Serum testosterone and sex hormone binding globulin levels in women with androgenetic alopecia

Serum levels of testosterone and sex hormone binding globulin (SHBG) were assessed in eight women suffering from male pattern alopecia. Eight healthy women of similar age served as controls. A statistically non-significant increase was observed in serum testosterone levels as compared with those of the controls (p greater than 0.1). On the other hand, a statistically significant fall was observed in serum SHBG levels as compared with those of the controls (p less than 0.001).     

Circulating testosterone, sex hormone binding globulin and prolactin in women with late onset or persistent acne vulgaris

Serum testosterone, sex hormone binding globulin (SHBG) and prolactin were measured in thirty-eight women with acne which persisted or started after the age of 18 years. One or more of these levels were abnormal in 76% of patients. Increased testosterone or low SHBG were present alone or in combination in 60% of patients. This group was presumed to have a raised level of non-protein bound, metabolically-available testosterone. Hyperprolactinaemia, which was present in 45% of patients, may be important in view of the reported association with increased adrenal androgens. The hormonal abnormalities may be causally related to the acne and a greater understanding of them may lead to better treatment.     

524例青春期后女性痤疮患者的性激素和血脂分析

目的: 检测青春期后女性痤疮患者血脂和性激素水平变化情况,探讨痤疮与性激素和血脂的关系.方法: 收集青春期后女性寻常痤疮患者和健康对照者,检测BMI、甘油三酯、高密度脂蛋白、垂体泌乳素、促卵泡生成素、促黄体生成素、睾酮和硫酸脱氢表雄酮水平和盆腔超声.结果: 共纳入524例青春期后女性痤疮患者(轻、中、重度痤疮分别为23...     

伴多囊卵巢综合征的痤疮性激素水平变化及相关分析

为探讨成年女性痤疮患者血清性激素水平的变化及与多囊卵巢综合征（PCOS）的相关性，对60例成年女性痤疮患者进行血清性激素水平测定和妇科B超检查，其中24例伴PCOS痤疮患者行腹腔镜下微波治疗。结果发现患者组血清睾酮（T），黄体生成素（LH）高于对照组（P＜0．05），微波术后其T，LH值明显下降（P＜0．05），该手术对痤疮治愈率和总有效率分别为58．3％和91．7％，提示成年女性痊痤疮与PCOS有相关性，高雄激素血症可能是引起女性痤疮的主要因素之一。     

Free and total plasma testosterone in men and women with acne

Androgens are important in the pathogenesis of acne, and free testosterone in the serum is regarded as the biologically active component. In this study, serum free and total testosterone levels were measured in men (34) and women (14), suffering from acne but otherwise healthy. The plasma values for both groups of patients did not differ significantly from those of the age matched control groups.     

老年脑梗死患者血清性激素变化的临床研究

目的:分析老年脑梗死与血清性激素变化之问的关系,并探讨性激素引起脑梗死可能的机制.方法:选取2008午6月-2011年10月笔者所在医院收治的68例老年急性脑梗死患者作为研究对象,选择同期的58例健康体检者作为对照组.采用放射免疫法测定两组患者血清雌二醇、睾酮、催乳素和血清孕酮的水平,并将两组测定结果进行比较.结果:男性脑梗死组急性和恢复期患者E2、E2/Te水平均明显高于男性对照组(P>0.05),女性脑梗死组急性期和恢复期患者E2、Te均明显低于女性对照组(P>0.05),而E2/Te与对照组比较差异无统计学意义(P<0.05).男女脑梗死患者急性期和恢复期的Pr、PRL与对照组比较差异均无统计学意义(P>0.05).结论:男性E2、E2/Te水平升高,而女性E2水平降低,可能是引起脑梗死的危险因素之一.对患者血清性激素的研究有助于了解脑梗死的发病情况.     

不同体质量指数多囊卵巢不孕患者性激素、SHBG、胰岛素、血脂水平对比分析

目的:探讨多囊卵巢综合征(PCOS)不孕患者体重指数与性激素、性激素结合球蛋白(SHBG)、空腹血糖、胰岛素、血脂水平的相关性。方法:120例PCOS不孕患者按体重指数(BMI)分为非肥胖组(BMI25kg/m2)和超重/肥胖组(BMI≥25kg/m2)各60例。比较两组患者基础血性激素、性激素结合球蛋白、空腹血糖、胰岛素和血脂情况。结果:超重/肥胖组PCOS患者的黄体生成素(LH)、性激素结合球蛋白显著低于非肥胖组(P0.01),其它性激素比较差异无统计学意义(P0.05);超重/肥胖组PCOS患者的胰岛素(INS)、甘油三酯(TG)显著高于非肥胖组(P0.01),低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(apo B)高于非肥胖组差异均有统计学意义(P0.05),其它糖脂代谢指标比较差异无统计学意义(P0.05)。结论:不同体重指数PCOS不孕患者性激素、性激素结合球蛋白、胰岛素、血脂代谢有高度异质性,超重/肥胖PCOS患者发生心血管疾病和糖尿病、代谢综合征风险显著增加,孕前应加强健康指导。     

Inflammatory responses in acne patients treated with 13-cis-retinoic acid (isotretinoin)

Twelve patients with acne vulgaris treated with isotretinoin for 4 months showed increased levels of immunoglobulins and helper T cells at 8 weeks and increased levels of B cells at 16 weeks.     

