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1.
Samira Rostom Karima Benbouaaza Bouchra Amine Rachid Bahiri Yousra Ibn Yacoub Sanae Ali Ou Alla Redouane Abouqal Najia Hajjaj-Hassouni 《Clinical rheumatology》2010,29(7):781-788
The objectives of this study are to translate, adapt in the Moroccan cultural context, and validate in patients with ankylosing
spondylitis (AS) the Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis Disease Activity
Index (BASDAI). The cross-cultural adaptation of the BASFI and BASDAI was obtained in accordance with the guidelines for translation
of the health status measures. Eighty-five patients with AS were included in the study. The test–retest reliability and the
internal consistency were analyzed, and both questionnaires were assessed for external construct validity. Structural validity
was analyzed with correlation matrix. Twenty-four-hour test–retest reliability was good: BASFI intraclass correlation coefficient
(ICC) = 0.96 (confidence interval (CI) at 95%, 0.93–0.97), BASDAI ICC = 0.93 (CI at 95%, 0.90–0.95). Cronbach’s alpha was
0.90 for the BASFI and 0.86 for BASDAI. The construct validity of the instruments was evaluated. The BASFI showed a strong
validity when correlating its results with Schober’s test (r = −0.56), occipital wall distance (r = 0.46), chest expansion (r = −0.46), BASDAI (r = 0.54), Bath Ankylosing Spondylitis Metrology Index (r = 0.70), Bath Ankylosing Spondylitis Global Score (BAS-G; r = 0.58), Bath Ankylosing Spondylitis Radiology Index (r = 0.61), and the radiological changes in sacroiliac joints (r = 0.54). A good correlation was observed between the BASDAI and the spinal pain (r = 0.53), the number of nocturnal awakenings (r = 0.57), the morning stiffness (r = 0.65), the enthesic index (r = 0.47), the BAS-G (r = 0.53), the BASFI (r = 0.54), and the erythrocyte sedimentation rate (r = 0.41; for all p < 0.001). The correlation matrix showed an intermediate correlation between items. The Moroccan version of the BASFI and
the BASDAI showed adequate reliability and validity. These instruments can be used in the clinical evaluation of Moroccan
and Arabic-speaking patients with AS. 相似文献
2.
Early diagnosis of spondyloarthritis (SpA) is essential as anti-tumor necrosis factor therapy can achieve significant symptomatic
relief and control of disease activity. This study aims to compare the clinical characteristics, disease activity, and functional
status of a Chinese cohort of SpA patients who were re-classified into ankylosing spondylitis (AS) patients fulfilling the
modified New York (MNY) criteria, those with undifferentiated SpA (USpA) fulfilling the European Spondyloarthropathy Study
Group (ESSG) classification criteria only (USpA/ESSG) and those who fulfill Assessment of SpondyloArthritis International
Society (ASAS) only (USpA/ASAS). Disease activity was evaluated by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI),
severity of morning stiffness, patient global assessment, and C-reactive protein. Functional status was evaluated by Bath
Ankylosing Spondylitis Functional Index (BASFI), modified Schober index, and dimension of chest expansion. One hundred and
twenty-eight patients with disease duration of 16.3 ± 10.4 years were recruited. Patients in USpA/ESSG and USpA/ASAS were
significantly younger (p = 0.01), had shorter disease duration (p < 0.01), and lower BASFI (p = 0.03) than established AS patients. All three groups have active disease with comparable BASDAI >3. BASFI correlated inversely
with dimension of chest expansion and negatively modified Schober index in AS patients (p < 0.01) and modestly with BASDAI (r = 0.25, p < 0.01). BASFI correlated moderately with BASDAI in USpA/ESSG (r = 0.61, p < 0.01) but not with chest expansion or modified Schober index. Compared with established AS patients recognized by MNY criteria,
patients fulfilling USpA defined by ESSG or ASAS criteria had earlier disease, as active disease and less irreversible functional
deficit. 相似文献
3.
