医务人员血源性病原体职业暴露调查

目的了解医务人员发生血源性病原体职业暴露的特点和危险因素,探讨防治对策。方法采用回顾性调查方法,运用《医务人员血源性职业暴露登记表》对某院2013年1月1日—2015年12月31日发生的血源性病原体职业暴露事件进行调查分析。结果共发生血液/体液职业暴露246例。职业暴露人群以在职护士为主(95例,占38.62%);职业暴露发生地点主要为病房(148例,60.16%);职业暴露方式以锐器伤为主(219例,占89.02%);医务人员发生职业暴露时的操作环节主要为手术意外(69例,占28.05%);暴露源主要为乙型肝炎病毒(HBV),共123例(占50.00%);暴露医务人员经局部处理和预防用药后,无1例发生感染。结论医疗机构应加强医务人员血源性病原体职业暴露相关培训,提高防护意识,规范操作行为,改善工作环境,最大限度地减少职业暴露的发生。     

Cancer mortality among agricultural workers from Serrana Region, state of Rio de Janeiro, Brazil

One of the proposed hypotheses to explain the higher incidence of specific-site cancers among agricultural workers is their higher exposure to pesticides. The role of pesticide exposure in morbidity and mortality profiles in Brazil is not well known. Therefore, in order to contribute to increase knowledge on this subject, an ecological analysis aiming to investigate cancer mortality among agricultural workers in an important agricultural area of the Rio de Janeiro State, Brazil, was performed. All causes of death for male workers 30-69 years old provided by the National Mortality Information System between 1979 and 1998 were evaluated. To estimate cancer mortality risks of selected sites, mortality odds ratio (MOR) was employed, and three reference populations were used. Higher mortality of esophagus, stomach, and larynx cancer in agricultural workers 50-69 years old was observed in the period from 1979 to 1988 and of esophagus and stomach cancer from 1989 to 1998. Agricultural workers 30-49 years old showed higher, but not statistically significant, mortality by stomach, esophagus, liver, testis, and prostate cancer, and soft-tissue sarcoma in the period of 1979-1988, and by testis and penis cancer, leukemia, and soft-tissue sarcoma in the period of 1989-1998. Despite the limitations of ecological approaches concerning causality ascertainment, we believe that this study raises questions of the possible role of pesticide exposure on the cancer mortality profile among Brazilian agricultural workers.     

Biomonitoring of tunnel workers exposed to heavy air pollution in Rio de Janeiro,Brazil

Epidemiological studies found an increased risk of cancers in occupants exposed to traffic air pollution. Fine particulate matter is toxic, can enter into the respiratory tract and circulatory system, and can adsorb various substances, such as polycyclic aromatic hydrocarbons and its amino, alkyl, and nitro derivates. The study was carried out with Rebouças tunnel workers (exposed group) and 11 healthy men (control group). This tunnel is very representative of Brazilian cities and the biggest tunnel of the city of Rio de Janeiro. Samples of buccal mucosa cells and peripheral blood were evaluated using micronucleus assay. Urine samples were used to estimate the concentration of 1-hydroxyprene (1-HOP) and 2-naphthol (2-NAP). A significantly higher frequency of micronucleus in buccal cells and binucleated lymphocytes was observed for the exposed workers than for the control group. Higher concentrations of 1-HOP and 2-NAP were detected in the exposure group. In conclusion, damage to the genetic material and the high concentrations of metabolites of polycyclic aromatic hydrocarbons detected in the biological samples taken from control group can be related to daily exposure to pollutants.     

Occupational exposures to influenza among healthcare workers in the United States

The objective of this study is to estimate the annual number of occupational exposures to influenza among healthcare workers that result from providing direct and supportive care to influenza patients in acute care, home care and long-term care settings. Literature review was used to identify healthcare utilization for influenza, and worker activity patterns. This information was used, with Monte Carlo simulation, to tabulate the mean annual number of occupational exposures. Given a medium-sized epidemic with a 6% annual symptomatic influenza incidence proportion, the mean number of occupational exposures was estimated to be 81.8 million annually. Among the approximately 14 million healthcare workers, this corresponds to 5.8 exposures per worker annually, on average. Exposures, however, are likely concentrated among subsets of healthcare workers. Occupational exposures were most numerous in ambulatory care settings (38%), followed by long-term care facilities (30%) and home care settings (21%). The annual number of occupational exposures to influenza is high, but not every occupational exposure will result in infection. Some infection control activities, like patient isolation, can reduce the number of occupational exposures.     

Cat-transmitted sporotrichosis, Rio de Janeiro, Brazil

Sporotrichosis is an emerging zoonosis in Rio de Janeiro, Brazil. From 1998 to 2003, 497 humans and 1,056 cats with culture-proven sporotrichosis were studied. A total of 421 patients, 67.4% with a history of a scratch or bite, reported contact with cats that had sporotrichosis.     

