共查询到20条相似文献,搜索用时 46 毫秒
1.
Stefania Vaga MS Manuela T. Raimondi PhD Franco Perona MD Maurizio Fornari MD Enrico G. Caiani PhD 《Journal of magnetic resonance imaging : JMRI》2009,29(6):1443-1449
Purpose
To evaluate the effects of reducing the number of segments in which the intervertebral disc (IVD) can be subdivided on the accuracy in estimating its sGAG content by computation of the parameter ΔT1 from delayed Gadolinium‐Enhanced MRI of Cartilage (dGEMRIC) protocol.Materials and Methods
Twenty‐three herniectomy patients underwent dGEMRIC acquisitions for IVD. Thirty‐one tissue samples were obtained at herniectomy from the same patients and biochemically analysed for their sGAG content. Eleven different division schemes (DS) were applied by processing dGEMRIC images, and ΔT1 values of the segments related to the surgical sampling locations were computed and correlated to the corresponding biochemical data. For each DS, the linear regression and Pearson's coefficient were computed.Results
Reducing the number of segments from 48 (4 annular rings and 12 angular sectors) to 12 (2 rings and 6 sectors), correlation with sGAG biochemical data did not decline (r > 0.7).Conclusion
A 12‐segment DS provided the best compromise between preserving accuracy and reducing the number of segments. J. Magn. Reson. Imaging 2009;29:1443–1449. © 2009 Wiley‐Liss, Inc. 相似文献2.
Ciavarro C Caiani EG Brayda-Bruno M Zerbi A Galbusera F Vaga S Lamartina C 《Journal of magnetic resonance imaging : JMRI》2012,35(5):1145-1151
Purpose:
To evaluate the mid‐term effects of implant of dynamic neutralization system (Dynesys) on disc tissue in patients with lumbar discopathy, through the quantification of glycosaminoglycans (GAG) concentration, both in treated and adjacent levels, by analysis of delayed gadolinium‐enhanced MRI contrast (dGEMRIC) images.Materials and Methods:
Ten patients with low back pain underwent the dGEMRIC diagnostic protocol before, 6‐months and after 2 years from surgery. Each patient was also evaluated with visual analog (VAS), Oswestry, and Prolo scales both at presurgery and during follow‐up. From dGEMRIC images, a ΔT1 parametric map was obtained for each disc, as quantitative indicator of its GAG concentration, and divided in 13 sectors, which were classified at presurgery as normal or abnormal, based on a 70‐ms threshold. Evolution of ΔT1 was studied during the follow‐up.Results:
Nine of ten patients completed the follow‐up. VAS, Oswestry, and Prolo grades showed an improvement. This was accompanied by a reduction of ΔT1 in abnormal segments while normal segments showed a pattern of initial worsening at 6 months, followed by an improvement after 2 years.Conclusion:
Our study confirmed the improvement in clinical evaluation, and for the first time related this to the changes in discs GAG concentration. J. Magn. Reson. Imaging 2012;35:1145‐1151. © 2011 Wiley Periodicals, Inc. 相似文献3.
Utility of delayed gadolinium-enhanced MRI (dGEMRIC) for qualitative evaluation of articular cartilage of patellofemoral joint 总被引:3,自引:0,他引:3
Takehiro Nojiri Nobuyoshi Watanabe Takehiko Namura Wataru Narita Kazuya Ikoma Takehiko Suginoshita Hisatake Takamiya Hiroto Komiyama Hirotoshi Ito Tsunehiko Nishimura Toshikazu Kubo 《Knee surgery, sports traumatology, arthroscopy》2006,14(8):718-723
Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was used for the measurement of relative proteoglycan depletion of articular cartilage in the patellofemoral (PF) joint following a proprietary protocol, which was compared with the X-ray images, proton density weighted MR images (PDWI) and arthroscopic findings. The study examined 30 knees. The ages ranged from 16 to 74 (average 40.3) years. The Gd-DTPA2–containing contrast medium was used in a single dose. The subjects were made to exercise the knee joint for 10 min; and MR images were taken 2 h after intravenous injection of contrast medium. T1-calculated images were produced and the region of interest (ROI) was set as follows. (1) ROI1: entire articular cartilage in a slice through the center of the patella. (2) ROI2: low signal region in T1-calculated images, which were set in a blind fashion by two observers. (3) ROI3: articular cartilage on one side that includes ROI2 where low signal region were detected (medial or lateral). ROI3 was set to examine the contrast of ROI2 with surrounding articular cartilage. The average T1 values of ROI1 was 393.5±33.6 ms for radiographic grade 0 and 361.3±11.1 ms for grade I, which showed a significant difference (P=0.036). The T1 value of ROI2 was 351.6±28.2 ms for grade I, 361.9±38.3 ms for grade II, 362.1±67.7 ms for grade III, and 297.8±54.1 ms for grade IV according to arthroscopic Outerbridge classification. All cases, that demonstrated decrease of T1 values on dGEMRIC (ROI2), showed abnormal arthroscopic or direct viewing findings. The ratio (ROI3/ROI2) in cases of only slight damage classified as Outerbridge grade I (6 cases) was an average of 1.04±0.02 and was 1.0 or greater in all cases, thereby indicating well-defined contrast with the surrounding cartilage. The diagnosis of damage in articular cartilage was possible in all 16 cases with radiographic K–L grade I on dGEMRIC, while the intensity changes were not found in 10 of 16 cases on PDWI. The dGEMRIC with a single-dose would be useful on a diagnosis of the area demonstrating early relative proteoglycan depletion in the articular cartilage of the PF joint prior to any discernible changes in the subchondral bone on X-ray images and exceeds to plain MR images for examining deterioration of articular cartilage. 相似文献
4.
