Inverse variations of plasma renin activity and renin substrate in normal man

Abstract. In the control subject, plasma angiotensin production is a linear function of plasma renin content. Upon incubation of this same plasma in the presence of an excess of homologous renin, angiotensin production is finally limited by the plasma content of renin substrate (PRS). By this method, PRS levels were measured and compared with levels of plasma renin activity (PRA), urinary aldosterone excretion, and sweat sodium and potassium content, in sixteen normal human subjects, aged twenty-five to thirty years, under three defined metabolic conditions: unrestricted sodium intake, salt depletion, constant sodium intake plus administration of desoxycorticosterone acetate (DOCA). 1) Unrestricted Sodium Intake. In these control subjects, in perfect health, there exist important individual differences in PRS levels. The PRS levels seem to be quite constant for a given subject under a given metabolic condition: the levels remained the same after a four month interval for a given subject. 2) Salt Depletion. Activation of the renin-angiotensinaldosterone system (RAAS), as shown by an elevation of PRA and of urinary aldosterone excretion, is accompanied by a decrease in PRS levels. 3) Constant Sodium Intake Plus Administration of DOCA. Inactivation of the RAAS, as shown by lowering of PRA and of urinary aldosterone excretion, is accompanied by a marked elevation of PRS levels. It would appear that, in human control subjects there exists an inverse relationship between PRS and PRA levels.     

Effectiveness of bromocriptine monotherapy or combination treatment with clomiphene for infertility in women with galactorrhea and normal prolactin: A systematic review and meta-analysis

Background: Among women with unexplained infertility, 28% to 55% of patients with galactorrhea are normoprolactinemic. Bromocriptine, a common treatment for infertile women with hyperprolactinemia, has been used in the treatment of unexplained subfertility in women with galactorrhea and normal prolactin; however, its effectiveness and safety profile have never been determined.Objective: The aim of this study was to determine the relative effectiveness and safety profile of bromocriptine monotherapy or as an adjunct to clomiphene citrate in women with galactorrhea and normal prolactin levels.Methods: We conducted a search of the Cochrane Subfertility Review Group specialized register of controlled trials (March 2010), CENTRAL (The Cochrane Library, Issue 3, 2010), MEDLINE (1950-March 2010), EMBASE (1980-March 2010), and the China Biological Medicine Database (inception to March 2010) for relevant randomized controlled trials (RCTs) using the following terms: controlled, randomized, blinded, clinical trials, humans, galactorrhea, prolactin, bromocriptine, infertility, and subfertility. Additionally, reference lists of identified articles were searched for relevant articles.Results: Of the 8 studies identified, 5 were excluded after full-text review for the following reasons: lack of a placebo group (2); difference in cointerventions (1); difference in end points (1); and systematic review (1). Therefore, 3 RCTs were included in this review. Bromocriptine administered in combination with clomiphene was found to be associated with a higher accumulative pregnancy rate compared with clomiphene monotherapy (fixed odds ratio [OR], 5.33; 95% CI, 2.62-10.88), and a lower miscarriage rate (fixed OR, 0.20; 95% CI, 0.05-0.76). Only 1 trial reported live birth as an outcome, and multiple pregnancy rates were poorly reported. Patient-reported adverse effects were mentioned in the studies, but reports were often incomplete.Conclusions: This review suggests the effectiveness of bromocriptine with clomiphene for infertility in women with galactorrhea and normal prolactin levels. Further RCTs of adequate power and of high methodologic quality are required to confirm these findings.     

The value of plasma prolactin levels in the prediction of the responsiveness of growth hormone secretion to bromocriptine and TRH in acromegaly

Abstract. The mechanism of the inhibition of growth hormone secretion in response to bromocriptine and the ability of thyrotropin releasing hormone to stimulate growth secretion in acromegaly is unknown. In the present study the relationship between the plasma prolactin concentration of untreated acromegalic patients and the reaction of growth hormone to thyrotropin releasing hormone and bromocriptine was investigated.
Plasma prolactin levels were elevated in thirty-three (42%) of seventy-nine untreated acromegalic patients. Seventeen patients had mildly elevated prolactin levels, but in sixteen the plasma prolactin concentration was higher than 30 ng/ml. Bromocriptine (2.5 mg) inhibited growth hormone secretion by more than 50% in 22% of the normoprolactinaemic, in 53% of the mild hyperprolactinaemic and in 88% of the patients with a prolactin level above 30 ng/ml ( P <0.01 v. normoprolactinaemic; P <0.01 v. mildly elevated prolactin levels). An increase of growth hormone secretion by more than 100% of the basal value in response to thyrotropin releasing hormone was observed in 44% of the normoprolactinaemic, in 59% of the mildly hyperprolactinaemic and in 75% of the clearly hyperprolactinaemic patients; ( P <0.01 v. normo-and mildly hyperprolactinaemic patients).
Conclusion: An increased plasma prolactin concentration in patients with acromegaly is accompanied in most patients by a higher sensitivity of growth hormone secretion to bromocriptine.     

