腮腺多形性低度恶性腺癌1例报道并文献复习

目的探讨多形性低度恶性腺癌(小叶性或终末导管癌)的临床病理特点、诊断及鉴别诊断。方法通过光镜和免疫组化，对1例腮腺多形性低度恶性腺癌进行病理组织学观察。结果多形性低度恶性腺癌细胞形态较单一，但组织结构具有多样性。上皮膜抗原(EMA)呈阳性。结论这是一种不常见的肿瘤，多发于小涎腺，尤其是腭部，腮腺少见。尽管其具有浸润性生物学行为，但仍属于低度恶性肿瘤。彻底切除病变，可防止肿瘤复发。     

Benign inflammatory pseudotumour of the parotid gland: a case report and literature review

We describe a rare case of benign inflammatory pseudotumour of the parotid gland. The literature concerning this condition is discussed.     

腮腺乳腺样分泌性癌一例并文献复习

正患者,男性,65岁,于1998年行右侧耳下肿块切除术,术后病理诊断不详。2017年11月因右侧颈部不适发现右侧耳下肿块,后肿块逐渐增大,未予诊断和治疗。2018年11月就诊于湖北省肿瘤医院门诊,以右侧腮腺肿瘤术后复发收入院。专科检查:右侧耳下见手术切口瘢痕约7 cm,可触及大小约4 cm×3 cm的肿物,无红肿、压痛,边界清楚,活动度尚可,颈部淋巴结无肿大。超声检查(LOGIQ E9彩色多普勒超声诊断仪;探头频率:6～15 MHz):右侧腮腺内可见大小2.57 cm×1.79 cm、边界欠清晰、形态不规则的低回声肿块,内部回声不均匀,其内可见钙化点,彩色多普勒血流显像示其内及周边可见血流信号(图1);     

低龄原发腮腺多形性腺瘤:1例报告并文献复习

多形性腺瘤最常见于腮腺,以30~50岁为多见,罕见低龄患者;其复发率高,并且具有癌变的潜在危险,在低龄患者中复发率较成人偏高。因此,在临床应尤其重视对低龄原发多形性腺瘤的治疗,这对预防其复发有着重要的意义。本文报道1例原发低龄腮腺多形性腺瘤患者的临床资料,并结合文献复习,讨论该疾病的临床特征与与年龄的关系,并得出:早期发现,选择合适的术式及切口,术后随访可有效降低低龄患者的肿瘤复发率。      

Extramedullary plasmacytoma of the parotid gland: report of a case and review of the literature

A case of primary extramedullary plasmacytoma (PEMP) with local amyloid deposition arising in the left parotid gland of a 78-year-old woman is described. The present case was studied with immunologic techniques with results confirming that the neoplastic cells were of monoclonal nature, producing lambda-light chains alone. PEMPs of the salivary glands are rare, with only 8 cases reported in the literature. The salient features of these 9 cases are summarized. Problems connected with the clinical, pathological and therapeutic aspects of PEMP with regard to the rare parotid location are discussed.     

腮腺基底细胞腺瘤超声表现1例报告及文献复习

基底细胞腺瘤是涎腺上皮性肿瘤中罕见的一种良性肿瘤．属于单形性腺瘤中的一种。我院于2011年2月收治1例,现报告如下。     

女性尿道周围腺癌1例报道并文献复习

目的提高对女性尿道腺癌的认识。方法通过光镜和免疫组化染色,对1例女性尿道周围腺癌进行病理学检查,并进行文献复习。结果本例术后病理诊断为尿道周围腺癌,肿瘤位于尿道与阴道之间,为不同分化程度及形态结构的腺癌。结论腺性尿道炎可能是女性尿道腺癌的起因之一。手术应彻底,女性尿道腺癌对化疗和放疗较敏感。     

Primary leiomyosarcoma of the thyroid gland with prior malignancy and radiotherapy:A case report and review of literature

