阿托伐他汀联合曲美他嗪治疗冠心病的疗效研究

目的：探讨阿托伐他汀联合曲美他嗪治疗冠心病的临床疗效。方法选取2012年11月—2013年10月我院收治的冠心病住院患者183例,按照治疗方案和性别将所有患者分为阿托伐他汀组、曲美他嗪组和联合治疗组,每组61例。3组患者入院后均给予常规治疗,阿托伐他汀组患者加用阿托伐他汀,曲美他嗪组患者加用曲美他嗪,联合治疗组患者加用阿托伐他汀联合曲美他嗪;3组患者均连续治疗2周为1个疗程。观察3组患者治疗前后血脂、心绞痛发作次数、每次心绞痛发作持续时间及治疗后心功能、治疗期间不良反应情况。结果3组患者治疗前总胆固醇（ TC）、三酰甘油（ TG）、高密度脂蛋白胆固醇（ HDL－C）、低密度脂蛋白胆固醇（ LDL－C）及心绞痛发作次数、每次心绞痛发作持续时间比较,差异均无统计学意义（ P＞0.05）。联合治疗组患者治疗后TC、 TG及LDL－C低于阿托伐他汀组和曲美他嗪组, HDL－C高于阿托伐他汀组和曲美他嗪组（ P＜0.05）;心绞痛发作次数少于阿托伐他汀组和曲美他嗪组,每次心绞痛发作持续时间短于阿托伐他汀组和曲美他嗪组（ P＜0.05）;左室舒张末期内径（ LVEDD）、左室收缩末期内径（LVESD）小于阿托伐他汀组和曲美他嗪组,左室射血分数（LVEF）大于阿托伐他汀组和曲美他嗪组（P＜0.05）。联合治疗组患者治疗期间不良反应发生率低于阿托伐他汀组和曲美他嗪组（P＜0.05）。结论阿托伐他汀联合曲美他嗪治疗冠心病安全有效,有利于提高患者降脂效果、改善患者心功能。     

阿托伐他汀联合曲美他嗪治疗冠心病80例的临床效果分析

目的探讨分析阿托伐他汀联合曲美他嗪治疗冠心病的疗效。方法选取2015年10月~2016年6月我院收治的冠心病患者80例作为研究对象,按照治疗方法的不同,将其分为联合组与对照组,各40例。对照组给予曲美他嗪治疗,联合组给予阿托伐他汀联合曲美他嗪治疗,治疗结束后,对比分析两组患者的心绞痛发作次数、持续时间以及不良反应发生率。结果经过对比发现,联合组患者的心绞痛发作次数、持续时间以及不良反应发生率均低于对照组,差异均有统计学意义(P0.05)。结论阿托伐他汀联合曲美他嗪治疗冠心病疗效显著,可有效的减少患者心绞痛发作次数,降低心绞痛发作时间,且不良反应较少,值得临床推广应用。     

阿托伐他汀联合曲美他嗪治疗冠心病的临床疗效

目的探讨阿托伐他汀联合曲美他嗪治疗冠状动脉粥样硬化性心脏病(冠心病)的临床疗效。方法选取2013年5月~2014年11月于首都医科大学附属复兴医院收治的140例冠心病患者,随机分为对照组和治疗组,每组70例。对照组患者在常规治疗基础上给予曲美他嗪,治疗组患者在对照组的基础上加用阿托伐他汀,比较两组患者的临床治疗效果、心绞痛发作情况、持续时间及不良反应。结果治疗组临床治疗总有效率为97.1%,明显高于对照组(82.8%),差异有统计学意义(P0.05)。两组患者治疗后总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平明显低于治疗前,高密度脂蛋白胆固醇(HDL-C)水平明显高于治疗前(P0.05),与对照组治疗后比较,治疗组的改善效果更明显(P0.05)。治疗组的心绞痛每周发作次数和每次心绞痛持续时间明显少于对照组(P0.05)。结论阿托伐他汀联合曲美他嗪治疗冠心病心绞痛安全有效,能够明显改善患者的心绞痛症状,改善患者的血脂情况。     

曲美他嗪和阿托伐他汀联合用于治疗冠心病心绞痛患者的疗效研究

目的研究联合应用曲美他嗪和阿托伐他汀治疗冠心病心绞痛的疗效。方法选取我院2015年10月~2016年5月收治的冠心病心绞痛患者72例作为研究对象,根据不同治疗方法分为对照组和观察组,各36例。对照组应用曲美他嗪治疗,观察组联合应用曲美他嗪和阿托伐他汀治疗,对比两组治疗后的疗效、心功能。结果观察组经治疗以后的心功能指标、心绞痛发作次数、发作时持续时间及总有效率优于对照组,差异有统计学意义(P0.05)。结论联合应用曲美他嗪和阿托伐他汀治疗冠心病心绞痛的疗效显著,可推广。     