To translate and cross-culturally adapt to the Brazilian-Portuguese language (BP), five items were added to Health Assessment
Questionnaire (HAQ) to validate the resulting HAQ-S BP version for ankylosing spondylitis (AS). The items were translated
into BP following translation and back-translation. To assess validity, 25 patients were evaluated using the HAQ, Bath AS
Functional Index (BASFI), Bath AS Disease Activity Index (BASDAI), Bath AS Metrology Index (BASMI), and laboratory variables
(erythrocyte sedimentation rate, C-reactive protein). One question required modification to adapt culturally to Brazilian
conditions. The test–retest and interobserver correlation coefficients were 0.990 (p < 0.05) and 0.993 (p < 0.05), respectively. HAQ-S BP correlated to BASFI (r = 0.574; p < 0.05) and to HAQ (r = 0.963; p < 0.05), but not to BASDAI (r = 0.282), BASMI (r = 0.194), and laboratory variable. Individually, the fifth item referring to driving correlated highly to neck rotation (r = 0.900; p < 0.05), while the HAQ-S BP correlated to the neck rotation component (r = 0.303), but did not reach statistical significance. The HAQ-S BP version demonstrated adequate reproducibility, internal
consistency and validity, confirming its utility in the research of AS in Brazil. 相似文献
4.
In this study, we evaluated the relationship between the severity of enthesitis and outcome of measurement indices, clinical
and laboratory parameters in patients with ankylosing spondylitis (AS). Thirty-three patients who fulfilled the modified New
York criteria for AS were included in this study. Patients were asked to record the severity of current pain, night pain and
morning stiffness on a 10-cm visual analogue scale. Stoke Enthesitis Index (SEI) was used to measure the severity of enthesitis.
Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath
Ankylosing Spondylitis Metrology Index (BASMI) were calculated. SEI was correlated positively only with BASDAI (r = 0.370, P = 0.034). There was no relation between SEI and laboratory parameters (Erythrocyte Sedimentation Rate and C Reactive Protein).
Our data suggest that using an enthesitis index such as SEI can be a valuable tool in the evaluation of disease activity in
patients with AS. However, evaluation of enthesitis severity is based on information given by patient and should be combined
with objective parameters such as spinal measurements when assessing disease activity. 相似文献
5.
Ibn Yacoub Y Amine B Laatiris A Abouqal R Hajjaj-Hassouni N 《Clinical rheumatology》2011,30(5):673-677
The main objective of this study was to assess the aspects of health-related quality of life (QOL) in patients with ankylosing
spondylitis (AS) and to explore the disease-related parameters influencing it. One hundred patients with AS according to New
York Classification criteria were recruited in this cross-sectional study. The Medical Outcomes Study Short Form 36 Health
Survey (SF-36) was used to assess health-related QOL. Assessment criteria included the evaluation of disease activity (Bath
Ankylosing Spondylitis Disease Activity index [BASDAI]), global well-being (Bath Ankylosing Spondylitis Global Index [BASGI]),
enthesitis (Mander enthesis index [MEI]), functional status (Bath Ankylosing Spondylitis Functional Index [BASFI]); metrology
(Bath Ankylosing Spondylitis Metrology Index [BASMI]) and radiographic damage (Bath Ankylosing Spondylitis Radiologic Index
[BASRI]). In this study, males comprised 67% of the subjects; mean age was 38 ± 13 years and mean disease duration was 9.5 ± 6.8 years.
Among these patients, 52% had hip involvement. Our patients had a moderately active disease and severe functional disability.
