去氧萍蓬碱的镇痛抗炎作用

从萍蓬草中提取的去氧萍蓬碱20mg/kg ip能显著提高小鼠热板法及电刺激法的痛阈,15～20mg/kg ip能显著降低醋酸所致扭体反应发生率。它亦能抑制醋酸所致的腹腔炎性渗出,且有明显的量—效关系。还能降低鸡蛋清所致踝关节肿胀程度,其强度与地塞米松4～8mg/kg相似。     

NO偶联双氯芬酸衍生物抗炎、镇痛、解热作用实验研究

目的：考察NO偶联双氯芬酸衍生物(澳通，CO-3)的抗炎、镇痛、解热作用。方法：通过小鼠耳二甲苯致炎、角叉菜胶致大鼠足跖肿胀、大鼠棉球肉芽肿及Ⅱ型胶原所致的大鼠关节炎等实验模型，观察CO-3的抗炎作用；通过小鼠醋酸扭体、热板刺激和大鼠甩尾等实验模型，观察CO-3的镇痛作用；通过大鼠啤酒酵母致热实验模型，观察CO-3的解热作用。结果：CO-3可明显抑制二甲苯所致小鼠耳肿胀、角叉菜胶致大鼠足跖肿胀、大鼠棉球肉芽组织增生及Ⅱ型胶原所致的大鼠关节炎；能显著抑制醋酸引起的小鼠扭体反应及提高甩尾及热板刺激的致痛阈值；对啤酒酵母致热大鼠有明显的解热作用。结论：CO-3具有良好的抗炎、镇痛、解热作用。     

氧化槐果碱抗惊厥和抗炎作用实验研究

目的观察氧化槐果碱的抗惊厥、抗炎作用。方法构建异烟肼和尼可刹米致小鼠惊厥模型,观察氧化槐果碱的抗惊厥作用;采用二甲苯致小鼠耳肿胀法和角叉菜胶致大鼠足跖肿胀法,观察氧化槐果碱的抗炎作用。结果氧化槐果碱(20,40,80mg/kg)可显著延长异烟肼所致惊厥小鼠的惊厥潜伏时间(P<0.05),减少惊厥小鼠例数与死亡小鼠例数,对尼可刹米所致的惊厥无对抗作用;氧化槐果碱(40,80mg/kg)可显著抑制二甲苯所致小鼠耳肿胀(P<0.05);氧化槐果碱(60mg/kg)可显著抑制角叉菜胶所致大鼠足跖肿胀(P<0.01),氧化槐果碱(30mg/kg)对致炎后2~4h的大鼠足跖肿胀有抑制作用。结论氧化槐果碱具有抗惊厥、抗炎作用。     

松潘乌头总碱的镇痛作用和身体依赖性的实验研究

松潘乌头总碱(TAS)ip,ig,sc给药均呈剂量依赖性抑制小鼠热板、扭体及嘶叫反应。TAS的镇痛作用明显强于高乌甲素。连续给药7 d,TAS的镇痛作用无耐受现象。小鼠跳跃试验和竖尾试验均为阴性结果,提示TAS是一种不同于吗啡的非成瘾性镇痛剂。     

前列宁栓抗炎镇痛作用实验

目的:研究前列宁栓的抗炎、镇痛作用。方法:采用二甲苯所致小鼠耳廓肿胀实验、角叉菜胶致大鼠足跖肿实验、大鼠棉球肉芽肿的影响实验、小鼠腹腔毛细血管通透性实验,细菌性(大肠杆菌)前列腺炎的抗炎作用。采用醋酸致小鼠扭体反应实验和小鼠热板法实验观察了前列宁栓的镇痛作用。结果:前列宁栓可明显抑制二甲苯所致的小鼠耳廓炎症;在多数时间降低角叉菜胶致大鼠足跖肿胀;明显抑制大鼠棉球肉芽肿的生成;明显降低小鼠腹腔毛细血管通透性;明显抑制大鼠细菌性前列腺炎;明显降低醋酸致小鼠扭体反应数;明显升高小鼠痛阈值。结论:前列宁栓具有明显的抗炎、镇痛作用。     