Vasoactive intestinal polypeptide (VIP) increases vaginal blood flow and inhibits uterine smooth muscle activity in women

The human vagina and uterus are heavily innervated by VIP-containing nerve fibres. In the present study, we have measured vaginal blood flow, transmucosal oxygen tension and uterine smooth muscle activity during stepwise intravenous infusion of vasoactive intestinal polypeptide (VIP) (0, 100, 300, 900 pmol kg-1 h-1) in non-pregnant women. Vaginal blood flow was measured by the heat clearance technique, transmucosal oxygen tension by an O2-electrode and uterine activity by a micro-tip pressure catheter in the uterine cavity. Arterial blood pressure, pulse frequency and the concentration of VIP in peripheral venous blood were monitored. VIP induced a concentration-dependent increase in vaginal blood flow. The transmucosal oxygen tension was not significantly changed by VIP. The maximum dose of VIP decreased systolic as well as diastolic blood pressure and increased pulse frequency. VIP inhibited uterine activity. These findings suggest that VIP participates as a neurotransmitter in the control of genital physiological responses.     

Effects of furosemide and orthostasis on active and inactive renin in normal and anephric man

Abstract. We investigated active and inactive (acid-activatable) plasma renin in anephric and in normal persons. In anephric patients ( n = 15) plasma concentration of active and inactive renin was 1.15 ± 0.2 and 40.7 ± 7.1 μU/ml, respectively; angiotensin II ( n = 13) was 14.5 ± 1.9 pg/ml. Furosemide ( n = 10), 40 mg i.v., and upright posture ( n = 8) did not change active or inactive renin in the anephric state. In normal men, furosemide ( n = 9) within 15 min increased active renin from 29.9 ± 5.8 to 82.4 ± 14.8 (μ/ml ( P lt; 0.001), while inactive renin slightly but not significantly decreased from 136.3 ± 29.9 to 121.1 ± 19.2 μU/ml; orthostasis ( n = 15) within 4 h stimulated active renin ( P < 0.001) and slightly raised inactive renin ( P < 005). Both furosemide and orthostasis increased ( P < 0.001, each) the proportion of active renin in normal persons. Studies in one patient within 24 h after bilateral nephrectomy indicated half-life to be 30–60 min for active and 2–4 h for inactive renin. Thus, we detected low levels of active renin and considerable amounts of inactive renin and angiotensin II in anephric patients. Our data suggest that about 30%, of inactive renin in normal plasma is of extrarenal origin. The stimulation of active renin by furosemide and orthostasis is bound to the presence of the kidney. Our studies provide indirect evidence that both manoeuvres may stimulate the conversion of inactive to active renin within the human kidney.     

The effect of pindolol on plasma renin activity in patients with essential hypertension

Twenty-two patients with essential hypertension were treated for 3 months with pindolol, and blood pressure and plasma renin activity were measured at rest and after stimulation (upright posture stimulation and insulin induced hypoglycaemia stimulation). Beta-receptor blockade produced a significant decrease in systolic and diastolic blood pressure. After treatment with pindolol the plasma renin activity was significantly lower. Under conditions of renin stimulation such as orthostasis and insulin produced hypoglycaemia, plasma renin activity was significantly lower in treated patients. There was no correlation between the fall of plasma renin activity and the decrease of blood pressure. Renin suppression is probably only one of the factors involved in the reduction in the blood pressure in these patients.     