观察阿托伐他汀联合曲美他嗪治疗冠心病的疗效

目的观察对冠心病患者采用曲美他嗪、阿托伐他汀联合治疗的效果。方法选取2015年3月~2016年12月本院收治的冠心病患者90例进行观察,采用随机分组法分为研究组和参照组,各45例。所有患者均给予常用治疗方案,参照组同时采用曲美他嗪治疗,研究组在常规治疗基础上采用曲美他嗪、阿托伐他汀联合治疗。治疗6周,观察两组患者心绞痛持续时间、心绞痛发作次数改善情况及治疗总有效率。结果研究组总有效率93.33%明显优于参照组80.00%,差异有统计学意义(P0.05);研究组心绞痛持续时间、心绞痛发作次数明显低于参照组,差异有统计学意义(P0.05)。结论曲美他嗪、阿托伐他汀联合用药有效的减轻了冠心病患者的心绞痛症状,安全性高,具有较高的临床应用价值。     

阿托伐他汀联合曲美他嗪治疗冠心病的疗效观察

目的探究阿托伐他汀联合曲美他嗪治疗冠心病的疗效。方法选取2011年3月~2014年5月我院收治的冠心病患者90例为研究对象,将其随机分为对照组和观察组,各45例。对照组进行阿托伐他汀治疗,观察组给予阿托伐他汀联合曲美他嗪治疗,对比两组患者的疗效、心绞痛发作次数、心绞痛发作时间、诱发心绞痛所用时间及ST段下降1 mm时间。结果观察组患者的总有效率明显高于对照组;同时观察组患者的心绞痛发作次数、心绞痛发作时间、诱发心绞痛所用时间及ST段下降1 mm时间均明显优于对照组,差异均有统计学意义(P0.05)。结论阿托伐他汀联合曲美他嗪治疗冠心病,疗效显著,值得推广与使用。     

阿托伐他汀联合曲美他嗪治疗冠心病的疗效

目的探讨阿托伐他汀联合曲美他嗪治疗冠心病(CHD)的疗效。方法选择CHD患者112例,随机分为治疗组(57例)和对照组(55例)。对照组给予曲美他嗪治疗,治疗组在使用曲美他嗪治疗的同时给予阿托伐他汀联合治疗,分别观察两组的疗效。结果治疗组总有效率(89.47%)明显高于对照组(83.63%)(P<0.05)。治疗组的血脂指标变化、心绞痛发作次数、持续时间的改善程度均优于对照组(P<0.05)。结论阿托伐他汀联合曲美他嗪的治疗疗效更为显著。     

阿托伐他汀联合曲美他嗪对冠心病患者心绞痛症状及血脂的影响

目的探讨阿托伐他汀联合曲美他嗪对冠心病患者心绞痛症状及血脂的影响。方法选取2015年4月至2016年2月商丘市第一人民医院收治的冠心病患者60例,随机分成对照组和试验组,各30例。对照组给予患者口服曲美他嗪,在此治疗基础上试验组患者加服阿托伐他汀。分析两组心绞痛发作情况、血脂指标水平及不良反应。结果对照组心绞痛发作时间及次数、总胆固醇(TC)、甘油三酯(TG)及低密度脂蛋白(LDL-C)水平均高于试验组,差异显著(P0.05);两组不良反应率无明显差异(P0.05)。结论阿托伐他汀与曲美他嗪联合治疗冠心病安全性良好,可有效缓解患者心绞痛症状,改善血脂水平。     

阿托伐他汀联合曲美他嗪治疗冠心病的临床疗效

目的探讨在冠心病治疗中,阿托伐他汀联合曲美他嗪的临床效果。方法选取接诊的冠心病患者84例,随机分为对照组与观察组,分别给予阿托伐他汀单一用药,阿托伐他汀与曲美他嗪联合用药,观测两组治疗4周后血液指标、发作症状以及临床效果。结果观察组治疗后TG、TC、LDL-C水平均低于对照组(P0.05);观察组治疗后心绞痛发作频率、持续时间均低于对照组(P0.05);对照组临床治疗总有效率为61.90%,观察组临床治疗总有效率为92.86%(P0.05)。结论通过阿托伐他汀与曲美他嗪联合用药方案,可有效改善冠心病患者血清指标,临床发病症状,且疗效确切。     

