿并发症发生率仅为9.68%,显著低于对照组22.58%;研究组患儿护理后心理负面情绪及患儿家属对护理工作满意度均显著优于对照组（P〈0.05）。结论对眼科疾病患儿给予常规护理与护理干预相结合的综合性临床护理,可显著降低患儿并发症的发生率,改善其负面心理情绪,提高患儿家属对护理工作的满意度,维持良好的护患关系。     

无创正压通气治疗小儿哮喘持续状态中针对性护理的应用效果观察

目的:分析针对性护理干预在无创正压通气治疗小儿哮喘持续状态中的临床效果。方法:任选82例我科2016年1月-2017年10月收治的哮喘持续状态患儿,均给予无创正压通气治疗,在此基础上,对照组给予常规护理干预,研究组实施针对性护理干预,观察两组护理效果。结果:研究组哮喘持续时间、哮鸣音消失时间、呼吸困难缓解时间均显著短于对照组(P<0.05)。研究组与对照组治疗有效率分别为95.2%和77.5%,组间差异有统计学意义(P<0.05)。研究组护理满意度为92.9%,对照组满意度为75.0%,组间差异有统计学意义(P<0.05)。结论:针对性护理干预应用于无创正压通气治疗小儿哮喘持续状态,可有效缩短患儿症状消失时间,提高临床疗效,从而提升患儿及家属对护理工作的满意度,可推广应用。     

全面优质护理干预对小儿哮喘雾化吸入效果的影响观察

目的研究探讨小儿哮喘雾化吸入的护理干预对策,为患儿提供全面优质的临床护理,以提高治疗效果和患儿家属满意度。方法选取该院收治的74例哮喘患儿,分为对照组和观察组,对照组进行常规护理,观察组在常规护理的基础上进行护理干预,通过治疗总有效率和护理满意度比较两组临床疗效差异。结果对照组患儿治疗总有效率为78.4%,护理满意度为70.3%;观察组患儿治疗总有效率为94.6%,护理满意度为97.3%。观察组治疗总有效率和护理满意度均明显高于对照组,两组比较差异有统计学意义(P<0.05)。结论为行哮喘雾化吸入的患儿提供全面优质的护理干预措施,可显著提高临床治疗质量和患儿家属满意度。     

系统化护理对支气管哮喘患儿治疗依从性及家属护理满意度的影响

目的研究系统化护理对支气管哮喘患儿治疗依从性及家属护理满意度的影响。方法抽取2014年6月至2016年7月商丘市妇幼保健院治疗的支气管哮喘患儿102例,根据随机数字表法分组,各51例。两组患儿均给予雾化吸入激素进行治疗;对照组实施常规护理,观察组给予系统化护理。对比两组患儿治疗依从性及家属护理满意度。结果观察组患儿治疗依从率为92.16%,明显高于对照组的74.51%,差异有统计学意义(P<0.05);观察组家属护理满意度评分为(95.56±2.45)分,明显高于对照组的(74.81±2.83)分,差异有统计学意义(P<0.05)。结论系统化护理可提高支气管哮喘患儿治疗依从性及家属护理满意度,值得临床推广。     

老年冠心病合并心绞痛整体护理干预

目的探讨整体护理干预对老年冠心病心绞痛患者的应用效果。方法对照组提供常规护理配合措施;研究组在常规护理基础上加入整体护理模式干预措施。记录两组患者护理前后治疗依从性及满意度,给予统计学分析并得出结论。结果经不同方法护理后研究组完全依从率高达82.50%,而对照组中完全依从率仅为27.50%(P0.05);研究组对护理工作满意度显著优于对照组(P0.05)。结论对老年冠心病心绞痛患者给予常规护理与整体护理模式干预相结合的综合性护理措施可显著提高其治疗积极性,有利于构建和谐的护患关系,收获意想不到的预期治疗效果。     

层级链式护理在毛细支气管炎患儿中的应用效果

目的：观察层级链式护理在毛细支气管炎患儿中的应用效果。方法：选取2019年6月至2021年6月该院收治的97例毛细支气管炎患儿进行前瞻性研究,依据随机数字表法将其分为对照组48例与研究组49例。两组均给予常规治疗,在此基础上,对照组行常规护理,研究组行层级链式护理,比较两组依从率、护理质量、护理前后家长健康知识掌握度评分和护理满意度。结果：研究组依从率为91.63%(40/49),高于对照组的62.50%(30/48),差异有统计学意义（P<0.05）;研究组责任心、健康宣教、病房环境、服务态度、心理干预、技能护理等护理质量评分均高于对照组,差异有统计学意义（P<0.05）;护理后,两组家长健康知识掌握度评分均高于护理前,且研究组高于对照组,差异有统计学意义（P<0.05）;研究组家长护理满意度为97.96%(48/49),高于对照组的83.33%(40/48),差异有统计学意义（P<0.05）。结论：层级链式护理应用于毛细支气管炎患儿可提高依从率、护理质量评分、家长健康知识认知度评分和家长护理满意度,效果优于常规护理。     

