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氟烷七氟醚对酶诱导缺氧大鼠脂过氧化反应的影响(氟烷性肝炎的… 总被引:1,自引:0,他引:1
雄性SD大鼠饮用含苯巴比妥(1mg/ml)的饮水一周后,随机分为6组,每组6例:NC,21%O2/79%N2;HC,14%O2/86%N2;NH,21%O2/79%N2/1.2MAC氟烷;HH,14%O2/86%N2/1.2MAC氟烷;NS,21%O2/79%N2/1.2MAC七氟醚;HS,14%O2/86%N2/1.2MAC七氟醚。吸入时间1h,24h后测定血浆及肝匀浆中MDA、SOD、游离巯基 相似文献
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30例绝经后妇女口服尼尔雌醇(CEE3),每2周2mg共1年。治疗前后均采用单光子吸收法(SPA)进行桡骨骨密度(BMD)测量,进行血骨钙素(BGP)、血降钙素(CT)、血雌二醇(E2)、血卵泡刺激素(FSH)及空腹尿钙/尿肌酐(Ca/Cr)测定。结果显示CEE3治疗1年后治疗组骨BMD增加1.1%,而对照组下降3.3%;血BGP显著下降(P<0.01);尿Ca/Cr下降。本文提示,CEE3能降低骨转换率,有效防止绝经后妇女的骨质疏松 相似文献
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氟烷,七氟醚对酶诱导,缺氧大鼠肝细胞钙平衡的影响:钙离子… 总被引:1,自引:0,他引:1
雄性Sprague-Dawley(SD)大鼠饮用含苯巴妥(1mg/ml)的水一周后,随机分为6组,分别吸入下列气体1小时:NC,21%O2/79%N;HC,14%O2/86%N;NS,21%O2/N2/1。2MAC七氟醚;HS,14%O2/N2/1。2MAC七氟醚;NH,21%O2/N2/1。2MAC氟烷;HH,14%O2/N2/1。2MAC氟烷。24小时后用草酸钾-焦锑酸钾沉淀法对肝脏钙离子进行 相似文献
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雄性SD大鼠饮用含苯巴比妥(1mg/ml)的饮水一周后,随机分为6组,每组6例:NC,21%O2/79%N2;HC,14%0;186%Ne;NH,21%O2/79%N2/1.2MAC氟烷;HH,14%O2/86%N2/1.2MAC氟烷;NS,21%O2/79%N2/1.2MAC七氟醚;HS,14%O2/86%N2/1.2MAC七氟醚。吸入时间1h,24h后测定血浆及肝匀浆中MDA、SOD、游离琉基的含量。结果HH、NH组肝匀浆及血浆中MDA、SOD的含量均高于其它各组(P<0.01,P<0.05),余各组间均无显著差异(P>0.05)。NH、HH组血浆及肝匀浆中游离琉基的含量显著低于其它各组(P<0.01)。提示氟烷所致的肝脂过氧化反应增强的作用可能与其肝毒性有关,而七氟醚无促进肝脏脂过氧化反应增强的作用。 相似文献
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1,25(OH)2D3口服冲击治疗透析患者继发性甲状旁腺功能亢进 总被引:1,自引:0,他引:1
1,25(OH)_2D_3口服冲击治疗透析患者继发性甲状旁腺功能亢进陶立坚,池田,孙明OBSERVATIONONSHORT-TIMEEFFECTOFORAI.1,25(OH)_2,D_3PULSETHERAPYINHEMODIALYSISPATIEN... 相似文献
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雄性SD大鼠饮用含苯巴比妥钠(1mg/ml)的饮水1周后,随机分为四组,每组8例,分别吸入:C,14%O_2/86%N_2;E,14%O_2/86%N_2/1.2MAC安氟醚;S,14%O_2/86%N_2/1.2MAC七氟醚;H,14%O_2/86%N_2/1.2MAC氟烷1h。24h后发现H组血浆ALT活性显著高于其它各组,并有明显的小叶中心性肝细胞坏死及汇管区炎细胞浸润,血窦重度充血。E组可见部分肝小叶内有小叶中心性坏死及空泡变性。H组肝匀浆及血浆中TXB_2含量显著高于其它各组。6-keto-PGF1a各组间均无显著差异。提示氟烷性肝炎与TXA_2/PGI_2平衡失调有一定的关系。 相似文献
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雄性SD大鼠饮用含苯巴比妥钠(1mg/ml)的饮水1周后,随机分为四组,每组8例,分别吸入:C,14%O2/86%N2;E,14%O2/86%N2/1.2MAC安氟醚;S,14%O2/86%N2/1.2MAC七氟醚;H,14%O2/86%N2/1.2MAC氟烷1h。24h后发现H组血浆ALT活性显著高于其它各组,并有明显的小叶中心性肝细胞坏死及汇管区炎细胞浸润,血窦重度充血。E组可见部分肝小叶内有 相似文献
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目的:观察自体造血干细胞移植(AHSCT)治疗恶性血液病和晚期肺癌(ALC)的疗效。方法:8例急性白血病(AL),2例恶性淋巴瘤(ML)和1例ALC用AHSCT治疗。AL,ML,ALC分别用MAC(马尘兰,阿糖胞苷,环磷酰胺),MeEAM(甲基环己亚硝脲,足叶乙甙,阿糖胞苷,马法兰),MeEEC(甲基环己亚硝脲,足叶乙甙,表阿霉素,环磷酰胺(方案预处理。 相似文献
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血液透析对尿毒症胰岛素拮抗和糖代谢的影响 总被引:3,自引:0,他引:3