Tissue warming and regulatory responses induced by radio frequency energy deposition on a whole-body 3-Tesla magnetic resonance imager 总被引:1,自引:0,他引:1
Boss A Graf H Berger A Lauer UA Wojtczyk H Claussen CD Schick F 《Journal of magnetic resonance imaging : JMRI》2007,26(5):1334-1339
PURPOSE: To quantify the B1-field induced tissue warming on a 3T-whole-body scanner, to test whether the patient is able to sense the temperature change, and to evaluate whether the imaging procedure constitutes a significant cardiovascular stress. MATERIALS AND METHODS: A total of 18 volunteers were divided into three equal groups for 3.0T MRI of the pelvis, the head, or the knee. An imaging protocol operating at first level mode was applied, allowing radio frequency (RF) irradiation up to the legal specific absorption rate (SAR) limits. An identical placebo protocol with active gradient switching but without RF transmission was used. Temperature changes were measured with a fiber-optic thermometer (FO) and an infrared camera (IR). RESULTS: Temperature differences to the placebo were highest for imaging of the pelvis (FO: DeltaT = 0.88 +/- 0.13 degrees C, IR: DeltaT = 1.01 +/- 0.15 degrees C) as compared to the head (FO: DeltaT = 0.46 +/- 0.12 degrees C, IR: DeltaT = 0.47 +/- 0.10 degrees C) and the knee (FO: DeltaT = 0.33 +/- 0.11 degrees C, IR: DeltaT = 0.37 +/- 0.09 degrees C). The volunteers were able to discriminate between imaging and placebo for pelvic (P < 0.0001) and head (P = 0.0005) imaging but not for knee imaging (P = 0.209). No changes in heart rate or blood pressure were detected. CONCLUSION: The 3.0T MRI in the first operational mode may lead to measurable and perceptible thermal energy deposition. However, it may be regarded as safe concerning the thermoregulatory cardiovascular stress. 相似文献
5.
Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis. 总被引:7,自引:0,他引:7
Carl Johan Tiderius Lars E Olsson Peter Leander Olle Ekberg Leif Dahlberg 《Magnetic resonance in medicine》2003,49(3):488-492
Delayed contrast-enhanced MRI of cartilage (dGEMRIC) is a noninvasive technique to study cartilage glycosaminoglycan (GAG) content in vivo. This study evaluates dGEMRIC in patients with preradiographic degenerative cartilage changes. Seventeen knees in 15 patients (age 35-70) with arthroscopically verified cartilage changes (softening and fibrillations) in the medial or lateral femoral compartment, knee pain, and normal weight-bearing radiography were included. MRI (1.5 T) was performed precontrast and at 1.5 and 3 hr after an intravenous injection of Gd-DTPA(2-) at 0.3 mmol/kg body weight. T(1) measurements were made in regions of interest in medial and lateral femoral cartilage using sets of five turbo inversion recovery images. Precontrast, R(1) (R(1) = 1/T(1), 1/s) was slightly lower in diseased compared to reference compartment, indicating increased hydration (P = 0.01). Postcontrast, R(1) was higher in diseased than in reference compartment at 1.5 hr, 3.45 +/- 0.90 and 2.64 +/- 0.58 (mean +/- SD), respectively (P < 0.01), as well as at 3 hr, 2.94 +/- 0.60 and 2.50 +/- 0.37, respectively (P = 0.01). The washout of the contrast medium was faster in diseased cartilage as shown by a higher R(1) at 1.5 than at 3 hr in the diseased but not in the reference compartment. In conclusion, dGEMRIC can identify GAG loss in early stage cartilage disease with a higher sensitivity at 1.5 than 3 hr. 相似文献
6.