阿托伐他汀联合曲美他嗪治疗冠心病心绞痛的疗效观察

目的：探讨阿托伐他汀联合曲美他嗪治疗冠心病心绞痛的临床疗效。方法选取我院2012年5月—2014年3月收治的冠心病心绞痛患者48例,随机分为对照组和观察组,每组24例。对照组患者在常规治疗基础上给予曲美他嗪,观察组患者在对照组治疗基础上给予阿托伐他汀。观察两组患者心绞痛症状改善情况、心电图改善情况及治疗期间不良反应情况。结果观察组患者心绞痛症状改善总有效率为95.8％,高于对照组的66.7％（χ^2＝4.923, P＜0.05）。观察组患者心电图改善总有效率为87.5％,高于对照组的62.5％（χ^2＝4.000, P＜0.05）。两组患者治疗期间均未出现明显不良反应。结论阿托伐他汀联合曲美他嗪治疗冠心病心绞痛安全有效,有助于改善患者临床症状和心功能。     

The immunoneuroendocrine role of melatonin

Abstract: A tight, physiological link between the pineal gland and the immune system is emerging from a series of experimental studies. This link might reflect the evolutionary connection between self-recognition and reproduction. Pinealectomy or other experimental methods which inhibit melatonin synthesis and secretion induce a state of immunodepression which is counteracted by melatonin. In general, melatonin seems to have an immunoenhancing effect that is particularly apparent in immunodepressive states. The negative effect of acute stress or immunosuppressive pharmacological treatments on various immune parameters are counteracted by melatonin. It seems important to note that one of the main targets of melatonin is the thymus, i.e., the central organ of the immune system. The clinical use of melatonin as an immunotherapeutic agent seems promising in primary and secondary immunodeficiencies as well as in cancer immunotherapy. The immunoenhancing action of melatonin seems to be mediated by T-helper cell-derived opioid peptides as well as by lymphokines and, perhaps, by pituitary hormones. Melatonin-induced-immuno-opioids (MHO) and lymphokines imply the presence of specific binding sites or melatonin receptors on cells of the immune system. On the other hand, lymphokines such as -γ-interferon and interleukin-2 as well as thymic hormones can modulate the synthesis of melatonin in the pineal gland. The pineal gland might thus be viewed as the crux of a sophisticated immunoneuroendocrine network which functions as an unconscious, diffuse sensory organ.     

Response of rat pineal melatonin to calcium, magnesium, and lithium is circadian stage dependent

Abstract: Herein we documented the response of pineal melatonin production to electrolytes known to be effective on pineal function in view of a possible circadian stage dependence. We studied the release of melatonin by perifused rat pineal glands at 2 different circadian stages corresponding to the middle of the light and dark periods, i.e., respectively, 7 and 19 HALO (Hours After Light Onset, L:D = 12:12). The initial efflux rates were, as expected, much higher in the perifusates of glands removed from rats sacrificed during the dark phase than of those removed during the light phase. After 3 hr of perifusion, melatonin release reached similar levels which were found constant up to the 8th hr of perifusion, whatever the circadian stage. Perifusion of the glands with physiological concentrations for the rat of calcium (5.2 mmol/1) and magnesium (1.34 mmol/1) resulted in a stimulatory effect on the pineal glands removed from rats sacrificed in the middle of the dark period (19 HALO), whereas no effects were observed on the pineal glands removed from rats sacrificed during the light (7 HALO). Lithium (0.28 and 0.55 mmol/1) was ineffective on melatonin release in pineal glands removed 7 and 19 HALO. Our results show differences in the initial efflux rates of melatonin and in the response of perifused pineal glands to calcium and magnesium according to the circadian stage.     

Changes in connexin43, the gap junction protein of astrocytes, during development of the rat pineal gland

Abstract: The abundance of gap junctions between rat pineal astrocytes formed by connexin43 (Cx43) was studied during development. Levels and distribution of Cx43 were measured by immunoblotting and indirect immunofluorescence, respectively. The amount of Cx43 in cells located within the gland was low until about the 7th postnatal day and increased to adult values between the 14th and 21st days postpartum. Although astrocytes, recognized by their vimentin immunoreactivity, were scarce before birth, they were abundant by the 7th postnatal day suggesting that the low levels of Cx43 found at this age corresponded to a low expression of this protein. Localization of the immunoreactivity to Cx43 and vimentin showed a close correlation, indicating that mature or immature pineal astrocytes form gap junctions made of Cx43. Since Cx43 levels attained their adult values at about the time the innervation and the functional state of the gland reached maturity (2–3 weeks after birth), it is proposed that astrocyte gap junctions are involved in the function of the adult rat pineal gland.     