Community development and HIV/STI-related vulnerability among female sex workers in Rio de Janeiro, Brazil

The Sonagachi Project of Kolkata, India has been recognized as a model community development and human immunodeficiency virus/sexually transmitted infection (HIV/STI) prevention intervention among female sex workers. Limited research has been conducted regarding its applicability outside the South Asian context. This study sought to document the process and effectiveness of integrating community development activities based on the Sonagachi model into an ongoing HIV/STI peer education program with female sex workers in Rio de Janeiro, Brazil. Structured cross-sectional surveys examining HIV/STI-related behaviors and community development measures were conducted among approximately 500 sex workers at pre- and post-intervention. We found that several community development components including social cohesion and mutual aid were significantly associated with consistent condom use among sex workers and their paying clients at pre-intervention. However, only a minority of women actively engaged in community-building activities over the 18-month study period. In turn, limited changes in community development components and no significant increases in the HIV/STI-related protective behaviors assessed were documented. Findings indicate that internalized stigma and socioeconomic pressures may have constrained the scope and pace of community mobilization in this setting during the study observation period.     

Factors associated with minor psychiatric disorders among women selected from a healthcare center in Rio de Janeiro, Brazil

The aim was to investigate factors potentially associated with minor psychiatric disorders, including maternal nutritional status variables. A cohort was studied with 479 women 15-45 years of age. The reduced General Health Questionnaire (GHQ-12 items) was applied at nine months post-partum with the 312 women who had completed follow-up. Minor psychiatric disorder was defined as a GHQ score of > or = 4 points and was treated as the response variable. Statistical analysis used hierarchical multivariate logistic regression models. The prevalence of minor psychiatric morbidity was 54.2% (95%CI: 48.6-59.7). According to the final model, the following variables remained statistically associated with minor psychiatric morbidity: level 1: total family income (1st quartile: OR = 2.71, 95%CI: 1.42-5.19; 2nd quartile: OR = 2.13; 95%CI: 1.13-4.04); level 3: body fat > or = 30% (OR = 1.66; 95%CI: 1.03-2.65). In conclusion, low income and obesity were the only factors potentially associated with minor psychiatric disorders, even after adjusting for confounding variables, while there are few studies relating maternal nutritional status and minor psychiatric morbidity.     

HIV vaccine evaluation center in Rio de Janeiro, Brazil

We conducted an HIV seroincidence study among high-risk men who have sex with men in Rio de Janeiro to determine whether this population would be suitable for vaccine and non-vaccine HIV prevention studies. There were 34 HIV seroconversions during the follow-up period, for a seroincidence of 3.1 per 100 person-years. The incidence among the youngest members of our cohort was over 8%, an extraordinarily high transmission rate for a homosexual male population. We have used the sensitive/less sensitive ELISA assay to identify a high-risk heterosexual population for intervention studies in Brazil. The estimated seroincidence was 1.9 and 2.8 per 100 person-years among heterosexual females and males, respectively. We are presently conducting a study to investigate behavior changes among 202 participants of a post-sexual-exposure chemoprophylaxis (PEP) study. During a median follow-up of 24 months, there were 11 HIV seroconversions, 10 of which were among non-PEP users. Additionally, we are conducting a phase 2 HIV vaccine trial of the ALVAC-HIV vector vCP1452 alone and in combination with a subunit vaccine, MN rgp120, in healthy adult volunteers. The primary goal of this trial is to define the immunogenicity and confirm the safety of the most promising vector-based vaccine alone and in combination with a recombinant envelope protein vaccine with an established safety and immunogenicity profile. A phase 3 HIV vaccine trial is planned to begin in the next 18-24 months.     

Factors associated with psychological distress among military police in Rio de Janeiro, Brazil

This study investigates factors associated with psychological distress among military police (n = 1,120) in Rio de Janeiro, Brazil. The article describes their social, economic, and demographic characteristics, quality of life, mental health, and work conditions. Measurement of psychological distress used the Self-Reported Questionnaire. Analysis of associations used logistic regression, considering factors associated with psychological distress. The results indicate an association between psychological distress and factors such as ability to react to difficult situations, dissatisfaction with life, health problems (especially digestive, nervous, and musculoskeletal symptoms), and adverse work conditions such as excessive workload, constant stress, and victimization. The article concludes by highlighting the need for health promotion interventions for the military police, focusing especially on their mental health.     

Knowledge of AIDS and HIV transmission among drug users in Rio de Janeiro, Brazil

Background  

Proper knowledge of HIV transmission is not enough for people to adopt protective behaviors, but deficits in this information may increase HIV/AIDS vulnerability.     