Increase of plasma renin activity at renal blood flow estimations with the Xenon133 wash-out technique in patients with renal artery stenosis

Summary. Eleven patients with hypertension and renal artery stenosis of fibromuscular type were investigated with renal blood flow estimations with Xenon¹³³ wash-out technique before and after alpha-receptor blockade with infusion of phenoxybenzamine in the stenosed renal artery. During the whole investigation frequent blood samples for renal vein renin estimations were drawn from both kidneys. Immediately after the Xenon injection renal vein renin elevations on the investigated side were observed in 9/11 patients. The renin peak was reached in 10 min and the mean increase for all patients was 152%. The mean duration of the peak was 19·25 min. A neurogenic renin release mechanism triggered by renal chemoreceptors and mediated by beta-adrenergic fibres was suggested. This finding with renin release stimulation at Xenon¹¹³ infusion in the renal artery is of great importance in judging results of investigations concerning renal blood flow and renin when the Xenon wash-out technique is used. Blood samples for renin estimations should not be taken within 25 min after intrarenal Xenon¹¹³ infusions.     

The effect of beta-adrenergic blockade on patterns of urinary sodium excretion, blood pressure and plasma renin activity in patients with essential and renovascular hypertension

The effects of beta-adrenergic blockade, using oxprenolol, were studied in plasma renin activity, urinary sodium excretion and blood pressure in ten normal subjects and in 120 patients with essential and renovascular hypertension. Blood pressure was reduced by oxprenolol administration. The hypotensive action of the drug was independent of either the basal plasma renin activity or of the plasma renin activity response. Oxprenolol decreased plasma renin activity in normal subjects and in patients with essential hypertension with normal or high basal plasma renin activity. Patients with low plasma renin activity may show a lack of response to the beta-blockade. In patients with renovascular disease the response of plasma renin activity to oxprenolol was not a discriminant factor between patients cured or not cured by surgery. Some renovascular patients were unresponsive to beta-blockade with oxprenolol.     

Effect of cold pressure test and 2-deoxy-D-glucose infusion on plasma renin activity in man

Abstract. It has been reported that catecholamines stimulate plasma renin activity (PRA) in vivo and in vitro. Yet the respective roles of endogenous epinephrine and norepinephrine are still debated. Therefore two tests were performed in human subjects: the cold pressure and the 2-deoxy-d -glucose tests. During these tests and on a control day, blood samples were taken at short intervals for PRA; in some subjects the excretion of epinephrine (E) and norepinephrine (NE) was also measured. In 9 healthy males the cold pressure test induced an immediate NE response with increase of systolic and diastolic blood pressure without change in the blood glucose concentration. There was no significant change in the mean value of PRA although in four subjects some rise of PRA occurred. The 2-deoxy-d -glucose induced, in response to an intracellular glucopaenia, an E discharge with a rise in the blood glucose concentration. In all 8 healthy males a striking rise of PRA was observed. Neither hyperglycaemia nor the concomitant decline of serum potassium could explain this rise of PRA, since the same changes during oral glucose test were not accompanied by a similar elevation. Patients with Addison's disease of tuberculous origin responded in a normal fashion to the cold pressure test, but failed to present a hyperglycaemia and a rise of PRA in response to 2-deoxy-d -glucose. This indicates that an intact adrenal medulla was required for the last stimulus but not for the former. From these studies in man it would appear that endogenous epinephrine stimulates renin more strongly than norepinephrine.     

Circulating endogenous vasoactive intestinal polypeptide (VIP) in patients with uraemia and liver cirrhosis

The concentration of vasoactive intestinal polypeptide (VIP) in peripheral venous plasma was median 6.0 pmol l-1 (range 0-20) in 112 normal subjects. In fifty-three patients with decreased kidney function plasma VIP was significantly increased (median 15.0 pmol l-1, range 0.5-70, P less than 0.0001) and positively correlated to serum creatinine concentration (r = 0.51, P less than 0.001). In 133 patients with liver cirrhosis peripheral venous VIP was slightly elevated (median 7.0 pmol l-1 range 0-86, P less than 0.01). Samples obtained during a central venous catheterization showed significant renal extraction of circulating VIP in control subjects (median extraction fraction 23%, P less than 0.05, n = 6) and in patients with cirrhosis (median 60%, P less than 0.02, n = 8), but not in uraemic patients (median 0%, NS n = 5). In control subjects and patients with cirrhosis the concentration of VIP in the hepatic vein was significantly below that of systemic plasma (-42%, P less than 0.05, n = 6 and -45%, P less than 0.01, n = 10, respectively). On the contrary, in uraemic patients hepatic venous VIP was almost similar to systemic VIP (-4%, NS, n = 7). The results indicate that in normal subjects and patients with cirrhosis both the liver and kidneys are involved in the biodegradation of VIP. The elevated level of circulating VIP in uraemic patients may in part be due to decreased renal and hepatic biodegradation but increased neuronal release of VIP, especially in the splanchnic system, may also contribute to the increased plasma VIP in this condition.     