三叶青藤醇提物的镇痛抗炎作用

目的:研究三叶青藤醇提物的镇痛及抗炎作用。方法:采用小鼠热水缩尾法和醋酸扭体法观察镇痛作用;采用二甲苯致小鼠耳肿胀、角叉菜胶诱导大鼠足肿胀的试验模型观察抗炎作用;并测定角叉菜胶诱导大鼠足肿胀炎性渗出液中前列腺素E2(PGE2)的含量。结果:三叶青藤醇提物能明显提高小鼠的痛阈值,但未能减少小鼠的扭体次数。同时,三叶青藤醇提物能显著减轻小鼠耳肿胀和大鼠足爪肿胀反应,能明显减少大鼠角叉菜胶性炎症渗出液中PGE2含量。结论:三叶青藤醇提物没有明确的镇痛作用,但有显著的抗炎作用,其机制可能与抑制PGE2的合成有关。     

松潘乌头总碱的镇痛作用和身体依赖性的实验研究

松潘乌头总碱(TAS)ip，ig，sc给药均呈剂量依赖性抑制小鼠热板、扭体及嘶叫反应。TAS的镇痛作用明显强于高乌甲素。连续给药7d，TAS的镇痛作用无耐受现象。小鼠跳跃试验和竖尾试验均为阴性结果，提示TAS是一种不同于吗啡的非成瘾性镇痛剂。     

国产尼美舒利的药效学研究

本文研究了国产尼美舒利在小鼠、大鼠及家兔体内的抗炎、镇痛和解热作用.结果表明.尼美舒利抑制巴豆油致小鼠耳廓肿胀(ED_(50)为49.2mg·kg~(-1));抑制角叉菜胶致大鼠足肿(ED_(50)为2.75mg·kg(-1));0.6mg·kg~(-1)剂量对大鼠佐剂关节炎有显著预防和治疗作用。100mg·kg~(-1)对小鼠醋酸扭体法的抑制率为68％;对热板法致痛的痛阈提高率为55％。ip给药对蛋白胨致家兔发热的解热作用.其最小有效剂量为2mg·kg~(-1);5mg·kg~(-1)ig可显著降低啤酒酵母致大鼠升高的体温.证实国产尼美舒利具有很强的抗炎、镇痛和解热作用。     

沙枣水提物抗炎、镇痛、解热及抗菌作用研究

目的研究沙枣水提物抗炎、镇痛、解热及抗菌作用。方法采用小鼠二甲苯致耳肿、角叉菜胶致足跖肿胀、乙酸致腹腔毛细管炎性渗出,实验观察抗炎作用;用小鼠扭体实验观察镇痛作用;用2,4-二硝基苯酚及干酵母片致大鼠发热实验观察解热作用,用正常小鼠肠道水分吸收实验观察对肠道水分吸收功能的影响;用常见肠道菌的抗菌实验观察抗菌作用。结果沙枣水提物能抑制二甲苯引起的耳肿胀(P<0.05)、角叉菜胶致小鼠足跖肿(P<0.05)和乙酸致腹腔毛细管炎性渗出(P<0.05);能减少乙酸诱发小鼠扭体反应次数(P<0.05);高剂量对干酵母致大鼠发热有退热作用;对痢疾杆菌的MIC为23.75 g.L-1,MBC为47.5 g.L-1。其对小鼠肠道水分吸收功能没有影响。结论沙枣水提物具有抗炎、镇痛、解热及抗福氏痢疾杆菌的作用。     