Gestational nightblindness among women attending a public maternity hospital in Rio de Janeiro, Brazil

This study evaluated the prevalence of gestational nightblindness among postpartum women seen at the University Maternal Hospital of the Federal University in Rio de Janeiro, Brazil and the association of this symptom with a biochemical indicator (serum retinol levels) and sociodemographic, anthropometric and antenatal care variables. In total, 262 postpartum women, who did not receive vitamin A supplementation during pregnancy, were interviewed. Gestational nightblindness was diagnosed through the standardized interview as proposed by WHO. Serum retinol levels were evaluated by spectrophotometry. Gestational nightblindness relating to low levels of serum retinol (<1.05 micromol/L, p = 0.000) was diagnosed in 17.9% of subjects interviewed. Less than five antenatal care appointments (odds ratio [OR] = 2.179; confidence interval [CI] 95% = 1.078 - 4.402) and a history of one or more miscarriage(s) (OR = 2.306; CI 95% = 1.185 - 4.491) were predictors for gestational nightblindness. These findings justify the need for nutritional counselling, aimed at improving the vitamin A nutritional status, especially among pregnant women with a history of previous miscarriages and poor antenatal care.     

Middle-class teenage sexuality and pregnancy in Rio de Janeiro, Brazil

The subject of this paper is teenage pregnancy among middle-class youth, a topic not sufficiently studied in Brazil. The paper is based on a qualitative, socio-anthropological study of 14 middle-class families in Rio de Janeiro, Brazil, whose children have remained single, living with their parents after the child's birth. A total of 25 in-depth interviews were conducted with 6 young men and 7 young women, ages 18 to 24, and their parents (11 mothers, one father), to examine the event in retrospect and its impact on these young people and their families. Three aspects are analyzed: difficulties young people face in internalizing contraception as a norm; late discovery of pregnancy; and how the decision to either have an abortion or give birth is made by young people and their parents. This research allows seeing teenage pregnancy as an event that hinges on the process of constructing a young person's autonomy, in which sexuality plays a prominent role. Concluding, the phenomenon should be analyzed in a specific historical and cultural context, with changes over the decades in the rules underlying the process of individualization among young people.     

Neonatal screening for hemoglobinopathies in Rio de Janeiro, Brazil]

OBJECTIVE: To describe the main results obtained in the first 15 months of neonatal screening for sickle cell disease in the state of Rio de Janeiro, Brazil, from August 2000 to November 2001. METHODS: Starting in August 2000, blood samples began to be collected for sickle cell disease screening from all newborns receiving care in primary health care clinics in the state of Rio de Janeiro. The samples were submitted to high-resolution liquid chromatography. If the resulting chromatogram was compatible with sickle cell disease, the child and the parents were referred for diagnostic confirmation and treatment. RESULTS: Between August 2000 and November 2001, 99 260 newborns were screened. There was one case of homozygous Hb C. On average, one of every 27 newborns who were screened presented sickle cell trait (Hb AS). Sickle cell disease was observed in 83 cases, or one new case in each 1 196 births. The 83 consisted of: 62 Hb S, 18 Hb SC, and 3 Hb SD. One child did not appear for diagnostic confirmation. The 82 children who were followed up by the program presented 15 intercurrent illnesses (upper respiratory infections, fever, splenic sequestration crises, hand-foot syndrome, and vascular occlusion), resulting in seven hospital admissions. Blood transfusions were necessary with 15 children, but none developed alloimmunization. All the other babies were doing well with the use of prophylactic penicillin. CONCLUSIONS: Our data show the importance of early diagnosis for sickle cell disease, so as to prevent the frequent infectious complications faced by these patients.     

Food consumption by pregnant adolescents in Rio de Janeiro, Brazil

The increase in teenage pregnancy has been viewed with concern by public health experts. Food consumption to help maintain high nutrient demands has been identified as one of the most relevant components. This study aims to present the habitual consumption of food and energy-specific nutrients by pregnant adolescents. A total of 1,180 adolescent mothers were interviewed in maternity hospitals in the City of Rio de Janeiro, and a simplified questionnaire on semi-quantitative frequency of food consumption was applied. Lower consumption of fruit juice, vegetables, and fruits was observed among adolescent mothers over 15. Adolescent mothers classified in the lowest quartile of consumption lack the minimum recommended consumption of energy and nutrients. An inverse association was found between the number of household members and energy and nutrient consumption. Adolescent mothers who received dietary information and changed their eating habits during pregnancy showed better results concerning the consumption of energy and nutrients. Prenatal care was a key factor for improving the results of pregnancy, emphasizing the importance of providing dietary information.     

临床医生发生血源性病原体职业暴露的调查分析

目的了解临床医生发生血源性病原体暴露的情况，为制定预防对策提供依据。方法建立血源性病原体职业暴露监测报告系统，调查医生在工作中发生暴露的相关情况。结果共收到106名医生发生血源性病原体职业暴露的报告。其中，血液或体液溅污20人，锐器伤86人。最常见的暴露物为血液。外科医生发生锐器伤的比率最高，达67．44％，暴露多发生在医生使用缝合针、穿刺针或刀片进行手术时。暴露源以乙型肝炎表面抗原（HBsAg）阳性患者最多见（51．89％），其次是梅毒抗体阳性患者（16．98％），抗HIV阳性患者2例。对发生职业暴露的医生及时进行相关干预，经追踪随访，无人因暴露而发生感染。结论外科医生在进行手术相关操作时易发生血源性病原体暴露，应加强职业安全防护意识，规范操作规程，暴露后及时进行干预以降低暴露后感染的危险。