All domains of SF-36 were deteriorated with low scores. The SF-36 subgroups most affected were role limitation (18.8 ± 28.1),
role emotional (19.4 ± 35), general health (44.9 ± 20.3) and vitality (38.0 ± 18.2). Lower scores of SF-36 had good statistically
significant correlations with altered functional status (BASFI), worse general well-being (BASGI), altered metrology (BASMI);
and moderate correlations with high disease activity (BASDAI), important radiological damage (BASRI); restricted chest expansion
and prolonged morning stiffness (p < 0.001). This study states that health-related QOL in Moroccan patients with AS is damaged in a significant way. Mental
as well as physical aspects were affected. Functional disability, patient’s well-being, metrology and disease activity are
the main factors associated with deteriorating domains of QOL in AS. Recognizing complicated relationships between clinical
measures and QOL in patients with AS can help us to develop further management strategies to improve their QOL. 相似文献
6.
Ole R. Madsen Anne Rytter Lonnie B. Hansen Charlotte Suetta Charlotte Egsmose 《Clinical rheumatology》2010,29(8):849-854
The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Function Index (BASFI) and
the Bath Ankylosing Spondylitis Global Score (BAS-G) (ranges 0–10) have gained widespread in use as self-reported measures
of disease activity, functional impairment and overall well-being in patients with ankylosing spondylitis and other spondyloarthropathies
(SpA). In Denmark, BASDAI, BASFI and BAS-G are systematically used to monitor treatment response in patients treated with
tumour necrosis factor (TNF) inhibitors. The purpose of the present study was to examine the reproducibility of the indices
in anti-TNF-treated SpA patients already familiar with the use of the indices. Testing was performed twice on two different
days (median interval 7 days, range 4–10 days) under standardised conditions in 26 out-clinic patients (median age 39 years,
range 22–56 years). Limits of agreement were calculated as the 95% likely range for the difference between paired scores.
Test–retest results were significantly intercorrelated with r
s = 0.90 for BASDAI, 0.92 for BASFI and 0.74 for BAS-G. Limits of agreement for BASDAI, BASFI and BAS-G were ±1.8, ±1.4 and
±3.2, respectively. Reproducibility as expressed as the mean of individual standard deviations was significantly poorer for
BAS-G than for BASDAI and BASFI (p < 0.01). Internal consistency reliability and construct validity of BASDAI and BASFI were acceptable. In conclusion, in a
sample of anti-TNF-treated patients experienced with the use of BASDAI, BASFI and BAS-G, random measurement errors of the
scores were not negligible. The finding should be considered when monitoring anti-TNF treatment in daily clinical practice. 相似文献
7.
Ariza-Ariza R Hernández-Cruz B López-Antequera G Navarro-Sarabia F 《Clinical rheumatology》2009,28(2):207-211
The objective of this study was to identify variables associated to the utility of the health states in patients with ankylosing
spondylitis (AS). A cross-sectional study was performed in a tertiary care centre. AS patients (New York modified criteria)
were included. Demographic and disease-related variables were collected. The social tariffs of the EuroQol-5D (EQ-5D) were
used to obtain utility values. Univariate and multivariate regression analyses were used in order to identify variables associated
with utility. Seventy patients, 52 male (74.3%), with age (mean ± SD) 43.7 ± 9.1 years and disease duration 10.8 ± 8.1 years,
were included. The mean utility was 0.5625 ± 0.3364. In the univariate analysis, patient global assessment, Bath Ankylosing
Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) had a good correlation
with the EQ-5D values (Pearson’s product moment correlation coefficient r > 0.6) whereas physician global assessment, patient pain assessment, and cervical rotation had a moderate correlation with
the EQ-5D (0.6 > r > 0.4). Patients with significant comorbidity had lower utility values (0.3563 ± 0.068) than those without it (0.6796 ± 0.041,
p = 0.0001). In the multivariate analysis, BASFI and BASDAI kept an independent association with utility and they explained
a 62% of the variance of the utility values. In this study, physical function and disease activity, two outcomes with good
responsiveness to the treatment, were the main determinants of the utility of the health states in AS patients. 相似文献
8.