目的研究血液透析对尿毒症胰岛素拮抗和糖代谢的影响。方法采用口服葡萄糖耐量试验(OGTT)和胰岛素释放试验(IRT)方法,检测22例血透(HD),22例非透析(ND)尿毒症者和12例正常者胰岛素敏感指数(ISI)、机体糖利用率(M)、糖和胰岛素反应曲线下面积(AUCG和AUCINS)。结果(1)HD组糖负荷后血糖、胰岛素水平及其AUCG、AUCINS均显著低于ND组,但仍明显高于正常对照组;(2)HD组ISI、M值显著高于ND组,但明显低于正常对照组,其胰岛素拮抗(IR)和糖耐量异常(IGT)发生率均显著低于ND组:(3)胰岛素拮抗组血透时间显著短于非胰岛素拮抗组,透析时间与ISI有正相关趋势;(4)HD组较ND组血pH值、血HCO-3水平显著增高,但N-PTH水平显著低下。结论HD可部分改善尿毒症胰岛素拮抗,高胰岛素血症和糖耐量异常。 相似文献
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雄性SD大鼠饮用含苯巴比妥(1mg/ml)的饮水一周后,随机分为6组,每组6例:NC,21%O2/79%N2;HC,14%O2/86%N2;NS,21%O2/79%N2/1.2MAC七氟醚;HS,14%O2/86%N2/1.2MAC七氟醚;NH,21%O2/79%N2/1.2MAC氟烷;HH,14%O2/86%N2/1.2MAC氟烷。吸入时间1h、24h后用高效液相色谱法测定血浆中11种游离氨基酸的含量。结果NH与HH组酪、精、丝、甘、丙、苏、谷氨酰胺含量升高,而支链氨基酸无明显变化。提示氟烷性肝炎的氨基酸谱的变化类似于急性暴发性肝衰竭。 相似文献
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Young KH Chan WC Fu K Iqbal J Sanger WG Ratashak A Greiner TC Weisenburger DD 《The American journal of surgical pathology》2006,30(8):954-961
The differentiation of B lymphocytes into plasma cells (PCs) is an antigen-mediated process that largely depends on the interaction between B cells and regulatory factors in their microenvironment. Long-lived PCs are derived from activated B cells in the germinal center (GC), whereas PC differentiation from naive B cells occurs in the extrafollicular areas and the PCs are short-lived. Consequently, lymphomas arising from post-GC B cells often exhibit plasmacytic differentiation, whereas lymphomas arising from naive B cells less commonly show plasmacytic differentiation. Herein, we report 2 cases of mantle cell lymphoma (MCL) with clonal PC differentiation. Both cases presented with the typical cytologic features of MCL and were characterized by a nodular and mantle-zone growth pattern. Clusters of clonal PCs with monotypic kappa light chain expression were identified in the centers of the tumor nodules and within reactive GCs. FICTION (Fluorescence immunophenotyping and Interphase Cytogenetics as a Tool for the Investigation Of Neoplasms) analysis demonstrated the characteristic t(11;14)(q13;q32) in both the MCL cells and clonal PCs, indicating that both cell types were derived from the same B-cell clone. These findings indicate that the clonal PC differentiation may occur within GCs in some cases of MCL. 相似文献
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番茄红素抑制前列腺癌LnCaP细胞增殖 总被引:6,自引:0,他引:6