Conservative management of perforated duodenal diverticulum： A case report and review of the literature

Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs.     

Presence of immunoreactive growth hormone and prolactin in the ovine pineal gland

Abstract: The use of antisera raised against bovine growth hormone (GH) and ovine prolactin (PRL) enabled the detection of related immunoreactive (ir) sequences of proteins in ovine pineal tissue. The isolation of PRL-like ir-material was accomplished using a 0.25 M ammonium sulphate (pH 5.5) extraction followed by ethanol precipitation, whereas the resulting 2.0 M ammonium sulphate (pH 7.0) precipitate contained a GH-like immunoreactivity. Gel chromatography of the GH-like immunoreactivity (Sephadex G-100) indicated the presence of several GH-like fragments ranging in the M_r range of 7,000 to 55,000. Analyses of the PRL-like ir-material found in pineal tissue on HPLC using a TSK 545-DEAE column led to the resolution into a single peak of immunoreactivity. A single peak of activity was also observed following chromatofocusing and hydrophobic interaction chromatography of the ir-peak from the TSK 545-DEAE column. The PRL-like ir-material inhibited the binding of [¹²⁵I]ovine PRL-S14 to anti-ovine PRL antibodies without showing an affinity for binding to anti-rat PRL or anti-bovine GH antibodies. Scatchard analysis of the binding of pineal PRL-like ir-material and pituitary ovine PRL-S14 to liver membranes from day-20 pregnant rats revealed similar affinity constants (K_a of 4.7 ± 0.2 × 10⁹ M^-1). In addition, the replication of Nb 2 Node rat lymphoma cells was stimulated by pineal PRL-like ir-material, an effect known to be specific for lactogenic hormones. The pineal PRL-like immunoreactivity appeared on sodium dodecyl sulfate polyacrylamide gels as a single major band of M_r 24,000. The functional status of PRL-and GH-like ir-material in the ovine pineal remains to be determined, but evidence is presented that the overall protein synthesis rate of the rat pineal responded to circulating concentrations of PRL.     

Microbiology of human immunodeficiency virus anorectal disease

PURPOSE: Individuals who are seropositive for the human immunodeficiency virus are at high risk for opportunistic infection and anorectal disorders. Little prospective information is available regarding anorectal pathogens in these patients. METHODS: One hundred sixty-three HIV-seropositive patients presented to the colorectal clinic between 1989 and 1992. Forty-seven (29 percent) patients were thought to have an infectious process and were prospectively studied using a standardized multiculture protocol. RESULTS: Mean age was 33 (range, 19–59) years. All were male; high-risk behavior accounted for 87 percent of HIV transmissions. Presenting complaints included anorectal pain (79 percent), pus per anum (28 percent), and blood per anum (26 percent). Examination revealed perianal tenderness (60 percent), condyloma (38 percent), perianal ulcers (38 percent), and anal fissures (34 percent). Sixty-six sets of cultures were performed; 28 patients had one set, 15 had two sets, and 4 had three sets. Thirty-two of these 47 patients (68 percent) had positive cultures including herpes (50 percent), cytomegalovirus (25 percent),Neisseria gonorrhoeae (16 percent), chlamydia (16 percent), acidfast bacilli (2 percent), and others (9 percent). Six of 32 patients with positive cultures had more than one organism cultured. Sixteen (50 percent) patients with positive cultures were treated medically, 8 (25 percent) were treated surgically and 8 (25 percent) were treated with both modalities. Sixty-one procedures were performed on 17 patients for condylomata. Eighteen patients had 20 procedures for abscesses, 50 percent of whom had positive cultures for other than common bowel flora; all improved. Fourteen patients underwent 33 procedures for perianal fistulas.Mycobacterium fortuitum was cultured from one patient who required 13 procedures for abscesses and fistulas. Forty-five (96 percent) patients were followed for an average of 12.5 months ±2.9 SEM (range, 1–94 months). Symptoms were improved or resolved in 22 of 32 (69 percent) patients with positive cultures and in 11 of 13 (84 percent) with negative cultures. CONCLUSIONS: Specific pathogens may often be identified in human immunodeficiency virus-seropositive patients with anorectal disorders if aggressively sought. Although patients without specific pathogens identified may be expected to improve with planned empiric treatment, positive identification allows more directed therapy.