Bedriye Mermerci Başkan Filiz Sivas Esra Erkol İnal Semra Duran Eda Elverici Kürşat Özoran Hatice Bodur 《Clinical rheumatology》2010,29(1):65-70
The objective of the present study was to compare two radiographic scoring methods (the modified Stoke Ankylosing Spondylitis
Spine Score (mSASSS) and the Bath Ankylosing Spondylitis Radiology Index-spine (BASRI-spine)) in terms of reliability, construct
validity, and feasibility in Turkish ankylosing spondylitis (AS) patients. The study involved seventy-four patients. The patients
were evaluated with 100-mm visual analog scale (VAS) for pain, global assessment of patient, and global assessment of doctor.
The laboratory evaluations of patients comprised erythrocyte sedimentation rate and serum C-reactive protein. Bath AS Disease
Activity Index (BASDAI), Bath AS Functional Index (BASFI), Bath AS Metrology Index (BASMI), and Bath AS Radiology Index (BASRI)
were calculated. Bilateral cervical, lumbar spine, and anteroposterior pelvis radiographs of all patients were obtained and
evaluated by two radiologists. Each radiograph was scored by two scoring methods, mSASSS and BASRI-spine, and these methods
were tested according to the aspects of the Outcome Measures in Rheumatology Clinical Trials filter: reliability, construct
validity, and feasibility. The BASRI-spine reached intra- and interobserver intraclass correlation coefficient (ICC) of 0.726
and 0.689, respectively. The mSASSS scores more reliable, with ICC of 0.831 and 0.840, respectively. The BASMI and BASFI correlated
significantly with the two scoring systems, respectively (mSASSS r: 0.557, r: 0.319; BASRI-spine r: 0.605, r: 0.285). For the two methods, the magnitude of the correlation with disease duration was similar (mSASSS p < 0.01 and BASRI p < 0.01), but no significant correlation was observed when compared to the BASDAI. It is known that the BASRI-spine is a feasible
method that reliably detects damage in patients with AS. However, the present authors believe that, in AS patients, mSASSS
should be the radiological scoring method to choose because of less radiation exposure, along with excellent intra- and interobserver
reliability. 相似文献
9.
This study was performed to determine the effects of short-term dynamic exercise on serum insulin-like growth factor-1 (IGF-1)
and insulin-like growth factor binding protein-3 (IGFBP-3) levels in the patients with rheumatoid arthritis (RA) and ankylosing
spondylitis (AS). Patients with RA or AS and healthy controls were recruited. Dynamic treadmill exercise therapy was accomplished
for 20 min/session with all of the participants. There were five sessions per week for 2 weeks. Morning stiffness duration,
body pain, Stanford health assessment questionnaire, Ritchie articular index, Bath ankylosing spondylitis disease activity
index (BASDAI), and Bath ankylosing spondylitis functional index (BASFI) were evaluated in the RA and AS patients. Laboratory
assessments included: erythrocyte sedimentation rate, serum C-reactive protein, IGF-1, and IGFBP-3. Clinical and laboratory
assessments were recorded at baseline and during exercise treatment on days 7 and 15. Twenty patients with RA, 15 with AS,
and 14 healthy controls were included in this study. The pain evaluation, Ritchie, BASDAI, and BASFI scores were significantly
improved by the exercise treatment in both patient groups. The important increases were found in circulating IGF-1 in RA (p < 0.001) and AS (p = 0.001) at the end of 2 weeks. In control individuals, serum IGF-1 levels showed a significant decline in the first week
(p < 0.05). No significant changes were observed on serum IGFBP-3 levels. Our data suggest that serum IGF-1 levels are increased
by the dynamic exercise program in RA and AS patients. The increased IGF-1 may play an important role in the beneficial effects
of dynamic exercise therapy in these patients. 相似文献
10.