dGEMRIC (delayed gadolinium-enhanced MRI of cartilage) indicates adaptive capacity of human knee cartilage. 总被引:3,自引:0,他引:3
Carl Johan Tiderius Jonas Svensson Peter Leander Thorsson Ola Leif Dahlberg 《Magnetic resonance in medicine》2004,51(2):286-290
Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is a new imaging technique to estimate joint cartilage glycosaminoglycan content by T1-relaxation time measurements after penetration of the hydrophilic contrast agent Gd-DTPA(2-). This study compares dGEMRIC in age-matched healthy volunteers with different levels of physical activity: Group 1 (n = 12): nonexercising individuals; Group 2 (n = 16): individuals with physical exercise averaging twice weekly; Group 3 (n = 9): male elite runners. dGEMRIC was performed 2 hr after an intravenous injection of Gd-DTPA(2-) at 0.3 mmol/kg body weight. T1 differed significantly between the three different levels of physical exercise. T1 values (mean of medial and lateral femoral cartilage) for Groups 1, 2, and 3 were: 382 +/- 33, 424 +/- 22 and 476 +/- 36, respectively (ms, mean +/- SD) (P = 0.0004, 1 vs. 2 and 0.0002, 2 vs. 3). Irrespective of the exercise level, T1 was longer in lateral compared to medial femoral cartilage (P = 0.00005; n = 37). In conclusion, this cross-sectional study indicates that human knee cartilage adapts to exercise by increasing the glycosaminoglycan content. Furthermore, results suggest a compartmental difference within the knee with a higher glycosaminoglycan content in lateral compared to medial femoral cartilage. A higher proportion of extracellular water, i.e., larger distribution volume, may to some extent explain the high T1 in the elite runners. 相似文献
7.
Esther E. Bron Jasper van Tiel Henk Smit Dirk H. J. Poot Wiro J. Niessen Gabriel P. Krestin Harrie Weinans Edwin H. G. Oei Gyula Kotek Stefan Klein 《European radiology》2013,23(1):246-252
Objectives
To evaluate the effect of automated registration in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) of the knee on the occurrence of movement artefacts on the T1 map and the reproducibility of region-of-interest (ROI)-based measurements.Methods
Eleven patients with early-stage knee osteoarthritis and ten healthy controls underwent dGEMRIC twice at 3?T. Controls underwent unenhanced imaging. ROIs were manually drawn on the femoral and tibial cartilage. T1 calculation was performed with and without registration of the T1-weighted images. Automated three-dimensional rigid registration was performed on the femur and tibia cartilage separately. Registration quality was evaluated using the square root Cramér–Rao lower bound (CRLBσ). Additionally, the reproducibility of dGEMRIC was assessed by comparing automated registration with manual slice-matching.Results
Automated registration of the T1-weighted images improved the T1 maps as the 90% percentile of the CRLBσ was significantly (P?<?0.05) reduced with a median reduction of 55.8 ms (patients) and 112.9 ms (controls). Manual matching and automated registration of the re-imaged T1 map gave comparable intraclass correlation coefficients of respectively 0.89/0.90 (patients) and 0.85/0.85 (controls).Conclusions
Registration in dGEMRIC reduces movement artefacts on T1 maps and provides a good alternative to manual slice-matching in longitudinal studies.Key Points
? Quantitative MRI is increasingly used for biomedical assessment of knee articular cartilage ? Image registration leads to more accurate quantification of cartilage quality and damage ? Movement artefacts in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) are reduced ? Automated image registration successfully aligns baseline and follow-up dGEMRIC examinations ? Reproducibility of dGEMRIC with registration is similar to that using manual slice-matching 相似文献8.
Bernd Bittersohl MD Harish S. Hosalkar MD MBMS FCPS DNB Tanja Haamberg MD Young‐Jo Kim MD Stefan Werlen MD Klaus A. Siebenrock MD Tallal C. Mamisch MD 《Journal of magnetic resonance imaging : JMRI》2009,30(1):224-228
Purpose
To investigate the reproducibility of dGEMRIC in the assessment of cartilage health of the adult asymptomatic hip joint.Materials and Methods
Fifteen asymptomatic volunteers (mean age, 26.3 years ± 3.0) were preliminarily studied. Any volunteer that was incidentally diagnosed with damaged cartilage on MRI (n = 5) was excluded. Ten patients that had no evidence of prior cartilage damage (mean age, 26.2 years ± 3.4) were evaluated further in this study. The reproducibility of dGEMRIC was assessed with two T1Gd exams performed 4 weeks apart in these volunteers. The protocol involved an initial standard MRI to confirm healthy cartilage, which was then followed by dGEMRIC. The second scan included only the repeat dGEMRIC. Region of interest (ROI) analyses for T1Gd‐measurement was performed in seven radial reformats. Statistical analysis included the student's t‐test and intra‐class correlation (ICC) measurement to assess reproducibility.Results
Overall 70 ROIs were studied. Mean cartilage T1Gd values at various loci ranged from 560.9 ms to 684.4 ms at the first set of readings and 551.5 ms to 662.2 ms in the second one. The mean difference per region of interest between the two T1Gd‐measurements ranged from 21.4 ms (3.7%) to 45.0 ms (6.8%), which was not found to be statistically significant (P = 0.153). There was a high reproducibility detected (ICC range, 0.667–0.915). Intra‐ and Inter‐observer analyses proved a high agreement for T1Gd assessment (0.973 and 0.932).Conclusion
We found dGEMRIC to be a reliable tool in the assessment of cartilage health status in adult hip joints. J. Magn. Reson. Imaging 2009;30:224–228. © 2009 Wiley‐Liss, Inc. 相似文献9.