Renal tubular sodium handling and plasma atrial natriuretic peptide, renin activity and aldosterone in untreated men under normal living conditions

The associations between renal tubular sodium handling and plasma levels of atrial natriuretic peptide, renin activity and aldosterone were studied in 295 untreated men under normal living conditions. The renal clearance of ingested lithium was used as a marker of proximal tubular sodium handling. Plasma atrial natriuretic peptide was inversely related to creatinine clearance (r = -0.148, P less than 0.01) and directly and significantly related to the overall fractional excretion of sodium (r = 0.213, P less than 0.001) and to distal (r = 0.151, P less than 0.01) fractional sodium excretion. Plasma renin activity was inversely related to sodium excretion at both proximal (r = -0.145, P less than 0.05) and distal (r = -0.236, P less than 0.001) tubular site, whereas plasma aldosterone was significantly and inversely related to distal sodium excretion only (r = -0.305, P less than 0.001). The association between plasma atrial natriuretic peptide and distal sodium excretion in a large sample of men under normal living conditions supports the view of a possible tubular effect of the hormone of the overall control of sodium excretion in man.     

Vasoactive substances in early dumping syndrome: effects of dumping provocation with and without octreotide

In patients after gastric surgery, early dumping symptoms can be provoked by oral glucose challenge. Octreotide effectively prevents the occurrence of dumping symptoms. We have studied plasma renin activity (PRA), aldosterone and atrial natriuretic peptide (ANP) concentrations in nine patients with early dumping, 10 surgical control subjects and nine healthy control subjects after an oral glucose challenge preceded by either placebo or 25 μg of octreotide subcutaneously (s.c.). In the dumping group, basal PRA was signifi-cantly ( P  < 0.01) higher (3.9 ± 0.6 μg L⁻¹ h⁻¹) than in either surgical or healthy control subjects (1.1 ± 0.3 μg L⁻¹ h⁻¹ and 1.1 ± 0.2 μg L⁻¹ h⁻¹ respectively) and showed a significant rise after glucose ingestion to 5.4 ± 0.9 μg L⁻¹ h⁻¹ that did not occur in control subjects. Aldosterone concentration showed a concomitant rise. In dumping patients, plasma ANP decreased after glucose ingestion from 31 ± 6 ng L⁻¹ to 21 ± 5 ng L⁻¹ ( P  < 0.05). This decrease did not occur in control subjects. Early dumping is associated with an activation of the renin–aldosterone axis and a decrease in plasma ANP, reflecting a hypovolaemic state. Octreotide prevents the occurrence of these changes.     

Low plasma aldosterone despite normal plasma renin activity in uncomplicated type 1 diabetes mellitus: effects of RAAS stimulation

BACKGROUND: Data on levels and responsiveness of PRA and aldosterone in type 1 diabetes mellitus are conflicting. Earlier studies were not standardized with respect to the type of diabetes mellitus, the presence of diabetic complications or sodium intake. Therefore, we studied plasma renin activity and plasma aldosterone in uncomplicated type 1 diabetes mellitus by evaluating the effects of endogenous (sodium restriction) and exogenous (angiotensin I infusion) stimulation. DESIGN: Twenty-four type 1 diabetic patients and 24 matched healthy subjects were studied after 1 week of liberal sodium diet (200 mmol 24 h-1) and 1 week of low sodium diet (50 mmol 24 h-1). Angiotensin (Ang)I was infused at 4 and 8 ng kg-1 min-1 during both study days. RESULTS: During liberal and low sodium intake, plasma aldosterone was lower in type 1 diabetic patients compared with healthy subjects both at 08:00 h (P < 0.05) and after a 2-h euglycaemic clamp (P < 0.05), despite similar PRA levels. The correlations between changes in PRA and changes in plasma aldosterone when shifting sodium intake were similar in both groups. During liberal sodium intake, the aldosterone levels after AngI infusion were lower in type 1 diabetic patients, whereas during low sodium they were not different. CONCLUSIONS: Plasma aldosterone was deceased relative to PRA in uncomplicated type 1 diabetic patients, irrespective sodium intake. The responsiveness to sodium restriction was adequate and sodium restriction was able to overcome the decreased plasma aldosterone response to exogenous AngI, which was observed during liberal sodium in diabetic patients. The lower aldosterone is not secondary to diabetic complications and does not depend on the level of sodium intake.     