全程护理在小儿哮喘雾化中的应用探讨

目的探究分析全程护理在小儿哮喘雾化中的应用效果。方法从2015年9月至2017年12月我院收治的哮喘患儿中抽选109例,采用数字随机分配法分为两组。实验组55例,接受全程护理;对照组54例,接受常规护理,两组患儿均采取雾化吸入治疗,对比两组护理效果。结果实验组治疗总有效率为94.55%,护理满意度为96.36%,服药依从性为83.64%;对照组治疗总有效率为75.93%,护理满意度为79.63%,服药依从性为55.56%。实验组治疗总有效率、护理满意度、服药依从性均明显高于对照组,P0.05,差异具有统计学意义。结论全程护理能够有效提升小儿哮喘雾化治疗效果,改善患儿临床症状,缩短治疗时间,患儿及其家属满意度较高,值得临床推广使用。     

临床护理路径在高热惊厥患儿中的应用

目的：临床护理路径在高热惊厥患儿中的应用。方法：选取我院2012年1月到2015年2月收治的60例高热惊厥患儿,将这些患儿依据护理方法的不同,分为研究组（30例）和对照组（30例）。给予对照组患儿,采取传统护理,即根据医嘱及护理常规实施护理,给予研究组患儿临床护理路径干预,对两组患儿临床疗效进行比较,分析在在高热惊厥患儿中应用临床护理路径的效果。结果：对研究组患儿,在经临床护理路径干预后,在患儿（家长）住院时间、健康知识掌握、护理质量及家属满意度等方面,与对照组患儿对比有明显改善,研究组临床疗效明显高于对照组（P ＜0．05）。结论：高热惊厥患儿采取临床护理路径护理效果显著,不仅可以提高护理工作效率,减少患儿住院时间,还可以降低患儿住院费用,提高家属满意度,利于患儿康复,值得临床推广。     

小儿哮喘急性发作时雾化吸入治疗的临床护理配合

目的 分析研究雾化吸入治疗的临床护理配合对于小儿哮喘急性发作时的疗效.方法 选取120例小儿哮喘急性发作患儿作为观察对象,随机分为对照组与实验组,各60例.对照组患儿采用常规护理方式,实验组在对照组基础之上采用临床护理干预进行护理.比较2组患儿在接受治疗期间的护理效果及患儿家属对护理工作的满意度.结果 对照组患儿的临床总有效率78.33％(47例)显著低于实验组的95.00％(57例);对照组患儿家属对护理工作满意度75.00％(45例)显著低于实验组的95.00％(57例),差异均具有统计学意义(P＜0.05).结论 在针对小儿哮喘急性发作时,应用临床护理干预可有效减轻患儿不适,提高治疗效果,增强患儿家属对护理工作的满意度,值得在临床中推广使用.     

对高热惊厥患儿进行综合护理干预的效果观察

目的：探讨分析对高热惊厥患儿进行综合护理干预的临床效果。方法：选取2011年10月～2013年10月间我院收治的高热惊厥患儿72例作为研究对象,采用随机数字表法将其分为对照组（36例）和观察组（36例）,为对照组患儿进行常规护理,为观察组患儿在进行常规护理的基础上实施综合护理干预,观察对比两组患儿的护理效果及其家属对护理工作的满意度,并将对比的结果及两组患儿的临床资料进行回顾性的分析。结果：对照组患儿护理的总有效率为78.38%,观察组患儿护理的总有效率为100.00%,观察组患儿的护理效果明显优于对照组患儿,差异显著（P＜0.05）,具有统计学意义。观察组患儿家属对护理工作的满意度为97.22%,对照组患儿家属对护理工作的满意度为69.44%,观察组患儿家属对护理工作的满意度明显优于对照组患儿家属,差异显著（P＜0.05）,具有统计学意义。结论：对高热惊厥患儿进行综合护理干预的临床效果显著,值得在临床上推广应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.