W D Foltz Y Yang J J Graham J S Detsky G A Wright A J Dick 《Magnetic resonance in medicine》2006,56(6):1311-1319
MRI evaluations of intramyocardial hemorrhage in acute infarction have relied on T(2) and T(2)(*) shortening only. We propose a more comprehensive evaluation of hemorrhagic infarction based on the concept that fluctuations in T(2) and T(1) relaxation in acute reperfused infarction will reflect transient edema and hemoglobin oxidative denaturation to uncompartmentalized methemoglobin. Anteroapical infarction was created via percutaneous balloon in young swine (22-25 kg, N = 12). T(2), T(1), diastolic wall thickness (DWT), and the Gd-DTPA partition coefficient (lambda) were measured on days 0, 2, and 7. DWT was elevated at 1 hr postreperfusion (128% +/- 53%, P = 0.0001), and alleviated on days 2 and 7 (48% +/- 10%, P = 0.008; 53% +/- 24%, P = 0.003). T(2) and T(1) elevations were coincident with early edema (DeltaT(2) = 55% +/- 24%, P < 0.0001; DeltaT(1) = 27% +/- 18%, P < 0.04). T(2) and T(1) were nearly normal on day 2 (DeltaT(2) = 8% +/- 8%, P = 0.27; DeltaT(1) = 0% +/- 1%, P = 0.65). On day 7, T(2) increased while T(1) decreased (DeltaT(2) = 27% +/- 16%, P = 0.005; DeltaT(1) = -14% +/- 10%, P = 0.02). Lambda was elevated by >150% at all time points (P < or = 0.002). Histology verified hemorrhagic injury. T(1) and T(2) fluctuations are consistent with transient edema, as well as hemoglobin oxidative denaturation to decompartmentalized methemoglobin. This methodological development may broaden our understanding of hemorrhagic microvascular injury and improve its detection in clinical populations. 相似文献
10.
Christoph Zilkens Falk R. Miese Clemens Crumbiegel Young-Jo Kim Monika Herten Gerald Antoch Rüdiger Krauspe Bernd Bittersohl 《Skeletal radiology》2013,42(5):699-705
Objective
To compare morphologically normal appearing cartilage in two age groups with delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and correlate magnetic resonance imaging (MRI) findings with histology.Materials and methods
Twenty femoral head specimens collected from ten lambs (group I) and ten young adult sheep (group II) underwent dGEMRIC and histological assessment. A region of 2 cm2 with morphologically normal-appearing cartilage was marked with a surgical suture for subsequent matching of MRI and histological sections. The MRI protocol included a three-dimensional (3D) double-echo steady-state sequence for morphological cartilage assessment, a B1 pre-scan with various flip angles for B1 field heterogeneity correction, and 3D volumetric interpolated breathhold examination for T1Gd mapping (dGEMRIC). Histological analysis was performed according to the Mankin scoring system.Results
A total of 303 regions of interest (ROI; 101 MRI reformats matching 101 histological sections) was assessed. Twenty-six ROIs were excluded owing to morphologically apparent cartilage damage or insufficient MR image quality. Therefore, 277 ROIs were analyzed. Histological analyses revealed distinct degenerative changes in various cartilage samples of group II (young adult sheep). Corresponding T1Gd values were significantly lower in the group of sheep (mean T1Gd?=?540.4 ms) compared with the group of lambs (mean T1Gd?=?623.6 ms; p?<?0.001).Conclusions
Although morphologically normal, distinct cartilage degeneration may be present in young adult sheep cartilage. dGEMRIC can reveal these changes and may be a tool for the assessment of early cartilage degeneration. 相似文献11.
