小学一年级受虐待学生死亡概念和自杀意念的分析

目的探讨儿童虐待对儿童死亡认知发展的影响,了解受虐待儿童产生自杀意念的情况。方法对符合入组标准的受虐待儿童和正常儿童各80名进行结构式访谈,并评定死亡概念问卷和自杀意念量表,分析两组之间死亡概念认知水平、认知特点和自杀意念的差异。结果受虐待组儿童对死亡概念的认知水平明显低于正常组儿童(水平Ⅲ:75.00%vs88.75%,P<0.05),对死亡特征和死亡外延的认识比对照组差(P<0.01),受虐待组儿童的自杀意念发生率和自杀意念强度均高于正常儿童[1年内:35.00%vs11.25%,(0.82±0.65)分vs(0.35±0.21)分,P<0.01]。结论虐待可对儿童的死亡认知发展过程产生明显的不良影响,使受虐待儿童对死亡概念的认识偏离正常,更容易产生自杀意念。     

小学一年级受虐待学生死亡概念和自杀意念的分析

目的探讨儿童虐待对儿童死亡认知发展的影响,了解受虐待儿童产生自杀意念的情况.方法对符合入组标准的受虐待儿童和正常儿童各80名进行结构式访谈,并评定死亡概念问卷和自杀意念量表,分析两组之间死亡概念认知水平、认知特点和自杀意念的差异.结果受虐待组儿童对死亡概念的认知水平明显低于正常组儿童(水平Ⅲ:75.00%vs 88.75%,P＜0.05),对死亡特征和死亡外延的认识比对照组差(P＜0.01),受虐待组儿童的自杀意念发生率和自杀意念强度均高于正常儿童[1年内:35.00%vs11.25%,(0.82±0.65)分vs(0.35±0.21)分,P＜0.01].结论虐待可对儿童的死亡认知发展过程产生明显的不良影响,使受虐待儿童对死亡概念的认识偏离正常,更容易产生自杀意念.     

小学生冲动性人格与受虐待经历的关系

目的 研究受虐待小学生冲动性人格的发展特点及其与受虐待经历的关系.方法 采用儿童期虐待史自评量表(PRCA)和Barratt冲动性人格量表(BIS-11),对172名小学五、六年级学生进行测评,分别评估他们的冲动性人格和受虐待情况.结果 受虐待者的无计划冲动性、动机冲动性和冲动性总分均高于未受虐待者[冲动性总分(40.39±10.68)分vs(30.34±10.26)分,t =5.96,P ＜0.01],男生的动机冲动性明显高于女生[(28.98±14.42)分vs(24.46±11.52)分,t =2.28,P ＜0.05].躯体虐待、情感虐待和虐待总分与无计划冲动性、动机冲动性和冲动性总分呈正相关(r =0.337～0.514,P ＜0.01),忽视与冲动性人格所有因子和总分呈正相关(r =0.187～0.419,P ＜0.05或P ＜0.01),性虐待仅与动机冲动性呈正相关(r =0.192,P ＜0.05).情感虐待对无计划冲动性、动机冲动性和冲动性总分具有正向预测作用(Beta值=0.185～0.395,t =1.975～5.589, P ＜0.05或P ＜0.01),忽视对无计划冲动性、注意冲动性和冲动性总分具有正向预测作用(Beta值=0.272～0.294,t =3.037～3.756,P ＜0.01),躯体虐待和性虐待对动机冲动性具有正向预测作用(Beta值=0.213,t =3.025,P ＜0.01;Beta值=0.157,t =2.441,P ＜0.05).结论 小学生的冲动性人格与受虐待经历有关,儿童虐待对冲动性人格的形成具有预测作用.     

儿童虐待对小学生行为问题的影响

目的研究受虐待小学生的行为问题及其与各种儿童虐待形式的关系。方法对179例小学生进行了儿童期虐待史自评量表(PRCA)和Achenbach儿童行为量表(CBCL)测试。结果受虐待组小学生CBCL各因子分和总分高于无虐待:CBCL总分[男生(45.02±43.46)分vs(14.41±14.37)分,t=4.79,P<0.01;女生(37.16±28.34)分vs(17.73±14.58)分,t=4.39,P<0.01],女生中11～12岁年龄组的社交退缩因子分高于9～10岁组[(3.80±2.91)分vs(2.47±2.94)分,t=2.19,P<0.05]。除性虐待外,PRCA各因子分和总分与CBCL各因子分和总分呈正相关(r=0.213～0.513,P<0.05或P<0.01)。情感虐待、躯体虐待、性虐待和忽视对男生行为问题具有正向预测作用(Beta值=0.213～0.510,t=2.060～5.032,P<0.05或P<0.01);忽视和情感虐待对女生行为问题具有正向预测作用(Beta值=0.199～0.332,t=2.012～3.441,P<0.05或P<0.01)。结论儿童虐待可对小学生行为自我调节能力的发展造成不良影响,躯体虐待、情感虐待、忽视和性虐待可显著预测个体的行为问题。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.