Zafer Günendi Aylin Sepici Dinçel Zeynep Erdoğan Özlem Aknar Selma Yanpal Feride Göğüş Fatma Atalay 《Clinical rheumatology》2010,29(10):1143-1147
We aimed to investigate the effect of regular supervised exercise program on functinal status, disease activity, and total
antioxidant status (TAS) level in patients with ankylosing spondylitis (AS). Thirty-two patients (mean age: 44 years) with
AS were included in the study and divided into two groups. Group 1, the exercise group (n = 16), attended a supervised exercise program that consisted of aerobic, strengthening, and stretching exercises for 1 h
a day, five times a week for 3 weeks. Group 2, the control group, received a home exercise program (n:16). Bath AS Activity Index (BASDAI) and Bath AS Functional Index (BASFI) were calculated and serum TAS levels were measured
for each patient at 0 and 3 weeks. There was no significant difference in patients' baseline characteristics (age, disease
duration, BASFI, and BASDAI scores) between exercise and control groups. In the exercise group, there were significant improvements
between pre-exercise and post-exercise assessments in BASFI (2.8 ± 1,8; 1.7 ± 1,40, p = 0.004) and BASDAI scores (2.1 ± 1.7; 1.2 ± 1.3, p = 0.01). Mean TAS levels were significantly decreased after supervised exercise program (1.48 ± 0.16 mmol/L; 1.36 ± 0.20 mmol/L,
p = 0.03). In the control group, BASFI score (2.4 ± 1.7; 2.9 ± 2.1, p = 0.19), BASDAI score (2.6 ± 2.2; 3.1 ± 2.6, p = 0.33), and mean TAS levels (1.38 ± 0.23 mmol/L; 1.39 ± 0.20 mmol/L, p = 0.66) did not differ significantly between 0 and 3 weeks. Short-term, supervised exercise program improved functional status
and decreased disease activity. However, the mechanism of this beneficial clinical effect does not seem to be through antioxidant
activity. 相似文献
11.
Hakkou J Rostom S Aissaoui N Berrada Ghezioul K Bahiri R Abouqal R Hajjaj-Hassouni N 《Clinical rheumatology》2012,31(3):441-445
The BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) is the most widely used instrument for the assessment of disease
activity in ankylosing spondylitis (AS). Objective. The aims to investigate whether the alternative BASDAI, here termed as the miniBASDAI [(Question (Q) 1 fatigue + Q2 spinal
pain) + mean of (Q5 strength morning stiffness + Q6 duration morning stiffness)] / 3], measures disease activity more accurately
in the subgroup of AS patients without peripheral manifestations. One hundred and ten patients were included in this cross-sectional
study according to the modified New York criteria for AS. Clinical and biological parameters were evaluated. The disease activity
was evaluated by the BASDAI. We calculated the miniBASDAI by omitting both the peripheral joints and the enthesitis questions:
questions 3 and 4. Patients were dichotomized into a “P+” group if peripheral manifestations were present (at least arthritis
or enthesitis) and a “P−” group, the subgroup without peripheral involvement (with either arthritis or enthesitis). Correlation
of the BASDAI and miniBASDAI with other disease parameters were examined with the Spearman's rank correlation analysis. One
hundred and ten patients were recruited. The percentage of patients with pure axial disease manifestation without peripheral
involvement “P − group” was 42.7%. We found a similarly good correlation of the miniBASDAI with patient global, physician
on disease activity, BASFI, ESR and CRP if compared to the correlation of the original BASDAI with these disease parameters,
also in the group without peripheral involvement. Our study suggests that the BASDAI remains valid in assessing disease activity
in AS patients with and without peripheral manifestations. 相似文献
12.