Patellar cartilage lesions: comparison of magnetic resonance imaging and T2 relaxation-time mapping 总被引:1,自引:0,他引:1
Hannila I Nieminen MT Rauvala E Tervonen O Ojala R 《Acta radiologica (Stockholm, Sweden : 1987)》2007,48(4):444-448
PURPOSE: To evaluate the detection and the size of focal patellar cartilage lesions in T2 mapping as compared to standard clinical magnetic resonance imaging (MRI) at 1.5T. MATERIAL AND METHODS: Fifty-five consecutive clinical patients referred to knee MRI were imaged both with a standard knee MRI protocol (proton-density-weighted sagittal and axial series, T2-weighted sagittal and coronal series, and T1-weighted coronal series) and with an axial multislice multi-echo spin-echo measurement to determine the T2 relaxation time of the patellar cartilage. MR images and T2 maps of patellar cartilage were evaluated for focal lesions. The lesions were evaluated for lesion width (mm), lesion depth (1/3, 2/3, or 3/3 of cartilage thickness), and T2 value (20-40 ms, 40-60 ms, or 60-80 ms) based on visual evaluation. RESULTS: Altogether, 36 focal patellar cartilage lesions were detected from 20 human subjects (11 male, nine female, mean age 40+/-15 years). Twenty-eight lesions were detected both on MRI and T2 maps, while eight lesions were only visible on T2 maps. Cartilage lesions were significantly wider (P = 0.001) and thicker (P<0.001) on T2 maps as compared to standard knee MRI. Most lesions 27 had moderately (T2 40-60 ms) increased T2 values, while two lesions had slightly (T2 20-40 ms) and seven lesions remarkably (T2 60-80 ms) increased T2 relaxation times. CONCLUSION: T2 mapping of articular cartilage is feasible in the clinical setting and may reveal early cartilage lesions not visible with standard clinical MRI. 相似文献
12.
T2 of articular cartilage in the presence of Gd-DTPA2-. 总被引:1,自引:0,他引:1
Miika T Nieminen Nina M Menezes Ashley Williams Deborah Burstein 《Magnetic resonance in medicine》2004,51(6):1147-1152
T(2) information and delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) are both used to characterize articular cartilage. They are currently obtained in separate studies because Gd-DTPA(2-) (which is needed for dGEMRIC) affects the inherent T(2) information. In this study, T(2) was simulated and then measured at 8.45 T in 20 sections from two human osteochondral samples equilibrated with and without Gd-DTPA(2-). Both the simulations and data demonstrated that Gd-DTPA(2-) provides a non-negligible mechanism for relaxation, especially with higher (1 mM) equilibrating Gd-DTPA(2-) concentrations, and in areas of tissue with high T(2) (due to weak inherent T(2) mechanisms) and high tissue Gd-DTPA(2-) (due to a low glycosaminoglycan concentration). Nonetheless, T(2)-weighted images of cartilage equilibrated in 1 mM Gd-DTPA(2-) showed similar T(2) contrast with and without Gd-DTPA(2-), demonstrating that the impact on T(2) was not great enough to affect identification of T(2) lesions. However, T(2) maps of the same samples showed loss of conspicuity of T(2) abnormalities. We back-calculated inherent T(2)'s (T(2,bc)) using a T(2)-relaxivity value from a 20% protein phantom (r(2) = 9.27 +/- 0.09 mM(-1)s(-1)) and the Gd-DTPA(2-) concentration calculated from T(1,Gd). The back-calculation restored the inherent T(2) conspicuity, and a correlation between T(2) and T(2,bc) of r = 0.934 (P < 0.0001) was found for 80 regions of interest (ROIs) in the sections. Back-calculation of T(2) is therefore a viable technique for obtaining T(2) maps at high equilibrating Gd-DTPA(2-) concentrations. With T(2)-weighted images and/or low equilibrating Gd-DTPA(2-) concentrations, it may be feasible to obtain both T(2) and dGEMRIC information in the presence of Gd-DTPA(2-) without such corrections. These conditions can be designed into ex vivo studies of cartilage. They appear to be applicable for clinical T(2) studies, since pilot clinical data at 1.5 T from three volunteers demonstrated that calculated T(2) maps are comparable before and after "double dose" Gd-DTPA(2-) (as utilized in clinical dGEMRIC studies). Therefore, it may be possible to perform a comprehensive clinical examination of dGEMRIC, T(2), and cartilage volume in one scanning session without T(2) data correction. 相似文献
13.
