经乳晕缘切口切除乳腺良性肿瘤的临床疗效

目的:探讨经乳晕缘切口切除乳腺良性肿瘤的临床疗效。方法:采用回顾性分析的方法,对120例行乳晕缘切口切除乳腺良性肿瘤患者的临床资料进行分析。结果:根据分析,其中120例患者中有117例患者的伤口Ⅰ期愈合,占总治疗效果的97.5%。结论:经乳晕缘切口治疗乳腺良性肿瘤在临床上有着较好的治疗效果,不仅能完整的切除病变的肿瘤,同时还不影响患者乳房的美观,值得在临床上推广应用。     

乳晕缘切口治疗乳腺良性肿瘤150例疗效分析

目的:探讨经乳晕缘切口切除乳腺肿物的临床疗效。方法:回顾性分析2008年1月~2010年12月住院行乳晕缘切口切除乳腺良性肿物150例患者的临床资料。结果:150例中148例伤口Ⅰ期愈合,占98.7%,疤痕隐蔽,乳房外形满意,保持了乳房的圆润外观。结论:乳晕缘切口治疗乳腺良性肿瘤,既能达到完整切除病变的目的,又不影响美观,值得推广应用。     

经乳晕切口行乳腺良性肿瘤切除的手术观察体会

目的探析对乳腺良性肿瘤患者应用经乳晕切口切除手术治疗的临床效果。方法选取2018年收治应用外科手术治疗的乳腺良性肿瘤患者群体,有60例,根据对患者外科治疗手段为准进行分组,设为对照组、观察组,各有30例,对应传统放射状切口乳腺良性肿瘤切除手术、经乳晕切口行乳腺良性肿瘤切除手术。比较两种手术对于乳腺良性肿瘤的临床效果。结果记录两种手术下患者的切口愈合率、切口渗液率,观察组患者评价所得各项数据均有显著优越性(P0.05)。结论对乳腺良性肿瘤患者应用经乳晕切口方案治疗能够取得令人满意的效果,手术方案不会导致患者乳房形象严重受损,在确保手术疗效前提下满足患者对美观的需求。     

乳晕缘切口在乳腺良性肿瘤切除中的应用分析

目的探讨乳晕缘切口在乳腺良性肿瘤切除中的应用效果。方法选取2010年1月—2014年1月我院收治的乳腺良性肿瘤240例,分为乳晕缘切口组和常规对照组各120例,对2组病例进行观察。结果 2组病例进行手术时间、术中出血量、皮下血肿、切口感染、术后复发情况统计并比较无显著性差异（P＞0.05）。结论乳晕缘切口不增加手术困难度、手术后并发症,既能够满足临床对肿瘤切除要求,又能够满足女性对乳房美观要求。     

乳晕切口治疗乳腺良性肿物215例

目的探讨乳晕外缘切口切除乳腺良性肿瘤的效果。方法回顾性分析215例行乳晕外缘弧形切口治疗的乳腺良性肿瘤,观察切口瘢痕及对乳房形态的影响。结果215例病人手术过程顺利,肿瘤均完整切除,214例切口甲级愈合,随访6个月～1年,患者对术后乳房形态满意度为99．5％。结论经乳晕外缘弧形切口切除乳腺良性肿瘤,切口设计简单,无需特殊设备,操作简便,术后瘢痕隐蔽,符合治病及美容要求,值得应用推广。     

乳晕小切口乳腺良性肿瘤切除术的临床疗效

目的:探究乳晕小切口术在治疗早期良性肿瘤的临床治疗效果及其临床意义。方法:将68例乳腺良性肿瘤患者随机分为创新组和对照组,创新组采用乳晕小切口术切除乳腺肿瘤;对照组采用传统放射状切口切除肿瘤,观察患者手术时间、术中出血量、切口愈合时间以及乳房美观状态。结果:对照组和创新组的手术时间、术中出血量差异无统计学意义(P>0.05),但是创新组患者的切口愈合时间明显少于对照组,差异明显(P<0.05)。创新组患者的术后乳房对称率(97.1%)、瘢痕可接受率(94.1%)以及术后患者总体满意度(88.2%)明显高于对照组的82.4%、70.6%、61.8%,差异有统计学意义(P<0.05)。出院2周后随访,乳头无黑色素沉着,血液循环良好,乳房表皮无变黑或坏死,乳头恢复较好,无病例出现乳腺肿瘤复发症状。结论:乳晕小切口良性肿瘤切除术具有切口小、瘢痕隐蔽、术后恢复快、乳房外形恢复佳等优势,能够有效满足患者对于乳房美观的要求,能够成功切除乳腺良性肿瘤,改善患者生活质量,该方法用于治疗乳腺良性肿瘤效果显著。     

乳晕切口在乳腺良性肿瘤切除术中的临床应用分析

目的:探讨研究乳晕切口切除乳腺良性肿物的手术优点及临床可行性。方法:回顾性分析采用乳晕切口切除乳腺良性肿瘤74例患者的临床资料。结果:本组74例患者术后切口全部一期愈合,无血肿、感染发生等不良反应。术后患者对手术切口满意。结论:采用乳晕弧形切口不仅能够完整切除乳腺良性肿物,又能保持切口美观,是目前临床上乳腺良性肿物一种值得推广的手术方式。     

手术治疗乳腺纤维瘤320例临床分析

目的探讨分析手术中采用环乳晕弧状切口治疗乳腺纤维瘤的临床效果.方法我院于2006年4月-2011年3月间共收治320例进行乳腺纤维瘤切除手术的患者,随机把320例患者分为两组:对照组(手术采用传统放射状切口)和实验组(手术采用环乳晕切口),每组各160例.术后对患者随访1年,从术后乳房外形美观、切口愈合、肿块复发以及术后并发症几个方面评价疗效.结果对照组和实验组患者术后在切口愈合、肿块复发、术后并发症方面比较,差异均无统计学意义(P>0.05);两组患者在术后乳房外形美观方面比较,差异有统计学意义(P<0.05).结论手术中采用环乳晕弧状切口切除乳腺纤维瘤可行性高,术后乳房外观较好,并且疗效理想,值得临床上推广应用.     

环乳晕切口与传统切口治疗乳腺良性肿瘤临床比较

目的:探讨手术治疗乳腺良性肿瘤的最佳切口选择。方法:78例乳腺良性肿瘤患者随机分为研究组与对照组,每组39例,对照组采用传统术式,以患侧乳头为中心点进行放射状切口手术;研究组患者采用环乳晕切口切除术处理。统计患者双侧乳房基本对称情况、乳头乳晕感觉情况、切口瘢痕可接受情况、复发情况,对手术效果加以综合评价。结果:两组双侧乳房基本对称例数分别为36例和28例,切口瘢痕可接受例数分别为37例和26例(P<0.05)。结论:环乳晕切口切除手术治疗乳腺良性肿瘤可以有效减轻术后瘢痕,保持女性乳房美观,适合临床推广。     

54例乳腺良性肿瘤手术与术后美容的临床研究

目的 对54例良性乳腺肿瘤患者手术方式与术后美容效果的临床研究与探讨.方法 对54例乳腺良性肿瘤患者分别行乳晕切口等手术并术后随访6个月～1年.结果采取乳腺美容切口基本上瘢痕很少,乳腺外观达到满意效果.结论 对乳腺良性肿瘤采用美容切口可吸收美容线,进行皮内缝合,促进伤口愈合,乳房外观无影响,美容效果好.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.