Hulejová H Levitová A Kuklová M Stochl J Haluzík M Pavelka K Vencovský J Senolt L 《Clinical rheumatology》2012,31(1):67-71
To investigate the effect of intensive physiotherapy on disease activity and serum levels of adipocytokines in patients with
ankylosing spondylitis (AS). Twenty-six patients with AS were included in this study. Intensive physiotherapy was performed
twice a week for a period of 3 months. The Bath AS Disease Activity Index (BASDAI) and the Bath AS Functional Index (BASFI)
were assessed at inclusion and after 3 months. Leptin, adiponectin, resistin and visfatin serum levels were analysed by ELISA
assays. Patients had mild to moderate disease activity. Baseline levels of adipocytokines did not correlate with indicators
of disease activity, functional status or acute-phase reactants. After the 3 months of intensive physiotherapy, BASDAI significantly
decreased from 2.98 to 1.8 (p = 0.01) and BASFI improved from 2.31 to 1.37 (p = 0.05), while there were no changes in serum levels of CRP, ESR and adipocytokines. In addition, baseline levels of adipocytokines
did not predict the change of disease activity or functional ability. Intensive physiotherapy effectively reduces all clinical
measures of disease activity, but it is not associated with a significant change in acute-phase reactants or serum levels
of adipocytokines. 相似文献
13.
The aims of this study were to evaluate quality of life (QOL) in patients with ankylosing spondylitis (AS) and to determine
the relationship between QOL and clinical condition/functional status. Forty-six AS patients (37 males) were included in the
study. The demographic data of the patients were recorded. Disease activity Bath Ankylosing Spondylitis Disease Activity Index
(BASDAI), enthesitis involvement Mander Ehthesis Index (MEI), functional evaluation Bath Ankylosing Spondylitis Functional
Index (BASFI), and quality of life Short-Form 36 (SF-36) were assessed. The mean age of the patients was 39.2 (SD: 11. 46)
years. Most MEI was found related to physical function (P = 0.014), physical role (P = 0. 01), pain (P = 0.002) and vitality (P = 0.004) in SF-36 subgroups. Among the subgroups, the best correlations with the general health was found in BASDAI (P = 0.014) and secondly in MEI (P = 0.038). None of the mental health and social function subgroups had any significant correlation with any of the parameters
(P > 0.05). A significant relationship was found between the emotional role and BASFI, and chest expansion (P = 0.004). Clinical and functional state were affecting QOL of patients with AS. It has been found out that in patients with
AS, the QOL subgroups are mostly related with enthesis involvement. 相似文献
14.
In this study, we evaluated the relationship between enthesitis and clinical, laboratory and quality-of-life parameters in
ankylosing spondylitis (AS) in Moroccan patients. Seventy-six patients were included in this cross-sectional study according
to the modified New York criteria for AS. All patients had enthesitis involvement. Clinical and biological parameters were
evaluated. Enthesitis were assessed by two indices: Mander Enthesis Index (MEI) and Maastricht Ankylosing Spondylitis Enthesitis
Score (MASES). Disease activity was evaluated by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Functional
impact was assessed by the Bath Ankylosing Spondylitis Functional Index (BASFI). The quality of life was measured by the Short
form-36 (SF-36). Severity of enthesitis was significantly correlated with disease activity, functional disability and degradation
of quality of life. There was no relation between enthesitis indices and disease duration or laboratory parameters. The clinical
assessment of enthesitis in AS is an important outcome measure, and enthesitis indices could be used to evaluate disease activity
in patients with AS. 相似文献
15.
The aims of this study were to investigate, firstly, the relationship between diet and disease activity and, secondly, the
presence of gastrointestinal symptoms and their relationship to diet among patients with ankylosing spondylitis (AS) using
a cross-sectional design. One hundred sixty-five individuals diagnosed with AS were invited to complete a self-administered
postal questionnaire regarding demographic data, diet, medication, and gastrointestinal symptoms in addition to two established
disease assessment questionnaires, i.e., the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing
Spondylitis Functional Index (BASFI). No significant correlation between diet and disease activity was found. Overall, 27%
of the patients reported aggravating gastrointestinal problems when consuming certain foodstuff(s). The 30% of patients who
reported suffering from gastrointestinal pain had significantly greater disease activity and poorer functional status according
to their BASDAI and BASFI scores (p < 0.01 and p = 0.01, respectively). Patients who reported gastrointestinal pain had a significantly higher consumption of vegetables (p < 0.01) and lower consumption of milk and soured milk (p = 0.04). No significant correlation was found between the use of non-steroidal anti-inflammatory drugs (NSAID) and gastrointestinal
symptoms. In multiple regression models, BASDAI and the consumption of vegetables were independent and statistically significant
predictors of gastrointestinal pain. To conclude, in a group of Swedish AS patients, no correlation between diet and disease
activity could be detected. There were, however, correlations between diet and gastrointestinal pain. Gastrointestinal problems
were also found to be prevalent in AS, independent of NSAID usage. 相似文献
16.