Molinari F Puderbach M Eichinger M Ley S Fink C Bonomo L Kauczor HU Bock M 《Investigative radiology》2008,43(6):427-432
OBJECTIVE: The clinical feasibility of oxygen-enhanced magnetic resonance imaging (MRI) of the lung may benefit from the use of a simple gas delivery method. In this study, the oxygen-induced T1 change of the lung obtained using a closed O(2) delivery system was compared with that obtained by a conventional nontight face mask. MATERIAL AND METHODS: Twenty-three healthy subjects (15 men, 8 women, mean age = 25 years, age range = 20-35 years) underwent oxygen-enhanced MRI of the lung using a closed O(2) delivery system composed by a tightly fitting face mask and a 60-L reservoir bag (equipment type A: n = 13, 9 men, 4 women, mean age = 24.4 years, age range = 20-32 years), or a clinically available nontight face mask (equipment type B: n = 10; 6 men, 4 women, mean age = 25.8 years, age range = 20-35 years). The effect of 100%-oxygen inhalation was assessed using a Snapshot FLASH T1-mapping technique (repetition time/echo time = 1.5-1.6/0.56 milliseconds; matrix = 128 x 90; acquisition time = 3.3-3.7 seconds; slice thickness = 15-20 mm; number of images = 40). By nonlinear curve fitting, the mean T1 values of the left and right lung at room air and 100%-oxygen ventilation were calculated (T1(room air, right); T1(oxygen, right); T1(room air, left); T1(oxygen, left)). The average T1 differences (DeltaT1 = T1(room air) - T1(oxygen)) of the 2 volunteer groups were compared (Wilcoxon signed rank test, Mann-Whitney U test). RESULTS: The mean T1 values obtained using the 2 respiratory equipments at room air or oxygen ventilation were not significantly different (A vs. B at room air ventilation: P = 0.85 for the right lung, P = 0.27 for the left lung; A vs. B at oxygen ventilation: P = 0.55 for the left lung, P = 0.29 for the right lung). With both systems, the mean T1 values decreased significantly after oxygen inhalation (P = 0.03-0.0002). For both lungs, the DeltaT1 obtained using the equipment type A was statistically equivalent to that obtained using the equipment type B: DeltaT1A, right = 96 +/- 19 milliseconds versus DeltaT1B, right = 97 +/- 34 milliseconds (P = 0.82); DeltaT1A, left = 74 +/- 47 milliseconds versus DeltaT1B, left = 68 +/- 63 milliseconds (P = 0.85). CONCLUSION: Gas delivery in oxygen-enhanced MRI of the lung can be performed with a clinically available standard face mask, without the need for closed sophisticated equipments. 相似文献
14.
Tallal Charles Mamisch Marcel Dudda Timothy Hughes Deborah Burstein Young‐Jo Kim 《Magnetic resonance in medicine》2008,60(4):768-773
The delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) technique has shown promising results in pilot clinical studies of early osteoarthritis. Currently, its broader acceptance is limited by the long scan time and the need for postprocessing to calculate the T1 maps. A fast T1 mapping imaging technique based on two spoiled gradient echo images was implemented. In phantom studies, an appropriate flip angle combination optimized for center T1 of 756 to 955 ms yielded excellent agreement with T1 measured using the inversion recovery technique in the range of 200 to 900 ms, of interest in normal and diseased cartilage. In vivo validation was performed by serially imaging 26 hips using the inversion recovery and the Fast 2 angle T1 mapping techniques (center T1 756 ms). Excellent correlation with Pearson correlation coefficient R2 of 0.74 was seen and Bland‐Altman plots demonstrated no systematic bias. Magn Reson Med 60:768–773, 2008. © 2008 Wiley‐Liss, Inc. 相似文献
15.
Babos M Schwarcz A Randhawa MS Marton B Kardos L Palkó A 《European journal of radiology》2008,65(1):133-139
PURPOSE: In vitro evaluation of different materials as potential alternative oral contrast agents for small bowel MRI. MATERIALS AND METHODS: The T1 and T2 relaxation times of rose hip syrup, black currant extract, cocoa, iron-deferoxamine solution and a commonly used oral contrast material (1 mM Gd-DTPA) were determined in vitro at different concentrations on a 1.0 T clinical MR scanner. T1 values were obtained with an inversion prepared spoiled gradient echo sequence. T2 values were obtained using multiple echo sequences. Finally the materials were visualized on T1-, T2- and T2*-weighted MR images. RESULTS: The relaxation times of the undiluted rose hip syrup (T1=110+/-5 ms, T2=86+/-3 ms), black currant extract (T1=55+/-3 ms, T2=39+/-2 ms) and 5 mM iron-deferoxamine solution (T1=104+/-4 ms, T2=87+/-2 ms) were much shorter than for a 1mM Gd-DTPA solution (T1=180+/-8 ms, T2=168+/-5 ms). Dilution of black currant extract to 30% or a 3 mM iron-deferoxamine solution conducted to T1 relaxation times which are quite comparable to a 1 mM Gd-DTPA solution. Despite its much lower metal content an aqueous cocoa suspension (100 g/L) produced T2 relaxation times (T1=360+/-21 ms, T2=81+/-3 ms) more or less in the same range like the 5 mM iron-deferoxamine solution. Imaging of our in vitro model using clinical sequences allowed to anticipate the T1-, T2- and T2*-depiction of all used substances. Cocoa differed from all other materials with its low to moderate signal intensity on T1- and T2-weighted sequences. While all substances presented a linear 1/T1 and 1/T2 relationship towards concentration, rose hip syrup broke ranks with a disproportionately high increase of relaxation at higher concentrations. CONCLUSIONS: Rose hip syrup, black currant extract and iron-deferoxamine solution due to their positive T1 enhancement characteristics and drinkability appear to be valuable oral contrast agents for T1-weighted small bowel MRI. Cocoa with its differing relaxation and signal enhancement properties is a promising oral contrast agent but needs further clinical evaluation. 相似文献
16.