氢溴酸槐果碱的镇痛及抗炎作用

sc氢滇酸槐果碱(简称So,3、8～30mg/kg),都能显著减少乙酸引起的小鼠扭体反应次数。热板法实验表明,ig 30和60mg/kg So不明显延长热痛反应潜伏期。小鼠ig 60mg/kg So显著抑制乙酸引起的腹腔毛细血管通透性增高,大鼠ig 40mg/kgSo也能显著抑制组胺引起皮肤毛细血管通透性增加。SC 30mg/kg So明显抑制二甲苯引起小鼠耳壳水肿。ig 20和40mg/kg So显著抑制鲜蛋清引起大鼠足跖水肿,且抑制作用持续7h以上。实验表明So具有抑制急性渗出性炎症作用和弱镇痛作用。     

Antiinflammatory and analgesic activities of the tissue culture of Saussurea involucrata

The tissue culture of Saussurea involucrata (TCSauI) KAR. et KIR. was studied to determine its antiinflammatory and analgesic activities in experimental animals. Similar to wild S. involucrata, TCSauI at doses of 75-300 mg/kg i.g. for 7 d markedly inhibited hindpaw edema induced by carrageenin in rats, ear edema induced by dimethylbenzene, and increased capillary permeability in the mouse abdominal cavity induced by acetic acid. Moreover, TCSauI had inhibitory activities against the writhing reaction induced by acetic acid and the hot plate reaction in mice. The present study provided evidence first that TCSauI has antiinflammatory and analgesic activities, suggesting the potential of the tissue culture technique to substitute for wild S. involucrata in the pharmaceutical industry.     

异谷树碱的抗炎作用

异谷树碱400mg/kg灌胃给药,可显著抑制毛细血管通透性增加,二甲苯、角叉菜胶、鸡蛋清和甲醛等致炎剂产生的水肿,白细胞游走和棉球肉芽肿增生。异谷树碱对酵母发热大鼠有明显解热作用。结果表明,异谷树碱具有抗炎效应。     

Anti-inflammatory, analgesic and anti-pyretic activities of a new anti-inflammatory compound, 2-[4-(3-methyl-2-butenyl)phenyl] propionic acid (TA), in experimental animals

Anti-inflammatory, analgesic and anti-pyretic activities of orally administered TA were investigated in experimental animals. Against acetic acid-induced vascular permeability in mice, carrageenin-induced hind paw edema in rats and ultra-violet ray-induced erythema in guinea pigs, TA produced a dose related inhibition at doses of 40-160 mg/kg, 10-40 mg/kg and 10-40 mg/kg, respectively. TA produced no inhibition against histamine-induced vascular permeability even at a dose of 200 mg/kg in rats. Cotton pellet-induced granuloma and adjuvant-induced arthritis in rats were significantly inhibited by repeated administration of TA at a dose of 50 mg/kg/day for 6 days and 25 mg/kg/day for 6 days, respectively. TA showed a dose related analgesic effect at a dose of 50-200 mg/kg in acetic acid writhing, Randall-Selitto and adjuvant arthritic pain methods. A high dose of TA was needed to produce an analgesic effect in the pressure method using mice. TA produced an anti-pyretic effect against the pyrexia induced by yeast in rats. On the other hand, TA showed no effect against normal body temperature in rats. These results suggest that anti-inflammatory, analgesic and anti-pyretic activities of TA are generally a little weaker than those of ibuprofen, and the mode of action of TA is similar to that of a typical acidic non-steroidal anti-inflammatory drug such as ibuprofen, indomethacin or phenylbutazone. The ulcerogenic activity of TA was about 2 and 4 times weaker than that of ibuprofen in rats and mice, respectively. TA showed a protective effect against gastric necrosis induced by HCl.(ABSTRACT TRUNCATED AT 250 WORDS)     

Mechanism of inhibitory action of mesaconitine in acute inflammations

Mesaconitine (MA) inhibited carrageenin-induced hind-paw edema in sham-operated mice as well as adrenalectomized mice. Hind-paw edema produced by subplantar injection of histamine, serotonin and prostaglandin E1 was suppressed by MA, indicating that it elicits the antiinflammatory activity at the early exudative stage of inflammations. However, MA did not affect the biosynthesis of the prostaglandins. Trazoline and propranolol had no effect on the inhibitory activity of MA on carrageenin-induced hind-paw edema. MA when administered i.c. at the doses where it shows marked analgesic activity produced dose-dependent antiinflammatory responses on paw edema produced by carrageenin and on vascular permeability accelerated by acetic acid and agar. The inhibitory activity of morphine on carrageenin-induced paw edema failed to be potentiated by the concurrent administration of MA, demonstrating that the mechanism of the antiinflammatory activity of MA involves the central nervous system.     