《Indian Journal of Rheumatology》2014,9(3):115-119
BackgroundThe assessment of disease activity in patients with ankylosing spondylitis (AS) continues to be a challenging issue. The currently available markers like C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) show poor correlation with clinical disease activity.ObjectivesTo compare serum IL-6 and hs-CRP levels between patients with AS with pure axial involvement and healthy controls; and to correlate them with Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI) and Bath ankylosing spondylitis metrology index (BASMI).MethodsSixty-two consecutive patients of AS with pure axial involvement satisfying the modified New York criteria and 60 age-matched healthy controls were recruited. In all patients, Bath indices were measured and fasting venous blood samples for serum IL-6 and hs-CRP levels were obtained. Comparison of median of serum IL-6 and hs-CRP levels was done between cases and healthy controls and levels also correlated with Bath indices by appropriate statistical methods.ResultsThe median serum IL-6 and hs-CRP levels were significantly higher in cases as compared to healthy controls (p = 0.001). Serum IL-6 levels correlated significantly with BASDAI and BASFI (r = 0.61, p = 0.001 and r = 0.27, p = 0.032 respectively) but no correlation was found with BASMI (r = −0.08, p = 0.53). Serum hs-CRP did not correlate with Bath indices except BASMI (r = 0.28, p = 0.03).ConclusionSerum IL-6 levels can be reliably used as an aid in monitoring of disease activity in AS patients with pure axial involvement. 相似文献
17.
This study was conducted to determine differences in ankylosing spondylitis (AS) between men and women in terms of clinical
characteristics, biological features, structural severity and quality of life (QoL). A total of 130 consecutive AS patients
fulfilling the modified New York criteria were included. Sociodemographic data were collected. The activity of disease was
assessed by the Bath ankylosing spondylitis disease activity index (BASDAI) and the functional disability by the Bath Ankylosing
spondylitis functional index (BASFI). Spinal mobility was measured using the occiput-to-wall distance, chest expansion, Schober
index and the Bath Ankylosing Spondylitis Metrology Index (BASMI). The Bath Ankylosing Spondylitis Radiologic Index (BASRI)
was used to evaluate structural damage. Fatigue was evaluated using a visual analogue scale and the QoL was measured by using
the generic instrument SF-36. Laboratory tests included the erythrocyte sedimentation rate (ESR) and the C-reactive protein
(CRP). In our sample, there were 87 (66.9%) men and 43 (33.1%) women. Women had significantly lower educational levels but
there were no differences in socioeconomic status, age at onset, diagnosis delay, disease duration or treatments. Also, women
had higher clinical disease activity (morning stiffness and BASDAI score), higher number of tender joints, more severe enthesitis
and higher scores of fatigue (for all p ≤ 0.05). Moreover, hip involvement was more prevalent in men and the impairment of spinal mobility was significantly worse
compared to women (for all p ≤ 0.001). Men had worse radiographic damage and lower scores in physical and social domains of QoL, but there were no differences
in functional impairment scores. In this study, we noticed that AS presents differently according to gender in our patients.
More longitudinal studies seem to be necessary to identify gender-related parameters of disease, thing that may help in diagnosis
and therapeutic management of our AS patients. 相似文献
18.