腰椎间盘退变的X线、MRI表现与病理对照 总被引:15,自引:0,他引:15
目的 观察腰椎间盘退变的病理变化及其MRI表现。方法 13具腰椎尸检标本共31个椎间盘均进行X线钼靶检查,其中5具标本的20个椎间盘进行MR检查,将X线及MRI所见与31个椎间盘的87个层面的病理大切片进行对照。结果 31个椎间盘病理均可见不同程度的纤维环退变,在T2WI上20个椎间盘的内外纤维环中均出现带状、片状高信号,或椎间盘大部呈高信号。病理见22(22/31)个纤维环成角折曲突向髓核(内折),18(18/31)个纤维环成角折曲突向周边(外折);在T1W1和T1WI内折表现为椎间盘内突向髓核成角折曲的低信号,外折表现为椎间盘内突向周边的折角低信号。病理见20(20/31)个椎间盘髓核内可见坏死的细胞碎渣,在T2WI表现为髓核中斑点状低信号(14/20)。Schmorl结节见于7个椎间盘,病理显示为椎间盘内的组织突破软骨终板进行入椎体内形成结节,7个Schmorl结节在T2WI均呈高信号。病理显示2个椎间盘纤维环内有大的裂隙形成,在T2WI表现为低信号带。病理显示6个椎间盘退变,纤维组织增生呈团块状、分支状和带状横贯于椎间盘之中,在T2WI表现为椎间盘中低信号带。平片示唇样增生3个椎体,Schmorl结节7个椎体;椎体上下面骨板硬化,呈孤形凹陷和锯齿状骨质侵蚀11个椎体,后者病理见凹陷处软骨板消失。结论 MRI对腰椎间盘退变有较高的诊断价值,X线平片可以间接显示软骨终板的消失。 相似文献
17.
Signal intensity in 23Na images is altered in pathologic conditions such as ischemia and may provide information regarding tissue viability complementary to MR diffusion and perfusion imaging. However, the multicomponent transverse relaxation of 23Na (spin 3/2) complicates the determination of tissue sodium concentration from 23Na images with nonzero echo-time. The purpose of this study was to measure the long component time constant of tissue sodium T*2 relaxation in the healthy human brain at 4 T. Multiecho gradient-echo 23Na images (10 echo-times ranging from 3.8-68.7 ms) were acquired in five healthy human volunteers. T*2 was quantified on a pixel-by-pixel basis using a nonnegative least squares fitting routine using 100 equally spaced bins between 0.5-99.5 ms and parametric maps were produced representing components between 0.5-3, 3.1-50, 50.1-98, and 98.1-99.5 ms. The long T*2 component of tissue sodium (average +/- standard deviation) varied between cortex (occipital = 22.0 +/- 2.4 ms), white matter (parietal = 18.2 +/- 1.9 ms), and subcortical gray matter (thalamus = 16.9 +/- 2.4 ms). These results demonstrate considerable regional variability and establish a foundation for future characterization of 23Na T*2 in conditions such as cerebral ischemia and cancer. 相似文献
18.
Boesen M Jensen KE Qvistgaard E Danneskiold-Samsøe B Thomsen C Ostergaard M Bliddal H 《Acta radiologica (Stockholm, Sweden : 1987)》2006,47(4):391-396
PURPOSE: To investigate and compare delayed gadolinium (Gd-DTPA)-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) in the hip joint using intravenous (i.v.) or ultrasound-guided intra-articular (i.a.) Gd-DTPA injection. MATERIAL AND METHODS: In 10 patients (50% males, mean age 58 years) with clinical and radiographic hip osteoarthritis (OA; Kellgren score II-III), MRI of the hip was performed twice on a clinical 1.5T MR scanner: On day 1, before and 90-180 min after 0.3 mmol/kg body weight i.v. Gd-DTPA and, on day 8, 90-180 min after ultrasound-guided i.a. injection of a 4 mmol/l Gd-DTPA solution. Coronal STIR, coronal T1 fat-saturated spin-echo, and a cartilage-sensitive gradient-echo sequence (3D T1 SPGR) in the sagittal plane were applied. RESULTS Both the post-i.v. and post-i.a. Gd-DTPA images showed significantly higher signal-to-noise (SNR) and contrast-to-noise (CNR) in the joint cartilage compared to the non-enhanced images (P < 0.002). I.a. Gd-DTPA provided significantly higher SNR and CNR compared to i.v. Gd-DTPA (P < 0.01). Furthermore, a better delineation of the cartilage in the synovial/cartilage zone and of the chondral/subchondral border was observed. CONCLUSION: The dGEMRIC MRI method markedly improved delineation of hip joint cartilage compared to non-enhanced MRI. The i.a. Gd-DTPA provided the best cartilage delineation. dGEMRIC is a clinically applicable MRI method that may improve identification of early subtle cartilage damage and the accuracy of volume measurements of hip joint cartilage. 相似文献
19.