BACKGROUND Leiomyosarcoma(LMS) of the thyroid gland is a rarely presented tumor that offers poor prognosis. To the best of the authors' knowledge, there currently exist only 28 known cases described in the literature(limited to English).CASE SUMMARY Herein a case is reported of a 60-year-old female patient who had an LMS of the thyroid, which was accompanied by periodic dysphonia and breathing disorder as well as the feeling of pressure in the chest and neck. At the time the disease was diagnosed, no metastases were detected. Prior to the diagnosis, the patient experienced a uterine adenocarcinoma that had been treated by surgical procedure and radiotherapy. For the LMS, a total thyroidectomy was performed,followed by radiotherapy. Since metastases were also discovered in the lungs,sternum, and femur, chemotherapy was administered as well.Immunohistochemically, the tumor cells in the thyroid indicated positively for alpha smooth muscle actin, calponin, and H-caldesmon, but were negative for CD34, p63, estrogen receptor, progesterone receptor, and Epstein-Barr virus.CONCLUSION Although the etiology of the LMS is as of yet unknown, prior malignancy and radiation should be considered as risk factors.     

CT并MRI误诊断腮腺非特异性腺癌1例

<正>患者男,34岁,右侧腮腺咬肌区肿胀伴张口受限1月余。患者自述1月前右侧下磨牙间断性疼痛,自行服用药物"布洛芬",疼痛未缓解。专科查体:右侧面颊部明显肿胀,肿胀区上界至耳屏前、颧弓区,下界至下颌骨下缘,前至咬肌前缘,后至颌后区,质地较硬,未触及明显深部波动感,皮温较对侧稍升高,轻度压痛,张口重度受限,右侧下颌磨牙区黏膜稍肿胀,双侧腮腺导管口红肿,挤压右侧腮腺未见明显分泌物。右侧颌下可触及肿物一枚,约3.5 cm×3.0 cm大小,     

腮腺结节性筋膜炎2例报道并文献复习

目的 探讨腮腺结节性筋膜炎的临床病理学特征及其鉴别诊断。方法 对2例发生在腮腺内的结节性筋膜炎进行光镜观察和免疫组化标记。结果 2例均表现为右耳下生长迅速的无痛性肿块。镜检病变周界相对清楚，均由增生的梭形细胞组成，呈不规则或交叉的短条束状排列，背景疏松，黏液水肿样。其中1例冷冻切片下酷似肉瘤。免疫组化标记显示增生的梭形细胞Vim、α-SMA和MSA( )，CK、S-100和CFAP(-)。结论 原发于腮腺内的结节性筋膜炎十分罕见，尽管在临床病理学方面与发生在其他部位的结节性筋膜炎并无差异，但易误诊为各种类型的肉瘤，尤其是在细胞丰富并可见到较多核分裂象时，尤应注意。     

Cystic teratoma of the parotid gland: A case report

BACKGROUNDTeratoma is a common tumor, but rarely occurs in the parotid region. Only nine cases have been reported in the current literature. Although it is generally detected in infancy or childhood, it is commonly asymptomatic. Computed tomography (CT) and magnetic resonance imaging (MRI) have important roles in the diagnosis of teratoma.CASE SUMMARYA 36-year-old man developed a lump located below the left auricular lobule 3 years ago. Physical examination revealed a nearly-circular tumor in the left parotid gland region with a defined border, firm texture, and significant movement. Calcification, fat, keratinized substances, and typical fat-liquid levels was observed on CT and MRI. A diagnosis of cystic teratoma of the parotid gland was established preoperatively and confirmed by postoperative pathology. Following surgery, the patient developed temporary facial paralysis. There was no recurrence of teratoma during the 15-mo follow-up period.CONCLUSIONWhen an asymptomatic mass in the parotid region is identified, parotid gland teratoma should be included in the differential diagnosis. Imaging examinations are helpful in the diagnosis.     

Papillary cystadenoma of the parotid gland: A case report

BACKGROUND Papillary cystadenoma is a rare benign epithelial tumor of the salivary gland,which is characterized by papillary structures and oncocytic cells with rich eosinophilic cytoplasm. We found only one case of papillary cystadenoma in nearly 700 cases of salivary gland tumors. Our case was initially mistaken for a tumor of the right temporomandibular joint(TMJ) capsule rather than of parotid gland origin. Preoperative magnetic resonance imaging(MRI) and computed tomography(CT) should be carefully studied, which allows for appropriate preoperative counseling and operative planning.CASE SUMMARY Here, we report an unusual case of a 54-year-old woman with a parotid gland papillary cystadenoma(PGPC) that was misdiagnosed as a tumor of the right TMJ capsule. She was initially admitted to our hospital due to a mass anterior to her right ear inadvertently found 5 d ago. Preoperative CT and MRI revealed a well circumscribed tumor that was attached to the right TMJ capsule. The patient underwent a resection through an incision for TMJ, but evaluation of an intraoperative frozen section revealed a benign tumor of the parotid gland. Then we removed part of the parotid gland above the temporal facial trunk. The facial nerve was preserved. Postoperative histopathological findings revealed that the tumor was PGPC. No additional treatment was performed. There was no recurrence during a 20-mo follow-up period.CONCLUSION The integrity of the interstitial space around the condyle in MRI or CT should be carefully evaluated for parotid gland or TMJ tumors.     