Circulating levels of prolactin are elevated in patients with rheumatoid arthritis: a meta-analysis

Background: Prolactin (PRL), an inflammatory hormone with cytokine properties, has long been proposed to play a crucial role in the pathogenesis of autoimmune disorders, including rheumatoid arthritis (RA). However, the circulating levels of PRL in RA were discordant among published studies.

Methods: PubMed, Embase, and The Cochrane Library database were systematically searched from inception up to 30 June 2018. The available studies were obtained from the initial search in accordance with the rigorous inclusion and exclusion criteria. Relevant data from the included literatures were extracted. Methodological quality was evaluated in order to refine the final search results. All statistical analyses were conducted using software STATA version 12.0.

Results: Of 698 articles were yielded for eligibility, a finally analysis involving 628 RA cases and 430 controls from 14 published studies were included. When compared to healthy controls, there was a significantly higher level of circulating PRL in patients with RA with a pooled SMD of 1.08 (95% CI = 0.41 to 1.74, P< 0.001), particularly in Asians, age ≥50, enzyme-linked immunosorbent assay (ELISA) group and subjects with erythrocyte sedimentation rate (ESR) ≥25 mm/h.

Conclusions: Our meta-analysis demonstrates a significantly higher level of circulating PRL in RA patients when compared to healthy controls, and it was associated with region, age, measurement type and ESR.     

Relationship between plasma concentrations of angiotensin I, angiotensin II and plasma renin activity during cardio-pulmonary bypass in man

Abstract. Several reports have demonstrated that the lungs are the most important site of conversion of angiotensin I to angiotensin II. The purpose of the present study was to assess the extent of extra-pulmonary conversion in man, during cardiopulmonary bypass. Plasma concentrations of angiotensin I and immunoreactive angiotensin II, and plasma renin activity were simultaneously determined, using specific radioimmunoassays, during extra-corporeal circulation in 13 patients undergoing major cardiac surgery. Generally the renin-angiotensin system was stimulated during cardiopulmonary bypass with maximum values occurring at different time. A highly significant correlation was found between plasma renin activity and angiotensin I and II concentrations respectively, as well as between these two peptides. Positive correlations were also obtained between arterial and venous samples for plasma renin activity and angiotensin I and II. Thus the presence of angiotensin II in plasma in the absence of pulmonary circulation and its parallel variations with plasma renin activity indicate that converting activity by extra-pulmonary sources is not negligible.     

Changes in plasma renin activity and haemodynamics during vasodilator therapy in conscious dogs with myocardial infarction or chronic volume overload

The aim of the study was to compare the changes in plasma renin activity induced by a vasodilator in normal dogs and in dogs with an impaired cardiac reserve. In normal conscious dogs, a 60-min nitroprusside infusion increased plasma renin activity from 1.05 +/- 0.26 to 8.35 +/- 1.20 ng, angiotensin I ml-1 h-1 (P less than 0.002) and heart rate from 83 +/- 6 to 149 +/- 15 beats/min (P less than 0.002). In five dogs in which a aortocaval fistula had been created 4 weeks earlier, the same infusion still increased plasma renin activity but significantly less than in normal dogs (0.90 +/- 0.29 to 4.44 +/- 0.64 ng ml-1 h-1; P less than 0.01) and the heart rate was unchanged (134 +/- 4 to 139 +/- 7 beats/min; NS). Similarly, in five dogs with a previous myocardial infarction, the heart rats response to nitroprusside was blunted (108 to 107 beats/min;NS) and plasma renin activity increased less than in normal dogs. Plasma renin activity also increased acutely after hydralazine administration in dogs which myocardial infarction (1.05 +/- 0.26 to 8.99 +/- 0.79 ng ml-1 h-1; P less than 0.05); after 1 week of hydralazine, plasma volume had increased from 54.9 +/- 0.9 ml kg-1 to 74.5 +/- 4.9 ml kg-1 (P less than 0.05) and plasma renin activity remained higher than control (4.66 +/- 0.66 ng ml-1 h-1; P less than 0.01). In conclusion, vasodilator therapy rapidly activates vasoconstrictor forces and fluid retention even in dogs with limited cardiac reserve. Although the regulation of plasma renin secretion appears altered in these models of heart disease, the renin response remains sufficient to seriously limit the beneficial effects of vasodilator therapy.     