《The Egyptian Rheumatologist》2022,44(2):103-108
Aim of the workTo assess serum level of bone morphogenetic protein-7 (BMP-7) and to study its relation to clinical and sonographic assessment of peripheral enthesitis in ankylosing spondylitis (AS) patients.Patients and methodsThis study involved 49 AS patients and 40 matched controls. The serum BMP-7 level was determined by enzyme linked immunosorbant assay (ELISA). Entheses were assessed by musculoskeletal ultrasound (MSUS) and scored using Madrid Sonographic Enthesitis Index (MASEI). The AS disease activity score-C-reactive protein (ASDAS-CRP), Bath AS disease activity index (BASDAI) and Bath AS Functional Index (BASFI) were assessed.ResultsPatients were 45 males and 4 females with a mean age of 35.57 ± 9.71 years and median disease duration of 10 (2–28) years. US lesions were frequently found at the insertions of Achilles (76.5%), quadriceps (57.1%), plantar fascia (51%) and triceps (43.8%) tendons. Serum level of BMP-7 was significantly increased in patients (41.8 ng/ml) compared to controls (38.5 ng/ml) (p = 0.031). BMP-7 serum level significantly correlated with age (p = 0.03), disease duration (p < 0.001) and BASFI (p = 0.02) but did not correlate with ASDAS CRP, BASDAI, clinical enthesitis or total MASEI. Total MASEI correlated significantly with age, disease duration, ASDAS-CRP, BASDAI and BASFI. MASEI is a good predictor of activity in AS patients at a cut-off score of 9.ConclusionAS patients have a significant higher level of serum BMP-7 compared to control which indicates that it may play an important pathogenetic role in AS. However, this level did not correlate with either clinical or sonographic assessment of peripheral enthesitis. 相似文献
19.
The aim of this study is to assess the gender differences in spondyloarthritides (SpAs) in terms of disease onset, clinical
presentation, and the Bath Ankylosing Spondylitis Disease Activity and Functional indices (BASDAI and BASFI). We analysed
data from a predominantly female cohort. Five hundred and 16 patients (male:female = 172:344) with SpA who were assessed at
our clinic were asked to complete a questionnaire addressing data related to their disease onset (first symptom at presentation,
age at which the first symptom presented, age of diagnosis, and delay in diagnosis), clinical presentation (main problem the
disease caused them, night pain/sleep disturbance, well-being over the past week, and well-being over the previous 6 months),
disease activity indices (erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and BASDAI), and functional index
(BASFI). Compared with men, women had greater age at presentation, longer disease duration, more delayed diagnoses and greater
age at diagnosis. Back pain was the main presenting symptom equally distributed for both genders. Women had more neck, knee
and hip pain as presenting symptoms, while men experienced more feet pain. Back pain is also the main problem that the disease
is causing to both sexes. More women had lower back pain, fatigue, neck pain, and pain with pressure as the main problems
caused by the disease, while men had more joint pains. Women had significantly greater night pain and sleep disturbance than
men. Furthermore, they experienced a worse well-being over past week and over past 6 months in addition to a higher mean ESR
(P < 0.005), CRP (NS), BASDAI (P < 0.005) and BASFI (P < 0.05) scores. With regard to the items of the BASDAI index, it displays that women experienced significantly more fatigue
(BASDAI 1; P < 0.001), total back pain (BASDAI 2; P < 0.05), and longer duration of morning stiffness (BASDAI 6; P = 0.09). With regard to the items of the BASFI index, women showed greater difficulty in reaching high shelves (BASFI 3;
P < 0.001), getting up from the floor when lying on their back (BASFI 5; P < 0.001), and looking over their shoulders (BASFI 8; P < 0.05). SpAs present and progress differently in men and women. Women have more neck, knee, and hip pain at presentation
and their main problems arise from the neck, back (lower and upper), fatigue and enthesitis during the course of the disease,
whilst in men, feet pain was reported more often as presenting symptom than in women, with joint pain being the main problem
caused by the disease. 相似文献