腮腺内面神经鞘瘤一例

<正>患者,女性,68岁。因5个月前发现左耳垂下无痛性包块入院。入院检查:左侧耳垂下可触及一大小约30 mm×25 mm的肿块,无明显压痛,质中,界不清,与周围组织稍粘连,活动度欠佳,左侧眼睑闭合不全,皱眉困难,左侧口角歪斜,张口度张口型正常,腮腺导管口无红肿及分泌物异常,咽侧壁无隆起,颌下及颈部淋巴结阴性。既往体健,无家族、遗传史。实验室检查:血常规示     

腮腺低度恶性筛状囊腺癌1例报告并文献复习

目的 提高对腮腺低度恶性筛状囊腺癌的认识.方法 通过对1例腮腺低度恶性筛状囊腺癌的临床资料和免疫组化结果 进行分析,并复习国内外相关文献.结果 腮腺低度恶性筛状囊腺癌是由单个或多个囊及邻近的导管内增生构成,导管内增生的导管上皮呈筛状、微乳头状和实性.免疫组化染色,导管内筛状增生细胞S-100弥漫阳性,Ki-67呈阳性,导管肌上皮细胞P63阳性.此例患者经过根治性手术后随访1a无复发.结论 腮腺低度恶性筛状囊腺癌在临床上是一种罕见的涎腺肿瘤,其确诊主要依靠病理学免疫组化检查,治疗以根治性手术为主.     

Rare submandibular gland metastasis of hepatocellular carcinoma: case report and review of the literature

Hepatocellular carcinoma (HCC), the most common primary hepatic tumor, metastasizes in more than 50% of cases. However, metastasis of HCC to the submandibular glands is very rare. HCC rarely metastasizes to the salivary glands; only six cases of metastasis to the parotid gland have been reported in the English-language literature. Moreover, only one case of metastasis of HCC to the submandibular glands has been reported to date, and the affected patient died of hepatic failure. This clinical report describes a 55-year-old man who had undergone two surgeries for liver cancer and subsequently presented with a 2-week history of a right submandibular mass. We performed dissection of the right submandibular triangle, and metastatic HCC of the submandibular gland was diagnosed. Although HCC metastases to the oral cavity have been reported, this is only the second case of HCC metastasis to the submandibular gland. Fine-needle aspiration biopsy is recognized as a simple, direct approach for morphologic diagnosis of salivary gland lesions; however, histological and immunohistochemical examination of the surgical specimen remains necessary.     

Diffuse large B-cell lymphoma with concurrent gastric adenocarcinoma: case report and literature review

The simultaneous occurrence of diffuse large B-cell lymphoma (DLBCL) and gastric carcinoma is rare. The present case report describes a 61-year-old man with DLBCL at the ileocaecal junction with several metastatic lymph nodes and concurrent gastric intramucosal adenocarcinoma. Both tumours, together with the enlarged lymph nodes, were successfully removed by surgery. At 1 month postoperatively, the patient received chemotherapy consisting of rituximab, cyclophosphamide, vindesine, epirubicin hydrochloride and dexamethasone; he responded well to treatment. Reports published in the literature between January 2006 and March 2011 of other cases of DLBCL combined with concurrent non-haematological malignancies in immunocompetent patients were reviewed. The identification of common factors is important for clarification of the mechanisms of lymphomagenesis and carcinogenesis, as well as the creation of preventive and therapeutic strategies. Such cases highlight the need routinely to perform preoperative imaging studies to exclude other synchronous tumours and, if possible, to biopsy any such masses in order to offer timely and appropriate therapy.