McKenzie CA Williams A Prasad PV Burstein D 《Journal of magnetic resonance imaging : JMRI》2006,24(4):928-933
PURPOSE: To implement and validate a three-dimensional (3D) T1 measurement technique that is suitable for delayed gadolinium (Gd)-enhanced MRI of cartilage (dGEMRIC) and can be easily implemented with clinically available pulse sequences at 1.5T and 3.0T. MATERIALS AND METHODS: A 3D inversion-recovery prepared spoiled gradient-echo (IR-SPGR) imaging pulse sequence with variable TR was used to implement a 3D T1 measurement protocol. The 3D T1 measurements were validated against a gold-standard single-slice 2D IR T1 measurement protocol in both phantoms and in vivo, in both asymptomatic volunteers and volunteers with osteoarthritis (OA). RESULTS: T1 measurements in phantoms showed a statistically significant correlation between the 2D and 3D measurements at 1.5T (R2=0.993, P<0.001) and 3.0T (R2=0.996, P<0.001). In vivo application demonstrated the feasibility of using this 3D IR-SPGR sequence to evaluate the molecular status of articular cartilage throughout the knee joint with 0.63x0.63x3.0 mm spatial resolution within a 20-minute acquisition, even with the measurement parameters set for the higher T1(Gd) of cartilage at 3T (range=400-900 msec mean T1 within a region of interest (ROI) in cartilage, compared to 200-600 msec mean T1 at 1.5T). CONCLUSION: This 3D T1 measurement protocol may prove useful for the evaluation and follow-up of cartilage dGEMRIC indices in clinical studies of OA. 相似文献
20.
Value of opposed-phase gradient-echo technique in distinguishing between benign and malignant vertebral lesions 总被引:4,自引:0,他引:4
Zampa V Cosottini M Michelassi C Ortori S Bruschini L Bartolozzi C 《European radiology》2002,12(7):1811-1818
Our objective was to evaluate the possible role of opposed-phase gradient-echo (GRE) sequence in predicting the nature of vertebral lesions supposing that in the case of malignancy fat is completely replaced while in the case of benign lesion fat is still present. Eighty-six patients with vertebral lesions underwent MR examination at 0.5 T. The MR protocol included a T1-weighted spin-echo (SE) and an opposed-phase GRE using the same parameters (TR=280-320 ms, flip angle=90 degrees, slice thickness=3.5-4 mm, matrix=256x160-192, field of view=34-36 cm, no. of excitations=2-4) except for TE (10 ms in SE vs 7 ms in GRE) to obtain opposed-phased images. Qualitative (nature of lesion, detectability, degree of signal intensity (SI), marrow pattern) and quantitative (SI on opposed-phase GRE minus SI on T1-weighted SE minus SI ratio=SI on out-of-phase GRE images divided by SI on T1-weighted SE images) analysis were performed. The SI ratio values were analysed using Mann-Whitney rank-sum test and receiver operating characteristics (ROC) curve. Lesions resulted to be malignant in 45 and benign in 41 patients (23 biopsies, 20 MR follow-ups, 43 clinical and other imaging follow-ups). Based on visual inspection of opposed-phased images, visual SI was evaluated high in 38 (34 malignant, 34 benign), mild in 28 (9 malignant, 19 benign) and low in 20 (2 malignant, 18 benign) patients. Based on region-of-interest measurements, SI ratio values range was 0.36-6.2 (mean value=1.68+/-0.82) for malignant and 0.07-1.54 (mean value=0.77+/-0.44) for benign lesions. A cut-off value of 1.2 gave a sensitivity, specificity, accuracy, negative predictive value and positive predictive value, respectively, of 88.8, 80.49, 84.88, 86.4 and 83.33%. The ROC analysis of the SI ratio showed an area under ROC curve of 0.92 and a statistically significant difference between the two groups of lesions was observed ( p<0.01). The GRE opposed-phase sequence can help to predict the nature of a vertebral lesion. This fast and widely available technique together with morphological criteria can improve the accuracy of MRI. 相似文献