目的:探讨人体血清中番茄红素(1ycopene)水平与前列腺癌发病相关性.方法:将在加入0.5μmol/L,5 μmol/L,10μmol/L,15 μmol/L不同浓度番茄红素溶液的培养基中生长48 h后的LnCaP细胞,与在相对应浓度番茄红素溶剂-四氢叶酸酯中以及RPMI1640培养基中生长的各组细胞增殖率进行比较.观察体外培养条件下不同浓度番茄红素对前列腺癌LnCaP细胞系增殖的影响.结果:与在相对应浓度溶剂中生长的细胞相比,番茄红素溶液的培养基中生长的LnCaP细胞,细胞增殖分别减少了2.66%,4.29%,3.73%,13.66%(P<0.05).与在RPMI培养基中生长的细胞相比,在加入5μmol/L,10μmol/L,15 μmol/L番茄红素溶液的培养基中生长的LnCaP细胞,细胞增殖分别减少了8.12%,6.33%,12.00%(P<0.05).结论:番茄红素在体外培养条件下对前列腺癌LnCaP细胞的增殖有显著的抑制作用. 相似文献
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HERMAN S FERNANDO SIMON J HAWKYARD PHILIP POON MOHAMMED MUSA 《International journal of urology》2006,13(7):985-986
We report a case of an elderly gentleman with renal cell carcinoma presenting with the rare entity of non-islet cell tumor hypoglycemia (NICTH). Non-islet cell tumor hypoglycemia syndrome is caused by the tumor producing insulin-like growth factor II, causing hypoglycemia. The syndrome is most commonly associated with very large fibromas or fibrosarcomas. 相似文献
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胚胎干细胞具有多向分化潜能,在组织修复治疗方面具有广阔的应用前景.近年研究表明,胚胎干细胞在细胞因子、激素、微环境等作用下能够分化为软骨细胞.本文对近年来胚胎干细胞向软骨细胞定向分化中的各种因素进行综述. 相似文献
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Stem cell regulation in continuous hematopoietic cell culture 总被引:3,自引:0,他引:3
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Small cell squamous and mixed small cell squamous--small cell anaplastic carcinomas of the lung 总被引:2,自引:0,他引:2
Five patients are presented who had neoplasms which, by light microscopy and in two cases cytologically, appeared to be small cell anaplastic (polygonal and fusiform cell type) carcinomas of the lung. However, by electron microscopy, four of the carcinomas exhibited squamous characteristics including desmosomes and tonofilament bundles, and lacked demonstrable neurosecretory granules, suggesting that they were small cell squamous carcinomas. The fifth carcinoma contained cells with neurosecretory granules as well as cells demonstrating squamous differentiation. One patient died within 3 months of presentation. Three patients survived for approximately 18 months each; two received chemotherapy but one was treated by surgical resection alone. The fifth patient had a peripheral coin lesion which was treated by surgical resection only; he is alive without evidence of recurrent carcinoma 1 year after operation. We suggest that some carcinomas of the lung with the light-microscopic and cytologic appearance of small cell anaplastic carcinoma are actually small cell variants of squamous cell carcinoma and lack the characteristic neurosecretory granules of classic small cell carcinoma. The behavior of these tumors needs to be determined. 相似文献