泌乳素与淋巴细胞亚群对精神分裂症患者免疫相关指标影响的初步研究

目的通过分析淋巴细胞亚群和免疫球蛋白(IgG、IgM、IgA)水平变化,初步探讨精神分裂症患者体内高浓度泌乳素对免疫系统的影响。方法流式细胞仪分别检测T淋巴细胞CD3~+、CD4~+、CD8~+亚群、NK细胞百分比以及CD4~+/CD8~+比值;应用免疫速率散射比浊法检测外周血体液免疫3项(IgG、IgM、IgA)。采用方差分析对数据进行统计分析。结果与健康对照组和精神分裂症泌乳素正常组比较,精神分裂症泌乳素增高组的T淋巴细胞CD4~+亚群百分比、CD4~+/CD8~+比值及IgG水平增高(P0.05);而精神分裂症泌乳素增高组的NK细胞百分比降低(P0.05)。结论高浓度的泌乳素可能通过影响淋巴细胞亚群之间的平衡以及免疫球蛋白的产生而对免疫系统产生一定的影响。     

急性颅脑伤患者血清生长激素、催乳激素、促甲状腺激素放射免疫测定

为了进一步了解急性颅脑伤患者下丘脑-垂体功能的变化,对患者伤后最初3天血清生长激素(GH)、催乳激素(PRL)、促甲状腺激素(TSH)进行了放射免疫测定。结果表明TSH含量均在正常范围,PRL含量伤后最初2天高于正常,而第3天已降至正常,GH含量均高于正常。死亡组伤后第1天PRL含量高于生存组。并对急性颅脑伤患者血清PRL、GH升高的机理进行了探讨,认为可能与下丘脑-垂体的梗塞、坏死及PRL、GH的应激作用有关。     

心力衰竭患者血清钠对血浆肾素、醛固酮和心钠素的影响

目的　探讨充血性心力衰竭患者血清钠水平对肾素 血管紧张素 醛固酮系统和心钠素 (ANP)活性的影响。方法　将 12 5例住院心衰患者按血清钠水平分为正常血钠组 (4 7例 )和低钠血症组 (78例 ) ,测定并比较两组患者的血浆肾素 (PRA)、醛固酮 (ALD)和ANP ;低钠血症组患者经补盐和 (或 )限水纠正血钠后 ,采用自身对照的方法 ,观察治疗前后血浆PRA、ALD和ANP的变化。结果　①低钠血症组患者血浆PRA和ALD水平明显高于正常血钠组患者 (2 .6 7± 0 .2 8与 2 .18± 0 .2 0 ,4 6 1± 2 6 .3与 4 36± 12 .5 ,P <0 .0 1) ,血浆ANP水平前者低于后者 (14 8.0± 14 .5与 174 .0± 15 .1,P <0 .0 1)。② 78例血钠水平被纠正后的低钠血症组患者血浆ANP和ALD水平较补盐前下降 (2 .18± 0 .2 0与 2 .70± 0 .2 6、4 36 .0± 12 .5与 4 6 7.0± 2 5 .9,P <0 .0 1) ,血浆ANP水平较补盐前上升 (172 .0± 16 .2、14 8.0± 14 .5 ,P <0 .0 1)。③心衰患者血清钠水平与血浆PRA和ALD水平呈负相关 (r=- 0 .198,r=- 0 .75 3,P <0 .0 1) ,与ANP水平呈正相关 (r=0 .739,P <0 .0 1)。结论　充血性心衰患者宜适当补盐以维持正常血钠水平 ,这将有利于肾素 血管紧张素 醛固酮系统和ANP之间的平衡。     

精神分裂症患者血清泌乳素水平与性相关精神症状对照研究

目的探讨精神分裂症患者血清泌乳素水平与性相关精神症状的关系。方法对297例精神分裂症患者（病例组）于治疗前及治疗第3周末,60例健康体检者（对照组）体检时,采用放射免疫法分别检测血清泌乳素水平,并进行对比分析;同时调查患者性有关精神症状,并与血清泌乳素检测结果进行相关分析。结果病例组治疗第3周末男女性血清泌乳素水平均显著高于治疗前（P〈0．01）;病例组无论是男性还是女性,治疗前血清泌乳素水平与对照组均无显著性差异（P〉0．05）,治疗第3周末均显著高于对照组（P〈0．01）。病例组患者无论男性还是女性,治疗前患者的性有关精神症状累计积分与其血清泌乳素水平似呈正相关,治疗后似呈负相关,但均无统计学意义（P〉0．05）。结论精神分裂症患者的血清泌乳素水平有不同程度的升高,与性有关精神症状无关,而与传统抗精神病药物的应用有关。