女性痤疮血清性激素及胰岛素样生长因子-1的研究

目的：探讨性激素和生长激素在痤疮发病中的作用。方法：采用放射免疫法检测了３０例女性痤疮患者血清睾酮（Ｔ）游离睾酮（ＦＴ）、二氢睾酮（ＤＨＴ）、脱氢表雄酮（ＤＨＥＡ）、雌二醇（Ｅ２）、孕酮（Ｐｒ）、泌乳素（ＰＲＬ）和胰岛素样生长因子－１（ＩＧＦ－１）水平。结果：女性痤疮患者血清ＤＨＴ、ＤＨＥＡ、ＩＧＦ－１明显高于正常对照（Ｐ〈０．０５）,其余指标无显著差异;轻、中、重型痤疮的激素水平无显著差异;ＩＧＦ－１与性激素水平无显著相关（Ｐ〉０．０５）。结论：性激素尤其雄激素和生长激素在痤疮的发病中起了一定的作用。     

Serum iron and total iron binding capacity in leprosy patients

Serum Iron and total Iron binding capacity was estimated by Ramsay's Method in 40 leprosy patients having different types of leprosy and 20 normal subjects serving as controls. Significantly low serum Iron and total Iron binding capacity were observed in lepromatous leprosy patients.     

66例痤疮患者血清睾酮及雌二醇水平研究

对６６例痤疮患者和２０名正常人的血清睾酮及雌二醇水平进行检测。结果显示：伴有多毛现象女性患者的血清睾酮水平和男性患者的雌二醇水平明显高于正常对照组（Ｐ〈０．０５），提示痤疮发生与性激素水平改变有关。     

女性黄褐斑患者血清性激素水平检测以及谷胱苷肽与维生素C治疗

目的探讨黄褐斑与血清性激素水平的关系,并观察谷胱苷肽合并维生素C治疗黄褐斑的疗效。方法随机选择60例黄褐斑患者采用放射免疫学方法检测其血清促卵泡刺激素,黄体生成素、雌二醇、孕酮、催乳素、睾酮的含量,同时设立随机对照对谷胱苷肽合并维生素C治疗黄褐斑的疗效进行比较。结果女性黄褐斑患者血清雌二醇、黄体生成素、促卵泡刺激素水平明显高于对照组(P<0.01),孕酮水平较高(P<0.05),睾酮、催乳素水平与对照组相比差异无显著性(P>0.05)。谷胱苷肽合并维生素C治疗黄褐斑,痊愈率44.45%,有效率81.49%,与对照组比较经统计学处理差异有显著性(P<0.01)。结论女性黄褐斑发病与下丘脑—垂体—性腺轴紊乱有关,谷胱苷肽合并维生素C治疗黄褐斑有明显疗效。     

妊娠期痤疮患者雄激素和垂体激素水平研究

目的:探讨妊娠期痤疮患者体内性激素水平的改变。方法:采用化学发光酶免疫分析法测定50例妊娠患者血清中的黄体生成素(LH)、卵泡刺激素(FSH)和睾酮(T)的水平,并以50例正常孕妇做对照。结果:患者组LH和FSH显著高于对照组(P<0.05),T略高于对照组,差异无显著性(P>0.05)。结论:在妊娠期痤疮患者中雄激素水平不是发病的决定性因素。     

女性外阴硬化性苔藓患者血清性激素水平与疾病严重程度的相关性分析

目的:探讨女性外阴硬化性苔藓(VLS)患者血清性激素水平与疾病严重程度的相关性。方法:收集2016年1月～2018年6月我院确诊的49例女性外阴硬化性苔藓患者作为VLS组,45例健康志愿者为对照组进行回顾性分析,比较两组受试者血清性激素水平间的差异,采用Pearson相关分析探讨血清性激素水平与外阴白斑面积及瘙痒程度积分的相关性。结果:外阴硬化性苔藓患者外阴白斑多位于大小阴唇、尿道口和阴蒂,外阴白斑面积严重程度为轻度的患者占67.35%(33/49),轻度瘙痒患者占65.30%(32/49),外阴白斑面积和瘙痒程度评分分别为(4.12±0.53)分和(1.18±0.67)分。外阴硬化性苔藓患者血清DHT和E_2水平分别为(0.13±0.01) nmol/L和(20.53±4.17) pg/mL,明显低于健康对照组DHT(0.52±0.06) nmol/L和E_2(27.45±6.63) pg/mL水平,且差异均具有统计学意义(t值分别为-33.35,-6.11,P值均<0.05)。复发的外阴硬化性苔藓患者血清DHT(0.09±0.01) nmol/L和E_2(17.35±6.13) pg/mL水平明显低于初发外阴硬化性苔藓患者血清DHT(0.15±0.07) nmol/L和E_2(23.58±3.48) pg/mL水平,且差异均具有统计学意义(t值分别为4.33、4.17,P值均<0.05)。外阴硬化性苔藓患者血清DHT和E_2水平与外阴白斑面积积分呈负相关性,相关系数r分别为-0.78和-0.21,且差异均具有统计学意义(P值均<0.05)。结论:外阴硬化性苔藓患者血清性激素水平与病情严重程度具有负相关性,低水平的DHT和E_2与其复发有关。     

Pronounced and early acne in Apert's syndrome: a case successfully treated with oral isotretinoin

An unusual case of widespread acne unresponsive to treatment with early onset in a child with Apert's syndrome is presented. The patient eventually responded to oral isotretinoin therapy. The morphological profile of the sebaceous glands and the expression of proliferative markers and androgen receptors were evaluated in seboblasts and sebocytes using morphological, ultrastructural and immunohistochemical techniques. There were no significant differences in staining for proliferative markers and nuclear expression of androgen receptors in the glands from the patient and four healthy controls. Our results support the view that acne in Apert's syndrome is not sustained by abnormalities of the sebaceous glands demonstrable with conventional morphological techniques, and that it does not depend on an increased expression of androgen receptors.