Analgesic and Anti-inflammatory Activities of the Aqueous Extract of Plantago major L.

This study aimed to validate the pharmacological effects of Plantago major L., a medicinal plant used to decrease pain and inflammation. The aqueous extract (AE) was prepared from the dried ground leaves. Pretreatment with AE (1 g/kg, p.o.) decreased writhing induced by acetic acid in mice, but it did not change the tail flick responses to heat nociceptive stimuli. In rats, AE (1 g/kg, p.o.) reduced the paw edema and pleurisy induced by carrageenin, but it did not alter the paw edema induced by dextran. The effect of AE on the carrageenin inflammatory responses was more intense than that obtained on the ear edema induced by croton oil in mice. In addition, daily treatment with AE (1 g/kg/day during 8 days, p.o.) inhibited the exudative process induced by croton oil injected into the air pouch of rats. The results indicate that the aqueous extract of Plantago major is endowed with effective antiinflammatory and analgesic activities.     

蝎毒多肽的镇痛及抗炎作用

采用热板法和醋酸扭体法证明腹腔注射蝎毒多肽０．６５０，０．４３３ｍｇ／ｋｇ能明显升高小鼠痛阈和减少小鼠的扭体次数．腹腔注射蝎毒多肽０．４３３，０．２１６ｍｇ／ｋｇ能明显对抗蛋清所致的大鼠足肿胀；连续７天腹腔注射蝎毒多肽０．２６０，０．１３０ｍｇ／ｋｇ能明显抑制大鼠棉球肉芽肿形成；腹腔注射蝎毒多肽０．６５０，０．４３３ｍｇ／ｋｇ能降低小鼠腹腔毛细血管通透性     

雷公藤茎、叶的抗炎镇痛药理作用研究

雷公藤叶吕提取物４００、２００ｍｇ／ｋｇｉ．ｇ给药,可明显减轻角又菜胶引起大鼠足跖肿胀和二甲苯引起小鼠耳廓的肿胀作用,对醋酸和小鼠扭体反应有明显抑制作用,表明雷公藤叶具有明显的抗炎,镇痛作用。     

国产与进口二氟尼柳的实验性镇痛和抗炎作用的比较

目的 :观察国产二氟尼柳 (diflunisal)的镇痛和抗炎作用。方法 :镇痛用小鼠热板法和醋酸引起的小鼠扭体模型实验 ,抗炎用二甲苯引起的小鼠耳肿胀和角叉菜胶引起的大鼠足跖肿胀实验。结果 :镇痛实验结果表明国产二氟尼柳可显著延长小鼠热板法的痛阈值 ,抑制醋酸引起小鼠扭体模型的ED50 为 1 2 .46mg·kg-1(9.79～ 1 5 .86mg·kg-1) ;抗炎实验表明二氟尼柳抑制二甲苯引起小鼠耳肿胀的ED50 为 1 1 .1 0mg·kg-1(8.93～1 3 .81mg·kg-1) ,抑制角叉菜胶引起大鼠足跖肿胀的ED50 (用药后 6h)为 1 0 .5 6mg·kg-1(8.47～ 1 3 .1 7mg·kg-1)。结论 :国产二氟尼柳的镇痛和抗炎作用与进口品相近。     

牛黄消炎片的镇痛抗炎作用实验研究

用0.05g/ml和0.025g/ml12个剂量进行试验,均能明显抑制二甲苯引起的小鼠耳肿及角叉菜胶引起的大鼠足趾肿胀,对醋酸诱发的小鼠扭体反应也有明显的抑制作用,试验表明牛黄消炎片有明显的镇痛抗炎作用。